JDR Clinical & Translational Research最新文献

{"title":"Cannabis and Oral Health Implications for 3 Priority Populations: A Special Communication.","authors":"F Arriola-Pacheco, B W Chaffee, A Jessani, H P Lawrence","doi":"10.1177/23800844251366974","DOIUrl":"10.1177/23800844251366974","url":null,"abstract":"<p><p>As the legal status and social perceptions of cannabis shift globally, the potential impact of cannabis use on health and well-being merits heightened attention among practitioners and researchers, including possible effects on oral health. Evidence suggests that cannabis use may be associated with adverse oral health outcomes, including periodontal disease and xerostomia, with less conclusive links to dental caries and oral cancer. It is also becoming increasingly clear that certain population segments are at greater risk of cannabis use and may consequently face a greater burden of oral disease, underscoring the need for focused research and targeted interventions. In response to these concerns, a group of researchers convened a symposium titled \"Cannabis and Oral Health: A Focus on Priority Populations\" at the 2025 AADOCR/CADR Annual Meeting and Exhibition (American Association for Dental, Oral, and Craniofacial Research and Canadian Association for Dental Research). This session aimed to highlight the unique oral health challenges faced by priority populations in the context of a changing landscape of cannabis use. The presenters examined cannabis' impact among populations with whom they closely work, including Indigenous Canadians, adolescents and young adults, and 2SLGBTQI+ youth (Two-Spirit, lesbian, gay, bisexual, transgender, queer or questioning, intersex, and people that identify with other sexual orientations, gender identities, and expressions). Understanding the specific effects of cannabis on these groups is crucial, as social determinants of health are deeply intertwined with oral health outcomes. Historical and societal inequities, compounded by emerging health risks, demand a participatory research approach and targeted public health strategies. Evidence presented at the symposium highlights the need of addressing cannabis-related oral health impacts through inclusive, population-specific research and policy. A nuanced understanding of this evolving issue can inform the development of clinical guidelines and public health initiatives aimed at mitigating harm among populations that have been vulnerable within our societies. The symposium and this communication serve as a call to action for the dental and research communities to prioritize these perspectives in future work.Knowledge Transfer Statement:Amid shifting social and legal contexts, cannabis takes on heightened importance as a potential risk factor for oral diseases. Among specific priority populations, cannabis is one of several confluent health determinants that merits greater recognition and tailored research attention to inform appropriate clinical and public health practice.</p>","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"306-310"},"PeriodicalIF":2.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13232572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whose Data Are They? Data Ownership and Sovereignty in Oral Health Research.","authors":"A Jessani, S A Gansky, F Ramos-Gomez, J Albino, T Tiwari","doi":"10.1177/23800844251382488","DOIUrl":"10.1177/23800844251382488","url":null,"abstract":"<p><p>In the complex and ever-evolving landscape of oral health research, community-based participatory research methods provide essential tools for meaningfully engaging with vulnerable and socially marginalized populations. These methods reflect community needs and integrate their perspectives into oral health research. However, issues of data control, equity, ownership, and sovereignty can lead to ethical and legal challenges. To discuss these concerns, a symposium was held in March 2025 in New York City at the American Association for Dental, Oral, and Craniofacial Research annual meeting. This event explored the intricate dynamics of data access, control, and sovereignty within the context of community-based participatory research, particularly involving vulnerable populations such as Two-Spirit, lesbian, gay, bisexual, transgender, queer or questioning, and other sexual orientations and gender identities (2SLGBTQ+), as well as Indigenous peoples, racial/ethnic minorities, and others. As oral health data become increasingly accessible across various platforms, it is incumbent on investigators to understand appropriate access, ownership, legitimate rights, and the ethical use and reuse of data to uphold equity, rights, and representation. The symposium examined the complex