Jornal Brasileiro De Pneumologia最新文献_第7页

The role of IL10 and IL17 gene polymorphisms in treatment response in children and adolescents with severe asthma IL10 和 IL17 基因多态性在重症哮喘儿童和青少年治疗反应中的作用

IF 2.7 4区医学

Jornal Brasileiro De Pneumologia Pub Date : 2023-12-20 DOI: 10.36416/1806-3756/e20230092

Mariana Isadora Ribeiro Vieira1, Mônica Versiani Nunes Pinheiro de Queiroz3, Maria Borges Rabelo de Santana2, Hatilla dos Santos Silva2, Almirane Oliveira2, Camila Alexandrina Viana Figueiredo2, Eduardo Martín Tarazona Santos4, Ryan dos Santos Costa2, Laura Maria de Lima Belizário Facury Lasmar1,2

{"title":"The role of IL10 and IL17 gene polymorphisms in treatment response in children and adolescents with severe asthma","authors":"Mariana Isadora Ribeiro Vieira1, Mônica Versiani Nunes Pinheiro de Queiroz3, Maria Borges Rabelo de Santana2, Hatilla dos Santos Silva2, Almirane Oliveira2, Camila Alexandrina Viana Figueiredo2, Eduardo Martín Tarazona Santos4, Ryan dos Santos Costa2, Laura Maria de Lima Belizário Facury Lasmar1,2","doi":"10.36416/1806-3756/e20230092","DOIUrl":"https://doi.org/10.36416/1806-3756/e20230092","url":null,"abstract":"Objective: To determine whether polymorphisms of the IL10 and IL17 genes are associated with severe asthma control and bronchodilator reversibility in children and adolescents with severe asthma. Methods: This was a cross-sectional study, nested within a prospective cohort study of patients with severe asthma. Two outcomes were evaluated: asthma control and bronchodilator reversibility. We extracted DNA from peripheral blood and genotyped three single nucleotide polymorphisms: rs3819024 and rs2275913 in the IL17A gene; and rs3024498 in the IL10 gene. For the association analyses, we performed logistic regression in three genetic models (allelic, additive, and dominant). Results: The rs3024498 C allele in the IL10 gene was associated with failure to achieve asthma control despite regular treatment (p = 0.02). However, the G allele of the IL17A rs3819024 polymorphism was associated with failure to respond to stimulation with a ß2 agonist. The rs2275913 polymorphism of the IL17A gene showed no relationship with asthma control or bronchodilator reversibility. Conclusions: In pediatric patients with severe asthma, the IL10 polymorphism appears to be associated with failure to achieve clinical control, whereas the IL17A polymorphism appears to be associated with a worse bronchodilator response. Knowledge of the involvement of these polymorphisms opens future directions for pharmacogenetic studies and for the implementation of individualized therapeutic management of severe asthma in pediatric patients.","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"59 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139169366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Angioinvasive aspergillosis in a patient with acute myeloid leukemia and influenza B virus infection 一名急性髓性白血病和 B 型流感病毒感染患者的血管侵袭性曲霉菌病

IF 2.7 4区医学

Jornal Brasileiro De Pneumologia Pub Date : 2023-12-20 DOI: 10.36416/1806-3756/e20230228

Samuel Santos de Freitas1, Ana Paula Zanardo1,2, Rafael Domingos Grando1,2

引用次数: 0

Predictors of reduced incremental shuttle walk test performance in patients with long post-COVID-19 COVID-19长期后患者往返步行测试成绩下降的预测因素

IF 2.7 4区医学

Jornal Brasileiro De Pneumologia Pub Date : 2023-12-18 DOI: 10.36416/1806-3756/e20220438

Mustafa Engin Sahin1, Seher Satar1, Pınar Ergün1

{"title":"Predictors of reduced incremental shuttle walk test performance in patients with long post-COVID-19","authors":"Mustafa Engin Sahin1, Seher Satar1, Pınar Ergün1","doi":"10.36416/1806-3756/e20220438","DOIUrl":"https://doi.org/10.36416/1806-3756/e20220438","url":null,"abstract":"Objective: One of the common limitations after COVID-19 pneumonia is the decrease in exercise capacity. The identification of the factors affecting exercise capacity and the assessment of patients at risk are important for determining treatment strategy. This study was conducted to determine the predictors of decreased exercise capacity in long post-COVID-19 patients. Methods: We investigated the association of exercise capacity as measured by the incremental shuttle walk test (ISWT) with age, sex, spirometric variables, respiratory and peripheral muscle strength, quality of life, fatigue, hospital anxiety depression scale, chest X-ray involvement, and hospitalization. The patients were divided into three groups: outpatients, inpatients, and ICU patients. Regression analysis was used to determine which parameters were significant predictors of exercise capacity. Results: Of the 181 patients included in the study, 56 (31%) were female. The mean ISWT in percentage of predicted values (ISWT%pred) was 43.20% in the whole sample, whereas that was 52.89%, 43.71%, and 32.21% in the outpatient, inpatient, and ICU patient groups, respectively. Linear regression analysis showed that predictors of decreased ISWT%pred were sex (ß = 8.089; p = 0.002), mMRC scale score (ß = -7.004; p = 0.001), FVC%pred (ß = 0.151; p = 0.003), and handgrip strength (ß = 0.261; p = 0.030). Conclusions: In long post-COVID-19 patients, sex, perception of dyspnea, restrictive pattern in respiratory function, and decrease in peripheral muscle strength are predictors of reduced exercise capacity that persists three months after COVID-19. In this context, we suggest that pulmonary rehabilitation might be an important therapy for patients after COVID-19.","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"233 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139173275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of subsolid nodules on chest CT scans during the COVID-19 pandemic 在 COVID-19 大流行期间胸部 CT 扫描中发现实性下结节

