JACC. Case reportsPub Date : 2025-06-11DOI: 10.1016/j.jaccas.2025.103635
Naba Farooqui MBBS , Andrew Williams MD , Lauren M. Webb MD , Arashk Motiei MD , Eugene L. Scharf MD
{"title":"Limb-Shaking Transient Ischemic Attacks in a Case of Brachiocephalic Artery Stenosis","authors":"Naba Farooqui MBBS , Andrew Williams MD , Lauren M. Webb MD , Arashk Motiei MD , Eugene L. Scharf MD","doi":"10.1016/j.jaccas.2025.103635","DOIUrl":"10.1016/j.jaccas.2025.103635","url":null,"abstract":"<div><h3>Background</h3><div>Limb-shaking transient ischemic attacks represent an atypical presentation of transient ischemic attacks usually seen with carotid artery stenosis but may occur in severe brachiocephalic stenosis.</div></div><div><h3>Case Summary</h3><div>We present the case of a 67-year-old woman with severe brachiocephalic artery stenosis but no significant right carotid disease with a 2-year history of alternating movements of the left upper and lower limbs with postural changes culminating in a large-vessel stroke, with resolution of the alternating movements after a left-to-right subclavian bypass.</div></div><div><h3>Discussion</h3><div>Only 4 cases of limb-shaking transient ischemic attacks secondary to subclavian/brachiocephalic artery stenosis have been described in literature. Cardiologists often see these patients in the vascular clinic. If recognition of these shaking movements in the context of transient ischemic attacks is missed, it can lead to a delay in appropriate intervention, thereby increasing the future risk of stroke.</div></div><div><h3>Take-Home Messages</h3><div>Proximal vessel stenosis can lead to TIAs. Timely recognition and early intervention (preferably surgical) in cases of brachiocephalic/subclavian stenosis with LSTIAs is important as it can be crucial for stroke prevention.</div></div>","PeriodicalId":14792,"journal":{"name":"JACC. Case reports","volume":"30 14","pages":"Article 103635"},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JACC. Case reportsPub Date : 2025-06-11DOI: 10.1016/j.jaccas.2025.103684
Mark Kheifets MD, Nicholas Howell MD, Inbar Nardi Agmon MD, Aviel Shetrit MD, Vladimír Džavík MD
{"title":"Life-Threatening Dynamic Coronary Obstruction in a Patient With Rhabdomyosarcoma Treated With Stenting","authors":"Mark Kheifets MD, Nicholas Howell MD, Inbar Nardi Agmon MD, Aviel Shetrit MD, Vladimír Džavík MD","doi":"10.1016/j.jaccas.2025.103684","DOIUrl":"10.1016/j.jaccas.2025.103684","url":null,"abstract":"<div><h3>Background</h3><div>Dynamic coronary obstruction is a rare and potentially lethal condition, which may cause an acute coronary syndrome (ACS).</div></div><div><h3>Case Summary</h3><div>A young patient with metastatic rhabdomyosarcoma was transferred to our center’s cardiac intensive care unit with a ventricular tachycardia (VT) storm. A cardiac mass was demonstrated on transthoracic echocardiography and computed tomography. Coronary angiography was performed owing to suspected compression of the coronary arteries. Dynamic obstruction in the left anterior descending artery (LAD) was demonstrated with the use of angiography and intravascular ultrasound. After successful ostial to mid-LAD stenting, there was no recurrence of VT episodes.</div></div><div><h3>Discussion</h3><div>VT storm is a lethal condition that requires rapid diagnosis and treatment. Rarely, it can be caused by dynamic coronary obstruction.</div></div>","PeriodicalId":14792,"journal":{"name":"JACC. Case reports","volume":"30 14","pages":"Article 103684"},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Role of Strain-Derived Echocardiography Modality in Risk Stratification of High-Risk-Feature Chronic Coronary Syndrome Patients","authors":"Rizky Hendiperdana MD , Hendry Purnasidha Bagaswoto MD","doi":"10.1016/j.jaccas.2025.103632","DOIUrl":"10.1016/j.jaccas.2025.103632","url":null,"abstract":"<div><div>Two patients presented with chronic coronary syndrome and type B Wellens electrocardiography with preserved left ventricular ejection fraction according to transthoracic echocardiography. Further myocardial systolic function assessment by means of left ventricular global longitudinal strain (LVGLS) and myocardial work index (MWI) showed reduced peak systolic strain and MWI value in the left anterior descending (LAD) coronary territory. Invasive coronary angiography found significant proximal LAD stenosis in both patients, and revascularization with stent placement was performed with good result (TIMI flow grade III). In the follow-up, improvement in LVGLS and MWI after LAD revascularization was observed in both cases.