Journal of Advanced Pharmaceutical Technology & Research最新文献_第8页

The radical scavenging activity of vanillin and its impact on the healing properties of wounds. 香兰素的自由基清除活性及其对伤口愈合性能的影响。

IF 1.4

Journal of Advanced Pharmaceutical Technology & Research Pub Date : 2023-04-01 Epub Date: 2023-04-13 DOI: 10.4103/japtr.japtr_631_22

Chutima Sinsuebpol, Kanokporn Burapapadh, Verisa Chowjaroen, Narumon Changsan

{"title":"The radical scavenging activity of vanillin and its impact on the healing properties of wounds.","authors":"Chutima Sinsuebpol, Kanokporn Burapapadh, Verisa Chowjaroen, Narumon Changsan","doi":"10.4103/japtr.japtr_631_22","DOIUrl":"10.4103/japtr.japtr_631_22","url":null,"abstract":"Vanillin, an extract from the Vanilla planifolia plant, is reported to possess potent antioxidant properties. The ability of vanillin to protect skin cells from reactive oxygen species (ROS)-induced damage and its potential use in the treatment of wounds were studied. Cytocompatibility and cytoprotective properties against ROS-induced damage were examined using keratinocyte and fibroblast cell models. Vanillin's effect on cell migration was studied using the scratch wound healing assay. Vanillin exhibited cytocompatibility and cytoprotective properties against cell damage induced by ROS. Human keratinocytes and fibroblast cells showed >80% survival when exposed to vanillin (10-500 μM). Both cells showed no evidence of necrosis or apoptosis, which was confirmed by acridine orange/propidium iodide staining. Both examined cells were exposed to 750 μM hydrogen peroxide to cause oxidative stress, and vanillin demonstrated the ability to inhibit ROS-induced cell death. In addition, a considerable increase in cell migration suggested that vanillin had the ability to heal wounds in vitro. Vanillin is safe and potentially useful in wound healing treatments.","PeriodicalId":14877,"journal":{"name":"Journal of Advanced Pharmaceutical Technology & Research","volume":"14 2","pages":"99-104"},"PeriodicalIF":1.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/32/31/JAPTR-14-99.PMC10226704.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9908544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Solvent preextraction influenced to coumarin and glucose binding capacity of cinnamomi's extracts. 溶剂预处理对肉桂提取物香豆素和葡萄糖结合能力的影响。

IF 1.4

Journal of Advanced Pharmaceutical Technology & Research Pub Date : 2023-04-01 Epub Date: 2023-04-13 DOI: 10.4103/japtr.japtr_671_22

Martha Ervina, Virgiana Kristin Coco Wea, Annisah Oktaviani, Lanny Hartanti, Restry Sinansari, Yufita Ratnasari Wilianto, Steven, Caroline

