Journal de mycologie medicale最新文献

{"title":"Pediatric pneumonia involving Penicillium rolfsii isolated from sputum culture following a plunge pool near-drowning incident","authors":"Shiori Kitaya ,&nbsp;Akira Watanabe ,&nbsp;Takashi Yaguchi ,&nbsp;Junya Nakade ,&nbsp;Hatsumi Otani ,&nbsp;Yusuke Matsuda ,&nbsp;Tatsuya Kubo ,&nbsp;Tomoko Azuma ,&nbsp;Yui Ikehata ,&nbsp;Hiroki Otani ,&nbsp;Hiroka Yamazaki ,&nbsp;Daichi Miyashita ,&nbsp;Yasunari Tanaka ,&nbsp;Yoshinori Takahashi ,&nbsp;Yoshitaka Zaimoku ,&nbsp;Megumi Oshima ,&nbsp;Taizo Wada ,&nbsp;Takumi Taniguchi ,&nbsp;Hajime Kanamori","doi":"10.1016/j.mycmed.2025.101589","DOIUrl":"10.1016/j.mycmed.2025.101589","url":null,"abstract":"<div><div><em>Penicillium</em> is a ubiquitous fungus found in the soil, decaying plant material, freshwater, and other habitats. Although <em>Penicillium</em> species are generally harmless to humans, they can act as opportunistic pathogens in patients with a compromised immune system. <em>Penicillium rolfsii</em> is primarily known as an endophytic fungus with antioxidant and antibacterial properties, which has not been previously reported in culture tests from invasive human infections. This study reports the case of an eight-year-old boy who developed pneumonia following a near-drowning incident in a river, with <em>P. rolfsii</em> detected in sputum culture. The patient underwent cardiopulmonary resuscitation at the scene and was subsequently transferred to the intensive care unit at our hospital. Chest computed tomography confirmed severe aspiration pneumonia, and empirical treatment with ampicillin–sulbactam was initiated. Based on elevated β-D-glucan levels, voriconazole was added. Sputum cultures revealed the presence of <em>Penicillium</em> species, which were identified as <em>P. rolfsii</em> based on the β-tubulin gene sequence analysis. The treatment was successful, and the patient recovered. An environmental investigation of the plunge pool where the near-drowning incident occurred detected <em>Penicillium</em> species in the water samples. This is the first reported case of <em>P. rolfsii</em> being detected in culture tests of a human invasive infection, particularly in an otherwise healthy child. This case highlights the need for healthcare professionals to consider environmental fungi in Japanese river water as potential causes of invasive infections, such as pneumonia, particularly after near-drowning incidents.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 4","pages":"Article 101589"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145556966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Terbinafine-resistant Trichophyton indotineae in two Italian MSM: a new emerging sexually transmissible infection","authors":"Luigi Pisano ,&nbsp;Deborah Cruciani ,&nbsp;Silvia Crotti ,&nbsp;Manuela Papini","doi":"10.1016/j.mycmed.2025.101578","DOIUrl":"10.1016/j.mycmed.2025.101578","url":null,"abstract":"<div><div>We report, to the best of our knowledge, the first two cases of <em>Trichophyton (T.) indotineae</em> infection observed in a couple of Italian engaged men who have sex with men (MSM), potentially acquired through sexual contact with a third man from India.</div><div>This article also provides a narrative review of the most recent existing literature on the potential sexual transmission of genital dermatophytoses. For dermatophytosis sexual transmission is a presumptive diagnosis but some clinical criteria may raise suspicion of sexual transmission, such as the occurrence of genital lesions in individuals with high-risk sexual behavior, without simultaneous involvement of the feet and/or nails, without a history of contact with infected animals, and the presence of similar lesions in sexual partners.