challenges surrounding data access, ownership, and control and their implications for community and individual rights, emphasizing the importance of implementing best practices in inclusive research and prioritizing the voices, rights, and meaningful integration of vulnerable populations. Speakers presented and advocated for multifaceted frameworks that integrate cultural values and traditions, aiming to promote equitable oral health outcomes. The symposium also underscored the critical role of ethical data stewardship in big data and community-based oral health research in American Indian, Hispanic, and Global East African contexts. Case studies showcased collaborative approaches that meaningfully engage community stakeholders and service users throughout the research process, ensuring that data are utilized ethically and yield genuine benefits for the populations involved.Knowledge Transfer Statement:This symposium emphasized the critical role of data ownership and sovereignty in advancing oral health equity, particularly for socially marginalized groups such as 2SLGBTQ+ communities, Indigenous peoples, racial minorities, and others. It highlighted best practices for ethical data stewardship and inclusive research that centers community voices. The session offered actionable frameworks to help researchers, policy makers, and institutions build trust, integrate community values, and ensure culturally sensitive outcomes in their efforts to advance health equity.</p>","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"296-300"},"PeriodicalIF":2.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12823166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145312838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combinatorial Pharmacotherapy of Herbal Medicine and Corticosteroids for Oral Lichen Planus: A Systematic Review.","authors":"W Y Kot, X X Deng, L W Zheng, C P McGrath, J W Li","doi":"10.1177/23800844251359982","DOIUrl":"10.1177/23800844251359982","url":null,"abstract":"<p><strong>Background: </strong>This systematic review aims to analyze the effectiveness of the combination of herbal medicine and corticosteroids in oral lichen planus (OLP) management. By providing an updated insight into the medicinal properties of this combined treatment approach, the review seeks to address the current gap in the understanding of its therapeutic potential for this chronic premalignant disorder.</p><p><strong>Materials and methods: </strong>PubMed, Web of Science, Scopus, Cochrane Library, CNKI, and WanFang databases were searched to identify randomized controlled trials comparing Chinese patent medicine (CPM) with corticosteroids and corticosteroids alone in treating OLP. Studies in English or Chinese that reported relief of symptoms and medicinal properties of CPM were included. Data on study and participant characteristics, intervention, and impact of therapy were extracted.</p><p><strong>Results: </strong>Nineteen randomized controlled trials with a total of 1,164 participants were included in the study. Eleven CPMs were identified, with reported outcomes including improved treatment effectiveness, reduced OLP recurrence rates, and mitigated drug-related complications. All studies reported that combinatory pharmacotherapy demonstrated a significant reduction in burning sensation, a decrease in lesion size and severity, and an improvement in treatment effectiveness as compared with the utilization of corticosteroid alone.</p><p><strong>Conclusion: </strong>The combination of herbal medicine and corticosteroids holds promise as a superior approach for OLP management. Further research is necessary to quantify the active chemical components within herbal remedies and elucidate their underlying mechanisms of action. Advanced scientific methods are crucial for validating the composition of CPMs and confirming their therapeutic effectiveness. The investigations are crucial to overcoming the limitations of the current treatment strategies for OLP and other oral potentially malignant disorders.Knowledge Transfer Statement:The findings of this systematic review provide valuable insights for clinicians regarding the potential benefits of combining herbal medicine with corticosteroids in the management of oral lichen planus. This information can aid in making informed decisions on treatment strategies to enhance the health outcomes of individuals affected by this condition.</p>","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"342-356"},"PeriodicalIF":2.