{"title":"Solvent preextraction influenced to coumarin and glucose binding capacity of cinnamomi's extracts.","authors":"Martha Ervina, Virgiana Kristin Coco Wea, Annisah Oktaviani, Lanny Hartanti, Restry Sinansari, Yufita Ratnasari Wilianto, Steven, Caroline","doi":"10.4103/japtr.japtr_671_22","DOIUrl":"10.4103/japtr.japtr_671_22","url":null,"abstract":"Cinnamon is one of the world's oldest spices that is also widely used as medicine for antimicrobe, anti-inflammation, and immune stimulant to now developed as an antidiabetic herbal medicine. Among its bioactive contents, the coumarin must have been controlled; since of its toxicities. Therefore, in this study aimed to reduce the amount of coumarin in the extracts by chloroform preextraction to dried powdered cinnamons and determine their glucose binding capacity. The extractions were used two methods by water infusion and ethanol soxhletation. To measure the coumarin's was used validated thin-layer chromatography (TLC)-densitometry, while for the chemical profiling of the extract was examined with liquid chromatography-mass spectrometry. The activity antidiabetic of the extracts was obtained by glucose binding. The TLC-densitometry method has been validated with silica gel 60F254 and n-hexane: ethyl acetate (8:2, v/v) systems. The coumarin's spot was observed at a wavelength of 285 nm on retention factor (Rf) 0.33, with tailings factor 1. The intraday and interday linearities tests showed a linear response result. The recovery value, coefficient of variation, and detection and a quantitation limit were met the standard requirements, respectively. Moreover, the results were observed (1) the solvent preextraction may reduce the coumarin content, (2) the coumarin content in the ethanol extract was higher than in the infusion, and (3) the preextraction solvents would reduce the glucose-binding capacity in ethanol and water cinnamomi's extract. These results may be developed further and applied for producing cinnamon's free coumarin extracts.","PeriodicalId":14877,"journal":{"name":"Journal of Advanced Pharmaceutical Technology & Research","volume":"14 2","pages":"69-74"},"PeriodicalIF":1.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ca/e4/JAPTR-14-69.PMC10226712.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9908546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of hyaluronic acid conditioned media on hDPSCs differentiation through CD44 and transforming growth factor-β1 expressions. 透明质酸条件培养基通过CD44和转化生长因子-β1表达对hDPSCs分化的影响。

IF 1.4

Journal of Advanced Pharmaceutical Technology & Research Pub Date : 2023-04-01 Epub Date: 2023-04-13 DOI: 10.4103/japtr.japtr_649_22

Dini Asrianti Bagio, Nia Agung Lestari, Wandy Afrizal Putra, Sylva Dinie Alinda, Shalina Ricardo, Indah Julianto

{"title":"The effect of hyaluronic acid conditioned media on hDPSCs differentiation through CD44 and transforming growth factor-β1 expressions.","authors":"Dini Asrianti Bagio, Nia Agung Lestari, Wandy Afrizal Putra, Sylva Dinie Alinda, Shalina Ricardo, Indah Julianto","doi":"10.4103/japtr.japtr_649_22","DOIUrl":"10.4103/japtr.japtr_649_22","url":null,"abstract":"Hyaluronic acid (HA) has the capability to influence dentin niche which is important in regenerative process. The CD44 as a specific receptor of HA was found to be related to dentin mineralization process. Meanwhile, transforming growth factor β1 (TGF-β1) has a vital role in the transition from proliferation into the differentiation of human dental pulp stem cell human dental pulp stem cells (hDPSCs) to become odontoblast cells and dentin mineralization. This study aims to analyzed HA's effect on dentin mineralization through CD44 and TGF-β1 expressions. Stem cells were cultured in four different supplemented conditioned media (control, +10 μg/mL, +20 μg/mL, and + 30 μg/mL of HA). Evaluation of CD44 expression was analyzed using flow cytometry and TGF-β1 was analyzed using enzyme-linked immunosorbent assay reader. Qualitative result using Alizarin red test after 21 days was done to confirm the formation of mineralization nodules. It was shown that HA expression of CD44 and TGF-β1 on hDPSCs were higher in AH groups compared to the control group and 30 μg/mL HA induced the highest TGF-β1 expression on hDPSCs. Alizarin red test also showed the highest mineralization nodules in the same group. Therefore, from this study, we found that supplemented 30 μg/mL of HA was proved in initiating hDPSCs differentiation process and promote dentin mineralization.","PeriodicalId":14877,"journal":{"name":"Journal of Advanced Pharmaceutical Technology & Research","volume":"14 2","pages":"89-93"},"PeriodicalIF":1.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/57/a6/JAPTR-14-89.PMC10226701.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9545216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of factorial design in formulation and evaluation of intrarectal in situ gel of sumatriptan. 析因设计在舒马曲坦直肠内原位凝胶制剂和评价中的应用。

IF 1.4

Journal of Advanced Pharmaceutical Technology & Research Pub Date : 2023-04-01 Epub Date: 2023-04-13 DOI: 10.4103/japtr.japtr_603_22