</div><div>In recent years, several reports have indicated a potential sexual transmission of genital dermatophytosis, mainly caused by <em>T. mentagrophytes</em> genotype VII (TMVII), first observed in heterosexual individuals and then also in groups of MSM, suggesting a potentially unnoticed epidemic at the European level. From 2020 onwards, the emergence of <em>T. indotineae</em>, a novel strain closely related to TMVII, yet often associated with Terbinafine resistance, has been documented in more than 30 countries worldwide. Laboratory identification requires advanced molecular techniques, as culture-based methods are unable to differentiate <em>T. indotineae</em> from other <em>Trichophyton</em> species. A proper species-level diagnosis is essential to establish the appropriate treatment. Dermatologists should be aware of the international spread of this new strain and its potential sexual transmission and conduct targeted mycological tests in at-risk populations.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 4","pages":"Article 101578"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145045651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, characterization, and antifungal activity of metallic nanoparticles and simvastatin against fungi that cause superficial infections","authors":"Diego Henrique Morandi ,&nbsp;Maria Gabriela Martins dos Reis ,&nbsp;Aline Ratuchne ,&nbsp;Ricardo Sérgio Couto de Almeida ,&nbsp;Guilherme Fonseca Reis ,&nbsp;Luciano Aparecido Panagio","doi":"10.1016/j.mycmed.2025.101580","DOIUrl":"10.1016/j.mycmed.2025.101580","url":null,"abstract":"<div><div>Superficial mycoses present several clinical manifestations, ranging from lesions of the skin and its appendages to progression into disseminated infections. Antifungal resistance to currently available drugs is a global public health concern, necessitating novel antimicrobial compounds. Metal nanoparticles or simvastatin (SIM), via drug repositioning, represent promising avenues. The aims of this study were to synthesize and characterize silver nanoparticles (AgNPs) and selenium nanoparticles (SeNPs) and to evaluate their antifungal activity in combination with simvastatin against <em>T. mentagrophytes, T. rubrum, N. gypsea, C. albicans, C. tropicalis</em>, and <em>M. pachydermatis</em>. Nanoparticles were biosynthesized using the supernatant of <em>L. ornata</em> and characterized by UV–Vis, FTIR, zeta potential analysis, DLS, and EDXRF. Their antifungal activity was assessed via broth microdilution (MIC) and checkerboard assays to evaluate agent interactions. MIC values ranged from 1 to 8.7 µg/mL for AgNPs, 194.5 to 778 µg/mL for SeNPs, and 78 to 312.5 µg/mL for simvastatin. A synergistic effect was observed between AgNPs and simvastatin against <em>T. rubrum</em> and <em>T. mentagrophytes</em>. The <strong><em>L. ornata</em></strong> strain demonstrated the ability to synthesize AgNPs and SeNPs, though further research is required to optimize SeNP production. The tested compounds displayed antifungal activity against most of the species analyzed, highlighting their potential as promising alternatives for treating superficial mycoses and combating antifungal resistance.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 4","pages":"Article 101580"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145308043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invasive fungal infections in the Nigerian paediatric population: A systematic review","authors":"Glory Bassey ,&nbsp;Mary Alex-Wele ,&nbsp;Usenobong Akpan ,&nbsp;Love Okafor ,&nbsp;Ofonime Benjamin ,&nbsp;Nsisong Udoudo ,&nbsp;Christian Ide ,&nbsp;Edet Usun ,&nbsp;Rosa Nwagboso ,&nbsp;Aje Ogar ,&nbsp;Anthony Offiong ,&nbsp;Stella Chukwuma ,&nbsp;Bassey Ekeng","doi":"10.1016/j.mycmed.2025.101587","DOIUrl":"10.1016/j.mycmed.2025.101587","url":null,"abstract":"<div><div>Invasive fungal infections (IFIs) are life-threatening affecting all age groups. Several studies on IFIs in Nigeria are documented, but reviews describing their occurrence in the paediatric population are lacking in the literature. We conducted a systematic review of the literature following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Using the PubMed database, we identified case reports, series, and observational studies reporting IFIs in the Nigerian paediatric population from inception to December 2024. We identified a total of 114 cases of IFIs from 35 articles published between 1964 and 2023. Eight IFIs were identified including invasive candidiasis (59.6 %, <em>n</em> = 68), histoplasmosis (16.7 %, <em>n</em> = 19), pneumocystis pneumonia (2.6 %, <em>n</em> = 3), aspergillosis (2.6 %, <em>n</em> = 3), cryptococcosis (5.3 %, <em>n</em> = 6), entomophthoromycosis (7.9 %, <em>n</em> = 9), mucormycosis (2.6 %, <em>n</em> = 3) and eumycetoma (0.9 %, <em>n</em> = 1). Two (1.8 %) cases were reported as phycomycosis, and it was unclear whether these were cases of entomophthoromycosis or mucormycosis, as the fungal cultures were unsuccessful. Diagnosis was predominantly by culture (<em>n</em> = 59, 51.8 %) and histopathology (<em>n</em> = 30, 26.3 %). Outcomes were stated in 72 cases: 47 (41.2 %) recovered, 23 (20.2 %) died, one (0.9 %) lost to follow up and one (0.9 %) left against medical advice. Fatal outcomes were associated with delayed diagnosis and the lack of appropriate antifungals. IFIs are severely underdiagnosed in Nigerian children with significant gaps in the management of cases, including a low index of suspicion, delayed diagnosis, lack of diagnostics, especially the non-culture-based assays and poor accessibility to appropriate antifungal agents. Collaborative efforts to drive awareness and active surveillance of IFIs with funding for research targeted at the Nigerian paediatric population will mitigate these gaps.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 4","pages":"Article 101587"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145416159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whole genome sequencing of terbinafine-sensitive canine strains of Trichophyton indotineae isolated from India","authors":"Prasad Thomas ,&nbsp;Sonu S. Nair ,&nbsp;Mostafa Y. Abdel-Glil ,&nbsp;Sudhir K. Prajapati ,&nbsp;Subbaiyan Anbazhagan ,&nbsp;Shubham Saini ,&nbsp;Athira V ,&nbsp;Bablu Kumar ,&nbsp;Vinod K. Chaturvedi ,&nbsp;Shivaprakash M Rudramurthy ,&nbsp;G. Saikumar ,&nbsp;Premanshu Dandapat ,&nbsp;Abhishek","doi":"10.1016/j.mycmed.2025.101584","DOIUrl":"10.1016/j.mycmed.2025.101584","url":null,"abstract":"<div><h3>Background</h3><div><em>Trichophyton indotineae</em> (earlier <em>Trichophyton mentagrophytes</em> ITS genotype VIII) is a newly defined dermatophyte species frequently reported from India. The strains representing <em>T. indotineae</em> cause dermatophytosis in humans, and some strains exhibit resistance to terbinafine.</div></div><div><h3>Objective</h3><div>This study aims to characterize the animal strains of <em>T. indotineae</em> at the genomic level and compare them with human strains and other <em>Trichophyton</em> species.</div></div><div><h3>Methods</h3><div>In this study, we report the generation of <em>de novo</em> WGS data for two strains of <em>T. indotineae</em> isolated from canines of northern India. The genome sequence was subjected to functional and structural annotation, followed by comparative genomics and phylogeny.</div></div><div><h3>Results</h3><div>Genome assembly and annotation revealed a 22 Mb genome in both strains, comprising approximately 6800 protein-coding genes, and a 24 Kb contig representing the mitochondrion. Functional annotations revealed the presence of around 200 CAZymes and secretomes. The identified proteins include various proteolytic enzymes, such as keratinases, lyases, fungalysins, subtilisins, and chitinases. Orthologous cluster comparison among <em>T. indotineae</em> and <em>T. rubrum</em> identified a LysM effector virulence factor associated with the sequestration of chitin oligosaccharides unique to <em>T. indotineae</em>. Taxonomic inferences involving 69 species representing the Genus <em>Trichophyton</em> revealed similar clustering in genome ANI, mash distance, and core-genome phylogeny. Within all approaches, a total of 16 Indian strains represented <em>T. indotineae</em>. The SNP difference between any two <em>T. indiotinae</em> strains ranged from 8 to 257, indicating limited strain variation within the species. The core-genome phylogeny revealed two major clusters, with no cluster indicating a specific host association. Correlating their phenotypic susceptibility to the anti-fungal drug terbinafine (TRB), the coding sequences (CDS) maintained no amino acid substitutions at key positions 393 and 397. The comparative analysis of the squalene epoxidase gene across the 16 strains revealed a high frequency of SNPs at the 397th position in the squalene epoxidase genes in terbinafine-resistant strains.