JDR Clinical & Translational Research最新文献

{"title":"ICDAS Adaptation for Early Childhood Caries: An Epidemiological Study in 11 Latin American Countries.","authors":"R S Villena, N Bordoni, A M Acevedo, L Alvarez, V Cepeda, T Chirife, A Gálvez, R A Giacaman, S Gómez, S Gudiño-Fernandez, S Martignon, S Paiva, O Zambrano, J Medina, H Eggertsson, N B Pitts, E D Beltrán-Aguilar","doi":"10.1177/23800844251368372","DOIUrl":"10.1177/23800844251368372","url":null,"abstract":"<p><strong>Background: </strong>The assessment of epidemiological information on the oral health of children younger than 6 y in the region of the Americas is challenging due to methodological differences. An International Association for Dental Research Regional Development Project supported researchers from 11 Latin American countries in Argentina, Brazil, Chile, Colombia, Costa Rica, Ecuador, Panama, Paraguay, Peru, Uruguay, and Venezuela to train and conduct standardized epidemiological studies of dental caries in children <6 y of age.</p><p><strong>Objectives: </strong>To assess the feasibility of an International Caries Detection and Assessment System (ICDAS)-adapted protocol in early childhood caries (ECC) epidemiological studies and provide comparable data.</p><p><strong>Methods: </strong>Eleven researchers from the selected countries were standardized using the following simplified criteria and protocol aimed to reduce the time of evaluation: (1) starting the examination with the detection of caries lesions, (2) eliminating ICDAS category 1 (as no air for drying), (3) applying one code for tooth surfaces with the same clinical finding (e.g., missing), and (4) using a customized data entry form. The 11 researchers trained and standardized 10 to 15 local examiners in each country and conducted cross-sectional studies in convenience samples of preschool children aged 12 to 71 mo living in disadvantaged communities according to each country's criteria.</p><p><strong>Results: </strong>A total of 4,535 children were included in the present analysis. There were notable differences by country and age. For example, the d_2-6 prevalence in the 12- to 23-mo group varied between 13% in Venezuela and 48% in Argentina, while the d_5-6 prevalence varied between 0% in Venezuela and 18% in Argentina. In general, the occurrence of more severe clinical presentations increased with age.</p><p><strong>Conclusions: </strong>There was a considerable variation in the prevalence of dental caries in the 11 countries. The wide variation with age indicates the need to report ECC estimates by detection threshold and individual age groups. The ICDAS-adapted protocol is suitable for ECC epidemiological studies.Knowledge Transfer Statement:The results of this study show the high occurrence and variation of early childhood caries (ECC) in Latin American children, which shows the need for more detailed and comprehensive surveillance efforts in this age group. The ICDAS-adapted protocol facilitates data entry and the recording of clinical observations for epidemiological studies in young children by reducing examination time. We have contributed to the standardization of ECC data collection in Latin America by using common ICDAS-adapted criteria.</p>","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"423-432"},"PeriodicalIF":2.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Young People's Valuations of Managing Compromised Molars: A Discrete Choice Experiment.","authors":"G D Taylor, D Boyers, C Exley, N Innes, L Vale, C R Vernazza","doi":"10.1177/23800844261452554","DOIUrl":"10.1177/23800844261452554","url":null,"abstract":"<p><strong>Introduction: </strong>Limited evidence exists to support optimal patient-centered management for compromised first permanent molars (cFPMs) in young people. Young people's preferences are important when planning their health care.</p><p><strong>Objectives: </strong>This study aimed to elicit young people's preferences for pathways to manage cFPMs.</p><p><strong>Methods: </strong>An online discrete choice experiment (DCE) was completed by young people (aged 12-16) from the United Kingdom. The design was informed by the literature, interviews with young people, and a concurrent adult-focused DCE. A statistically optimal d-efficient design generated 18 choice tasks across two blocks. Each respondent answered 1 block of 9 tasks. Choice tasks varied across four characteristics: treatment type, care provider, management decision-maker, and number of future visits avoided. An opt-out (no treatment) was included. Conditional (fixed effects) logit models were used for data analysis.