Hanan J Kassab, Hussein K Alkufi, Lina S Hussein

{"title":"Use of factorial design in formulation and evaluation of intrarectal in situ gel of sumatriptan.","authors":"Hanan J Kassab, Hussein K Alkufi, Lina S Hussein","doi":"10.4103/japtr.japtr_603_22","DOIUrl":"10.4103/japtr.japtr_603_22","url":null,"abstract":"The study's goal was to create an in situ intrarectal mucoadhesive gel of sumatriptan (SMT) combining mucoadhesive polymer (xyloglucan) and thermosensitive polymers (poloxamer 407 and poloxamer 188) to prolong rectal residence time for treatment of migraines. Nine SMT mucoadhesive rectal in situ gel (RIG) formulas were created by mixing poloxamer 407 (18%, 19%, or 20%) with poloxamer 188 (5%), a mucoadhesive polymer at various doses (0.1, 0.2, and 0.3) as well as SMT (25 mg/ml). The prepared suppositories underwent for mucoadhesive force, gelation temperature, and gelation time. When SMT and mucoadhesive polymer were added to the poloxamer mixture, the gelation temperature dropped; however, poloxamer 188 had the opposite effect. These polymers supported the prepared liquids' ability to adhere to mucous membranes and form a strong gel. The transition gelation temperature of the poloxamer solution rose as a result of the addition of poloxamer 188. The findings showed that the formula RIG5 which is composed of poloxamer 407 (19%), poloxamer 188 (5%), and xyloglucan (0.2%) had an ideal transition temperature of 36.33°C, gel strength of 44.66°C, mucoadhesive force of 6409°C, and in vitro drug release of 93.98% over an 8-hour period. In light of this, it can be said that SMT was successfully manufactured as RIG without causing any chemical reaction with its additives.","PeriodicalId":14877,"journal":{"name":"Journal of Advanced Pharmaceutical Technology & Research","volume":"14 2","pages":"119-124"},"PeriodicalIF":1.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/80/58/JAPTR-14-119.PMC10226710.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9908543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

COVID-19 olfactory dysfunction, evaluation of onset, and persistence. 新冠肺炎嗅觉功能障碍、发病评估和持续性。

IF 1.4

Journal of Advanced Pharmaceutical Technology & Research Pub Date : 2023-04-01 Epub Date: 2023-04-13 DOI: 10.4103/japtr.japtr_48_23

Abdulhusein Mizhir Almaamuri, Mohammed M Mohammed

{"title":"COVID-19 olfactory dysfunction, evaluation of onset, and persistence.","authors":"Abdulhusein Mizhir Almaamuri, Mohammed M Mohammed","doi":"10.4103/japtr.japtr_48_23","DOIUrl":"10.4103/japtr.japtr_48_23","url":null,"abstract":"Olfactory dysfunction (OD) is a common feature of COVID-19. The goal of the study was to define the modes of onset of OD in the clinical course of the disease and to follow the cases for 12-18 months in order to estimate the differences in the recovery time from OD over the course of the disease. We managed to follow a total of 325 patients (females: 198, males: 127) in the Babylon governorate in Iraq. All were COVID-19 patients who should have OD during the course of the disease. COVID-19 infection was established in all patients by swab test, i.e. polymerase chain reaction (PCR) and/or chest computed tomography findings of pneumonia compatible with COVID-19. Detailed medical records were obtained directly from the patients or their relatives. The patients were then followed up by telephone and questioned with structured questionnaires concentrating upon general clinical features and the sense of olfaction. Information about the presence of olfactory disorders, their occurrence, and development was recorded. Based on the onset of OD, the patients were categorized into three groups. Olfactory functions were assessed primarily by face-to-face interview and then (if necessary) by a telephone questionnaire assessing self-reported olfactory function and olfactory-related quality of life, which measures the subjective olfactory capability (SOC). In the first 2 weeks, 148 (45.5%) patients reported complete recovery from OD, of which 90 (73.2%) patients joined at the end of the 1st month. OD persistence was observed in 11 (3.3%) patients toward the end of the 1st year, in 5 (1.5%) patients at the end of the 15th month, and only in two (0.6%) patients at the end of the 18th month. We found no significant correlation between the type of onset of OD and the duration and persistence of OD. Most sufferers of COVID-associated OD recover their sense of smell within the 1st month.","PeriodicalId":14877,"journal":{"name":"Journal of Advanced Pharmaceutical Technology & Research","volume":"14 2","pages":"137-141"},"PeriodicalIF":1.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/99/05/JAPTR-14-137.PMC10226702.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9551415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of antioxidant and antimicrobial bioactive compounds based on the quinoline-hydrazone and benzimidazole structure. 基于喹啉腙和苯并咪唑结构的抗氧化和抗菌活性化合物的合成。