</div></div><div><h3>Conclusion</h3><div>To conclude, the study indicates similar genome composition in strains of <em>T. indiotineae</em> from canine and human origin, irrespective of the TRB resistance phenotype. The pathogen and genotypes circulating among humans and animals need to be continuously monitored to determine the exact role of animals in the transmission and endemicity of <em>T. indotineae</em> in India.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 4","pages":"Article 101584"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145354922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Candidozyma auris candidemia in critically ill patients: epidemiology, predictive factors and prognostic impact","authors":"Anis Chaari ,&nbsp;Shaikha Ali Asheer ,&nbsp;Muqtadir Malik ,&nbsp;Mohamad Saif Khan ,&nbsp;Manaf Alqahtani","doi":"10.1016/j.mycmed.2025.101588","DOIUrl":"10.1016/j.mycmed.2025.101588","url":null,"abstract":"<div><h3>Purpose</h3><div>To describe the epidemiology of <em>Candidozyma auris</em> (<em>Candida auris</em>) candidemia, identify its predictive factors, and evaluate its prognostic impact in critically ill patients.</div></div><div><h3>Methods</h3><div>This retrospective study was conducted in the intensive care units (ICUs) of two tertiary hospitals. All adult patients with candidemia admitted between 01.01.2022, and 31.03.2024 were included. Two groups were compared: <em>C. auris</em> (CA) and non-<em>Candidosyma auris</em> (NCA) candidemia.</div></div><div><h3>Results</h3><div>A total of 51 patients were included, of whom 27 (52.9 %) had <em>C. auris</em> candidemia. <em>C. auris</em> candidemia was significantly associated to higher rate of colonisation with carbapenem-resistant <em>Enterobacteriales</em> (51.9 vs 20.8 %; <strong><em>p</em></strong> <strong>= 0.022</strong>). Additionally, patients in the CA group were more frequently exposed to ceftazidime – avibactam (40.7 % vs 8.3 %; <em>p</em> = 0.008), tigecycline (44.4 % vs 12.5 %; <em>p</em> = 0.012), and antifungals (74.1 % vs 33.3 %; <em>p</em> = 0.004). multivariate analysis identified previous exposure to antifungals as the only independent predictor of <em>C. auris</em> candidemia (OR = 6.5 CI95 % [1.7–25.3]; <strong><em>p</em></strong> <strong>=</strong> <strong>0.007</strong>).</div><div>Candidemia was associated with a higher incidence of septic shock (83.3 % vs 40.7 %; <strong><em>p</em></strong> <strong>=</strong> <strong>0.002</strong>), and increased need for mechanical ventilation (95.8 % vs 63 %; <strong><em>p</em></strong> <strong>=</strong> <strong>0.004</strong>) in patients with <em>non-Candidosyma. auris</em> fungemia.The 28-day mortality was 66.7 %, with no significant difference between CA and NCA groups (OR = 0.3 95 % CI [0.1–1.1]; <em>p</em> = 0.08).</div></div><div><h3>Conclusion</h3><div><em>Candidozyma auris</em> has become the dominant isolate in our ICUs. Prior exposure to antifungals is the main predictive factor compared to NCA fungemia. Both CA and NCA exhibit similar 28-day mortality rates.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 4","pages":"Article 101588"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145462633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of recombinase polymerase amplification-based assay (RPA) for rapid detection of fungal pathogens in clinical samples of patients in Abidjan, Côte d’Ivoire","authors":"David Koffi ,&nbsp;Francis K. Kouadjo ,&nbsp;Stephane T. Koui ,&nbsp;Kader Diarrassouba ,&nbsp;Benjamin Djedji ,&nbsp;Jon Salmanton-García ,&nbsp;Valerie Ira-Bonouman ,&nbsp;Joseph A. Djaman ,&nbsp;Andre O. Toure","doi":"10.1016/j.mycmed.2025.101579","DOIUrl":"10.1016/j.mycmed.2025.101579","url":null,"abstract":"<div><h3>Background</h3><div>The diversity of fungal species involved in medical mycology and the increasing rates of resistances make antifungal therapy increasingly challenging. A strategic approach aims to prevent the spread of resistant fungal pathogens and address the prolonged culture time required for fungal identification. The identification of microscopic fungi in biological samples has gained growing interest in molecular biology. The promising isothermal amplification technique can overcome the shortcomings of conventional methods by offering a short reaction time, as well as high specificity and sensitivity.