</p><p><strong>Results: </strong>In total, 122 young people completed the DCE. Restoring a cFPM was preferred to having a partial gap, prosthetic replacement with a bridge, orthodontic closure, or a full-unit gap. Preferences ranged from no preference to a preference for spontaneous closure compared to a restoration (odds ratio = 1.40; 95% confidence interval, 0.98-1.99; <u>P</u> = 0.063). Young people had no preference for the health professional providing their care (general dentist, dentist with enhanced skills, or a specialist pediatric dentist). Participants did not have a clear preference for whether treatment decisions were made by the dentist alone, the patient alone, or on a shared decision-making basis between patient, parent, and dentist.</p><p><strong>Conclusion: </strong>Young people wished to manage cFPMs and expressed preferences for restorations rather than any other management, resulting in a gap, and for orthodontic or prosthetic closure. They want and should be included as part of a shared decision-making process for these teeth, rather than their preferences being assumed solely by parental proxies. Young people aged 12 to 16 were able to understand and complete this DCE.Knowledge Transfer Statement:Young people (aged 12-16) attending primary and secondary care dental clinics in the United Kingdom clearly expressed preferences on how compromised first permanent molars should be managed. They want and should be included as part of a shared decision-making process for these teeth, rather than their preferences being assumed solely by parental proxies.</p>","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"23800844261452554"},"PeriodicalIF":2.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148368720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Closing the Oral Health Divide: System-Level Care for Mothers and Young Children-A Forgotten Disparity in the United States, United Kingdom, and Sweden.","authors":"J Xiao, G Tsakos, I Brännemo, T Dye, P Ashley, D T Kopycka-Kedzierawski, C Meyerowitz","doi":"10.1177/23800844251372513","DOIUrl":"10.1177/23800844251372513","url":null,"abstract":"<p><p>Maternal and child oral health disparities often share similar phenomena: high disease burdens, limited access to care, and insufficient preventive strategies. These systemic challenges undermine community confidence in oral health solutions. The Eastman Oral Health Institutes in the United Kingdom, Sweden, and the United States of America, through the Eastman International Alliance, facilitated critical discussions in November 2024 on this topic in international grand rounds by highlighting the need to translate research into impactful oral health policies. This special communication calls for global action to elevate maternal and child oral health into system health by leveraging policies, enhancing service integration, addressing inappropriate industry influence (particularly in terms of sugar consumption), and using digital technology. We describe the often-overlooked oral health divide in high-income countries, using the United States, United Kingdom, and Sweden as examples, to assess shared challenges, distinct obstacles, and opportunities for global collaboration. The differences between developed countries including the United States, United Kingdom, and Sweden and the challenges faced by lower-income nations underscore the need for shared learning and a global commitment to integrated oral health care. Policymakers, health care providers, and public health advocates worldwide must work together to break down barriers and strengthen services.Knowledge Transfer Statement:Improving maternal and child oral health requires a system-level approach in all countries. Integrating oral health into system health is not just an option but a necessity for building healthier communities. Leveraging partnerships between dental academic institutions and oral health delivery organizations that are embedded in medical institutions, such as the Eastman Oral Health Institutes globally, offers a powerful vehicle for identifying, sharing, and scaling effective solutions to improve system-level oral health.</p>","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"301-305"},"PeriodicalIF":2.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating Reporting Completeness in Oral Health Clinical Guidelines: A Meta-Research Study.","authors":"P Lancry, P Lyra, J J Mendes, G G Nascimento, V Machado, J Botelho","doi":"10.1177/23800844251357235","DOIUrl":"10.1177/23800844251357235","url":null,"abstract":"<p><strong>Background: </strong>To assess the adherence to clinical practice guidelines (CPGs) reporting guidelines for oral health.</p><p><strong>Methods: </strong>A literature search was carried out in PubMed, Embase and Web of Science from March 2016 to December 2023, selecting CPGs related to oral health. The study selection and data extraction were conducted independently by 2 researchers. Guidelines were cross-checked against the 23-item Appraisal of Guidelines, Research, and Evaluation (AGREE). The results were then collected, and the overall adherence and adherence to each AGREE item and section were calculated. Regression analyses were performed considering journal characteristics, such as quartile, year, and publishing options in journals' guideline endorsement. There were no language restrictions.