JACC. Case reportsPub Date : 2025-10-08DOI: 10.1016/j.jaccas.2025.105298
Guang-an Liu MD, Bo Shao MD, Ruoxi Zhang MD, Binquan You MD, Feng Liu MD
{"title":"Zero Fluoroscopy Radiofrequency Ablation of Paroxysmal Atrial Fibrillation and Epicardial Ventricular Tachycardia","authors":"Guang-an Liu MD, Bo Shao MD, Ruoxi Zhang MD, Binquan You MD, Feng Liu MD","doi":"10.1016/j.jaccas.2025.105298","DOIUrl":"10.1016/j.jaccas.2025.105298","url":null,"abstract":"<div><h3>Background</h3><div>Paroxysmal atrial fibrillation (AF) and epicardial ventricular tachycardia (VT) are complex arrhythmias requiring precise, safe ablation. Zero-fluoroscopy radiofrequency ablation (RFA) minimizes radiation exposure while maintaining procedural accuracy.</div></div><div><h3>FIH/Early Reports Summary</h3><div>A 56-year-old male with diabetes, hypertrophic cardiomyopathy, AF, and VT underwent zero-fluoroscopy, single-stage RFA for both AF and epicardial VT. Integration of intracardiac echocardiography (ICE) and CARTO 3D mapping enabled effective ablation and restored sinus rhythm with symptom relief.</div></div><div><h3>Discussion</h3><div>This case highlights the utility of ICE and CARTO 3D in enhancing procedural precision and safety. Eliminating fluoroscopy reduces radiation risks, particularly in complex cases.</div></div><div><h3>Novelty</h3><div>This is the first report of single-stage, zero-fluoroscopy RFA for both AF and epicardial VT using ICE and 3D mapping.</div></div>","PeriodicalId":14792,"journal":{"name":"JACC. Case reports","volume":"30 31","pages":"Article 105298"},"PeriodicalIF":0.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145242256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JACC. Case reportsPub Date : 2025-10-08DOI: 10.1016/j.jaccas.2025.105301
Erasmus Mutabi MD , Charles Ebersbacher DO , Colin Pesyna MD , Candice Lee MD , Craig Alpert MD , Ryan Watson MD , Karthikeyan Ranganathan MD
{"title":"Patent Foramen Ovale Closure in Right Ventricular Failure on Mechanical Circulatory Support","authors":"Erasmus Mutabi MD , Charles Ebersbacher DO , Colin Pesyna MD , Candice Lee MD , Craig Alpert MD , Ryan Watson MD , Karthikeyan Ranganathan MD","doi":"10.1016/j.jaccas.2025.105301","DOIUrl":"10.1016/j.jaccas.2025.105301","url":null,"abstract":"<div><h3>Background</h3><div>Right-to-left shunting through a patent foramen ovale (PFO) can cause severe hypoxemia in right ventricular (RV) failure; however, closure may worsen RV function and risk hemodynamic collapse.</div></div><div><h3>Case Summary</h3><div>A 40-year-old man with arrhythmogenic RV dysplasia and profound RV failure developed refractory hypoxemia due to a large PFO while supported on venoarterial extracorporeal membrane oxygenation and intra-aortic balloon pump. After multidisciplinary assessment, he underwent successful percutaneous PFO closure, leading to improved oxygenation, RV stability, and decannulation from mechanical circulatory support.</div></div><div><h3>Discussion</h3><div>This rare case involving dual mechanical support illustrates the complexity of managing PFOs in RV failure. It challenges conventional caution against closure and emphasizes the importance of individualized, team-based decision-making guided by careful physiological assessment.</div></div><div><h3>Take-Home Messages</h3><div>PFO closure may be feasible in RV failure with mechanical circulatory support. Multidisciplinary planning is essential to optimize outcomes.</div></div>","PeriodicalId":14792,"journal":{"name":"JACC. Case reports","volume":"30 31","pages":"Article 105301"},"PeriodicalIF":0.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145242257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JACC. Case reportsPub Date : 2025-10-08DOI: 10.1016/j.jaccas.2025.105324
Chukwunonyelum Odukwe MD , Ahmed Abdelrahman MD , Ali N. Zaidi MD , Barry Love MD , Ismail El-Hamamsy MD, PhD , Munir Ghesani MD , Kali A. Hopkins MD
