JACC. Case reports最新文献_第2页

Successful Management of Oxacillin-Induced Eosinophilic Myocarditis and Review of the Literature 奥西林致嗜酸性心肌炎的成功治疗及文献综述

JACC. Case reports Pub Date : 2025-10-08 DOI: 10.1016/j.jaccas.2025.105297

Arnold Gan MD , Morgan Burke MD , Eric Yang MD , Tiffany Lien MD , Khalida Arif MD , Maxine Stachel MD

{"title":"Successful Management of Oxacillin-Induced Eosinophilic Myocarditis and Review of the Literature","authors":"Arnold Gan MD , Morgan Burke MD , Eric Yang MD , Tiffany Lien MD , Khalida Arif MD , Maxine Stachel MD","doi":"10.1016/j.jaccas.2025.105297","DOIUrl":"10.1016/j.jaccas.2025.105297","url":null,"abstract":"<div><h3>Background</h3><div>Numerous medications have been implicated in precipitating eosinophilic myocarditis (EM), particularly antipsychotics and cytotoxic drugs. Antibiotic-induced EM, scarcely reported in the literature, carries a high mortality rate.</div></div><div><h3>Case Summary</h3><div>A 56-year-old man with a history of atypical hemolytic uremic syndrome presented with acute heart failure after completing oxacillin treatment for methicillin-susceptible <em>Staphylococcus aureus</em> bacteremia. Diagnosis of antibiotic-induced EM was established with endomyocardial biopsy, and the patient made full recovery with high-dose steroid treatment.</div></div><div><h3>Review Summary</h3><div>Prompt diagnosis and early steroid treatment is essential in reducing mortality in patients with antibiotic-induced EM. Multidisciplinary discussion is vital, and development of clinical scoring criteria to identify high-risk patients may assist clinicians in pursuing early endomyocardial biopsy to expedite diagnosis.</div></div><div><h3>Take-Home Message</h3><div>Antibiotic-induced EM is exceedingly rare but should be suspected when acute heart failure is associated with systemic inflammatory symptoms.</div></div>","PeriodicalId":14792,"journal":{"name":"JACC. Case reports","volume":"30 31","pages":"Article 105297"},"PeriodicalIF":0.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145242211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repair of Congenital Cardiac Disease Requiring Bypass for a Pediatric Patient With Paroxysmal Nocturnal Hemoglobinuria 阵发性夜间血红蛋白尿患儿先天性心脏病需要搭桥治疗的修复

JACC. Case reports Pub Date : 2025-10-08 DOI: 10.1016/j.jaccas.2025.105359

Miriam Blumenthal MD , Ananya Chandra MD , McKenna Robinette APN , Narutoshi Hibino MD, PhD , Kristen Nelson-McMillan MD , Saara Kaviany DO , Madhusudan Ganigara MD , Stephen Pophal MD

{"title":"Repair of Congenital Cardiac Disease Requiring Bypass for a Pediatric Patient With Paroxysmal Nocturnal Hemoglobinuria","authors":"Miriam Blumenthal MD , Ananya Chandra MD , McKenna Robinette APN , Narutoshi Hibino MD, PhD , Kristen Nelson-McMillan MD , Saara Kaviany DO , Madhusudan Ganigara MD , Stephen Pophal MD","doi":"10.1016/j.jaccas.2025.105359","DOIUrl":"10.1016/j.jaccas.2025.105359","url":null,"abstract":"<div><h3>Background</h3><div>Paroxysmal nocturnal hemoglobinuria (PNH) is a life-threatening disease characterized by cytopenias, hemolysis, and thrombosis. There are only a handful of documented cases of cardiac bypass surgery performed on patients with PNH, none in the pediatric population.</div></div><div><h3>Case Summary</h3><div>A 16-year-old male adolescent presented with abdominal pain and fatigue, with laboratory studies revealing severe anemia, thrombocytopenia, and leukopenia. Based on flow cytometry, he was diagnosed with PNH. During cardiac screening prior to central line placement, he was incidentally found to have superior sinus venosus atrial septal defect with partial anomalous pulmonary venous return. The patient required surgical repair of the cardiac defect prior to PNH treatment with stem cell transplant.</div></div><div><h3>Discussion</h3><div>Cardiac surgery in patients with PNH requires careful multidisciplinary planning, including cardiology, cardiothoracic surgery, hematology, and infectious disease.</div></div><div><h3>Take-Home Message</h3><div>The presence of PNH alongside a cardiac defect in a pediatric patient highlights the complexity and challenges of performing cardiac bypass in this population.</div></div>","PeriodicalId":14792,"journal":{"name":"JACC. Case reports","volume":"30 31","pages":"Article 105359"},"PeriodicalIF":0.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145242267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiac Manifestations of Alkaptonuria 尿酸钠的心脏表现

