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Investigative ophthalmology最新文献

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Successful therapy of herpes hominis keratitis in rabbits by 5-iodo-5'-amino-2'5'-dideoxyuridine (AIU): a novel analog of thymidine. 5-碘-5′-氨基-2′-5′-双脱氧尿苷(AIU)成功治疗兔人疱疹角膜炎:一种新的胸腺嘧啶类似物。
Investigative ophthalmology Pub Date : 1976-06-01
D M Albert, M Lahav, P N Bhatt, T W Reid, R E Ward, R C Cykiert, T S Lin, D C Ward, W H Prusoff
{"title":"Successful therapy of herpes hominis keratitis in rabbits by 5-iodo-5'-amino-2'5'-dideoxyuridine (AIU): a novel analog of thymidine.","authors":"D M Albert,&nbsp;M Lahav,&nbsp;P N Bhatt,&nbsp;T W Reid,&nbsp;R E Ward,&nbsp;R C Cykiert,&nbsp;T S Lin,&nbsp;D C Ward,&nbsp;W H Prusoff","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The efficiency of 5-iodo-5'-amino-2'5'-dideoxyuridine (AIU) in the therapy of experimental herpes keratitis in rabbits has been examined. Virus infections were established bilaterally in 40 animals using herpes simplex, type 1 (NIH strain 11124). Twenty-four hours after infection the rabbits were divided into five matched groups of eight and each group was treated, double-blind, with topical drugs at four-hour intervals for a total of 72 hours. The solutions instilled were: (1) saline; (2) IdUrd, 1 mg. per milliliter; (3) AIU, 1 mg. per milliliter; (4) AIU, 4 mg. per milliter; and (5) AIU, 8 mg. per milliliter. Each eye was examined daily for 12 days and graded independently by two ophthalmologists. Although IdUrd and AIU (8 mg. per milliliter) were effective therapeutically, IdUrd had a greater effect. The AIU at 1 and 4 mg. per milliliter were less active, but showed more rapid healing than the saline control. Viral recovery studies are consistent with the clinical observations. A second independent experiment, similar to that described above, gave essentially identical results. Although less potent than IdUrd, AIU does provide effective therapy for herpes keratitis.</p>","PeriodicalId":14844,"journal":{"name":"Investigative ophthalmology","volume":"15 6","pages":"470-8"},"PeriodicalIF":0.0,"publicationDate":"1976-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12114983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intraocular pressure decrease in normal volunteers following timolol ophthalmic solution. 替马洛尔眼液后正常志愿者眼压下降。
Investigative ophthalmology Pub Date : 1976-06-01
I M Katz, W A Hubbard, A J Getson, A L Gould
{"title":"Intraocular pressure decrease in normal volunteers following timolol ophthalmic solution.","authors":"I M Katz,&nbsp;W A Hubbard,&nbsp;A J Getson,&nbsp;A L Gould","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Timolol ophthalmic solutions 0.5 per cent, 1.0 per cent, and 1.5 per cent lowered intraocular pressures significantly in normal human volunteers. Maximum lowering of the intraocular pressures was reached at two hours with the 0.5 per cent solution of timolol and at one hour with the 1.0 per cent and 1.5 per cent timolol ophthalmic solutions. The effect lasted the full seven hours of observations. No objective or subjective evidence of ocular irritation could be attributed to the drug. A single dose of timolol applied topically to the eyes of normal human volunteers had no effect on pupillary size, visual acuity, blood pressure, or pulse rate.</p>","PeriodicalId":14844,"journal":{"name":"Investigative ophthalmology","volume":"15 6","pages":"489-92"},"PeriodicalIF":0.0,"publicationDate":"1976-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11230503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
pH-dependent temperature sensitivity of rat lens phosphofructokinase. 大鼠晶状体磷酸果糖激酶的ph依赖性温度敏感性。
Investigative ophthalmology Pub Date : 1976-06-01
H M Cheng, L T Chylack
{"title":"pH-dependent temperature sensitivity of rat lens phosphofructokinase.","authors":"H M Cheng,&nbsp;L T Chylack","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Rat lens phosphofructokinase (PFK) has been found to be cold-labile at acidic pH, even in the presence of sulfate and inorganic phosphate, two known positive effectors. The inactivation appears to be an irreversible process, but can be prevented by including ATP in the incubating media. The enzyme is relatively stable at pH 8.2 incubated at 0 to 4 degrees, 25 degrees, or 37 degrees C. in the absence of the effectors, but is extremely thermolabile if the pH is lowered to 7.30 or lower. The thermolability is counteracted by many effectors, among them sulfate and ATP are the most effective. The physiologic significance of PFK instability and effector protection in the lens are discussed.</p>","PeriodicalId":14844,"journal":{"name":"Investigative ophthalmology","volume":"15 6","pages":"505-9"},"PeriodicalIF":0.0,"publicationDate":"1976-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11230505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of interruption of the short posterior ciliary arteries on slow axoplasmic transport and histology within the optic nerve of the rhesus monkey. 阻断短后睫状动脉对恒河猴视神经内慢轴浆运输和组织学的影响。