{"title":"Culture-Negative Transcatheter Pulmonary Valve Endocarditis","authors":"Chukwunonyelum Odukwe MD , Ahmed Abdelrahman MD , Ali N. Zaidi MD , Barry Love MD , Ismail El-Hamamsy MD, PhD , Munir Ghesani MD , Kali A. Hopkins MD","doi":"10.1016/j.jaccas.2025.105324","DOIUrl":"10.1016/j.jaccas.2025.105324","url":null,"abstract":"<div><h3>Clinical Condition</h3><div>We present a case of transcatheter pulmonary valve endocarditis in a 38-year-old woman with a history of atrial septal defect, pulmonary stenosis, and bicuspid aortic valve, all previously repaired with mechanical and bioprosthetic valve replacements. Despite negative initial studies, <sup>18</sup>F-fluorodeoxyglucose positron emission tomography–computed tomography revealed septic pulmonary emboli and abnormal uptake at the pulmonary valve. Metagenomic sequencing identified <em>Haemophilus parainfluenzae</em> as the pathogen.</div></div><div><h3>Key Questions</h3><div>What is the differential diagnosis of a cardiac mass in this context? How should imaging and laboratory testing be approached in prosthetic valve endocarditis with negative studies? What surgical factors matter in patients with prior cardiac repairs?</div></div><div><h3>Outcome</h3><div>The patient underwent successful replacement of the pulmonary and aortic valves and completed a course of antibiotics, with full recovery.</div></div><div><h3>Take-Home Message</h3><div>Consider bioprosthetic valve endocarditis in patients with persistent fevers and negative cultures. Use advanced diagnostics early when the clinical suspicion is high.</div></div>","PeriodicalId":14792,"journal":{"name":"JACC. Case reports","volume":"30 31","pages":"Article 105324"},"PeriodicalIF":0.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145242262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cardiac Mass, Bacteremia, and Embolic Stroke","authors":"Ngoc Thai Kieu MD , Mahmoud Elamin MD , Syed Haseeb MD , Rija Shahid MBBS , Thuy Hao Nguyen MD , Husam Katib MD , Vien T. Truong MD , Ahmed Ali MBBS , Noman Chaudhary MBBS , Thach Nguyen MD","doi":"10.1016/j.jaccas.2025.105339","DOIUrl":"10.1016/j.jaccas.2025.105339","url":null,"abstract":"<div><h3>Background</h3><div>Cardiac masses may mimic tumors or vegetations. Differentiation is essential, particularly in the context of bacteremia and embolic complications.</div></div><div><h3>Case Summary</h3><div>A 75-year-old man presented with fatigue, myalgia, and new-onset atrial fibrillation. Transesophageal echocardiography revealed a mitral valve mass with features suggestive of fibroelastoma or myxoma. Blood cultures were positive for <em>Streptococcus mitis</em>. The patient subsequently developed an intracerebral hemorrhage requiring craniotomy. Serial imaging demonstrated resolution of the mitral valve mass, supporting a diagnosis of vegetation.</div></div><div><h3>Discussion</h3><div>Diagnosis of infective endocarditis requires integration of clinical context, microbiologic data, and serial imaging rather than reliance on echocardiographic appearance alone. Anticoagulation strategies must be individualized after hemorrhagic events.</div></div><div><h3>Take-Home Messages</h3><div>Cardiac masses in the setting of bacteremia require careful interpretation as lesions that appear benign may represent vegetations. Accurate diagnosis depends on integration of Duke criteria and serial transesophageal echocardiography evaluations, rather than reliance on a single echocardiogram.</div></div>","PeriodicalId":14792,"journal":{"name":"JACC. Case reports","volume":"30 31","pages":"Article 105339"},"PeriodicalIF":0.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145242258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JACC. Case reportsPub Date : 2025-10-08DOI: 10.1016/j.jaccas.2025.105296
Isa Khan MD , Kevin Rajakariar MBBS , Yuvaraj Malaiapan MBBS, MD
{"title":"Rare Mechanism of Anterior Myocardial Infarction Secondary to Aortic Dissection","authors":"Isa Khan MD , Kevin Rajakariar MBBS , Yuvaraj Malaiapan MBBS, MD","doi":"10.1016/j.jaccas.2025.105296","DOIUrl":"10.1016/j.jaccas.2025.105296","url":null,"abstract":"<div><div>A 76-year-old woman presented with anterolateral ST-segment elevation myocardial infarction complicated by incessant ventricular arrhythmia. Angiography did not find obstructive coronary disease. Echocardiography demonstrated “double valve sign,” pathognomonic of aortic dissection, which was subsequently confirmed on computed tomography. The coronary arteries arose from the true lumen; thus, it was understood that her presentation was caused by external coronary ostia compression by the growing false aortic lumen. It has long been understood that when aortic dissection involves the coronary arteries, it typically affects the right artery. This case highlights a rare complication of aortic dissection affecting the left coronary artery.</div></div>","PeriodicalId":14792,"journal":{"name":"JACC. Case reports","volume":"30 31","pages":"Article 105296"},"PeriodicalIF":0.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JACC. Case reportsPub Date : 2025-10-08DOI: 10.1016/j.jaccas.2025.105328