JACC. Case reports Pub Date : 2025-10-08 DOI: 10.1016/j.jaccas.2025.105327

María Belén Solís Chávez MD , Lourdes Montero Cruces PhD , Silvia Romiti MD , Melchor Saiz-Pardo Sanz MD , Luis Carlos Maroto Castellanos PhD

{"title":"Cardiac Manifestations of Alkaptonuria","authors":"María Belén Solís Chávez MD , Lourdes Montero Cruces PhD , Silvia Romiti MD , Melchor Saiz-Pardo Sanz MD , Luis Carlos Maroto Castellanos PhD","doi":"10.1016/j.jaccas.2025.105327","DOIUrl":"10.1016/j.jaccas.2025.105327","url":null,"abstract":"<div><h3>Background</h3><div>Alkaptonuria is a rare autosomal recessive disorder characterized by homogentisic acid accumulation, leading to ochronosis and multisystemic manifestations including cardiovascular complications.</div></div><div><h3>Case Summary</h3><div>A 63-year-old male with a known family history of alkaptonuria presented with dyspnea and severe aortic stenosis. Coronary angiography revealed diffuse, severe calcific coronary artery disease The patient underwent successful mechanical aortic valve replacement, revealing characteristic ochronotic pigmentation intraoperatively.</div></div><div><h3>Discussion</h3><div>Cardiovascular involvement in alkaptonuria, although rare, can cause sever valvular and coronary artery disease. Early recognition through biochemical testing and imaging is essential. Early-onset valvular disease should raise suspicion of underlying systemic disorders such as alkaptonuria.</div></div><div><h3>Take-Home Messages</h3><div>Alkaptonuria, although primarily known for musculoskeletal and connective tissue involvement, can lead to significant cardiovascular complications. Routine screening with echocardiography and computed tomography coronary angiography should be considered in patients with alkaptonuria to detect early valvular and coronary artery disease in order to ensure timely intervention.</div></div>","PeriodicalId":14792,"journal":{"name":"JACC. Case reports","volume":"30 31","pages":"Article 105327"},"PeriodicalIF":0.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145242561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Prenatally Diagnosed Rare Vascular Ring Formed by Left Aortic Arch and Right Ductus Arteriosus 由左主动脉弓和右动脉导管形成的罕见的产前诊断血管环。

JACC. Case reports Pub Date : 2025-10-08 DOI: 10.1016/j.jaccas.2025.105275

Nana Matsuzawa MD, PhD , Yuka Yamamoto MD, PhD , Eri Kitamura MD, PhD , Yuri Ishida MD, PhD , Jun Takeda MD, PhD , Noboru Tanaka MD, PhD , Lisa K. Hornberger MD , Atsuo Itakura MD, PhD