</p><p><strong>Results: </strong>Twenty-one CPGs were included in this study. The mean overall AGREE adherence was 48.7%. The results showed considerable variability in the rates of compliance with the reporting guidelines. Three areas appear to have (much) higher levels of compliance than the others, notably \"Clarity of Presentation\" (83.6%, 95% confidence interval [CI]: 75.4%-91.8%), \"Scope and Purpose\" (74.0%, 95% CI: 67.1%-80.9%), and \"Stakeholder Involvement\" (54.5%, 95% CI: 43.4%-65.7%). The lowest level of agreement was found in \"Applicability,\" with a level of agreement of 18.5% (95% CI: 11.4%-25.6%). Four of the 6 domains had a complete lack (0.0%) of adherence. Journal quartiles were significant, as guidelines published in the second- (B = -27.3%; standard error [SE] = 6.1) and third-quartile (B= -22.8%; SE = 10.6) impact factor journals displayed a lower overall adherence than those published in first-quartile journals. Guideline endorsement by journals was also a significant variable (B = -20.9%, SE = 5.9).</p><p><strong>Conclusion: </strong>Reporting completeness in dental/oral CPGs is suboptimal and is associated with the journal's quartile and guideline endorsement. Increasing awareness of CPG reporting guidelines and ensuring their rigorous application are decisive toward better adherence.Knowledge Transfer Statement:The quality of reporting in dental and oral clinical practice guidelines (CPGs) is low and linked to the journal's impact factor and the endorsement of the guidelines. Enhancing knowledge of CPG reporting guidelines and implementing them rigorously are critical for improved adherence.</p>","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"412-422"},"PeriodicalIF":2.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13232573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Water Fluoridation Debates on Meta Platforms Using Advanced Machine Learning Approaches.","authors":"N Torwane, R Lalloo, D Ha, L Do","doi":"10.1177/23800844251369336","DOIUrl":"10.1177/23800844251369336","url":null,"abstract":"<p><p>Social media platforms, such as Facebook and Instagram, play a pivotal role in shaping public opinion on health interventions, including community water fluoridation (CWF). Despite its recognition as a safe and effective public health measure, CWF remains a polarizing topic, with misinformation on these platforms contributing to public mistrust. This study collected 109,117 Facebook and Instagram posts from 2014 to 2023 to examine public sentiment surrounding CWF. The analysis revealed a mix of opinions, with 42.1% positive, 39.1% negative, and 18.8% neutral sentiments. Trends highlighted a surge in negative sentiment during 2017-2019, likely influenced by misinformation and significant public events, while positive sentiment has gradually regained ground in recent years. Key themes included health benefits, safety concerns, and government trust, with positive discussions emphasizing CWF's role in public health and negative discussions focusing on risks and chemical exposure. The study employed advanced sentiment analysis models to highlight the importance of monitoring public discourse and addressing misinformation, thereby promoting trust and support for evidence-based health policies, such as CWF. These findings offer digital data-driven insights for public health communication strategies, enhancing community understanding and acceptance of vital health interventions.Knowledge Transfer Statement:The findings of this study can inform public health agencies and policymakers about public concerns and support for water fluoridation. By identifying sentiment trends and misinformation on social media, communication strategies can be tailored to improve public understanding and acceptance of fluoridation as a preventive health measure.</p>","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"454-464"},"PeriodicalIF":2.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13232570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Key Mediators Reducing Socioeconomic Inequality in Early Childhood Caries.","authors":"A T M Dao, L G Do, N Stormon, H V Nguyen, D H Ha","doi":"10.1177/23800844251365536","DOIUrl":"10.1177/23800844251365536","url":null,"abstract":"<p><strong>Objectives: </strong>Socioeconomic status (SES) has a significant effect on the burden of early childhood caries (ECC), yet addressing SES disparities remains challenging. This study aimed to identify and quantify the most impactful mediator linking SES effect to the occurrence of ECC using advanced causal mediation analysis, to inform targeted interventions that reduce SES-related disparities in ECC.