Investigative ophthalmology Pub Date : 1976-06-01
N S Levy
{"title":"The effect of interruption of the short posterior ciliary arteries on slow axoplasmic transport and histology within the optic nerve of the rhesus monkey.","authors":"N S Levy","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Tritiated leucine was injected into the vitreous of rhesus monkey eyes to make it available for protein synthesis by the ganglion cells. The short posterior ciliary arteries were cut three hours later or several weeks prior to the leucine injection. A reduction of labeled protein within the retrolaminar optic nerve was seen in all eyes so treated. Autoradiography revealed a diffuse reduction of axoplasmic transport into these optic nerve heads. There was consistent evidence of focal obstruction of labeled protein at the interface between the lamina scleralis and retrolaminar optic nerve. Vacuoles appeared in the most severely affected areas. These histologic changes were followed by gliosis in the areas of ischemic damage. Glaucomatous cupping of the optic nerve head was not seen within six weeks following the induced ischemia.</p>","PeriodicalId":14844,"journal":{"name":"Investigative ophthalmology","volume":"15 6","pages":"495-9"},"PeriodicalIF":0.0,"publicationDate":"1976-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11280514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Centrioles and cilia in the mesothelial cells of the pericanalicular region. 管周区间皮细胞中的中心粒和纤毛。
Investigative ophthalmology Pub Date : 1976-06-01
M G Wickham, D M Worthen
{"title":"Centrioles and cilia in the mesothelial cells of the pericanalicular region.","authors":"M G Wickham,&nbsp;D M Worthen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An evaluation of 70 trabecular meshwork biopsies obtained at the time of therapeutic surgery in glaucomatous and cataractous eyes revealed that the mesothelial cells in the iridocorneal angle had a marked abundance of cilia and centrioles. The distribution of cells showing cilia and/or centrioles is positively correlated with the apparent aqueous humor outflow pathway. The morphology and arrangement of the cilia-centriole complexes in the angle are highly variable and show many forms not previously reported in a single tissue. There were no obvious correlations between organelle abundance and the identifiable factors affecting the patients involved in this study.</p>","PeriodicalId":14844,"journal":{"name":"Investigative ophthalmology","volume":"15 6","pages":"499-502"},"PeriodicalIF":0.0,"publicationDate":"1976-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12114987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vitro demonstration of cytotoxic antibodies and their possible role in corneal graft rejections. 细胞毒性抗体的体外证明及其在角膜移植排斥反应中的可能作用。
Investigative ophthalmology Pub Date : 1976-06-01
P S Binder, J W Chandler, H E Kaufman
{"title":"In vitro demonstration of cytotoxic antibodies and their possible role in corneal graft rejections.","authors":"P S Binder,&nbsp;J W Chandler,&nbsp;H E Kaufman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Rabbit corneas were exposed to heterologous guinea pig anti-rabbit antibodies in the presence of complement and cytotoxic damage to the endothelium was demonstrated using para nitroblue tetrazolium. The possible role of such antibodies as \"blocking antibodies\" and as cytotoxic antibodies in the corneal graft rejection process are discussed.</p>","PeriodicalId":14844,"journal":{"name":"Investigative ophthalmology","volume":"15 6","pages":"481-4"},"PeriodicalIF":0.0,"publicationDate":"1976-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11973450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The phacoemulsification procedure. I. The effect of intraocular irrigating solutions on the corneal endothelium. 超声乳化术。1 .眼内冲洗液对角膜内皮的影响。
Investigative ophthalmology Pub Date : 1976-06-01
B E McCarey, F M Polack, W Marshall