{"title":"A Prenatally Diagnosed Rare Vascular Ring Formed by Left Aortic Arch and Right Ductus Arteriosus","authors":"Nana Matsuzawa MD, PhD , Yuka Yamamoto MD, PhD , Eri Kitamura MD, PhD , Yuri Ishida MD, PhD , Jun Takeda MD, PhD , Noboru Tanaka MD, PhD , Lisa K. Hornberger MD , Atsuo Itakura MD, PhD","doi":"10.1016/j.jaccas.2025.105275","DOIUrl":"10.1016/j.jaccas.2025.105275","url":null,"abstract":"<div><h3>Background</h3><div>A vascular ring arises during the development of the fetal arches and is often associated with a double aortic arch or right-sided aorta, an aberrant left subclavian artery with a posterior esophageal component, and a left-sided ductus arteriosus.</div></div><div><h3>Case Summary</h3><div>This is a rare vascular ring formed by a left aortic arch, aberrant right subclavian artery, and right ductus arteriosus that was diagnosed prenatally by fetal echocardiography. The 3-vessels and trachea (3VT) view with 2-dimensional and color Doppler sweeps were helpful in defining the vascular pathology. Tracheomalacia was also noted, and genetic tests confirmed the presence of 22q11.2 deletion.</div></div><div><h3>Discussion</h3><div>The distal portions of the right sixth and right eighth dorsal arches were persistent, whereas the right fourth and distal part of the left sixth arches disappeared in the process of fetal development.</div></div><div><h3>Take-Home Message</h3><div>Use of the 3VT echocardiography sweep facilitates prenatal diagnosis of rare vascular rings.</div></div>","PeriodicalId":14792,"journal":{"name":"JACC. Case reports","volume":"30 31","pages":"Article 105275"},"PeriodicalIF":0.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction of Tricuspid Regurgitation in Pulmonary Arterial Hypertension 肺动脉高压患者三尖瓣反流的矫正。

JACC. Case reports Pub Date : 2025-10-08 DOI: 10.1016/j.jaccas.2025.105323

Antonio Orlando MD , Andrea Vergara MD , Robert Naeije MD, PhD , Michele D'Alto MD, PhD

{"title":"Correction of Tricuspid Regurgitation in Pulmonary Arterial Hypertension","authors":"Antonio Orlando MD , Andrea Vergara MD , Robert Naeije MD, PhD , Michele D'Alto MD, PhD","doi":"10.1016/j.jaccas.2025.105323","DOIUrl":"10.1016/j.jaccas.2025.105323","url":null,"abstract":"<div><h3>Background</h3><div>Pulmonary hypertension is a contraindication to correction of tricuspid regurgitation.</div></div><div><h3>Case Summary</h3><div>A 75-year-old Italian woman with previous episodes of right heart failure was diagnosed with World Health Organization (WHO) functional class IV pulmonary arterial hypertension (PAH) complicated by torrential tricuspid regurgitation. After 6 months of treatment with diuretic agents, macitentan, and tadalafil, she improved to WHO functional class III, with a pulmonary vascular resistance (PVR) decreasing from 5.4 to 3 Wood units. She then underwent transcatheter valve repair. One year later, she was in WHO functional class I with a PVR of 2.2 Wood units.</div></div><div><h3>Discussion</h3><div>Right heart failure with a moderate increase in PVR in PAH may be caused by severe tricuspid insufficiency. Transtricuspid valve repair under optimized medical treatment may then be successful.</div></div><div><h3>Take-Home Message</h3><div>Severe tricuspid regurgitation in PAH may be the dominant cause of right heart failure and is amenable to transcatheter repair under optimal medical therapy.</div></div>","PeriodicalId":14792,"journal":{"name":"JACC. Case reports","volume":"30 31","pages":"Article 105323"},"PeriodicalIF":0.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Full Issue PDF 完整版PDF

JACC. Case reports Pub Date : 2025-10-08 DOI: 10.1016/S2666-0849(25)02429-5

引用次数: 0

Antineutrophil Cytoplasmic Antibody Negative Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss) Presenting as Acute Decompensated Heart Failure 抗中性粒细胞胞浆抗体阴性的嗜酸性肉芽肿病伴多血管炎（Churg-Strauss）表现为急性失代偿性心力衰竭