</p><p><strong>Methods: </strong>Data were drawn from the Study of Mothers' and Infants' Life Events, a cohort of 2,182 mother-child dyads recruited from Adelaide's 3 largest public hospitals (2013-2014). Baseline questionnaires captured family SES, while ECC clinical indicators were assessed at age 5 y. Three mediation pathways linking SES and ECC were examined including dietary intake represented by free sugar intake (FSI); oral hygiene practices, including toothbrushing habits and plaque presence; and dental visiting patterns. Mediation effects were quantified as natural indirect effects (NIE) using causal mediation analysis based on the counterfactual framework, with validation via 5-fold cross-validation to ensure robustness.</p><p><strong>Results: </strong>FSI was the only pathway with a significant mediation effect. Each 1-standard-deviation increase or decrease in SES was associated with a corresponding 6% reduction or increase in ECC risk at age 5 y through the mediating effect of FSI at age 2 y. The NIE of FSI accounted for 52% of SES's total effect on ECC. In contrast, oral hygiene and dental visiting patterns showed no significant mediation effects.</p><p><strong>Conclusions: </strong>Reducing early childhood FSI could mitigate half of SES-related disparities in ECC. Targeted interventions focusing on FSI reduction hold promise for lowering ECC risk, with future research needed to evaluate their effectiveness.Knowledge Transfer Statement:Clinicians and policymakers should prioritize nutrition education and sugar reduction initiatives as key components of early prevention in pediatric dentistry, especially for low-SES populations. Incorporating FSI screening into routine visits enables medical and dental practitioners to educate caregivers on the impact of free sugars on dental health.</p>","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"444-453"},"PeriodicalIF":2.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13232583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of TiF₄ Varnish on the Oral Biofilm Microbiome in High-Caries-Risk Patients.","authors":"S M Moraes, T T Araújo, G F Abuna, A Dionízio, T S Carvalho, F N Reis, V Pardi, R M Murata, M A R Buzalaf","doi":"10.1177/23800844251348180","DOIUrl":"10.1177/23800844251348180","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Dental caries is a prevalent global disease, influenced by biofilm formation, dietary sugars, and host factors. Fixed orthodontic appliances increase the risk of noncavitated lesions, highlighting the need for effective prevention. Fluoride varnishes reduce demineralization and promote remineralization; however, their impact on the oral biofilm microbiome in high-caries-risk patients remains underexplored.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To profile microbial biofilms involved in caries lesions after treatment with sodium fluoride (NaF) and titanium tetrafluoride (TiF&lt;sub&gt;4&lt;/sub&gt;) varnishes using 16S rRNA sequencing of the oral biofilm microbiome.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A randomized crossover study was conducted with 13 participants (12-18 y) with fixed orthodontic appliances and at least 1 active noncavitated lesion. Participants underwent 4 stages: G1 (nontreatment), G2 (professional prophylaxis; PP), G3 (PP + NaF varnish), and G4 (PP + TiF&lt;sub&gt;4&lt;/sub&gt; varnish). Clinical analyses (Nyvad and plaque indices) and supragingival biofilm sampling were performed. Bacterial DNA was extracted and amplified for 16S rRNA sequencing. Repeated-measures analysis of variance, Friedman/Wilcoxon with Bonferroni correction, Pearson chi-squared, and permutational multivariate analysis of variance tests were performed ( P &lt; 0.05).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Shannon diversity (median, 25%-75%) values were as follows: G1 (6.25, 6.21-6.27), G2 (5.81, 5.77-5.83), G3 (5.63, 5.64-5.71), and G4 (5.76, 5.72-5.78). G2, G3, and G4 differed significantly from G1, with no difference among them ( P &lt; 0.05). The most abundant genera were Veillonella (G1: 7.6%, G2: 10.6%, G3: 9.4%, G4: 5.7%), Corynebacterium (G1: 8.2%, G2: 7.3%, G3: 6.8%, G4: 10.4%), and Neisseria (G1: 4.0%, G2: 9.2%, G3: 9.6%, G4: 9.6%). Significant reductions were observed in the Prevotella/Haemophilus, &lt;i&gt;Prevotella/Neisseria&lt;/i&gt;, and &lt;i&gt;Prevotella/Rothia&lt;/i&gt; log-ratios compared with G1 ( &lt;i&gt;P&lt;/i&gt; = 0.001). G2 reduced &lt;i&gt;Prevotella/Haemophilus&lt;/i&gt;. G3 reduced &lt;i&gt;Prevotella/Haemophilus&lt;/i&gt; and &lt;i&gt;Prevotella/Neisseria&lt;/i&gt;. G4 reduced &lt;i&gt;Prevotella&lt;/i&gt; relative to all 3 genera, indicating broader microbiome modulation.