IF 1.4

Journal of Advanced Pharmaceutical Technology & Research Pub Date : 2023-04-01 Epub Date: 2023-04-13 DOI: 10.4103/japtr.japtr_599_22

Antonius Herry Cahyana, Devin Halim, Laely Amaliyah

{"title":"Synthesis of antioxidant and antimicrobial bioactive compounds based on the quinoline-hydrazone and benzimidazole structure.","authors":"Antonius Herry Cahyana, Devin Halim, Laely Amaliyah","doi":"10.4103/japtr.japtr_599_22","DOIUrl":"10.4103/japtr.japtr_599_22","url":null,"abstract":"Quinoline and its derivatives are known to have various biological activities such as antibacterial and antioxidant. Therefore, this study aims to synthesize quinoline moiety from isatin and ethyl acetoacetate by Pfitzinger reaction under acidic conditions. The benzimidazole derivative was synthesized from quinoline and o-phenylenediamine by a solvent-less reaction, while the hydrazone derivative was formed by the reaction with hydrazine hydrate and aromatic aldehyde. In addition, 4-hydroxybenzaldehyde was used as an aromatic aldehyde. The four compounds formed were characterized by thin-layer chromatography (TLC), melting point measurement, Fourier-transform infrared, liquid chromatography-mass spectrometry, and ultraviolet-visible spectrophotometry. They were also evaluated for their antioxidant and antimicrobial activities using the 2,2-diphenyl-1-picrylhydrazyl assay and the disc diffusion method, respectively. All compounds showed weak antioxidant activity compared to ascorbic acid; the quinoline-hydrazone derivative showed the best antioxidant activity with IC50 = 843.52 ppm, while the IC50 value for quinoline-benzimidazole was 4784.66 ppm. All synthesized compounds have not been confirmed to be effective against Staphylococcus aureus and Escherichia coli bacteria in a concentration range of 75-1000 ppm. The bioactive compounds based on the quinoline-hydrazone and benzimidazole structures have been successfully synthesized and tested for their activity as antioxidant and antimicrobial agents.","PeriodicalId":14877,"journal":{"name":"Journal of Advanced Pharmaceutical Technology & Research","volume":"14 2","pages":"125-132"},"PeriodicalIF":1.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/75/68/JAPTR-14-125.PMC10226708.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9553587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modafinil-excipient compatibility study using differential scanning calorimetry. 莫达非尼赋形剂相容性的差示扫描量热法研究。

IF 1.4

Journal of Advanced Pharmaceutical Technology & Research Pub Date : 2023-04-01 Epub Date: 2023-04-13 DOI: 10.4103/japtr.japtr_663_22

Derar Omari, Assayed Sallam, Hasan Al-Hmoud, Iyad Rashid

引用次数: 1

Long-term water sorption/solubility of two dental bonding agents containing a colloidal dispersion of titanium dioxide. 含有二氧化钛胶体分散体的两种牙科粘合剂的长期吸水性/溶解性。

IF 1.4

Journal of Advanced Pharmaceutical Technology & Research Pub Date : 2023-04-01 Epub Date: 2023-04-13 DOI: 10.4103/japtr.japtr_47_23