</div></div><div><h3>Objective</h3><div>This study was initiated to develop a rapid method for identifying fungi from patient biological samples.</div></div><div><h3>Materials.and.Methods</h3><div>Ninety biological samples were collected from patients and various anatomical sites. The samples were cultured, and DNA extraction was performed on the isolates and biological products. The obtained DNA was used for amplification via RPA (Recombinase Polymerase Amplification).</div></div><div><h3>Results</h3><div>The results demonstrated varying sensitivity and specificity depending on the type of biological sample, with high sensitivity and specificity for mucosal samples (100 %, respectively), followed by those of invasive mycoses (80 % and 67 %, respectively), and superficial mycoses (72 % sensitivity).</div></div><div><h3>Conclusion</h3><div>The overall sensitivity and specificity of the RPA method across all sample types were elevated, with 92 % and 100 %, respectively.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 4","pages":"Article 101579"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145045652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the lungs: a case report of disseminated cutaneous aspergillosis highlighting clinical dilemmas in invasive fungal infections of critically ill patients","authors":"Yao Xu,&nbsp;Jiansan He,&nbsp;Peng Jin,&nbsp;Mingming Fei,&nbsp;Shaohui Cheng","doi":"10.1016/j.mycmed.2025.101573","DOIUrl":"10.1016/j.mycmed.2025.101573","url":null,"abstract":"<div><div>With opportunistic fungal pathogens increasingly recognized as a global public health threat, the population at high risk for invasive fungal infections (IFIs) has expanded beyond traditionally immunocompromised individuals—such as those with malignancies, organ transplantation, diabetes mellitus, or acquired immunodeficiency syndrome (AIDS)—to include critically ill patients in intensive care units (ICUs) receiving invasive support and immunomodulatory therapies. Invasive aspergillosis (IA) is one of the most lethal opportunistic infections in this population, characterized by insidious onset, clinical heterogeneity, and a lack of specific signs, often resulting in delayed diagnosis. Disseminated or breakthrough aspergillosis carries an exceedingly high mortality rate. We report the case of a female patient admitted to the ICU with fulminant myocarditis who required extracorporeal membrane oxygenation (ECMO), continuous renal replacement therapy (CRRT), and immunomodulation. Her hospitalization was complicated by a progressive pulmonary infection, and metagenomic next-generation sequencing (mNGS) of respiratory specimens identified <em>Candida albicans, Aspergillus</em> spp. and <em>Staphylococcus hominis</em>, prompting an adjustment in antimicrobial therapy. Subsequently, the patient developed multiple cutaneous nodules, which tissue biopsy and mNGS confirmed as invasive cutaneous aspergillosis. Despite aggressive antifungal treatment with isavuconazole and amphotericin B, her condition deteriorated rapidly, leading to disseminated cutaneous necrosis, irreversible septic shock and multiorgan failure. This case highlights the clinical importance of recognizing atypical IFI presentations. Heightened clinical suspicion for disseminated fungal disease is warranted in critically ill patients with extrapulmonary lesions. Prompt microbiological diagnosis and antifungal resistance surveillance are essential for effective antifungal therapy.