{"title":"细胞毒性抗体的体外证明及其在角膜移植排斥反应中的可能作用。","authors":"P S Binder, J W Chandler, H E Kaufman","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Rabbit corneas were exposed to heterologous guinea pig anti-rabbit antibodies in the presence of complement and cytotoxic damage to the endothelium was demonstrated using para nitroblue tetrazolium. The possible role of such antibodies as \"blocking antibodies\" and as cytotoxic antibodies in the corneal graft rejection process are discussed.</p>","PeriodicalId":14844,"journal":{"name":"Investigative ophthalmology","volume":"15 6","pages":"481-4"},"PeriodicalIF":0.0000,"publicationDate":"1976-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"In vitro demonstration of cytotoxic antibodies and their possible role in corneal graft rejections.\",\"authors\":\"P S Binder, J W Chandler, H E Kaufman\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Rabbit corneas were exposed to heterologous guinea pig anti-rabbit antibodies in the presence of complement and cytotoxic damage to the endothelium was demonstrated using para nitroblue tetrazolium. The possible role of such antibodies as \\\"blocking antibodies\\\" and as cytotoxic antibodies in the corneal graft rejection process are discussed.</p>\",\"PeriodicalId\":14844,\"journal\":{\"name\":\"Investigative ophthalmology\",\"volume\":\"15 6\",\"pages\":\"481-4\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1976-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Investigative ophthalmology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Investigative ophthalmology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
In vitro demonstration of cytotoxic antibodies and their possible role in corneal graft rejections.
Rabbit corneas were exposed to heterologous guinea pig anti-rabbit antibodies in the presence of complement and cytotoxic damage to the endothelium was demonstrated using para nitroblue tetrazolium. The possible role of such antibodies as "blocking antibodies" and as cytotoxic antibodies in the corneal graft rejection process are discussed.