Journal de mycologie medicale最新文献

{"title":"Disseminated histoplasmosis in erythematosus systemic lupus: A case report and review","authors":"Carlos Solórzano,&nbsp;Johiner Vanegas,&nbsp;Maria Alejandra Caro,&nbsp;Maria Camila Rubio","doi":"10.1016/j.mycmed.2025.101581","DOIUrl":"10.1016/j.mycmed.2025.101581","url":null,"abstract":"<div><div>Histoplasmosis is an endemic mycosis in some regions affecting particularly immunosuppressed individuals. The global prevalence of disseminated histoplasmosis in systemic lupus erythematosus (SLE) patients is &lt;1 %, but rises in endemic areas such as Colombia. Clinical manifestations in those patients are atypical, ranging from non-specific symptoms to severe cases of multi-organ failure. Given its rarity and the nonspecific nature of its symptoms, disseminated histoplasmosis in the context of systemic lupus erythematosus remains a diagnostic challenge.</div><div>A 28-year-old female patient with a history of SLE diagnosed in 2009 presented to our clinic in February 2024. The patient reported an acute onset of non-specific symptoms, with a subsequent treatment for a suspected bacterial lung infection and successfully discharged. However, due to persistent fever and ongoing weight loss, she returned for further evaluation. Initially a thoracic computed tomography and fiberoptic bronchoscopy was performed, with negative results for tuberculosis (TB), however TB treatment was empirically initiated according to imagenological findings. During hospitalization, the patient developed gastrointestinal bleeding, prompting further investigations and confirming <em>Histoplasma capsulatum</em> in a biopsy. Despite the antifungal therapy, the patient’s condition deteriorated, culminating in multiorgan failure and death 10 days later.</div><div>This case underscores the importance of prompt and accurate diagnosis of disseminated histoplasmosis in patients with SLE. The clinical presentation can mimic a lupus flare or other infectious diseases, potentially delaying the initiation of appropriate therapy. In endemic regions such as Latin America, it is critical to include disseminated histoplasmosis in the differential diagnosis of febrile illness in immunosuppressed patients.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 4","pages":"Article 101581"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145045653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebral aspergillosis in a patient treated with acalabrutinib, a second generation Bruton's tyrosine kinase inhibitor","authors":"Scheherazade Rezig ,&nbsp;Jean-Philippe Talarmin ,&nbsp;Solène Le Gal ,&nbsp;Hussam Saad","doi":"10.1016/j.mycmed.2025.101586","DOIUrl":"10.1016/j.mycmed.2025.101586","url":null,"abstract":"<div><div>Bruton’s tyrosine kinase (BTK) inhibitors are key drugs in the frontline therapy of chronic lymphocytic leukemia. Invasive fungal infection is a well-documented adverse event in patient treated with first-generation BTK inhibitors. This rare but severe adverse event has been described in several case-reports and series in patients receiving ibrutinib, particularly invasive aspergillosis, especially of cerebral location. Second-generation BTK inhibitors such as acalabrutinib are more selective for BTK and are as effective and better tolerated than ibrutinib. Only six case-reports have described an opportunistic fungal infection occurring with second-generation BTK inhibitors. Here, we report the case of a patient who developed fatal invasive pulmonary and cerebral aspergillosis while being treated with acalabrutinib.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 4","pages":"Article 101586"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145358540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tinea capitis in adults: A 14-year retrospective study in central Tunisia","authors":"Hamed Chouaieb ,&nbsp;Mohammad Akhoundi ,&nbsp;Nadia Ghariani Fetoui ,&nbsp;Yasmine Kalboussi ,&nbsp;Samar Ismail ,&nbsp;Imen Khammari ,&nbsp;Sophie Brun ,&nbsp;Mohamed Denguezli ,&nbsp;Akila Fathallah","doi":"10.1016/j.mycmed.2025.101582","DOIUrl":"10.1016/j.mycmed.2025.101582","url":null,"abstract":"<div><h3>Objectives</h3><div>Tinea capitis (TC) is a common fungal infection predominantly affecting school-aged children while being rare among adults. Few studies, particularly in Tunisia, have specifically focused on TC in adults. This retrospective study aimed to assess the epidemiological and mycological profile of adult TC in central Tunisia (North Africa).