Gajon Uthayakumaran MBBS , Matthew Liava'a MBChB, MS , Julian Ayer MBBS, PhD , David Murphy MBBS , Claire Lawley MBBS, PhD
{"title":"Persistent Fifth Aortic Arch in a Right-Sided Aortic Arch Associated With Tetralogy of Fallot","authors":"Gajon Uthayakumaran MBBS , Matthew Liava'a MBChB, MS , Julian Ayer MBBS, PhD , David Murphy MBBS , Claire Lawley MBBS, PhD","doi":"10.1016/j.jaccas.2025.105328","DOIUrl":"10.1016/j.jaccas.2025.105328","url":null,"abstract":"<div><div>Persistent fifth aortic arch is a rare congenital cardiac anomaly. We report the imaging findings of a subtype of persistent fifth aortic arch in an infant with tetralogy of Fallot and a right-sided aortic arch.</div></div>","PeriodicalId":14792,"journal":{"name":"JACC. Case reports","volume":"30 31","pages":"Article 105328"},"PeriodicalIF":0.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Renal Artery Perforation During Transcatheter Aortic Valve Replacement","authors":"Saleh Altaf MD, Hammad Shafique MD, Alexander Tindale MD, Konstantinou Konstantinos MD, Tito Kabir MD","doi":"10.1016/j.jaccas.2025.105299","DOIUrl":"10.1016/j.jaccas.2025.105299","url":null,"abstract":"<div><h3>Background</h3><div>Transcatheter aortic valve replacement (TAVR) is a well-established modality to treat severe aortic stenosis.</div></div><div><h3>Case Summary</h3><div>We report a case of a woman in her 70s who underwent TAVR. The procedure was complicated owing to right renal artery perforation by a 0.038-inch angled-tip hydrophilic guidewire during closure of the left femoral artery, requiring implantation of a covered stent in renal artery to achieve hemostasis.</div></div><div><h3>Discussion</h3><div>In cases of shock during TAVR, injury to nonaccess site vessels should be considered. Treatment of iatrogenic renal artery injury with covered stent deployment achieves rapid hemostasis and preserves kidney function.</div></div><div><h3>Take-Home Messages</h3><div>In case of periprocedural hemorrhagic shock during TAVR, injury to nonaccess site vessels should be considered. Meticulous fluoroscopic guidance should always be used when advancing guidewires to prevent vascular damage. Awareness of patient-specific anatomical variation of arteries can help the operator to be more cautious and avoid entering that artery.</div></div>","PeriodicalId":14792,"journal":{"name":"JACC. Case reports","volume":"30 31","pages":"Article 105299"},"PeriodicalIF":0.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145242204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JACC. Case reportsPub Date : 2025-10-08DOI: 10.1016/j.jaccas.2025.105340
Lida Koskina MBBS , Andrew Ndakotsu MD , Antony Kaliyadan MD , John Wang MD , Shaikh B. Iqbal DO
{"title":"High-Risk TAV-in-TAV","authors":"Lida Koskina MBBS , Andrew Ndakotsu MD , Antony Kaliyadan MD , John Wang MD , Shaikh B. Iqbal DO","doi":"10.1016/j.jaccas.2025.105340","DOIUrl":"10.1016/j.jaccas.2025.105340","url":null,"abstract":"<div><h3>Objective</h3><div>The objective of this study is to describe a high-risk transcatheter aortic valve-in-valve in a Lotus valve requiring coronary artery protection.</div></div><div><h3>Key Steps</h3><div>Thorough preoperative assessment for valve sizing and coronary obstruction risk assessment are performed. Access is obtained for a pigtail catheter, a guiding catheter for percutaneous coronary intervention, and the transcatheter aortic valve replacement delivery system. Coronary access is secured with a coronary wire and a guide extension catheter before valve deployment. Proper alignment of the new valve is ensured. A snorkel stent is deployed and maximal expansion is ensured.