Extracellular HSP90 in Cancer Invasion and Metastasis: From Translational Research to Clinical Prospects

During the last decade, the extracellular molecular chaperone HSP90 (eHSP90) has been identified as a critical effector in cancer cell invasion and metastasis by virtue of its interaction with a diverse cohort of molecules that serve as key nodal points in oncogenic pathways. Thus eHSP90 has most recently emerged as a novel target in cancer therapeutics, subsequently becoming the focus of several drug development efforts. This review highlights recent studies on the mechanisms through which eHSP90 exhibits its tumor cell invasion action. It also presents latest efforts to translate this cumulative knowledge into clinical practice to disable eHSP90-driven metastasis.