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;PP, whether or not combined with fluoride varnishes, modified the biofilm microbiota. PP + TiF&lt;sub&gt;4&lt;/sub&gt; varnish affected a greater number of bacterial log-ratios associated with commensal-dysbiotic balance, although no significant differences were found between treatment groups.Knowledge Transfer Statement:The findings from this study can guide clinicians in selecting the most effective fluoride varnish for high-caries-risk patients. By understanding how sodium fluoride (NaF) and titanium tetrafluoride (TiF&lt;sub&gt;4&lt;/sub&gt;) varnishes modulate the oral microbiome, clinicians can develop more targeted and effective prevention strategies. This knowledge has the potential to enhance patient outcomes by optimizing caries","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"433-443"},"PeriodicalIF":2.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapamycin's Role in Periodontal Health and Therapeutics: A Scoping Review.","authors":"V M Joshi, S B Gururaj, V Thumbigere-Math, M S Kugaji, E Kandaswamy","doi":"10.1177/23800844251366967","DOIUrl":"10.1177/23800844251366967","url":null,"abstract":"<p><strong>Introduction: </strong>Periodontitis is a chronic inflammatory disease that leads to progressive destruction of periodontal tissues and eventual tooth loss, significantly affecting the patient's quality of life. Dysregulated mechanistic target of rapamycin (mTOR) signaling contributes to periodontitis pathogenesis by influencing inflammation, autophagy, senescence, and bone metabolism. Rapamycin, a well-established mTOR inhibitor with geroprotective properties, has emerged as a promising therapeutic candidate in mitigating periodontal inflammation and preserving alveolar bone.</p><p><strong>Objective: </strong>This scoping review systematically synthesizes preclinical and clinical evidence on rapamycin's effects on periodontal structures and disease etiopathogenesis, evaluating its potential as a therapeutic intervention for periodontitis.</p><p><strong>Methods: </strong>A systematic literature search was conducted in PubMed to identify studies evaluating rapamycin's effect on periodontal health. Eligible studies were characterized into in vitro, animal, and clinical studies in terms of study design and research focus.</p><p><strong>Results: </strong>From 122 screened studies, 53 met inclusion criteria (18 in vitro, 21 in vivo, and 9 clinical). In vitro studies demonstrated that rapamycin enhances osteogenic differentiation, upregulates autophagy, suppresses inflammatory cytokines, and delays cellular senescence. Animal studies confirmed rapamycin's role in alveolar bone preservation, inhibition of biofilm formation, immune modulation, and periodontal inflammation attenuation. Clinical studies primarily focused on rapamycin's effects on gingival overgrowth in transplant recipients, with limited data on periodontitis outcomes. However, survey data from off-label rapamycin users reported improved periodontal health and reduced caries.</p><p><strong>Conclusion: </strong>Rapamycin exerts a multifaceted role in periodontal health by regulating autophagy, osteogenesis, inflammation, microbial composition, and cellular senescence. Given the U.S. Food and Drug Administration's approval of rapamycin for other conditions, well-designed clinical trials are needed to establish its efficacy, optimize dosing strategies, and ensure long-term safety for periodontal therapy.Knowledge Transfer Statement:The findings highlighted in this scoping review can help researchers understand the potentially mechanistic pathways of rapamycin on periodontal tissues and guide future research on the therapeutic potential of rapamycin for the treatment of periodontitis.</p>","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"357-367"},"PeriodicalIF":2.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recommendations for Integrating Caries Risk Assessment into Primary Care for Indigenous Children.","authors":"O O Olatosi, R J Schroth, D DeMaré, B-A Mittermuller, M Manigque, J Edwards, M Amin, A Nicolae, J Lavoie, J Sanguins, P Chelikani, P Wong, J Lamoureux, M Bertone, K Yerex, R Campbell","doi":"10.1177/23800844251372545","DOIUrl":"10.1177/23800844251372545","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to identify strategies for implementing and integrating the Canadian Caries Risk Assessment (CRA) tool for preschoolers into the primary care of First Nations and Métis children in Manitoba, Canada, based on the perspectives of nondental primary care providers (NDPCPs).</p><p><strong>Methods: </strong>An exploratory qualitative design was employed to gather insights from NDPCPs who provide care to Indigenous children aged <6 y. Fifty participants were purposefully recruited from 10 urban, rural, and remote communities across Manitoba. Data were collected through 8 focus groups and 12 in-depth key informant interviews conducted between April 2023 and September 2024. Interviews were transcribed verbatim and analyzed thematically via an inductive approach informed by a social constructivist framework.