</div></div>","PeriodicalId":14792,"journal":{"name":"JACC. Case reports","volume":"30 14","pages":"Article 103632"},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rare Case of STEMI Involving an Anomalous Single Coronary Artery Arising From the Ascending Aorta","authors":"Deepak Reddy Karumuri MD, Vinod Kumar Balakrishnan MD, DM, Manickavasagam Meenakshisundaram MD, DM, Sindhuja Therani MD, Ramesh Sankaran MD, DM, Nagendra Boopathy Senguttuvan MD, DM, Preetam Krishnamurthy MD, DM, Rajoo Ramachandran MD, K.V. Ramya Lakshmi MD","doi":"10.1016/j.jaccas.2025.103607","DOIUrl":"10.1016/j.jaccas.2025.103607","url":null,"abstract":"<div><h3>Background</h3><div>ST-segment elevation myocardial infarction in an anomalous single coronary artery with high take-off is a rare occurrence with very few cases reported to date.</div></div><div><h3>Case Summary</h3><div>A 42-year-old man with testicular seminoma undergoing chemotherapy presented with an inferior ST-segment elevation myocardial infarction. Coronary angiography revealed a thrombotic lesion of the anomalous single coronary artery. The patient underwent percutaneous intervention with thrombus aspiration, was managed with dual-antiplatelet therapy and anticoagulation, and was followed up in an outpatient setting with a computed tomography angiogram.</div></div><div><h3>Discussion</h3><div>Stenting was deferred, considering the patient's complex coronary anatomy and overall clinical condition. The possible mechanism of the event may be multifactorial but is likely to be precipitated by the recent chemotherapy-associated vascular toxicity.</div></div><div><h3>Take-Home Messages</h3><div>This case highlights the diagnostic and therapeutic challenges of such unusual clinical presentations, highlighting the importance of multimodality evaluation and treatment, which should be individualized to each patient scenario.</div></div>","PeriodicalId":14792,"journal":{"name":"JACC. Case reports","volume":"30 14","pages":"Article 103607"},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JACC. Case reportsPub Date : 2025-06-11DOI: 10.1016/j.jaccas.2025.103612
Vaibhav J. Bhastana MBBS, MD, DM, Bhishma C. Donepudi MBBS, MD, DM, Rajeev V. Menon MBBS, MD, DNB, Bhupathiraju S. Raju MBBS, MD, DM
{"title":"The Vanishing Stent","authors":"Vaibhav J. Bhastana MBBS, MD, DM, Bhishma C. Donepudi MBBS, MD, DM, Rajeev V. Menon MBBS, MD, DNB, Bhupathiraju S. Raju MBBS, MD, DM","doi":"10.1016/j.jaccas.2025.103612","DOIUrl":"10.1016/j.jaccas.2025.103612","url":null,"abstract":"<div><h3>Background</h3><div>Extraluminal stent migration is exceptionally rare and can lead to severe complications such as vessel closure, coronary thrombosis, and myocardial infarction.</div></div><div><h3>Case Summary</h3><div>A 68-year-old man who underwent percutaneous coronary intervention (PCI) with stent deployment in the right coronary artery 4 years earlier presented with progressive angina. Initially, he had experienced a stent infection and sepsis shortly after the procedure. Coronary angiography revealed that the stent had migrated to the lung, with chronic total occlusion of the right coronary artery. The patient underwent successful coronary artery bypass grafting and surgical removal of the migrated stent.</div></div><div><h3>Discussion</h3><div>Extraluminal stent migration is often linked to coronary artery aneurysms, arterial injury from balloons or stents, and infections. This case, involving late stent migration into the lung, is the first of its kind documented.</div></div><div><h3>Take-Home Message</h3><div>The case underscores the need for careful aseptic technique and intravascular imaging during PCI.</div></div>","PeriodicalId":14792,"journal":{"name":"JACC. Case reports","volume":"30 14","pages":"Article 103612"},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JACC. Case reportsPub Date : 2025-06-11DOI: 10.1016/j.jaccas.2025.103615
Hussam Al Hennawi MD , Sergio Mellado Flores MD , Michael B. Little MD , Lacy Harville MD , Ahmad Almomani MD , Muhammad Hammadah MD
