Successful therapy of herpes hominis keratitis in rabbits by 5-iodo-5'-amino-2'5'-dideoxyuridine (AIU): a novel analog of thymidine.

Investigative ophthalmology Pub Date : 1976-06-01
D M Albert, M Lahav, P N Bhatt, T W Reid, R E Ward, R C Cykiert, T S Lin, D C Ward, W H Prusoff
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Abstract

The efficiency of 5-iodo-5'-amino-2'5'-dideoxyuridine (AIU) in the therapy of experimental herpes keratitis in rabbits has been examined. Virus infections were established bilaterally in 40 animals using herpes simplex, type 1 (NIH strain 11124). Twenty-four hours after infection the rabbits were divided into five matched groups of eight and each group was treated, double-blind, with topical drugs at four-hour intervals for a total of 72 hours. The solutions instilled were: (1) saline; (2) IdUrd, 1 mg. per milliliter; (3) AIU, 1 mg. per milliliter; (4) AIU, 4 mg. per milliter; and (5) AIU, 8 mg. per milliliter. Each eye was examined daily for 12 days and graded independently by two ophthalmologists. Although IdUrd and AIU (8 mg. per milliliter) were effective therapeutically, IdUrd had a greater effect. The AIU at 1 and 4 mg. per milliliter were less active, but showed more rapid healing than the saline control. Viral recovery studies are consistent with the clinical observations. A second independent experiment, similar to that described above, gave essentially identical results. Although less potent than IdUrd, AIU does provide effective therapy for herpes keratitis.

5-碘-5′-氨基-2′-5′-双脱氧尿苷(AIU)成功治疗兔人疱疹角膜炎:一种新的胸腺嘧啶类似物。
研究了5-碘-5′-氨基-2′-5′-二脱氧尿苷(AIU)治疗兔实验性疱疹性角膜炎的疗效。用1型单纯疱疹(NIH株11124)在40只动物中建立了双侧病毒感染。感染24小时后,将家兔分为5组,每组8只,每组进行双盲治疗,每隔4小时局部用药,共72小时。灌注溶液为:(1)生理盐水;(2)伊杜德,1毫克。每毫升;(3) AIU, 1mg。每毫升;(4) AIU, 4毫克。每milliter;(5) AIU, 8mg。每毫升。每只眼睛每天检查12天,并由两名眼科医生独立评分。虽然碘和AIU(8毫克)。(每毫升)在治疗上是有效的,IdUrd的效果更大。1毫克和4毫克的AIU。每毫升的活性较低,但愈合速度比生理盐水对照组快。病毒恢复研究与临床观察一致。第二个独立的实验,类似于上面描述的,给出了基本相同的结果。AIU虽然不如IdUrd有效,但它确实为疱疹性角膜炎提供了有效的治疗。
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