Journal of Analytical Oncology最新文献_第10页

Mutagenesis Associated with DNA-Damage-Stress Response 突变与dna损伤应激反应相关

Journal of Analytical Oncology Pub Date : 2016-04-05 DOI: 10.6000/1927-7229.2016.05.01.4

R. Skopec

引用次数: 2

Abiraterone Acetate in Patients with Advanced Castrate Resistant Prostate Cancer: Initial Real Life Experience in 2 Cancer Units 晚期去势抵抗性前列腺癌患者的醋酸阿比特龙:2个癌症单位的初始真实生活经验

Journal of Analytical Oncology Pub Date : 2016-04-05 DOI: 10.6000/1927-7229.2016.05.01.6

J. Zekri, A. Ramadan, Muthu Kumar, R. Haggag

{"title":"Abiraterone Acetate in Patients with Advanced Castrate Resistant Prostate Cancer: Initial Real Life Experience in 2 Cancer Units","authors":"J. Zekri, A. Ramadan, Muthu Kumar, R. Haggag","doi":"10.6000/1927-7229.2016.05.01.6","DOIUrl":"https://doi.org/10.6000/1927-7229.2016.05.01.6","url":null,"abstract":"Introduction : Abiraterone Acetate (AA) improves outcome of patients with castrate resistant prostate cancer (CRPC) and is currently recommended for chemo-naA¯ve patients and after progression on chemotherapy. We reviewed our initial experience with the use of AA in these patients. Patients and Methods : Forty six consecutive CRPC patients were treated with AA 1000 mg/day and prednisolone 5 mg twice daily in 2 cancer centres in England and Saudi Arabia. Treatment was continued until disease progression or unacceptable toxicity. Patients achieving prostate specific antigen decline (PSA) â‰¥ 50% were considered as marker responders. Results : Median age was 76 (52-91) years. 28 and 18 patients received AA in pre-chemotherapy and post-chemotherapy setting respectively. PSA marker response was achieved in 56.1% (23/41) assessable patients. Objective radiological response rate was seen in 31.6% (6/19) and stable disease in 15.8% (3/19) assessable patients. After a median follow up of 20 months, median time to PSA progression was 12 months (95% CI: 9.5-14.5) and median overall survival was not reached (mean = 21 months, 95% CI: 18-24.5). Toxicity was assessed in 18 patients. All grades adverse events of special interest were hypokalaemia (22%) and hypertension (11%). Conclusion : In daily clinical practice, AA is an effective treatment for patients with CRPC. It produces meaningful marker and objective responses, marker progression free survival and OS that are comparable to those reported in clinical trials. Monitoring of blood pressure and serum potassium is recommended.","PeriodicalId":14957,"journal":{"name":"Journal of Analytical Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81666094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Peritoneal Carcinomatosis and Multi-Organ Metastases are Prognostic Factors in Colorectal Cancer: A Retrospective Analysis 腹膜癌和多器官转移是结直肠癌的预后因素:回顾性分析

Journal of Analytical Oncology Pub Date : 2016-04-05 DOI: 10.6000/1927-7229.2016.05.01.1

J. Garde-Noguera, M. Gil-Raga, AsunciÃ³n JuÃ¡rez-MarroquÃ, S. Maciá-Escalante, Manuel Terradez-Gurrea, C. Camps-Herrero, A. Llombart-Cussac

{"title":"Peritoneal Carcinomatosis and Multi-Organ Metastases are Prognostic Factors in Colorectal Cancer: A Retrospective Analysis","authors":"J. Garde-Noguera, M. Gil-Raga, AsunciÃ³n JuÃ¡rez-MarroquÃ, S. Maciá-Escalante, Manuel Terradez-Gurrea, C. Camps-Herrero, A. Llombart-Cussac","doi":"10.6000/1927-7229.2016.05.01.1","DOIUrl":"https://doi.org/10.6000/1927-7229.2016.05.01.1","url":null,"abstract":"Background : Peritoneal carcinomatosis and multi-organ metastases might be prognostic factors in patients with advanced colorectal cancer and inoperable metastases at diagnosis. Methods : A retrospective study was performed to examine the relationship between patient clinical characteristics and prognosis in patients with colorectal cancer and indication for first-line systemic chemotherapy. Results : One hundred and twelve patients were accrued. According to univariate analysis, peritoneal carcinomatosis, lack of primary tumour resection and multi-organ metastases were associated with poor overall survival. According to multivariate analysis, patients with peritoneal carcinomatosis and patients with multi-organ metastases had a shorter overall survival (12 vs 27.0 months, p<0.001 and 14,6 vs 27 months, p=0.007, respectively). Conclusions : Our results indicate that presence of peritoneal carcinomatosis and multi-organ metastases are independent predictors of poor outcome for patients with colorectal cancer undergoing first line treatment with standard chemotherapy.","PeriodicalId":14957,"journal":{"name":"Journal of Analytical Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77138644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cancer Stem-Cell Related miRNAs: Novel Potential Targets for Metastatic Prostate Cancer 癌症干细胞相关mirna:转移性前列腺癌的新潜在靶点