{"title":"Plug and Coil Procedure for Management of Large Postinfarct Ventricular Septal Defect","authors":"Hussam Al Hennawi MD , Sergio Mellado Flores MD , Michael B. Little MD , Lacy Harville MD , Ahmad Almomani MD , Muhammad Hammadah MD","doi":"10.1016/j.jaccas.2025.103615","DOIUrl":"10.1016/j.jaccas.2025.103615","url":null,"abstract":"<div><div>Acute surgical mortality for postinfarction ventricular septal rupture remains alarmingly high at approximately 50%. In comparison, medical mortality is nearly 100% and likely exceeds historical levels because of the declining frequency of these acute surgeries, with many surgeons now performing fewer than 1 or 2 annually. Percutaneous device closure has become a feasible option for managing postinfarction ventricular septal defects in carefully selected patients. However, this technique may be associated with challenges such as significant residual shunting, delayed endothelialization, hemolysis, and extended hospital stays. Here, we present a novel approach using coil packing to enhance closure and reduce shunting.</div></div>","PeriodicalId":14792,"journal":{"name":"JACC. Case reports","volume":"30 14","pages":"Article 103615"},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JACC. Case reportsPub Date : 2025-06-11DOI: 10.1016/j.jaccas.2025.103688
Alberto Giannoni MD, PhD , Martina Modena DSc, PhD , Sabrina Montuoro MS , Francesca Bonanni MD , Chrysantos Grigoratos MD, PhD , Andrea Barison MD, PhD , Giancarlo Todiere MD, PhD , Andrea Rossi MD , Simona Vittorini DSc , Michele Emdin MD, PhD , Nicoletta Botto DSc
{"title":"A Novel Homozygous Mutation of the Desmoplakin Gene With Biventricular Arrhythmogenic Cardiomyopathy","authors":"Alberto Giannoni MD, PhD , Martina Modena DSc, PhD , Sabrina Montuoro MS , Francesca Bonanni MD , Chrysantos Grigoratos MD, PhD , Andrea Barison MD, PhD , Giancarlo Todiere MD, PhD , Andrea Rossi MD , Simona Vittorini DSc , Michele Emdin MD, PhD , Nicoletta Botto DSc","doi":"10.1016/j.jaccas.2025.103688","DOIUrl":"10.1016/j.jaccas.2025.103688","url":null,"abstract":"<div><h3>Background</h3><div>A 23-year-old male with arrhythmic syncope and a presumed diagnosis of COVID-19 myocarditis was ultimately diagnosed with biventricular arrhythmogenic cardiomyopathy based on cardiac magnetic resonance imaging (MRI) and genetic testing (next-generation sequencing).</div></div><div><h3>Case Summary</h3><div>The patient presented with recurrent syncope, frequent ventricular ectopics, and reduced left ventricular ejection fraction. Cardiac MRI revealed biventricular dysfunction and nonischemic late gadolinium enhancement with ring-like pattern. Genetic analysis identified a novel homozygous desmoplakin (DSP) mutation. He was treated with heart failure therapy and received an implantable cardioverter-defibrillator due to high arrhythmic risk. Family screening revealed heterozygous carriers among his relatives.</div></div><div><h3>Discussion</h3><div>This case underscores the importance of integrating advanced imaging with genetic testing in early-onset cardiomyopathies and expands the phenotype of DSP-related disease.</div></div>","PeriodicalId":14792,"journal":{"name":"JACC. Case reports","volume":"30 14","pages":"Article 103688"},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JACC. Case reportsPub Date : 2025-06-11DOI: 10.1016/j.jaccas.2025.103628
Nishath Quader MD , Tsuyoshi Kaneko MD , Noah Williford MD , Mark Sintek MD , Puja Kachroo MD , Alexander A. Brescia MD, MSc , Harold G. Roberts Jr. MD , Alan Zajarias MD
{"title":"Transesophageal Echocardiography and Intracardiac Echocardiography to Guide EVOQUE","authors":"Nishath Quader MD , Tsuyoshi Kaneko MD , Noah Williford MD , Mark Sintek MD , Puja Kachroo MD , Alexander A. Brescia MD, MSc , Harold G. Roberts Jr. MD , Alan Zajarias MD","doi":"10.1016/j.jaccas.2025.103628","DOIUrl":"10.1016/j.jaccas.2025.103628","url":null,"abstract":"<div><h3>Objective</h3><div>We demonstrate a step-by-step intraprocedural imaging guide using transesophageal echocardiography (TEE) and intracardiac echocardiography (ICE) to guide EVOQUE in cases with poor intraprocedural imaging.