Journal of Advanced Pharmaceutical Technology & Research最新文献

{"title":"The knowledge and anxiety toward the implementation of COVID-19 vaccination.","authors":"Lintje Boekoesoe,&nbsp;Nur Ayini S Lalu,&nbsp;K Sarinah Basri,&nbsp;Zul Fikar Ahmad,&nbsp;Andi Nirmasita","doi":"10.4103/japtr.japtr_614_22","DOIUrl":"10.4103/japtr.japtr_614_22","url":null,"abstract":"<p><p>The aim of the study was to analyze the relationship between the level of knowledge and anxiety regarding the implementation of the COVID-19 vaccination in the community. The research was conducted in the Dulupi Health Center work area from March to April 2022, with an analytical observational research design using a cross-sectional approach. The research population is the Dulupi Public Health Center work area community, with a total sample of 297 people taken using the cluster random sampling technique and calculated by Slovin's formula. Data were collected through a questionnaire which were then analyzed by univariate and bivariate. The knowledge variable, most of them had less knowledge (91.9%), and in the anxiety variable, most of the respondents experienced mild anxiety (55.2%). In the implementation variable, most of the respondents were not vaccinated, 245 people (82.5%), while those who were vaccinated were 52 people (17.5%). The level of knowledge and anxiety is primarily related to the implementation of COVID-19 vaccination, with <i>P</i>-values of (0.047) and (0.000) <<i>P</i> (0.05). There is a significant correlation between knowledge and anxiety regarding implementing COVID-19 vaccination in the Dulupi Health Center work area, Boalemo Regency.</p>","PeriodicalId":14877,"journal":{"name":"Journal of Advanced Pharmaceutical Technology & Research","volume":"14 1","pages":"2-5"},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b1/91/JAPTR-14-2.PMC10026326.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9166600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flavonoid from <i>Moringa oleifera</i> leaves revisited: A review article on <i>in vitro</i>, <i>in vivo,</i> and <i>in silico</i> studies of antidiabetic insulin-resistant activity","authors":"Triana Hertiani, Wahyuning Setyani, Retno Murwanti, TeukuNanda Saifullah Sulaiman","doi":"10.4103/japtr.japtr_290_23","DOIUrl":"https://doi.org/10.4103/japtr.japtr_290_23","url":null,"abstract":"Diabetes mellitus (DM) occurs when the body experiences insulin deficiency or is unable to use insulin appropriately, which increases the blood glucose levels over the threshold. Moringa oleifera leaf is a widely used and scientifically proven herbal medicine to treat DM. The demand for the development of new drugs has prompted in vitro, in vivo, and in silico studies of antidiabetic insulin-resistant activity. This study aims to conduct a comprehensive study of the types of flavonoid and nonflavonoid compounds that have antidiabetic activity in insulin resistance mellitus using in vitro, in vivo, and in silico approaches. The literature review was conducted in accordance with the offered reporting items for systematic review. Major bibliographic databases, i.e. Scopus, PubMed, and DOAJ, covering original articles about the aforementioned issues between January 1, 2011 and December 31, 2021 were used. In this study, 274 articles were retrieved, of which 4 were duplicates, and after the titles were read, only 108 were left for analysis. After the abstract screening, 32 articles were eligible for the literature review. The results exhibit that flavonoids, including quercetin and kaempferol, and nonflavonoids, including anthraquinone, cytogluside (glycoside), hemlock tannin, phenolic steroid, and 2-phenylchromenylium (anthocyanins), have potential insulin-resistant antidiabetic activity in vitro, in vivo, and in silico. This has broadened the research into the development of new drugs.","PeriodicalId":14877,"journal":{"name":"Journal of Advanced Pharmaceutical Technology & Research","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134887762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perception and preference of pharmacy students toward e-learning during the COVID-19 pandemic","authors":"MohammedMahmood Mohammed, AbeerAbdulhadi Rashid, AshwaqNajemaldeen Abbas","doi":"10.4103/japtr.japtr_101_23","DOIUrl":"https://doi.org/10.4103/japtr.japtr_101_23","url":null,"abstract":"This study is designed to evaluate students’ knowledge and perceptions about the online learning of pharmacy curricula in Iraq during the COVID-19 quarantine. A descriptive, cross-sectional study involving 278 pharmacy students was done between October 2020 and June 2021. About 42.44% preferred face–face