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Investigative ophthalmology最新文献

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Hydrostatic pressure effects on deswelling of de-epithelialized and de-endothelialized corneas. 静水压力对去上皮化和去内皮化角膜肿胀的影响。
Investigative ophthalmology Pub Date : 1976-07-01
K A Bowman, K Green
{"title":"Hydrostatic pressure effects on deswelling of de-epithelialized and de-endothelialized corneas.","authors":"K A Bowman,&nbsp;K Green","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effects of varying hydrostatic pressure on the thinning rate of preswollen de-epithelialized or de-endothelialized corneas has been determined in the specular microscope. The appropriate membrane was removed, the cornea given access to Ringer to swell, and then fluid exchange at that surface blocked with oil. De-epithelialized corneas thin more slowly as hydrostatic pressure on the posterior surface is increased, until fluid movement ceases at 60 to 70 mm. Hg. Fluid movement can occur, therefore, against a considerable hydrostatic pressure. De-endothelialized corneas thin at a higher rate as hydrostatic pressure is increased; this effect is probably a mechanical one with increasing pressure forcing fluid out across the epithelium.</p>","PeriodicalId":14844,"journal":{"name":"Investigative ophthalmology","volume":"15 7","pages":"546-50"},"PeriodicalIF":0.0,"publicationDate":"1976-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12113817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rod disc turnover in the dog. 杆盘翻在狗身上。
Investigative ophthalmology Pub Date : 1976-07-01
N Buyukmihci, G D Aguirre
{"title":"Rod disc turnover in the dog.","authors":"N Buyukmihci,&nbsp;G D Aguirre","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Tritiated l-leucine was injected intravitreally into normal adult dogs to study rod outer segment renewal. Eyes were removed at various times after injection and the retinas prepared for light microscope autoradiography. Rod outer segment disc turnover was found to be similar to other species, i.e., discs were produced at the base of the outer segments and migrated sclerad with time. The time for turnover averaged 6 days. Cone outer segments never showed banding of the labeled protein but rather a diffuse label such as reported in other species.</p>","PeriodicalId":14844,"journal":{"name":"Investigative ophthalmology","volume":"15 7","pages":"579-84"},"PeriodicalIF":0.0,"publicationDate":"1976-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12115764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of splenectomy on corneal graft rejection. 脾切除术对角膜移植排斥反应的影响。
Investigative ophthalmology Pub Date : 1976-07-01
W M Bourne, B M Gebhardt, A Sugar, R F Meyer, H E Kaufman
{"title":"The effect of splenectomy on corneal graft rejection.","authors":"W M Bourne,&nbsp;B M Gebhardt,&nbsp;A Sugar,&nbsp;R F Meyer,&nbsp;H E Kaufman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Recent studies have suggested that the spleen may be essential for the \"immunologic privilege\" enjoyed by corneal grafts. We tested this hypothesis in rabbits by performing 38 exchange penetrating keratoplasties between 19 normal rabbits and 19 rabbits that had undergone splenectomy. No significant difference was found in the number of corneas rejected or the mean graft survival time between the normal and splenectomized rabbits.</p>","PeriodicalId":14844,"journal":{"name":"Investigative ophthalmology","volume":"15 7","pages":"541-2"},"PeriodicalIF":0.0,"publicationDate":"1976-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11973452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Etiology of corneal striae accompanying hydrogel lens wear. 伴水凝胶晶体磨损的角膜条纹的病因学。
Investigative ophthalmology Pub Date : 1976-07-01
K A Polse, R B Mandell
{"title":"Etiology of corneal striae accompanying hydrogel lens wear.","authors":"K A Polse,&nbsp;R B Mandell","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Vertical striae in the posterior cornea were produced experimentally in ten human subjects by depriving the anterior corneal surface of its normal oxygen supply and inducing corneal edema. These striae were similar in appearance and time of occurrence to those observed in gel lens wearers. Three subjects also wore gel lenses and developed vertical striae while wearing their lenses. These striae were eliminated by increasing the oxygen concentration at the anterior lens surface. The data confirm many clinical observations which have suggested that verical striae are caused by corneal edema accompanying gel lens wear.</p>","PeriodicalId":14844,"journal":{"name":"Investigative ophthalmology","volume":"15 7","pages":"553-6"},"PeriodicalIF":0.0,"publicationDate":"1976-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12113819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An acquired color defect of the opponent-color system. 对手色系统的一种后天的颜色缺陷。
Investigative ophthalmology Pub Date : 1976-07-01
P E King-Smith, K Kranda, I C Wood
{"title":"An acquired color defect of the opponent-color system.","authors":"P E King-Smith,&nbsp;K Kranda,&nbsp;I C Wood","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An acquired unilateral color defect in a 22-year-old man has been investigated with standard clinical tests and by using techniques which, it is thought, test specifically for the sensitivity of the luminance and opponent-color systems. The spectral sensitivity of the defective left eye, using 1 degree 200 ms. test flashes on a white background, has a single broad peak at about 550 nm. and resembles the photopic luminosity curve; in contrast, the normal curve, measured in the same conditions, has three peaks at about 440, 520, and 600 nm. However, the subject's spectral sensitivity curve for detecting 20 Hz. flicker is quite normal and is similar to his curve for 200 ms. flashes. It has recently been proposed that the three peaks of the normal curve for 200 ms. flashes reflect the activity of the opponent-color system, whereas the single peak for flicker detection is related to the luminance system. The preceding observations may thus be interpreted in terms of a specific loss of the subject's opponent-color system and this would explain his poor color discrimination. His luminance system appears to be normal, and evidence is presented for the maintained function of red- and green-sensitive (but not blue-sensitive) cones. The spectral sensitivity of the subject's right eye is nearly normal, suggesting a precortical origin of the defect; however, there seems to be some abnormality in this eye, indicating a less developed form of the same defect.</p>","PeriodicalId":14844,"journal":{"name":"Investigative ophthalmology","volume":"15 7","pages":"584-7"},"PeriodicalIF":0.0,"publicationDate":"1976-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12264511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pathways of the eye's response to topical nitrogen mustard. 眼睛对局部氮芥反应的途径。