</div></div><div><h3>Key Steps</h3><div>ICE right ventricular (RV) inflow/outflow view with biplane along with 3-dimensional (3D) multiplanar reconstruction (MPR). TEE gastric views for wire placement. ICE 3D MPR to guide delivery system and device depth. Anchors to leaflet relationship; adequate leaflet capture using 3D ICE. Confirm posterior leaflet capture using 2-dimensional (2D) and 3D TEE gastric images. Atrial and ventricular expansion of device using 3D and 2D ICE. 3D MPR ICE to guide wire out of the RV. Assess final results.</div></div><div><h3>Potential Pitfalls</h3><div>Frame rate of 3D MPR on ICE is lower than that of TEE, cost of ICE catheters, lack of reimbursement for ICE.</div></div>","PeriodicalId":14792,"journal":{"name":"JACC. Case reports","volume":"30 14","pages":"Article 103628"},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JACC. Case reportsPub Date : 2025-06-11DOI: 10.1016/j.jaccas.2025.103625
Worawan B. Limpitikul MD, PhD , Pattara Rattanawong MD , Gregory F. Michaud MD
{"title":"Septal VA Time","authors":"Worawan B. Limpitikul MD, PhD , Pattara Rattanawong MD , Gregory F. Michaud MD","doi":"10.1016/j.jaccas.2025.103625","DOIUrl":"10.1016/j.jaccas.2025.103625","url":null,"abstract":"<div><h3>Background</h3><div>A septal ventriculoatrial interval (VAI) of <70 ms often excludes atrioventricular reentrant tachycardia (AVRT) as a mechanism of supraventricular tachycardia (SVT).</div></div><div><h3>Case summary</h3><div>A 49-year-old woman presented with symptomatic Wolff–Parkinson–White syndrome. Her electrophysiology study showed an AVRT with an unusually short VAI of 45 ms. The difference between the atrial signal interval during right ventricular pacing in sinus rhythm and the VAI during SVT was 30 ms. A functional left bundle branch block was induced, with a VAI of 85 ms (40 ms longer than the narrow complex SVT), suggesting conduction through an ipsilateral accessory pathway. Antegrade accessory pathway activation was mapped to the ostium of the middle cardiac vein and successfully ablated, resulting in the loss of antegrade pre-excitation.</div></div><div><h3>Discussion</h3><div>This case report highlights the importance of considering AVRT when the VAI is <70 ms and establishes a new shortest VAI of 45 ms.</div></div>","PeriodicalId":14792,"journal":{"name":"JACC. Case reports","volume":"30 14","pages":"Article 103625"},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144263401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JACC. Case reportsPub Date : 2025-06-11DOI: 10.1016/j.jaccas.2025.103621
Arya Ardehali BSc, Aaria Sooch, Marla Kiess MD, Eve Aymong MD, Philipp Blanke MD, Aaisha Ferkh MBBS, Jasmine Grewal MD
{"title":"Severe Coronary Vasospasm Complicated by Thyrotoxicosis in Early Pregnancy","authors":"Arya Ardehali BSc, Aaria Sooch, Marla Kiess MD, Eve Aymong MD, Philipp Blanke MD, Aaisha Ferkh MBBS, Jasmine Grewal MD","doi":"10.1016/j.jaccas.2025.103621","DOIUrl":"10.1016/j.jaccas.2025.103621","url":null,"abstract":"<div><h3>Background</h3><div>Although rare, thyrotoxicosis can precipitate anginal symptoms secondary to coronary vasospasm.</div></div><div><h3>Case Summary</h3><div>A woman presented in early pregnancy with new-onset retrosternal chest pain associated with nausea, vomiting, palpitations, and dyspnea. Further investigations revealed non-ST-segment elevation myocardial infarction secondary to coronary vasospasm owing to thyrotoxicosis. She was managed conservatively to restore euthyroidism with slow resolution of vasospasm.</div></div><div><h3>Discussion</h3><div>Although the link between elevated thyroid hormone and coronary vasospasm is known, its occurrence during pregnancy is not well-documented. Likely a combination of pregnancy physiology, thyrotoxicosis, and coronary anatomical variance contributed to this severe case of coronary vasospasm. We highlight the importance of timely investigations and conservative management strategies during pregnancy.</div></div><div><h3>Take-Home Messages</h3><div>Coronary vasospasm should be considered early for patients with anginal symptoms and a history of hyperthyroidism. Conservative management to restore euthyroidism should be recognized as the standard of care when treating pregnant women with this condition.</div></div>","PeriodicalId":14792,"journal":{"name":"JACC. Case reports","volume":"30 14","pages":"Article 103621"},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144263402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}