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Current Cigarette, E-Cigarette, and Cannabis Use with Xerostomia.","authors":"B W Chaffee","doi":"10.1177/23800844251364158","DOIUrl":"10.1177/23800844251364158","url":null,"abstract":"<p><strong>Objectives: </strong>This investigation aimed to examine the associations between xerostomia and the use of cigarettes, e-cigarettes, and cannabis in a nationally representative cross-sectional sample of adults.</p><p><strong>Methods: </strong>Data from the Population Assessment of Tobacco and Health Study included <i>N</i> = 29,721 United States adults (age ≥18 y) surveyed during 2022 to 2023 about xerostomia (experiencing dry mouth \"frequently\" or \"always\") and their use of 9 types of tobacco products and cannabis. Survey-weighted multivariable regression models estimated the associations of xerostomia with various specifications of cigarette, e-cigarette, and cannabis use, adjusted for sociodemographic and health status variables.</p><p><strong>Results: </strong>Overall, 9.7% of participants experienced xerostomia. In adjusted models, past 30-d use of cigarettes, e-cigarettes, and cannabis were each associated with greater odds of xerostomia. The daily use of cigarettes (adjusted odds ratio: 1.7; 95% confidence interval: 1.4, 2.0), e-cigarettes (1.8; 1.5, 2.2), and cannabis (2.1; 1.7, 2.7) was also associated with greater odds of xerostomia. The greatest odds of xerostomia was associated with the use of all 3 products in combination within the past 30 d (3.8; 2.8, 5.2).</p><p><strong>Conclusions: </strong>The use of cigarettes, e-cigarettes, or cannabis, particularly when used together, is associated with a greater occurrence of oral dryness among adults. Among other adverse health effects of these products, potential xerostomia risk may encourage cessation, contribute to dental patient advising, and inform appropriate tobacco and cannabis regulations and policies.Knowledge Transfer Statement:Based on the findings of this study, dental professionals and patients should anticipate a higher prevalence of xerostomia among adults who use cigarettes, e-cigarettes, and/or cannabis. Dental professionals should incorporate this information into xerostomia management, treatment planning, and the guidance and cessation support provided to patients who use these products. Potential adverse oral health effects should be considered in tobacco and cannabis policies and regulations.</p>","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"484-492"},"PeriodicalIF":2.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating Health Care with Concurrent Jaw and Neck Pain: A Patient-Centered Perspective.","authors":"A Böthun, A Fjellman-Wiklund, J Durham, F Hellström, B Häggman-Henrikson, A Lövgren","doi":"10.1177/23800844251365594","DOIUrl":"10.1177/23800844251365594","url":null,"abstract":"<p><strong>Introduction: </strong>Concurrent pain in the jaw and neck is common; however, little is known about how it develops. Previous studies have focused mainly on biological factors with limited focus on psychosocial factors and patients' perspectives. To enhance understanding of concurrent jaw and neck pain, knowledge is needed about patients' perspectives on the development of symptoms and their management within health care that also includes dentistry.</p><p><strong>Objective: </strong>To explore patients' perspectives on the development of concurrent jaw and neck pain in relation to navigating the health care system.</p><p><strong>Methods: </strong>Sixteen individuals (11 women and 5 men, aged 19 to 56 y) with concurrent jaw and neck pain were recruited using purposive sampling. Participants were patients referred to an orofacial pain specialist in Sweden. Individual semi-structured interviews were used and analyzed using qualitative content analysis.</p><p><strong>Results: </strong>Data analysis resulted in the theme \"Seeking understanding, confirmation, and simplified navigation in the health care system.\" The main theme consisted of 3 subthemes: (1) understanding and interpreting the body and emotions holistically, (2) seeking affirmation and legitimacy from health care, and (3) wishing for clear and easily navigable health care pathways. Patients expressed thoughts regarding their own sensemaking in respect to causes for their pain. Moreover, they requested confirmation from health care along with simplified health care navigation and a holistic approach regarding pain management.</p><p><strong>Conclusions: </strong>A mismatch exists between the patient's own sensemaking regarding the cause of their jaw and neck pain and the care they receive from their health care provider. Having pain from multiple sites that is managed in different medical systems makes it difficult to navigate within health care. A clear care pathway could reduce the risk of pain chronicity, and an increased collaboration between dentistry and medical care would be desirable.Knowledge Transfer Statement:Concurrent jaw and neck pain is common but often managed separately in dentistry and health care. This can result in a mismatch between a patient's understanding regarding concurrent jaw and neck pain and directions from their health care provider. A holistic approach and increased collaboration between dentistry and health care are needed to support patients navigating health care providers and reduce the risk of pain chronification.