</div></div><div><h3>Methods</h3><div>A retrospective study of adult TC cases diagnosed at the Farhat Hached University Hospital of Sousse, in Tunisia, has been carried out over a 14-year period (2009–2022). Diagnosis was based on clinical presentation and mycological culture. Of 3711 patients examined, 41 adult patients (24 women and 17 men) were diagnosed with TC. The mean age was 43 years old. Ten patients had a history of corticosteroid therapy. Physical examination revealed associated tinea corporis in 6 cases (14.6 %), onychomycosis in 10 cases (24 %) and both those conditions concomitantly in one patient (2.4 %). Direct examination was positive in 97.5 % of cases. The most prevalent species of dermatophyte were <em>Trichophyton violaceum</em> (46 %) and <em>Microsporum canis</em> (34 %). In the majority of cases, the course of treatment was favorable.</div></div><div><h3>Conclusion</h3><div>We highlight TC as an uncommon condition in adults, with a higher prevalence observed in women, particularly postmenopausal women. Adult TC, though uncommon, should be considered in differential diagnoses for scalp lesions in elderly patients due to potential atypical presentations. <em>Trichophyton violaceum</em> is the most frequent species in central Tunisia. Accurate mycological diagnosis and identification of contributing factors remain crucial.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 4","pages":"Article 101582"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular characterization and antifungal susceptibility profile of Podospora bulbillosa keratitis: case series and review of literature","authors":"Sourav Das ,&nbsp;Amrita Mohanty ,&nbsp;Esther Sheba ,&nbsp;Joveeta Joseph","doi":"10.1016/j.mycmed.2025.101585","DOIUrl":"10.1016/j.mycmed.2025.101585","url":null,"abstract":"<div><h3>Purpose</h3><div><em>Podospora</em> species are rarely reported as etiological agents of keratitis. This study reports a series of fungal keratitis caused by Podospora bulbillosa, detailing their clinical presentation, treatment outcomes, in vitro antifungal susceptibility and molecular characterization.</div></div><div><h3>Methods</h3><div>Cases of fungal keratitis caused by Podospora bulbillosa between January-March 2025, were retrospectively reviewed from the electronic medical records (EMR). Following microbiological work up, fungal identification was confirmed by large subunit 28S and internal transcribed spacer (ITS) region sequencing and molecular phylogenetic tree was constructed by Maximum Likelihood method. In vitro antifungal susceptibility testing was conducted using the Clinical &amp; Laboratory Standards Institute (CLSI) broth microdilution method (M38-A2).</div></div><div><h3>Results</h3><div>Five male patients (aged 5–72 years) presented with Podospora bulbillosa keratitis, all following ocular trauma as the predisposing factor. Clinical presentation included central or paracentral pigmented plaque-like stromal infiltrates with surrounding edema and varying degrees of thinning and hypopyon in advanced cases. All patients received topical natamycin 5 % as primary therapy; while one case involved polymicrobial infection with Corynebacterium pseudodiphtheriticum. Three patients showed clinical resolution with scarring following medical management alone. All Podospora bulbillosa isolates showed low MICs (0.03–0.125 µg/mL) to natamycin, azoles, echinocandins, and amphotericin B, indicating potent in vitro activity.</div></div><div><h3>Conclusion</h3><div>Notably, all five P. bulbillosa isolates clustered within a single subclade, indicating close genetic relatedness. Podospora bulbillosa keratitis responds well to standard antifungal agents. Molecular tools are crucial for accurate identification of rare, non-sporulating fungal pathogens.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 4","pages":"Article 101585"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145308100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone marrow cryptococcosis in an HIV-infected patient: A case report and literature review","authors":"Sirine Chtourou ,&nbsp;Fatma Hammami ,&nbsp;Amal Chakroun ,&nbsp;Ons Boudawara ,&nbsp;Tahia Boudawara ,&nbsp;Makram Koubaa ,&nbsp;Mounir Ben Jemaa","doi":"10.1016/j.mycmed.2025.101572","DOIUrl":"10.1016/j.mycmed.2025.101572","url":null,"abstract":"<div><h3>Background and Purpose</h3><div>Cryptococcosis is a common opportunistic fungal infection in immunocompromised individuals. It is typically isolated from cerebrospinal fluid, sputum, or skin lesions. However, disseminated cryptococcosis involving the bone marrow is an extremely rare occurrence.