突变与dna损伤应激反应相关

R. Skopec
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引用次数: 2

摘要

在这份手稿中,我们的目标是采取争议在肿瘤学,如那些有关的成本和筛选指南。我们最近是否处于现有方法的新转折点?在过去的30年里,意识和筛查方法的发展使人们重视癌症的早期诊断,而不仅仅是癌症。最近的趋势和临床试验表明,这些目标尚未实现。国际数据表明,早期疾病显著增加,而晚期疾病没有成比例减少。我们需要在方法上更加区分,因为癌症具有多种途径的异质性,并非所有的途径都进展为转移和死亡。这种更广泛的癌症定义还必须包括在患者一生中不会造成伤害的惰性疾病。过度诊断和过度治疗导致数十亿美元的金钱浪费。我们的方法论必须以适当考虑现实环境的方法来完成。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mutagenesis Associated with DNA-Damage-Stress Response
In this manuscript we aim to take on the controversies in oncology, such as those related to costs and screening guidelines. Are we recently at new turning point with our existing methodology? During the past 30 years of evolution methods of awareness and screening have lead to an emphasis on early diagnoses of cancer and not only cancer. Recent trends and clinical trials show that these goals have not been met. International data demonstrate significant increase in early stage disease, without a proportional decrease in later-stage disease. We need to more differentiate in methodology because cancers are heterogenous with multiple paths, not all of which progress to metastases and death. This broader definition of disease named cancer must include also indolent disease that causes no harm during patients lifetime. Overdiagnosis and overtreatment result in billions of USD of wasted money. Our methodology must be completed with methods which take proper account of the real-life environment.
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