lecturers over other modes of delivery for lectures in the pharmacy curriculum. Most participants preferred both active learning and face–face lectures. The results show that 72.66% of responders chose to stay at home as one of the privileges of e-learning. However, the main barriers that associated with e-learning were lack of patient involvement and some technical issues regarding IT equipment, (74.82%) and (62.23%), respectively. E-learning is seen as a lack of social presence, less social contact, and synchronization of connections. However, e-learning undoubtedly benefits students in several ways. Online learning is an essential podium for students to achieve their studies in periods of crisis.","PeriodicalId":14877,"journal":{"name":"Journal of Advanced Pharmaceutical Technology & Research","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134887914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors affecting on in vitro release of miconazole from in situ ocular gel","authors":"FatimaJalal Al_Gawhari","doi":"10.4103/japtr.japtr_91_23","DOIUrl":"https://doi.org/10.4103/japtr.japtr_91_23","url":null,"abstract":"The reason for conducting this study is to prolong release of miconazole in the ocular site of action by ocular-based gels (OBGs) formulations. The formulation factors affecting on the release from OBG should be studied using various gelling agents in various concentrations to achieve the improvement in retention and residence time in response to prolonged release. In this study, the formulations were prepared using carbopol 940, pectin, sodium alginate, poloxamer 407, and poly(methacrylic acid) at 0.5%, 1%, and 1.5% w/v, respectively. Hydroxypropyl methylcellulose E5 (HPMC E5) 1% was added as thickening agent/viscosity builder. The formulation containing carbopol 940, pectin and sodium alginate at 1.5% w/v, displayed a noticable improvement in viscosity, gelling capacity, and extended release for 7 h in comparison with the reference drug. Overall, the release showed that the sodium alginate with HPMC E5 form in situ gel which had longer time of release reach to 12 h compared with other polymers. the release of miconazole from the OBGs affected significantly by two factors includes gelling capacity and viscosity builder. The novelty of this study is supporting the delivery of ocular drugs through a cornea as an important key of the eye instead of dependence on an internal blood supply using an oral or a parental administration.","PeriodicalId":14877,"journal":{"name":"Journal of Advanced Pharmaceutical Technology & Research","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134888007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of nitrogen mustard-based fluorophores for cell imaging and cytotoxicity studies.","authors":"Yuanwei Liang,&nbsp;Maojun Liang,&nbsp;Cuiyu Li,&nbsp;Daini Wang,&nbsp;Xiaoxuan Gong,&nbsp;Kaiji Zheng","doi":"10.4103/japtr.japtr_574_22","DOIUrl":"10.4103/japtr.japtr_574_22","url":null,"abstract":"<p><p>Nitrogen mustards are important alkylating anticancer drugs used for neoplasms treatment. However, little research about the integration of luminophore into nitrogen mustard-based compounds for both imaging and therapeutic application was reported. In this study, we report a series of novel nitrogen mustard-containing 1-furyl-2-en-1-one and 1-thienyl-2-en-1-one derivatives as intramolecular charge transfer-based luminophore for research in both imaging subcellular localization and antiproliferation toward lung cancer cells. The target products were prepared by Knoevenagel condensation and characterized by nuclear magnetic resonance and high-resolution mass spectrometer. The absorption and fluorescence studies were carried out by ultraviolet-visible and fluorescence spectrophotometers, respectively. Cell morphology was observed under an inverted microscope. Cytotoxicity test was detected by MTT assay. Cellular localization was observed by a confocal laser scanning microscope. Colony formation ability was carried out by colony formation assay. Cell migration ability was detected by transwell migration assay. Differences between the two groups were analyzed by two-tailed Student's <i>t</i>-test. The difference with <i>P</i> < 0.05 (*) was considered statistically significant. The compounds were synthesized in high yield. The λ_max and Stokes shift of these compounds reach up to 567 and 150 nm, respectively. These compounds exhibited good antiproliferative activity against lung cancer cells, with compound 3h exhibiting the best IC₅₀ of 13.1 ± 2.7 μM. Furthermore, the selected compound 3h is located preferentially in lysosomes and a small amount in nuclei, effectively inhibiting cell colony formation and migration abilities toward A549 cells. These findings suggested that nitrogen mustard-based fluorophores might be a potential effective chemotherapeutic agent in lung cancer therapy.