</p>","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"401-411"},"PeriodicalIF":2.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13232580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Population Case Study of Structural Racism in Dental Services Utilization in Brazil and Colombia.","authors":"R A Bomfim, R K Celeste, M L Macedo, L A Sánchez-Alfaro, M K Navarro-Ramírez, C C Guarnizo-Herreño","doi":"10.1177/23800844251368892","DOIUrl":"10.1177/23800844251368892","url":null,"abstract":"<p><strong>Introduction: </strong>Racial inequalities are expressions of racism, a phenomenon that is pervasive in different countries in Latin America and reinforced by social structure. This research analyzed the intersections between race and income in dental care utilization in Brazil and Colombia.</p><p><strong>Methods: </strong>Two nationwide Brazilian and Colombian population oral health surveys were used, as conducted in 2010 and 2014, respectively. The samples included individuals from different age groups. Three outcomes were considered: 1) Ever been to a dentist (yes/no)? 2) Have you visited a dentist in <1 y (yes/no)? 3) Last dental visit for urgent treatment (yes/no)? The main explanatory variables were race and income (the per capita minimum wage). Relative excess risk due to interaction and synergy index were calculated to verify interactions between race and income, adjusted for age and sex. Specific age group analyses were carried out for both countries to assess pervasive racial inequities.</p><p><strong>Results: </strong>Upper-income White persons in Brazil (odds ratio, 3.61; 95% CI, 3.20 to 4.07) and Colombia (odds ratio, 2.54; 95% CI, 2.21 to 3.07) had higher odds of not using urgent dental services than lower-income Black persons and lower-income Afro-Colombians. Relative excess risk due to interaction and synergy index showed synergistic interactions in both countries.</p><p><strong>Conclusion: </strong>Compounded racial and income-related disparities in dental care utilization were observed in Brazil and Colombia, which may reflect underlying structural inequities. Public policies need to consider the complex intersections between socioeconomic conditions affecting underprivileged racial groups in Latin America.Knowledge Transfer Statement:This study highlights how structural racism and socioeconomic disparities intersect to limit dental care access in Brazil and Colombia, emphasizing the need for public policies addressing racial and economic inequities in oral health.</p>","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"493-500"},"PeriodicalIF":2.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Toothache in Adults: A Meta-Analysis of Worldwide Studies.","authors":"A L Porporatti, Â G D Schroder, N Moreau, E Paszynska, A Lebel, Y Boucher","doi":"10.1177/23800844251366893","DOIUrl":"10.1177/23800844251366893","url":null,"abstract":"<p><strong>Objectives: </strong>Toothache is defined as pain originating from a tooth and its supporting structures, often described as the most frequent type of orofacial pain. Therefore, this systematic review aimed to assess the prevalence of toothache in adults.</p><p><strong>Methods: </strong>The study selection process adhered to the PECOS inclusion criteria: Population (P): Adults; Exposure (E): Toothache; (C): None; Outcome (O): Prevalence; Studies (S): Observational studies.</p><p><strong>Results: </strong>The initial search yielded 1,781 studies, and after eligibility criteria were applied, 48 studies were included in the analysis. The overall prevalence of toothache was found to be 24% (95% confidence interval [21, 27.2]; <i>n</i> = 447,373).</p><p><strong>Conclusions: </strong>When categorized, the prevalence among adults was as follows: 34.6% currently experiencing tooth pain, 14.5% in the past month, 19.5% in the past 6 mo, and 29.0% in the past 12 mo. Geographically, toothache prevalence varied as follows: 43.2% in Africa, 30.6% in Asia, 24.6% in Europe, 17.0% in South America, 15.0% in Oceania, and 13.44% in North America.