</div></div><div><h3>Case Report</h3><div>This case describes a 34-year-old male patient living with HIV who developed fever, abdominal pain, and pancytopenia. Diagnostic evaluation, including bone marrow aspiration and biopsy, revealed encapsulated yeasts consistent with <em>Cryptococcus</em> sp. Although blood and cerebrospinal fluid cultures failed to identify fungal agents, the diagnosis of isolated bone marrow cryptococcosis was confirmed. A literature review of 21 previously reported cases (up to October 2024) was conducted, revealing a predominance of immunocompromised patients, with male patients being more frequently affected. Cytopenia was a common finding in all cases, and bone marrow biopsy was essential for diagnosis. Treatment protocols remain unstandardized.</div></div><div><h3>Conclusion</h3><div>Bone marrow cryptococcosis, while rare, should be considered in the differential diagnosis of pancytopenia in immunocompromised patients, particularly those with HIV.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 4","pages":"Article 101572"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pneumo-médiastin : une cause rare de douleur thoracique aigue de l’enfant asthmatique au scanner à propos de deux cas","authors":"IDRISS Abdoulaye Acyl, SOUHO Bénédicte, Massaga Dagbé, Pihou Gbandé, Tchaou Mazamaesso, AMADOU Abdoulatif, Lantam Sonhaye, ADJENOU Victor","doi":"10.55715/jaim.v17i4.855","DOIUrl":"https://doi.org/10.55715/jaim.v17i4.855","url":null,"abstract":"Pneumomediastinum is a rare condition in pediatric patients and may be associated with any predisposing pulmonary disease, including asthma. Its incidence is estimated at 1/32,896 in the general population. Asthma is the most common associated condition in children, with a frequency of 38.4%. Standard chest X-ray is the first investigation performed for its diagnosis; however, chest computed tomography without contrast injection is more sensitive for detecting small amounts of mediastinal air. We report here two cases of spontaneous pneumomediastinum diagnosed by CT scan, a complication of acute asthma at the Lomé University Hospital. RÉSUME Le pneumo médiastin est une entité rare chez les patients pédiatriques, pouvant être associé à toute pathologie pulmonaire prédisposante dont l'asthme. Son incidence est estimée à 1/32896 dans la population générale. L’asthme constitue la pathologie associée la plus courante chez l’enfant, avec une fréquence de 38,4 %. La radiographie standard du thorax est la première investigation réalisée pour son diagnostic ; Cependant, la tomodensitométrie thoracique sans injection de produit de contraste est plus sensible pour détecter de petites quantités d’air médiastinales. Nous rapportons ici deux cas de pneumomédiastin spontané diagnostiqués au scanner, complication d’asthme aigue au CHU campus de Lomé.","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"17 4","pages":"291-294"},"PeriodicalIF":0.0,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://jaim-online.net/index.php/jaim/article/download/855/362","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147889364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraventricular mould infection suggestive of Aspergillosis in a 2-year-old child with successful clinical outcomes","authors":"HCV Tulasi Ram ,&nbsp;Madhivanan Karthigeyan ,&nbsp;Aravind Sekar ,&nbsp;Harsimran Kaur ,&nbsp;Pravin Salunke","doi":"10.1016/j.mycmed.2025.101569","DOIUrl":"10.1016/j.mycmed.2025.101569","url":null,"abstract":"<div><div>Pediatric isolated central nervous system (CNS) mould infections are uncommon but potentially fatal if not promptly diagnosed and treated. Such invasive lesions usually present as abscesses in parenchymal locations. Although the newer azole antifungals have shown improved outcomes, treatment data are limited in the pediatric age group, especially in young children. We report a case of a very young child with an unusual location of mould infection, in the temporal horn of the lateral ventricle, managed successfully. The 2-year-old-male child with prior COVID-19 infection and no other apparent immune dysfunction presented with features of raised intracranial pressure. CT/MRI imaging demonstrated a left temporal horn cystic lesion. Following an initial