</p>","PeriodicalId":14877,"journal":{"name":"Journal of Advanced Pharmaceutical Technology & Research","volume":"14 1","pages":"6-11"},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3e/2b/JAPTR-14-6.PMC10026329.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9159698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computational approach in searching for dual action multitarget inhibitors for osteosarcoma.","authors":"Maria Apriliani Gani,&nbsp;Ahmad Dzulikri Nurhan,&nbsp;Bulan Rhea Kaulika Hadinar Putri,&nbsp;Andhi Suyatno,&nbsp;Shakil Ahmed Khan,&nbsp;Chrismawan Ardianto,&nbsp;Fedik Abdul Rantam,&nbsp;Junaidi Khotib","doi":"10.4103/japtr.japtr_541_22","DOIUrl":"10.4103/japtr.japtr_541_22","url":null,"abstract":"<p><p>Osteosarcoma is a common primary malignant bone tumor that typically manifests in the second decade of life. This study aimed to identify osteogenic compounds that potentially serve as multitarget inhibitors for osteosarcoma. The study was a molecular docking study of nine Food and Drug Administration-approved compounds with osteogenic properties to the key membrane proteins of osteosarcoma. The ligands used were raloxifene, simvastatin, dexamethasone, risedronate, ibandronate, zoledronic acid, ascorbic acid, alendronate, and β-glycerophosphate, whereas the target proteins used were RET, fibroblast growth factor receptor 1, KIT, PDGFRA, VEGFR1, and VEGFR2. Chem3D version 15.0.0.106 was used for ligand preparation, and AutoDockTools version 1.5.6 was used for protein preparation, whereas molecular docking was conducted using AutoDock Vina. Raloxifene, simvastatin, and dexamethasone had the lowest binding activity to the target proteins. The binding affinity of raloxifene was from -8.4 to -10.0 kcal mol^-1, that of simvastatin was -8.3 to -9.2 kcal mol^-1, whereas dexamethasone ranged from -6.9 to -9.1 kcal mol^-1. Most types of interactions were hydrophobically followed by hydrogen bonding. The current study suggests that raloxifene, simvastatin, and dexamethasone have the potential to act as multitarget inhibitors for osteosarcoma with the ability to induce bone remodeling.</p>","PeriodicalId":14877,"journal":{"name":"Journal of Advanced Pharmaceutical Technology & Research","volume":"14 1","pages":"18-23"},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/29/1b/JAPTR-14-18.PMC10026319.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9159702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and pattern of third molars impaction: A retrospective radiographic study.","authors":"Ramizu Bin Shaari,&nbsp;Mohamad Arif Awang Nawi,&nbsp;Ameera Kamal Khaleel,&nbsp;Ali Sultan AlRifai","doi":"10.4103/japtr.japtr_489_22","DOIUrl":"10.4103/japtr.japtr_489_22","url":null,"abstract":"<p><p>Third molar impaction is considered a prevalent issue. The research aimed to study the pervasiveness and pattern of impaction in Karbala/Iraqi population. Orthopantomograms were studied regarding its angulation, impaction depth, and correlation with ramus. The outcomes manifested that the prevalence of 3^rd impacted molars was 34.71%, with the proportion of male to female as 0.83:1. Impacted mandibular 3^rd molars were significantly encountered. The prevalence of vertical angulation, mesioangular, horizontal, and inverted were significantly associated with the impacted mandibular 3^rd molars (<i>P</i> < 0.05). However, the prevalence of distoangular and bucco/lingual was significantly associated (<i>P</i> < 0.05) with the upper impacted 3^rd molars. Level C of impaction was significantly (<i>P</i> < 0.05) the most typical level in the maxilla impacted the 3^rd molar, and level A and level B of impaction were significantly (<i>P</i> < 0.05) the most prevalent level correlated with the mandibular 3^rd molar impaction. Class II was significantly (<i>P</i> < 0.05) the frequently occurring condition subsequent to Classes III and I. In conclusion, the impaction of 3^rd molars was significantly predominant in females and lower jaw. The vertical angulation, level C of impaction associated with maxillary 3^rd molars and levels A and B of impaction related with mandibular 3^rd molars, and Class II are the most encountered conditions.</p>","PeriodicalId":14877,"journal":{"name":"Journal of Advanced Pharmaceutical Technology & Research","volume":"14 1","pages":"46-50"},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fd/86/JAPTR-14-46.PMC10026324.