JACC. Case reports Pub Date : 2025-10-08 DOI: 10.1016/j.jaccas.2025.105332

Tanner R. Chase , Dakota E. Colby , John D. Peterson MD , Mark D. Baldwin DO

{"title":"Antineutrophil Cytoplasmic Antibody Negative Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss) Presenting as Acute Decompensated Heart Failure","authors":"Tanner R. Chase , Dakota E. Colby , John D. Peterson MD , Mark D. Baldwin DO","doi":"10.1016/j.jaccas.2025.105332","DOIUrl":"10.1016/j.jaccas.2025.105332","url":null,"abstract":"<div><h3>Background</h3><div>Eosinophilic granulomatosis with polyangiitis (EGPA) is a chronic inflammatory condition with eosinophilic infiltration of the respiratory system, heart, peripheral nerves, integumentary system, and gastrointestinal tract.</div></div><div><h3>Case Summary</h3><div>A man in his mid-60s presented with a 3-month history of progressive dyspnea. He was found to have a large pleural effusion. Over the subsequent 3 months, dyspnea returned, and echocardiography demonstrated left ventricular hypokinesis with an ejection fraction of 40%. He was later admitted for altered mental status and found to have an elevated total eosinophil count with negative antineutrophil cytotoxic antibodies. Repeat echocardiography revealed ventricular thrombi and ejection fraction of 20%. Endomyocardial biopsy revealed eosinophilic infiltration, necrosis, and fibrosis. He was treated with oral prednisone and intravenous cyclophosphamide for 6 months and maintained on oral azathioprine and prednisone.</div></div><div><h3>Discussion</h3><div>Antineutrophil cytotoxic antibody–negative EGPA is associated with a cardiac-predominant presentation, which is effectively treated with induction and maintenance immunosuppression.</div></div><div><h3>Take-Home Message</h3><div>Cardiac involvement should be further evaluated on recognition of EGPA.</div></div>","PeriodicalId":14792,"journal":{"name":"JACC. Case reports","volume":"30 31","pages":"Article 105332"},"PeriodicalIF":0.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145242209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rilonacept for Recurrent Postcardiac Injury Syndrome Pericarditis in a Young Hockey Player 利洛那普治疗复发性心脏损伤综合征心包炎一例年轻冰球运动员

JACC. Case reports Pub Date : 2025-10-08 DOI: 10.1016/j.jaccas.2025.105326

Faysal Massad MD, Akiva Rosenzveig MD, Samuel Reiss MD, Abdel Hadi El Hajjar MD, Muhammed Ehsan MD, Jibran Ikram MD, Ridhima Kaul MD, Allan Klein MD

{"title":"Rilonacept for Recurrent Postcardiac Injury Syndrome Pericarditis in a Young Hockey Player","authors":"Faysal Massad MD, Akiva Rosenzveig MD, Samuel Reiss MD, Abdel Hadi El Hajjar MD, Muhammed Ehsan MD, Jibran Ikram MD, Ridhima Kaul MD, Allan Klein MD","doi":"10.1016/j.jaccas.2025.105326","DOIUrl":"10.1016/j.jaccas.2025.105326","url":null,"abstract":"<div><h3>Background</h3><div>Postcardiac injury syndrome (PCIS) pericarditis is a common complication following cardiac surgery. Exercise counseling is critical for recovery, but guidelines for return-to-activity are often generalized.</div></div><div><h3>Case Summary</h3><div>A 35-year-old male experienced a ventricular tachycardia arrest due to a left anterior descending infarct while playing hockey. He underwent coronary artery bypass grafting and developed acute pericarditis due to PCIS. Despite colchicine and prednisone, he had 3 recurrences of pericarditis. Rilonacept (an interleukin-1 blocker) was started in October 2023. After 6 months, his condition improved, and exercise was gradually reintroduced with heart rate limits, initially <130 beats/min, later increasing to 145 to 150 beats/min.</div></div><div><h3>Discussion</h3><div>Exercise restriction is essential in acute and recurrent pericarditis until symptoms resolve and inflammatory markers normalize. Limited data exist regarding exercise while on interleukin-1 blockers such as rilonacept, and shared decision-making is critical.</div></div><div><h3>Take-Home Message</h3><div>Gradual reintroduction of exercise based on clinical stability and inflammatory markers is key in managing recurrent pericarditis due to PCIS after coronary artery bypass grafting.</div></div>","PeriodicalId":14792,"journal":{"name":"JACC. Case reports","volume":"30 31","pages":"Article 105326"},"PeriodicalIF":0.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145242213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Outcomes of Large-Bore Aspiration Thrombectomy for Tumor Pulmonary Embolism in Renal Cell Carcinoma 大口径吸栓术治疗肾细胞癌肺栓塞的临床效果

