脾切除术对角膜移植排斥反应的影响。

Investigative ophthalmology Pub Date : 1976-07-01

W M Bourne, B M Gebhardt, A Sugar, R F Meyer, H E Kaufman

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摘要

最近的研究表明，脾脏可能对角膜移植物享有的“免疫特权”至关重要。我们在兔子身上验证了这一假设，在19只正常兔子和19只接受过脾切除术的兔子之间进行了38次交换穿透性角膜移植术。正常和脾切除兔在角膜排斥数和平均移植存活时间上无显著差异。

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The effect of splenectomy on corneal graft rejection.

Recent studies have suggested that the spleen may be essential for the "immunologic privilege" enjoyed by corneal grafts. We tested this hypothesis in rabbits by performing 38 exchange penetrating keratoplasties between 19 normal rabbits and 19 rabbits that had undergone splenectomy. No significant difference was found in the number of corneas rejected or the mean graft survival time between the normal and splenectomized rabbits.

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Investigative ophthalmology

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