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 4","pages":"Article 101573"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A one health perspective on Diutina catenulata: Phenotypic traits, stress sensitivity, and virulence across diverse isolates","authors":"Ianca Karine Prudencio de Albuquerque ,&nbsp;Florent Morio ,&nbsp;Marjorie Albassier ,&nbsp;Luc Baron ,&nbsp;Léa Duchesne ,&nbsp;Patrice Le Pape ,&nbsp;Isabelle Ourliac-Garnier","doi":"10.1016/j.mycmed.2025.101583","DOIUrl":"10.1016/j.mycmed.2025.101583","url":null,"abstract":"<div><div><em>Diutina catenulata</em>, formerly <em>Candida catenulata</em>, is found in diverse substrates, including soil, food, animals, and humans. It is recognized as an emerging human pathogen responsible for various diseases, including invasive infections in susceptible hosts, particularly in immunocompromised individuals. This study aimed to assess the phenotypic profiles, <em>in vitro</em> responses to various stressful conditions, and <em>in vivo</em> virulence of <em>D. catenulata</em> isolates from different origins (human, veterinary, and environmental). <em>In vitro</em> antifungal susceptibility to fluconazole, voriconazole, micafungin and amphotericin B was also determined for all isolates. Most <em>D. catenulata</em> isolates exhibited a light blue coloration on CHROMID® <em>Candida</em> agar. Different profiles were observed on the Spider medium, suggesting different behavior among the isolates. All isolates of <em>D. catenulata</em> were highly sensitive to oxidative and osmotic stress as demonstrated by exposure to H₂O₂ and 1.5 M NaCl, respectively whereas no unique pattern was evidenced concerning the response to cell wall stressors or membrane stressors. In addition to acquired azole resistance for some isolates, these findings provide valuable insights into the strain-dependent responses of <em>D. catenulata</em> to various stress factors. Using <em>Galleria mellonella,</em> we highlighted a wide range of virulence profiles among the isolates. Overall, this research demonstrates that the observed responses are strain-dependent rather than sample-source-dependent.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 4","pages":"Article 101583"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disseminated histoplasmosis in erythematosus systemic lupus: A case report and review","authors":"Carlos Solórzano,&nbsp;Johiner Vanegas,&nbsp;Maria Alejandra Caro,&nbsp;Maria Camila Rubio","doi":"10.1016/j.mycmed.2025.101581","DOIUrl":"10.1016/j.mycmed.2025.101581","url":null,"abstract":"<div><div>Histoplasmosis is an endemic mycosis in some regions affecting particularly immunosuppressed individuals. The global prevalence of disseminated histoplasmosis in systemic lupus erythematosus (SLE) patients is &lt;1 %, but rises in endemic areas such as Colombia. Clinical manifestations in those patients are atypical, ranging from non-specific symptoms to severe cases of multi-organ failure. Given its rarity and the nonspecific nature of its symptoms, disseminated histoplasmosis in the context of systemic lupus erythematosus remains a diagnostic challenge.</div><div>A 28-year-old female patient with a history of SLE diagnosed in 2009 presented to our clinic in February 2024. The patient reported an acute onset of non-specific symptoms, with a subsequent treatment for a suspected bacterial lung infection and successfully discharged. However, due to persistent fever and ongoing weight loss, she returned for further evaluation. Initially a thoracic computed tomography and fiberoptic bronchoscopy was performed, with negative results for tuberculosis (TB), however TB treatment was empirically initiated according to imagenological findings. During hospitalization, the patient developed gastrointestinal bleeding, prompting further investigations and confirming <em>Histoplasma capsulatum</em> in a biopsy. Despite the antifungal therapy, the patient’s condition deteriorated, culminating in multiorgan failure and death 10 days later.</div><div>This case underscores the importance of prompt and accurate diagnosis of disseminated histoplasmosis in patients with SLE. The clinical presentation can mimic a lupus flare or other infectious diseases, potentially delaying the initiation of appropriate therapy. In endemic regions such as Latin America, it is critical to include disseminated histoplasmosis in the differential diagnosis of febrile illness in immunosuppressed patients.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"35 4","pages":"Article 101581"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145045653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}