</p><p><strong>Results: </strong>Four interrelated themes were identified by participants as central to CRA implementation and integration. Strengthening primary care systems involved training in fluoride varnish application, management endorsement, electronic medical record integration, standardized documentation, and incentives such as fee-for-service models. Building trust and culturally safe connections with Indigenous communities included establishing respectful relationships, embedding CRA into trusted programs, and addressing access barriers such as transportation and oral health supplies. Educating and engaging families focused on developing accessible educational materials and using trusted communication channels such as Facebook and local radio to improve oral health literacy. Advocating for policy changes involved calls for billing codes, sugar reduction policies, and CRA integration into existing well-child programs.</p><p><strong>Conclusion: </strong>NDPCPs in Manitoba are supportive of integrating the CRA tool into Indigenous pediatric primary care. Their recommendations offer a practical road map for CRA implementation, emphasizing systemic support, culturally responsive care, education, and policy alignment. These findings contribute to broader efforts to reduce oral health disparities and improve early childhood caries prevention in underserved populations.Knowledge Transfer Statement:Nondental primary care providers recommend integrating Caries Risk Assessment tools into Indigenous children's care through enhanced training, culturally safe engagement, and supportive policy development to address persistent oral health inequities.</p>","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"388-400"},"PeriodicalIF":2.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13232579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Health and the SDGs: Unlocking Missed Potential for Global Health Gains.","authors":"M R Mathur, S Listl, S S Syed, D Nagrath, V K Mishra, H Benzian","doi":"10.1177/23800844261455290","DOIUrl":"https://doi.org/10.1177/23800844261455290","url":null,"abstract":"<p><strong>Introduction: </strong>Oral health is a crucial yet neglected aspect of the global health and development agenda. Although oral diseases affect almost half of the world's population, they receive little attention and public investment by policymakers, undermining progress toward the Sustainable Development Goals (SDGs).</p><p><strong>Objective: </strong>The study aimed to 1) analyse the SDG framework through an oral health lens, identifying links across goals and targets, and 2) quantify the reduction in oral disease burden required by 2030 under a counterfactual status quo projection and 2 policy benchmark scenarios: one-third reduction of noncommunicable disease prevalence aligned with SDG target and 10% reduction based on the World Health Organization Global Oral Health Strategy & Action Plan (GOHAP) target.</p><p><strong>Methods: </strong>A systematic content analysis was conducted on the UN resolution \"Transforming Our World: The 2030 Agenda for Sustainable Development.\" Linkages were categorised across 4 dimensions: disease burden, determinants, system integration, and policy alignment. The Global Burden of Disease data were used to model a counterfactual status quo projection using the compound annual growth rate (CAGR) (2015-2019), disaggregated by World Bank income groups. \"Improvement ambition,\" representing potential preventable disease burden, was calculated as the difference between the status quo projection and each target.</p><p><strong>Results: </strong>Oral health was directly or indirectly linked to all 17 SDGs and 37 of 169 SDG targets, particularly SDGs 3, 4, 6, and 10. Achieving the SDG-aligned target could avert 981 and 649 million cases of caries of permanent teeth and periodontal disease, respectively, by 2030. Even with the GOHAP target of a 10% reduction, 373 and 272 million cases could be averted, respectively.</p><p><strong>Conclusion: </strong>Oral health is linked to the SDGs through shared risk factors and determinants with implications for equity and global development. The \"improvement ambition\" metric provides a practical tool for policymakers to benchmark progress and guide investments during this decisive decade.Knowledge Transfer Statement:Integrating oral health into SDG-aligned policy could avert up to 981 million cases of permanent caries and 649 million cases of periodontal disease by 2030. Even achieving the WHO Global Oral Health Action Plan target would prevent hundreds of millions of cases globally. Our \"improvement ambition\" metric helps policymakers and researchers benchmark progress toward Universal Health Coverage, noncommunicable disease prevention, and health equity, highlighting that excluding oral health results in losses in health, productivity, and social progress.</p>","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"23800844261455290"},"PeriodicalIF":2.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148368662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}