</p><p><strong>Clinical significance: </strong>Based on the available evidence, this systematic review suggests that the overall prevalence of toothache in adults is 24%, with higher rates in Africa (43.2%) and Asia (30.6%) and lower rates in Oceania (15.0%) and North America (13.4%).Knowledge Transfer Statement:The worldwide prevalence of toothache was found to be 24%. Toothache prevalence varied by continent as follows: 43.2% in Africa, 30.6% in Asia, 24.6% in Europe, 17.0% in South America, 15.0% in Oceania, and 13.44% in North America.</p>","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"324-341"},"PeriodicalIF":2.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping Tooth Loss at the Tooth Level: Associations with Demographic, Health, and Behavioral Factors.","authors":"K M McCormick, G Mejia, L Luzzi, L Jamieson","doi":"10.1177/23800844251384952","DOIUrl":"10.1177/23800844251384952","url":null,"abstract":"<p><strong>Objective: </strong>This cross-sectional observational study analyzed patterns of tooth loss across different population groups using National Health and Nutrition Examination Survey (NHANES) data from 2009 to 2018, aiming to identify the teeth most at risk and the key contributing factors.</p><p><strong>Methods: </strong>Data from 24,945 adults aged 20 y and older were analyzed. Tooth presence/absence was modeled in relation to age, income, education, smoking history, and glycemic status. To improve robustness, missing covariate data were imputed using k-nearest neighbors, and survey weights were applied in regression analyses to account for NHANES's complex sampling design. A 2-step analytic approach was used: (1) survey-weighted quasi-Poisson regression estimated associations with total tooth count and (2) unweighted generalized estimating equations identified explanatory variables associated with individual tooth loss, accounting for intraoral clustering. Dental implants were excluded.</p><p><strong>Results: </strong>Tooth-level models suggested distinct intraoral and demographic patterns. Males retained more posterior teeth but lost more mandibular incisors than females did. Older adults (≥60 y) exhibited markedly higher loss in mandibular anterior and premolar regions. High-income and high-education participants retained more teeth overall but were more likely to lack first premolars, likely reflecting orthodontic extractions. Smoking and diabetes were associated with anterior tooth loss, especially in visible, functionally important regions. Glycemic control showed a clear gradient, with low-normal HbA1c levels protective in posterior sites.</p><p><strong>Conclusions: </strong>Tooth-level modeling suggested anatomically and socially patterned vulnerabilities often masked in whole-mouth analyses. Findings underscore the need for site-specific prevention strategies that address biological risk and structural inequity, advancing more equitable approaches to oral health care and policy.Knowledge Transfer Statement:This study identified which specific teeth are most at risk of loss across age, health, and socioeconomic groups. Understanding these tooth-level patterns can help clinicians tailor preventive care to vulnerable patients, guide patient education, and inform public health strategies that target oral health disparities. These findings support more precise, equitable dental care to help people keep their natural teeth longer.</p>","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"465-475"},"PeriodicalIF":2.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13232582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145345312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental Visits and Changes in Oral Health over Time among Australian Adults.","authors":"P Liu, K G Peres, A Singh, M A Peres","doi":"10.1177/23800844261448206","DOIUrl":"https://doi.org/10.1177/23800844261448206","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the causal relationship between dental visiting patterns and changes in oral health outcomes among Australian adults aged 18 and older.</p><p><strong>Methods: </strong>Longitudinal analyses were conducted using data from the Australian National Study of Adult Oral Health, collected in 2004 to 2006 and 2017 to 2018 (n = 1,707). Routine attendance (RA) was defined as dental checkups within the past 12 months, primarily for preventive reasons. Three exposure groups were identified: those with (1) routine visits at both times, (2) one routine visit, and (3) nonroutine visits at both times. Three oral health outcomes were evaluated: changes in self-rated oral health, self-rated toothache, and pathology-related tooth loss. Confounders included sex and country of birth as baseline variables. Household income, age, education, employment status, general health rating, smoking status, and dental visit sites were treated as time-varying confounders. Marginal structural models with inverse-probability weighting were used to evaluate causal effects. Propensity scores were calculated using logistic regression, incorporating all confounders listed above.