non-diagnostic aspiration of the cyst contents, the child underwent excision of the lesion. The potassium hydroxide stain of the content revealed hyaline septate hyphae, but the fungal culture was sterile. Histopathology of the specimen was highly suggestive of aspergillosis. The child was adequately treated with voriconazole, and had excellent clinical outcome at 22-month follow up. Rarely, CNS mould infection can manifest as an intraventricular space occupying lesion in children. Such a differential must be borne in mind. In our case, the infection was possibly a COVID-19 sequelae. The case also highlights the potential for successful clinical outcomes with an early and aggressive voriconazole treatment in pediatric intracranial mould infections, most likely aspergillosis.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 3","pages":"Article 101569"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144614606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coccidioidomycosis Lymphadenitis in a patient with Lupus nephritis: A case report","authors":"Gustavo Abraham Canales-Azcona ,&nbsp;Abraham Castellanos-Maldonado ,&nbsp;Héctor Raúl Ibarra-Sifuentes ,&nbsp;Yadhira María González-Amador","doi":"10.1016/j.mycmed.2025.101559","DOIUrl":"10.1016/j.mycmed.2025.101559","url":null,"abstract":"<div><div>Coccidioidomycosis is a fungal infection endemic to arid regions. Although it usually presents as a pulmonary infection, extrapulmonary dissemination is rare, and cervical lymphadenitis is even more unusual with fewer than five cases reported in the literature. Diagnosis of this disease remains a clinical challenge due to its rarity and similarity to other clinical entities. A 34-year-old woman with lupus nephritis on immunosuppressive therapy presented with a painful cervical mass associated with unquantified fever of six weeks of evolution. The patient is a resident of Coahuila, Mexico, in a region adjacent to the Texas–Mexico border. Diagnostic imaging and excisional biopsy with histopathology and culture confirmed cervical lymphadenitis due to Coccidioides. Treatment with oral fluconazole (Diflucan) was started, achieving complete clinical resolution after 12 months. This case highlights the importance of considering different fungal infections in immunocompromised patients presenting with lymphadenopathy. Early diagnosis by biopsy and culture, as well as specific antifungal treatment are essential to obtain favorable results.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 3","pages":"Article 101559"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144517151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fungal infection does not impair flow cytometry signals induced by nCD64 and mCD169 biomarkers during co-infection with bacteria and viruses","authors":"Sandrine Henri,&nbsp;Adélaïde Chesnay,&nbsp;Inès Ait Belkacem,&nbsp;Loïc Gonzalez,&nbsp;Emilie Barsac,&nbsp;Fabrice Malergue,&nbsp;Guillaume Desoubeaux","doi":"10.1016/j.mycmed.2025.101562","DOIUrl":"10.1016/j.mycmed.2025.101562","url":null,"abstract":"","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 3","pages":"Article 101562"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144536041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aspergillus fumigatus lung abscess in two adolescents with cystic fibrosis","authors":"Maria Noni ,&nbsp;Anna Katelari ,&nbsp;Konstantinos Iosifidis ,&nbsp;Christina Kanaka-Gantenbein ,&nbsp;Aristea Velegraki ,&nbsp;Georgia Papaioannou ,&nbsp;Stavros-Eleftherios Doudounakis","doi":"10.1016/j.mycmed.2025.101570","DOIUrl":"10.1016/j.mycmed.2025.101570","url":null,"abstract":"<div><div>Lung abscess is a severe but rare complication among non-transplanted cystic fibrosis (CF) patients. &lt;10 cases have been reported in the international literature so far and bacteria were considered the responsible pathogen. We present two cases of CF adolescent patients who developed lung abscess from <em>A. fumigatus</em>, critically revealed with chest Computed Tomography. In one patient, a thyroid abscess was additionally detected. Both patients presented with fever, not responding to antibiotic therapy. Microbial cultures and molecular testing aided detection of the pathogen. Both patients responded well to antifungal treatment.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 3","pages":"Article 101570"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144581379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}