</div></div><div><h3>Potential Pitfalls</h3><div>Coronary artery anatomy, which is at high risk for obstruction, can lead to coronary ischemia or sequestration after valve deployment. Improper alignment of the new valve can lead to poor apposition and paravalvular leak. Injury to the aorta during valve deployment or when postdilation is required.</div></div><div><h3>Take-Home Message</h3><div>Successful transcatheter aortic valve-in-valve in a Lotus valve is feasible with proper preoperative planning, individualized device selection, and coronary protection when indicated.</div></div>","PeriodicalId":14792,"journal":{"name":"JACC. Case reports","volume":"30 31","pages":"Article 105340"},"PeriodicalIF":0.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145242206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JACC. Case reportsPub Date : 2025-10-08DOI: 10.1016/j.jaccas.2025.105361
Thomas C. Pointer , John F. Keaney III MD, MPH , Samuel W. Reinhardt MD , Tony Pastor MD
{"title":"ALCAPA Diagnosed in an Elderly Patient","authors":"Thomas C. Pointer , John F. Keaney III MD, MPH , Samuel W. Reinhardt MD , Tony Pastor MD","doi":"10.1016/j.jaccas.2025.105361","DOIUrl":"10.1016/j.jaccas.2025.105361","url":null,"abstract":"<div><h3>Background</h3><div>Anomalous left coronary artery origin arising from the pulmonary artery (ALCAPA) occurs in less than 0.01% of the general population, with symptoms often manifesting within the first 3 months of life. Without surgical repair, early mortality is the most common outcome.</div></div><div><h3>Case Summary</h3><div>Here, we present the case of a 66-year-old woman who was found to have previously undiagnosed ALCAPA. Our patient did not undergo surgical management and instead became asymptomatic with medical management alone, in part owing to substantial collaterals and a dilated right coronary artery.</div></div><div><h3>Discussion</h3><div>In rare circumstances, patients with ALCAPA have been known to survive into adulthood without surgical intervention. For patients with ALCAPA presenting in adulthood, surgical intervention must be considered in the setting of symptoms, medical therapy, and surgical risk; conservative therapy may be the most appropriate approach in certain patients.</div></div>","PeriodicalId":14792,"journal":{"name":"JACC. Case reports","volume":"30 31","pages":"Article 105361"},"PeriodicalIF":0.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145242268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JACC. Case reportsPub Date : 2025-10-08DOI: 10.1016/j.jaccas.2025.105335
Yuktesh V. Kalidindi BS , Rida Khan BA , Ece Isin Akduman MD , Divya Ratan Verma MD , Ramy Shoela MD
{"title":"Full-Scale 3D Printing as a Guide to Right Ventricular Pseudoaneurysm Due to Chronic Pacemaker Lead Erosion","authors":"Yuktesh V. Kalidindi BS , Rida Khan BA , Ece Isin Akduman MD , Divya Ratan Verma MD , Ramy Shoela MD","doi":"10.1016/j.jaccas.2025.105335","DOIUrl":"10.1016/j.jaccas.2025.105335","url":null,"abstract":"<div><h3>Background</h3><div>Ventricular pseudoaneurysm formation due to longstanding lead erosion is rare, and standardized guidelines for diagnosis and management are limited.</div></div><div><h3>Case Summary</h3><div>We present a case of a right ventricular pseudoaneurysm noted on computed tomography after a patient with a pacemaker, originally placed in 2013, was admitted for respiratory failure. PolyJet three-dimensional printing was employed to assist in presurgical planning and evaluating the spatial anatomic relationship of the lead to the ventricular outpouching. The pseudoaneurysm was eventually excised, and the myocardial defect was closed.</div></div><div><h3>Discussion</h3><div>Pseudoaneurysms lack both standardized clinical presentations and management guidelines, making diagnosis challenging. Imaging is crucial for timely diagnosis and treatment.</div></div><div><h3>Take-Home Messages</h3><div>Cardiac-gated computed tomography is particularly valuable in diagnosing right ventricular pseudoaneurysms when other imaging modalities are technically challenging or inconclusive. Three-dimensional printing enhances the diagnosis of and preoperative planning for rare conditions such as pseudoaneurysms.</div></div>","PeriodicalId":14792,"journal":{"name":"JACC. Case reports","volume":"30 31","pages":"Article 105335"},"PeriodicalIF":0.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}