JACC. Case reports Pub Date : 2025-10-08 DOI: 10.1016/j.jaccas.2025.105358

Anand Mulji MD, Tony Rizk DO, Yara Younan MD, Stephen Stringfellow MD, Antony Gayed MD

引用次数: 0

Double-Guide Catheter “Criss-Cross” Technique and Left Main Bifurcation Rotational Atherectomy 双导导管“交叉”技术与左主干分叉旋转动脉粥样硬化切除术

JACC. Case reports Pub Date : 2025-10-08 DOI: 10.1016/j.jaccas.2025.105336

Giuseppe Colletti MD , Tim Noterdaeme MD , Laura Peter MD , Agostino Spanò MD , Marouane Boukhris MD , Amine Mamoun Boutaleb MD , Alexandre Natalis MD , Adrien Jossart MD , Olivier Gach MD, PhD , Claudiu Ungureanu MD

{"title":"Double-Guide Catheter “Criss-Cross” Technique and Left Main Bifurcation Rotational Atherectomy","authors":"Giuseppe Colletti MD , Tim Noterdaeme MD , Laura Peter MD , Agostino Spanò MD , Marouane Boukhris MD , Amine Mamoun Boutaleb MD , Alexandre Natalis MD , Adrien Jossart MD , Olivier Gach MD, PhD , Claudiu Ungureanu MD","doi":"10.1016/j.jaccas.2025.105336","DOIUrl":"10.1016/j.jaccas.2025.105336","url":null,"abstract":"<div><h3>Background</h3><div>Rotational atherectomy of severely calcified left main (LM) bifurcation lesions can be hazardous, especially when maintaining a protective guidewire in one branch is mandatory.</div></div><div><h3>Case Summary</h3><div>An 82-year-old man underwent successful percutaneous coronary intervention of a calcified LM bifurcation using a double-guide catheter “criss-cross” technique to reduce periprocedural ischemia and iatrogenic dissection risk associated with a single larger catheter. Rotational atherectomy was safely performed on a tight proximo-ostial circumflex lesion while retaining a protective guidewire in the dissected left anterior descending artery.</div></div><div><h3>Discussion</h3><div>Although protective microcatheters have been described, bench studies show consistent microcatheter damage, risk of nonorganic material embolization, and problematic guidewire interactions. Proper positioning of guide catheters modifies wire bias, improving guidewire separation and minimizing burr-wire interactions. Bench testing confirmed this advantage.</div></div><div><h3>Take-Home Messages</h3><div>The novel double-guide catheter criss-cross technique potentially increases safety in complex calcified proximo-ostial LM lesions by reducing guidewire interactions. Modification of wire bias could extend to all proximo-ostial coronary lesions.</div></div>","PeriodicalId":14792,"journal":{"name":"JACC. Case reports","volume":"30 31","pages":"Article 105336"},"PeriodicalIF":0.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145242255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0