IF 2.7 4区医学

Jornal Brasileiro De Pneumologia Pub Date : 2023-12-13 DOI: 10.36416/1806-3756/e20230300

Ana Paula Zanardo1,2, Vicente Bohrer Brentano2, Rafael Domingos Grando1,2, Rafael Ramos Rambo1,2, Felipe Teixeira Hertz2, Luís Carlos Anflor Júnior2,3, Jônatas Fávero Prietto dos Santos1,2, Gabriela Schneider Galvão1,2, Cristiano Feijó Andrade4,5

引用次数: 0

GOLD 2024: a brief overview of key changes 黄金 2024：主要变化概述

IF 2.7 4区医学

Jornal Brasileiro De Pneumologia Pub Date : 2023-12-06 DOI: 10.36416/1806-3756/e20230369

Alvar Agusti1, Claus F. Vogelmeier2

引用次数: 0

Eosinophils and therapeutic responses to steroids and biologics in COPD: a complex relationship 嗜酸性粒细胞与慢性阻塞性肺病患者对类固醇和生物制剂的治疗反应：复杂的关系

IF 2.7 4区医学

Jornal Brasileiro De Pneumologia Pub Date : 2023-12-06 DOI: 10.36416/1806-3756/e20230360

Parameswaran Nair1

引用次数: 0

Crafting a research protocol: a stepwise comprehensive approach 起草研究方案：循序渐进的综合方法

IF 2.7 4区医学

Jornal Brasileiro De Pneumologia Pub Date : 2023-12-05 DOI: 10.36416/1806-3756/e20230371

Ricardo Gassmann Figueiredo1,2, Cecilia María Patino,2,3, Juliana Carvalho Ferreira 2,4

引用次数: 0

Brazilian Thoracic Association recommendations for the management of post-tuberculosis lung disease 巴西胸科协会关于肺结核后肺病治疗的建议

IF 2.7 4区医学

Jornal Brasileiro De Pneumologia Pub Date : 2023-11-28 DOI: 10.36416/1806-3756/e20230269

Denise Rossato Silva1, Ana Paula Santos2,3, Dina Visca4,5, Sidney Bombarda6, Margareth Maria Pretti Dalcolmo7, Tatiana Galvão8, Silvana Spíndola de Miranda9, Ana Alice Amaral Ibiapina Parente10, Marcelo Fouad Rabahi11, Roberta Karla Barbosa de Sales12, Giovanni Battista Migliori13, Fernanda Carvalho de Queiroz Mello2

{"title":"Brazilian Thoracic Association recommendations for the management of post-tuberculosis lung disease","authors":"Denise Rossato Silva1, Ana Paula Santos2,3, Dina Visca4,5, Sidney Bombarda6, Margareth Maria Pretti Dalcolmo7, Tatiana Galvão8, Silvana Spíndola de Miranda9, Ana Alice Amaral Ibiapina Parente10, Marcelo Fouad Rabahi11, Roberta Karla Barbosa de Sales12, Giovanni Battista Migliori13, Fernanda Carvalho de Queiroz Mello2","doi":"10.36416/1806-3756/e20230269","DOIUrl":"https://doi.org/10.36416/1806-3756/e20230269","url":null,"abstract":"ABSTRACT Historically, all efforts against tuberculosis were focused on rapid diagnosis and effective treatment to break the chain of transmission of Mycobacterium tuberculosis. However, in the last few years, more and more evidence has been found on the dramatic consequences of the condition defined as post-tuberculosis lung disease (PTLD). Approximately one third of patients surviving pulmonary tuberculosis face considerable ongoing morbidities, including respiratory impairment, psychosocial challenges, and reduced health-related quality of life after treatment completion. Given the important global and local burden of tuberculosis, as well as the estimated burden of PTLD, the development of a consensus document by a Brazilian scientific society-Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)-was considered urgent for the prevention and management of this condition in order to allocate resources to and within tuberculosis services appropriately and serve as a guide for health care professionals. A team of eleven pulmonologists and one methodologist was created by the SBPT to review the current evidence on PTLD and develop recommendations adapted to the Brazilian context. The expert panel selected the topics on the basis of current evidence and international guidelines. During the first phase, three panel members drafted the recommendations, which were divided into three sections: definition and prevalence of PTLD, assessment of PTLD, and management of PTLD. In the second phase, all panel members reviewed, discussed, and revised the recommendations until a consensus was reached. The document was formally approved by the SBPT in a special session organized during the 2023 SBPT Annual Conference.","PeriodicalId":14845,"journal":{"name":"Jornal Brasileiro De Pneumologia","volume":"29 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139215615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nephrobronchial fistula: a diagnostic challenge in a patient with IgG4-related disease 肾支气管瘘：一名 IgG4 相关疾病患者的诊断难题

IF 2.7 4区医学

Jornal Brasileiro De Pneumologia Pub Date : 2023-11-27 DOI: 10.36416/1806-3756/e20230317

Glauco Cabral Marinho Plens1, Guilherme das Posses Bridi1, Ellen Caroline Toledo do Nascimento2, Rodrigo Caruso Chate3, Bruno Guedes Baldi1, Fábio Eiji Arimura1, Ronaldo Adib Kairalla1,3

引用次数: 0

Paraseptal emphysema 副隔膜气肿

IF 2.7 4区医学

Jornal Brasileiro De Pneumologia Pub Date : 2023-11-21 DOI: 10.36416/1806-3756/e20230340

Edson Marchiori1, Bruno Hochhegger2, Gláucia Zanetti1

引用次数: 0