Mohammed Ali Fadhil Al-Abd Al-Abbas, Rafid Jihad Al-Badr, Muaid S Abbas Shamash

{"title":"Long-term water sorption/solubility of two dental bonding agents containing a colloidal dispersion of titanium dioxide.","authors":"Mohammed Ali Fadhil Al-Abd Al-Abbas, Rafid Jihad Al-Badr, Muaid S Abbas Shamash","doi":"10.4103/japtr.japtr_47_23","DOIUrl":"10.4103/japtr.japtr_47_23","url":null,"abstract":"The aim was to analyze the influence of the incorporation of 4% by mass of colloidal dispersion of titanium dioxide (TiO2) nanoparticles on the long-term water sorption and solubility of two commercial universal bonding agents. In vitro studies. A colloidal dispersion of TiO2 nanoparticles was formulated and blended into two commercial dental bonding agents, i.e., Ambar Universal (FGM, Brasil) and G-Premio Bond Universal (GC, America) at 4% by mass. Forty bonding agent discs were fabricated and segregated into four bonding agent groups of 10 discs each, i.e., GA: Ambar Universal (control), GB: Ambar Universal (4% TiO2 incorporated), GC: G-Premio Bond universal (control), and GD: G-Premio Bond (4% TiO2 incorporated). The bonding agent discs were developed by dispensing the bonding agents into a silicone cast of 5 mm diameter and 1 mm depth. After bonding agent discs were desiccated, the cured discs were weighed and kept in distilled water to be evaluated for water sorption and solubility over 1 year storage period. Statistical analysis was performed by independent variable t-test performed using the IBM SPSS software (Chicago, IL: SPSS Inc). The incorporated bonding agent groups (GA and GB) showed significantly lower (P < 0.05) water sorption and solubility following 1 year of water storage in comparison to the control bonding agents. Both GC and GD demonstrated remarkably lower water sorption and solubility than GA and GB. Incorporation of the colloidal dispersion of TiO2 nanoparticles at 4% by mass into the universal bonding agents has significantly reduced their water sorption and solubility contrast to their control groups.","PeriodicalId":14877,"journal":{"name":"Journal of Advanced Pharmaceutical Technology & Research","volume":"14 2","pages":"142-146"},"PeriodicalIF":1.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/64/b2/JAPTR-14-142.PMC10226709.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9606367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation renin inhibitor activity from flavonoids derivates by in silico study. 利用计算机模拟研究黄酮类衍生物的肾素抑制剂活性。

IF 1.4

Journal of Advanced Pharmaceutical Technology & Research Pub Date : 2023-04-01 Epub Date: 2023-04-13 DOI: 10.4103/japtr.japtr_660_22

Aprilita Rina Yanti Eff, Ivana Theresia Yenhart, Yonatan Eden, Sri Teguh Rahayu, Putu Gita Mayawidyaswari Mahayasih