Journal of Analytical Oncology Pub Date : 2015-12-11 DOI: 10.6000/1927-7229.2015.04.04.4

A. Singh, Anand P Khandwekar, Neeti Sharma

{"title":"Cancer Stem-Cell Related miRNAs: Novel Potential Targets for Metastatic Prostate Cancer","authors":"A. Singh, Anand P Khandwekar, Neeti Sharma","doi":"10.6000/1927-7229.2015.04.04.4","DOIUrl":"https://doi.org/10.6000/1927-7229.2015.04.04.4","url":null,"abstract":"Globally Prostate Cancer is the second most commonly diagnosed and sixth leading cause of Cancer mortalities in men worldwide but currently there is no cure for metastatic castration-resistant prostate cancer (CRPC). Chemoresistance and metastasis are the main causes of treatment resistance and mortality in Prostate Cancer patients. Although several advances have been made to control yet there is an urgent need to investigate the mechanisms and pathways for chemoresistance and prostate cancer (PCa) metastasis. Cancer stem cells (CSCs), a sub-population of cancer cells characterised by self-renewal and tumor initiation, have gained intense attention as they not only play a crucial role in cancer relapse but also contribute substantially to chemoresistance. Contributing to the role of CSCs are the miRNAs which are known key regulators of the posttranscriptional regulation of genes involved in a wide array of biological processes including tumorigenesis. The altered expressions of miRNAs have been associated with not only with tumor development but also with invasion, angiogenesis, drug resistance, and metastasis. Thus identification of signature miRNA associated with EMT and CSCs would provide a novel therapeutic strategy for the improvement of current treatment thus leading to increase in patientâ€™s survival.","PeriodicalId":14957,"journal":{"name":"Journal of Analytical Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86116154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

pH Monitoring of Tumor Microenvironment and Low Volume of Urine in Experimental Rats 实验大鼠肿瘤微环境与低尿量pH监测

Journal of Analytical Oncology Pub Date : 2015-12-11 DOI: 10.6000/1927-7229.2015.04.04.3

T. Kisková, Steffekova Zuzana, Karasova Martina, Kokosova Natalia

引用次数: 0

The Role of the IGF Axis in Epithelial-to-Mesenchymal Transition during the Progression of Prostate Cancer 前列腺癌进展过程中IGF轴在上皮向间质转化中的作用

Journal of Analytical Oncology Pub Date : 2015-12-11 DOI: 10.6000/1927-7229.2015.04.04.5

R. Mansor, A. Bahl, J. Holly, C. Perks

{"title":"The Role of the IGF Axis in Epithelial-to-Mesenchymal Transition during the Progression of Prostate Cancer","authors":"R. Mansor, A. Bahl, J. Holly, C. Perks","doi":"10.6000/1927-7229.2015.04.04.5","DOIUrl":"https://doi.org/10.6000/1927-7229.2015.04.04.5","url":null,"abstract":"Prostate cancer is the second most common lethal cancer in men worldwide. Despite the fact that the prognosis for patients with localized disease is good, many patients succumb to metastatic disease with the development of resistance to hormone treatments. This is normally termed castration-resistant prostate cancer (CRPC). The development of metastatic, castration-resistant prostate cancer has been associated with epithelial-to-mesenchymal transition (EMT), a process where cancer cells acquire a more mesenchymal phenotype with enhanced migratory potential, invasiveness and elevated resistance to apoptosis. The main event in EMT is the repression of epithelial markers such as E-cadherin and upregulation of mesenchymal markers such as N-cadherin, vimentin and fibronectin. The insulin-like growth factor (IGF) signalling axis is essential for normal development and maintenance of tissues, including that of the prostate, and dysregulation of this pathway contributes to prostate cancer progression and malignant transformation. It is becoming increasingly clear that one of the ways in which the IGF axis impacts upon cancer progression is through promoting EMT. This review will explore the role of EMT in prostate cancer progression with a specific focus on the involvement of the IGF axis and its downstream signalling pathways in regulating EMT in prostate cancer.","PeriodicalId":14957,"journal":{"name":"Journal of Analytical Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84782494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