Investigative ophthalmology Pub Date : 1976-06-01
L M Jampol, A Axelrod, H Tessler
{"title":"Pathways of the eye's response to topical nitrogen mustard.","authors":"L M Jampol,&nbsp;A Axelrod,&nbsp;H Tessler","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We studied the effect of prior corneal herpes simplex infection with its resultant corneal hypesthesia on the irritative response of the rabbit eye to topical nitrogen mustard. Both the miosis and the breakdown of the blood-aqueous barrier that follow the application of topical nitrogen mustard were diminished in eyes infected three weeks previously with herpes simplex virus. Nonspecific corneal scarring did not affect the response. This suggests again that an axon reflex requiring intact sensory innervation mediates the response to nitrogen mustard. Pretreatment of normal (noninfected) rabbits with systemic H1 and H2 antihistamines, topical scopolamine hydrobromide, or topical and systemic corticosteroids was ineffective in blocking the miosis or increased protein in the aqueous humor following topical nitrogen mustard.</p>","PeriodicalId":14844,"journal":{"name":"Investigative ophthalmology","volume":"15 6","pages":"486-9"},"PeriodicalIF":0.0,"publicationDate":"1976-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11230502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: Surgical approach to the vitreous. 编辑:玻璃体手术入路。
Investigative ophthalmology Pub Date : 1976-06-01
C R Fitzgerald
{"title":"Editorial: Surgical approach to the vitreous.","authors":"C R Fitzgerald","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":14844,"journal":{"name":"Investigative ophthalmology","volume":"15 6","pages":"447-8"},"PeriodicalIF":0.0,"publicationDate":"1976-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12114980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stromal sodium binding after glycosaminoglycan digestion. 糖胺聚糖消化后基质钠结合。
Investigative ophthalmology Pub Date : 1976-06-01
K Green, S Downs, K Bowman
{"title":"Stromal sodium binding after glycosaminoglycan digestion.","authors":"K Green,&nbsp;S Downs,&nbsp;K Bowman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The glycosaminoglycans of isolated rabbit corneal stroma, clamped between two lucite plates at near normal hydration, were digested with testicular hyaluronidase in saline solution. After equilibration with 0.9 per cent saline solution alone the sodium and chloride content of the stroma was determined. Chloride was in equilibrium with both normal and hyaluronidase-treated stroma, allowing use of the Donnan calculation for excess or bound sodium to be made. Normal stromas contained 200 mEq. bound sodium per kilogram of dry weight calculated from the Donnan calculation; hyaluronidase-treated stromas contained 110 mEq. bound sodium per kilogram of dry weight. The data show that about half of the bound sodium in the corneal stroma is on nonsaccharide binding sites. Quantitative verification of the loss of glycosaminoglycans was performed.</p>","PeriodicalId":14844,"journal":{"name":"Investigative ophthalmology","volume":"15 6","pages":"484-6"},"PeriodicalIF":0.0,"publicationDate":"1976-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12114985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sialic acid in rabbit lacrimal gland fluid. 兔泪腺液中的唾液酸。
Investigative ophthalmology Pub Date : 1976-06-01
J Kreuger, N Sokoloff, S Y Botelho
{"title":"Sialic acid in rabbit lacrimal gland fluid.","authors":"J Kreuger,&nbsp;N Sokoloff,&nbsp;S Y Botelho","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>To date, there has been no attempt to determine which of the orbital glands contribute the sialic acid, which has been found in tears and tear mucoids. In the present study, sialic acid was found in the fluid collected directly from the lacrimal gland excretory duct, uncontaminated by the secretions of the other orbital glands (Nictitans, Harderian, conjunctival) as well as in the fluid secreted into the conjunctival sac by the other orbital glands, uncontaminated by lacrimal gland fluid. At all flow rates, the rate of secretion of sialic acid increased as flow rate increased in both fluids and the rate of secretion of sialic acid by the lacrimal gland was three times that by the other orbital glands. This is the first demonstration that a substance, which can be derived from either nonserum glycoproteins, such as the tear mucoids, or alpha-globulins, is a component of the secretions of the lacrimal gland, as well as of the secretion of the other orbital glands.</p>","PeriodicalId":14844,"journal":{"name":"Investigative ophthalmology","volume":"15 6","pages":"479-81"},"PeriodicalIF":0.0,"publicationDate":"1976-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12114984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
On the presence of bilirubin in the ocular humors of premature infants. 早产儿眼体液中胆红素的存在。
Investigative ophthalmology Pub Date : 1976-06-01
R B Kurzel, R L Heinrikson
{"title":"On the presence of bilirubin in the ocular humors of premature infants.","authors":"R B Kurzel,&nbsp;R L Heinrikson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The yellow pigments observed in the ocular humors of premature infants were identified as the plasma pigments bilirubin and oxyhemoglobin. The blood/vitreous humor barrier to bilirubin was estimated to be (1/0.11) for total bilirubin and (1/0.25) for direct-acting bilirubin. Hall method histochemical staining for bilirubin in sections of premature infant eyes was highly positive for the vitreous humor, and suggestive of uptake of bilirubin by the neural-retinal cells.</p>","PeriodicalId":14844,"journal":{"name":"Investigative ophthalmology","volume":"15 6","pages":"509-12"},"PeriodicalIF":0.0,"publicationDate":"1976-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12114988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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