{"title":"The phacoemulsification procedure. I. The effect of intraocular irrigating solutions on the corneal endothelium.","authors":"B E McCarey,&nbsp;F M Polack,&nbsp;W Marshall","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Irrigating solutions for intraocular purposes were evaluated for their possible damaging effects on the corneal endothelial cell structure and function. Rabbit corneal endothelium was perfused in vitro with Tis-u-Sol, Travenol Ringer's Solution, or Travenol Sodium Chloride. The irrigating solutions caused an immediate corneal swelling of 67 mum per hour +/- 5 (mean +/- standard error), which was not modified by a previous stabilization perfusion with glutathione-bicarbonate Ringer's (GBR). In contrast, the Plasma-lyte-148 solution which is used in the phacoemulsification procedure, did not cause corneal swelling for more than twenty minutes, and for more than sixty minutes if the cornea was perfused after a GBR stabilization. After more than sixty minutes of corneal swelling, endothelial intercellular junction separations appeared. This breakdown was present with the tested irrigating solutions except for Travenol Ringer's Solution, which contained calcium. Plasma-lyte was also evaluated in conjunction with the surgical phacoemulsification procedure. The complete procedure or just irrigation with ultrasound did not cause endothelial cell damage similar to a prolonged in vitro irrigation. Instead, endothelial cells were traumatically damaged in varying degrees by the surgical manipulations.</p>","PeriodicalId":14844,"journal":{"name":"Investigative ophthalmology","volume":"15 6","pages":"449-57"},"PeriodicalIF":0.0,"publicationDate":"1976-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12114981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The adrenergic receptors of the intraocular muscles of the human eye. 肾上腺素受体人眼眼内肌的肾上腺素能受体
Investigative ophthalmology Pub Date : 1976-06-01
G W van Alphen
{"title":"The adrenergic receptors of the intraocular muscles of the human eye.","authors":"G W van Alphen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The adrenergic receptors in man were analyzed using isolated sphincter, dilator, and ciliary muscle strips, dissected from eyebank eyes. The dilator is mainly alpha, the sphincter both alpha and beta, and the ciliary muscle predominantly beta adrenergic.</p>","PeriodicalId":14844,"journal":{"name":"Investigative ophthalmology","volume":"15 6","pages":"502-5"},"PeriodicalIF":0.0,"publicationDate":"1976-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11230504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of isoproterenol and norepinephrine on regional ocular blood flows. 异丙肾上腺素和去甲肾上腺素对眼部局部血流的影响。
Investigative ophthalmology Pub Date : 1976-06-01
A B Malik, W A van Heuven, L F Satler
{"title":"Effects of isoproterenol and norepinephrine on regional ocular blood flows.","authors":"A B Malik,&nbsp;W A van Heuven,&nbsp;L F Satler","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effects of norepinephrine and isoproterenol on regional ocular blood flows were studied by the labeled microspheres using the reference sample method in pigs. Total and regional ocular flows increased in response to norepinephrine and isoproterenol infusions. Increase in flows during norepinephrine infusion may be due to increased ocular perfusion pressure induced by the drug, thereby masking its reported direct vasoconstrictor effect in isolated perfused ocular vessels. Increase in flows during isoproterenol infusion occurred despite a decrease in arterial pressure suggesting the existence of vasodilatory beta-adrenergic receptors in the ocular circulation of the pig.</p>","PeriodicalId":14844,"journal":{"name":"Investigative ophthalmology","volume":"15 6","pages":"492-5"},"PeriodicalIF":0.0,"publicationDate":"1976-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12114986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: Bruch's membrane and vascular growth. 编辑:布鲁赫氏膜和血管生长。
Investigative ophthalmology Pub Date : 1976-06-01
M F Goldberg
{"title":"Editorial: Bruch's membrane and vascular growth.","authors":"M F Goldberg","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":14844,"journal":{"name":"Investigative ophthalmology","volume":"15 6","pages":"443-6"},"PeriodicalIF":0.0,"publicationDate":"1976-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12114979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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