TCTP silencing in ovarian cancer cells results in actin cytoskeleton remodeling and motility increase 卵巢癌细胞中TCTP沉默导致肌动蛋白细胞骨架重塑和运动性增加

Journal of Analytical Oncology Pub Date : 2015-12-11 DOI: 10.6000/1927-7229.2015.04.04.1

Yianzhu Liu, Li Zhang, N. Tejpal, J. Kubiak, R. Ghobrial, X. Li, M. Kloc

引用次数: 1

Extracellular HSP90 in Cancer Invasion and Metastasis: From Translational Research to Clinical Prospects 细胞外热休克蛋白90在肿瘤侵袭和转移中的作用:从转化研究到临床前景

Journal of Analytical Oncology Pub Date : 2015-12-11 DOI: 10.6000/1927-7229.2015.04.04.7

D. Thomaidou, E. Patsavoudi

引用次数: 1

Standardized Extract of the Persian Gulf Sponge, Axinella Sinoxea Selectively Induces Apoptosis through Mitochondria in Human Chronic Lymphocytic Leukemia Cells 波斯湾海绵标准提取物Axinella Sinoxea通过线粒体选择性诱导人慢性淋巴细胞白血病细胞凋亡

Journal of Analytical Oncology Pub Date : 2015-12-11 DOI: 10.6000/1927-7229.2015.04.04.2

A. Salimi, Mehrnoush Pir Saharkhiz, A. Motallebi, Enayatollah Seydi, A. Mohseni, M. Nazemi, J. Pourahmad

{"title":"Standardized Extract of the Persian Gulf Sponge, Axinella Sinoxea Selectively Induces Apoptosis through Mitochondria in Human Chronic Lymphocytic Leukemia Cells","authors":"A. Salimi, Mehrnoush Pir Saharkhiz, A. Motallebi, Enayatollah Seydi, A. Mohseni, M. Nazemi, J. Pourahmad","doi":"10.6000/1927-7229.2015.04.04.2","DOIUrl":"https://doi.org/10.6000/1927-7229.2015.04.04.2","url":null,"abstract":"Sponges are important components of the Persian Gulf animal communities. The marine sponges of the genus Axinella sinoxea is are a genus of sponges in the family Axinellidae . Species of Axinella sinoxea occur in the India, Pacific Oceans and also Persian Gulf. Chronic lymphocytic leukemia (CLL) is a disease characterized by the relentless accumulation of CD5 + B lymphocytes. CLL is the most common leukemia in adults, about 25â€“30% of all leukemias. In this study B lymphocytes mitochondria (both cancerous and non-cancerous) were isolated using differential centrifugation from peripheral blood samples and succinate dehydrogenase activity, mitochondrial reactive oxygen species (ROS) production, collapse of mitochondrial membrane potential (MMP), mitochondrial swelling and finally release of cytochrome C were examined following the addition of methanolic extract of Axinella sinoxea . Our results showed that only in mitochondria isolated from cancerous BUT NOT normal lymphocytes a significant (P < 0.05) increase in mitochondrial ROS formation, MMP collapse, mitochondrial swelling and cytochrome c release. These results showed that Axinella sinoxea extract has a selective toxicity on chronic lymphocytic leukemia lymphocytes and their mitochondria and hence may be considered as a promising anti CLL candidate for further studies needed as a supplement for cancer patients in the future","PeriodicalId":14957,"journal":{"name":"Journal of Analytical Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78117159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Neuroendocrine Differentiation and Epithelial to Mesenchymal Transition in Prostate Cancer: cAMP-Dependent Signaling as a Therapeutic Target 前列腺癌的神经内分泌分化和上皮向间质转化:camp依赖信号作为治疗靶点

Journal of Analytical Oncology Pub Date : 2015-12-11 DOI: 10.6000/1927-7229.2015.04.04.6

C. Myers

引用次数: 0