</p><p><strong>Results: </strong>Descriptive analysis indicated that individuals with two-time RA had better oral health than those with one-time or no RA did. After accounting for selected confounders using propensity score weighting, compared to two-time RA, one-time RA had higher probabilities of poor self-rated dental health (risk ratio [RR] (95% confidence interval [CI]): 2.07 [1.32, 3.23]) and more frequent self-rated toothache (RR [95% CI]: 1.69 [1.31, 2.17]). No RA had even higher risks (RR [95% CI]: 3.74 [2.46, 5.69] for poor dental health; RR [95% CI]: 1.76 [1.37, 2.26] for toothache). The RR demonstrated more pathology-related tooth loss (RR [95% CI]: 1.21 [0.96, 1.54]) among the one-time or no RA than the two-time RA.</p><p><strong>Conclusion: </strong>This study demonstrated that routine dental visits improved self-rated oral health, reduced frequency of toothache, and were associated with less pathology-related tooth loss.Knowledge Transfer Statement:These findings highlight the importance of routine dental checkups in maintaining long-term oral health. Clinicians and policymakers can use this evidence to support preventive care strategies and promote regular dental attendance, which may lead to improved self-rated oral health, reduced toothache, and lower risk of tooth loss among adults.</p>","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"23800844261448206"},"PeriodicalIF":2.2,"publicationDate":"2026-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148198899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Public Perception of Fluoride: An Infodemiological Analysis of YouTube Videos and Comments.","authors":"S Liao, T K A Chan, W Zhao, R Zhang, C H Chu, E C M Lo, C M Jiang","doi":"10.1177/23800844261446256","DOIUrl":"https://doi.org/10.1177/23800844261446256","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to analyze the public's perception of fluoride by investigating the most-viewed YouTube videos and their associated comments addressing fluoride in dental/public health contexts.</p><p><strong>Methods: </strong>Metadata and comments of YouTube videos were retrieved using the YouTube Data application programming interface (YouTube Data API) via Python. The top 100 most-viewed YouTube videos related to fluoride and their comments were analyzed. Sentiment analysis, Latent Dirichlet Allocation (LDA) topic modeling, word co-occurrence analysis, and word frequency analysis were performed. Statistical analyses including Spearman's correlation, Kruskal-Wallis tests, and Mann-Whitney U tests were conducted to assess potential associations.</p><p><strong>Result: </strong>A total of 76 eligible videos and 88,126 comments were analyzed. Approximately half (45%) of the retrieved videos were uploaded in 2024 and 2025. The mean (±standard deviation) and median sentiment scores were 9.5 ± 15.9 and 5.4, respectively. Significant negative correlations were observed between sentiment scores and both video views (r = -0.247, P = 0.032) and the number of comments (r = -0.486, P < 0.001). Among professional uploaders, videos by dental hygienists had a higher sentiment score compared with those by dentists (17.5 vs. -0.5). Topic modeling revealed that the term \"poison\" appeared 6 times more frequently in negative comments than in positive comments, followed by \"conspiracy\" and \"bad,\" whereas \"love,\" \"care,\" and \"safe\" were predominant in positive comments.</p><p><strong>Conclusion: </strong>Fluoride has emerged as a controversial societal topic. The terms \"poison\" and \"conspiracy\" reflect prominent public concerns. Dental hygienists play a critical role in disseminating online information on fluoride, highlighting the need for targeted strategies to mitigate public anxiety and promote the appropriate use of fluoride in dental care.Knowledge Transfer Statement:The present study provides insights into public health communication. First, empowering professionals and optimizing video formats (eg, tutorials, skills-based demonstration, and short dramas) could enhance the reach and acceptance of evidence-based fluoride advocacy. Second, policymakers should address societal and historical factors shaping public distrust, rather than relying solely on scientific dissemination. Finally, due to contagion of negative emotions, there is a need to monitor and alleviate negative sentiments.</p>","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"23800844261446256"},"PeriodicalIF":2.2,"publicationDate":"2026-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148029290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}