{"title":"Investigation renin inhibitor activity from flavonoids derivates by in silico study.","authors":"Aprilita Rina Yanti Eff, Ivana Theresia Yenhart, Yonatan Eden, Sri Teguh Rahayu, Putu Gita Mayawidyaswari Mahayasih","doi":"10.4103/japtr.japtr_660_22","DOIUrl":"10.4103/japtr.japtr_660_22","url":null,"abstract":"Flavonoids have various pharmacological activities, such as antihypertensive, anticancer, and and antidiabetic effects. Several studies have shown that luteolin, quercetin, kaempferol, myricetin, naringenin, hesperetin, and epicatechin have antihypertensive effects, but the mechanism of action has yet to be discovered with certainty. This study aims to identify flavonoids from luteolin, quercetin, kaempferol, myricetin, naringenin, hesperetin, and epicatechin as renin inhibitors through in silico study; seven flavonoid compounds were docked with 2V0Z with renin inhibitor (Aliskiren) in humans (Homo sapiens 6 LU7) using AutoDock v4.2.6. SwissADME was used to evaluate the pharmacokinetic characteristics of these substances. Results molecular binding of luteolin, quercetin, kaempferol, myricetin, naringenin, hesperetin, and epicatechin, has potential as renin inhibitors with affinity energy values lower than those of aliskiren of -9.3; -9.3; -10.0; -9.2; -9.9; -9.3; and -9.7 kcal/mol. The interactions of these seven compounds have the same catalytic activity as aliskiren on two aspartic acid residues, Asp32 and Asp215. The analysis of pharmacokinetic profiles and the search for physical and chemical properties showed that the seven compounds violated three of the five Lipinski rules, while aliskiren violated one. Hesperitin, kaempferol, and naringenin had similarities with aliskiren on the amino-acid residues in the renin-binding pocket. However, based on pharmacokinetic analysis, the three compounds had an oral pharmacokinetic profile that could have been better than aliskiren.","PeriodicalId":14877,"journal":{"name":"Journal of Advanced Pharmaceutical Technology & Research","volume":"14 2","pages":"82-88"},"PeriodicalIF":1.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/29/a5/JAPTR-14-82.PMC10226698.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9924298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of mobile phone electromagnetic radiation on thyroid glands and hormones in Rattus norvegicus brain: An analysis of thyroid function, reactive oxygen species, and monocarboxylate transporter 8. 手机电磁辐射对褐家鼠大脑甲状腺和激素的影响：甲状腺功能、活性氧和单羧酸转运蛋白8的分析。

IF 1.4

Journal of Advanced Pharmaceutical Technology & Research Pub Date : 2023-04-01 Epub Date: 2023-04-13 DOI: 10.4103/japtr.japtr_680_22

Hendra Zufry, Achmad Rudijanto, Djoko Wahono Soeatmadji, Setyawan Purnomo Sakti, Khairul Munadi, Hidayat Sujuti, Karyono Mintaroem

{"title":"Effects of mobile phone electromagnetic radiation on thyroid glands and hormones in Rattus norvegicus brain: An analysis of thyroid function, reactive oxygen species, and monocarboxylate transporter 8.","authors":"Hendra Zufry, Achmad Rudijanto, Djoko Wahono Soeatmadji, Setyawan Purnomo Sakti, Khairul Munadi, Hidayat Sujuti, Karyono Mintaroem","doi":"10.4103/japtr.japtr_680_22","DOIUrl":"10.4103/japtr.japtr_680_22","url":null,"abstract":"The aim of this study was to investigate the effects of mobile phone electromagnetic radiation (MP-EMR) on the thyroid glands and hormones in Rattus norvegicus brain in term of thyroid function, reactive oxygen species (ROS), and monocarboxylate transporter 8 (MCT8) concentration. Forty rats were divided into different groups: control (without EMR exposure), EMR1 (120-min/day exposure), EMR2 (150-min), and EMR3 (180-min). The levels of serum thyroid stimulating hormone (TSH), thyroxine (T4), and malondialdehyde (MDA) and brain and MCT8 were measured using enzyme-linked immunosorbent assay. One-way analysis of variance followed by the Duncan test was used to analyze the data. Our data indicated that the levels of serum TSH and T4 in all the EMR groups were lower significant postexposure compared to the control with P < 0.01 (EMR1 and EMR2) and P < 0.001 (EMR3), suggesting hypothyroidism due to MP-EMR exposure. Increased MDA and decreased MCT8 levels were also observed following the intervention; however, the changes in both concentrations were notably significant after being subjected to 150-min and 180-min of exposure. In conclusion, a significant reduction in TSH, T4, and MCT8 levels indicated thyroid dysfunction due to MP-EMR exposure.","PeriodicalId":14877,"journal":{"name":"Journal of Advanced Pharmaceutical Technology & Research","volume":"14 2","pages":"63-68"},"PeriodicalIF":1.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/54/2f/JAPTR-14-63.PMC10226703.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9553245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0