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9175062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increasing the stability of incense gum extract (<i>Styrax benzoin</i>) with a mixture of surfactants.","authors":"Nora Susanti,&nbsp;Jamalum Purba,&nbsp;M Yosia Gopas Oetama","doi":"10.4103/japtr.japtr_539_22","DOIUrl":"10.4103/japtr.japtr_539_22","url":null,"abstract":"Styrax benzoin is a type of incense produced in North Tapanuli, Indonesia. The content of metabolite compounds provides wide use in pharmaceuticals. The occurrence of deposits in the extract makes this preparation unstable; this instability creates problems, especially in the concentration of the extract and is impractical so it needs to be redissolved. The method of using surfactants can be used as a suspending agent, a mixture of two types of surfactants gives variations in hydrophilic and lipophilic balance (HLB), by finding the optimum HLB value to create optimum solution stability and organoleptic, various mixture ratios were carried out with test parameters such as organoleptic, pH, viscosity, particle size, and components of chemical compounds. The results show that the optimum HLB of S. benzoin is 12.7 in surfactants Tween 80 and Span 80.","PeriodicalId":14877,"journal":{"name":"Journal of Advanced Pharmaceutical Technology & Research","volume":"14 1","pages":"24-28"},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bd/48/JAPTR-14-24.PMC10026331.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9534658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioassay for total serum bioactivity of <i>Atractylodes lancea</i>.","authors":"Kesara Na-Bangchang,&nbsp;Anurak Cheoymang,&nbsp;Nadda Muhamad,&nbsp;Inthuon Kulma","doi":"10.4103/japtr.japtr_431_22","DOIUrl":"10.4103/japtr.japtr_431_22","url":null,"abstract":"<p><p>The study aimed to establish a bioassay for total bioactivity of <i>Atractylodes</i> <i>lancea</i> (AL) in human serum samples. Inhibition of bacterial growth (<i>Staphylococcus</i> <i>aureus</i> ATCC 25923) was assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. The calibration curve (0, 0.39, 0.78, 1.56, 3.13, 2.56, and 50 ng/μl) was linear with correlation coefficients >0.990. The limit of quantification (LOQ) was 1.66 mg/ml using 20-ml serum sample. The developed bioassay method meets the standard of the bioanalytical method for determination of serum bioactivity of AL.</p>","PeriodicalId":14877,"journal":{"name":"Journal of Advanced Pharmaceutical Technology & Research","volume":"14 1","pages":"51-55"},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0a/f0/JAPTR-14-51.PMC10026330.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9159697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Panton-Valentine leukocidin and toxic shock syndrome toxin-1 genes in methicillin-resistant <i>Staphylococcus aureus</i> isolated from nose of restaurant workers in Kirkuk city.","authors":"Najdat Bahjat Mahdi","doi":"10.4103/japtr.japtr_508_22","DOIUrl":"10.4103/japtr.japtr_508_22","url":null,"abstract":"<p><p><i>Staphylococcus aureus</i> resides naturally in the nasal cavity of healthy individuals, including those working in restaurants, so they may be a source for spreading this bacterium to restaurant customers directly or indirectly through cooked meals. This bacterium has several virulence factors enabling it to cause many diseases in different parts of the body. It has also the capability to resist conventional antibiotics including methicillin. To investigate methicillin-resistant <i>S. aureus</i> (MRSA), 170 nasal swabs were collected from food preparation workers in 30 restaurants (5-6 workers in each restaurant) in Kirkuk city. After collection, the samples were directly transferred to the laboratory and cultured on selective media like mannitol salt agar (MSA). Microbiological examination including morphological, biochemical, and confirmatory tests showed that 24/170 of collected samples were positive for <i>S. aureus</i> with a rate of 14.12%. Among 24 isolates, 20 (83.3%) belonged to MRSA. All isolates were resistant to oxacillin and penicillin (100%), whereas sensitive to other antibiotics (gentamicin, chloramphenicol, and rifampicin). Polymerase chain reaction exhibited that 13 (65%) of MRSA isolates have toxic shock syndrome toxin-1 gene and only 4 (20%) have Panton-Valentine leukocidin gene.</p>","PeriodicalId":14877,"journal":{"name":"Journal of Advanced Pharmaceutical Technology & Research","volume":"14 1","pages":"34-38"},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6d/59/JAPTR-14-34.PMC10026320.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9159705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}