Intraocular pressure decrease in normal volunteers following timolol ophthalmic solution.

Investigative ophthalmology Pub Date : 1976-06-01
I M Katz, W A Hubbard, A J Getson, A L Gould
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Abstract

Timolol ophthalmic solutions 0.5 per cent, 1.0 per cent, and 1.5 per cent lowered intraocular pressures significantly in normal human volunteers. Maximum lowering of the intraocular pressures was reached at two hours with the 0.5 per cent solution of timolol and at one hour with the 1.0 per cent and 1.5 per cent timolol ophthalmic solutions. The effect lasted the full seven hours of observations. No objective or subjective evidence of ocular irritation could be attributed to the drug. A single dose of timolol applied topically to the eyes of normal human volunteers had no effect on pupillary size, visual acuity, blood pressure, or pulse rate.

替马洛尔眼液后正常志愿者眼压下降。
替莫洛尔眼科溶液0.5%、1.0%和1.5%显著降低了正常人志愿者的眼压。使用0.5%噻洛尔溶液2小时,使用1.0%和1.5%噻洛尔眼用溶液1小时,眼压达到最大降低。这种效应持续了整整七个小时的观察。没有客观或主观证据表明该药物可引起眼部刺激。将单剂量的噻莫洛尔局部应用于正常人类志愿者的眼睛,对瞳孔大小、视力、血压或脉搏率没有影响。
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