JDR Clinical & Translational Research最新文献

{"title":"Prenatal Dental Visits, Perceived Benefits of Oral Health, and Preterm Birth Outcome, 2009-2021.","authors":"H Lee, N Hong, T Janevic","doi":"10.1177/23800844251318698","DOIUrl":"https://doi.org/10.1177/23800844251318698","url":null,"abstract":"<p><strong>Background: </strong>Previous studies have demonstrated a significant association between maternal oral health and pregnancy complications, including preterm birth (<37 wk). However, research on the impact of dental care utilization during pregnancy on these outcomes has produced both positive and negative results.</p><p><strong>Objective: </strong>The current study investigated the association between preterm birth and dental care utilization, focusing on dental visits for cleaning during pregnancy as well as the perceived benefits of oral health during pregnancy.</p><p><strong>Methods: </strong>This secondary data analysis cross-sectional study used data from the Pregnancy Risk Assessment Monitoring System in the United States from 2009 to 2021. Descriptive and multivariate logistic regression analyses were performed to examine the association between dental variables and preterm birth.</p><p><strong>Results: </strong>The study included 399,847 women with a recent single live birth, representing 21,218,114 women across 48 states and New York City. After adjusting for factors such as race and ethnicity, age, marital status, medical insurance type, education level, adequacy of prenatal care, and other medical variables associated with preterm birth, women who had dental visits for cleaning during pregnancy had a lower odds of preterm birth (adjusted odds ratio [aOR] = 0.90, 95% confidence interval [CI] [0.86, 0.93], <i>P</i> < 0.001) compared with those who did not. A significant association between prenatal dental cleaning and reduced preterm birth was observed only among women who perceived the benefits of oral health during pregnancy (aOR = 0.93, 95% CI [0.88, 0.97], <i>P</i> = 0.002) and among non-Hispanic White women (aOR = 0.88, 95% CI [0.83, 0.93], <i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>This study revealed an inverse relationship between dental cleaning visits during pregnancy and preterm birth outcomes, notably among women who recognized the benefits of oral health and among non-Hispanic White women. The results emphasize the significance of dental visits and the perception of oral health benefits during pregnancy.</p><p><strong>Knowledge transfer statement: </strong>The study demonstrated an inverse association between dental visits for cleaning during pregnancy and preterm birth outcomes, with this relationship being significant among women who perceived the benefits of oral health during pregnancy and among non-Hispanic White women. These findings suggest that both the dental visits and the perception of oral health benefits may be important factors linked to preterm birth outcomes, with potential racial and ethnic variations. Policy makers and clinicians could integrate oral health care and prenatal oral health education into prenatal care as essential components of primary health care to improve both oral and overall health outcomes for women.</p>","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"23800844251318698"},"PeriodicalIF":2.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Factors and Dental Caries among Adolescents: Eight-Year Follow-up Study.","authors":"M Methuen, V F Kukkonen, V Anttonen, S Mikkonen, J Väistö, S Soininen, M Närhi, T A Lakka, A L Suominen, A-M Eloranta","doi":"10.1177/23800844251314856","DOIUrl":"https://doi.org/10.1177/23800844251314856","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to conduct a longitudinal investigation of the associations between changes in dietary factors and changes in caries experience among Finnish children and adolescents participating in the Physical Activity and Nutrition in Children (PANIC) study.</p><p><strong>Methods: </strong>Among 487 children included at baseline at the age of 6 to 8 y, 406 were reexamined at 2-y follow-up and 202 at 8-y follow-up. Food consumption, nutrient intake, and eating frequency were assessed using 4-d food records; diet quality was assessed using the Baltic Sea Diet Score; and eating behavior was evaluated using the Children's and Adult's Eating Behaviour Questionnaires. At baseline and 2-y follow-up, caries findings were recorded using the World Health Organization guidelines and at 8-y follow-up using the International Caries Detection and Assessment System criteria. Generalized linear mixed-effects regression analyses were used.</p><p><strong>Results: </strong>Over 8 y from childhood to adolescence, improved diet quality (β = -0.017, P = 0.046) and increased consumption of butter and butter-oil mixtures (β = -0.009, P = 0.044) were associated with decreased caries experience. Increased number of snacks (β = 0.072, P = 0.032), increased consumption of sour milk products (β = 0.001, P = 0.039) and salty snacks (β = 0.006, P = 0.010), and increased calcium intake (β = 2.41 × 10^-4, P = 0.022) were associated with increased caries experience. However, the latter association was explained by the consumption of sour milk products (β = 1.88 × 10^-4, P = 0.090). Increased enjoyment of food was associated with decreased caries experience (β = -0.121, P = 0.046), and increased slowness in eating (β = 0.113, P = 0.051) and food fussiness (β = 0.140, P = 0.009) were associated with increased caries experience.</p><p><strong>Conclusions: </strong>A healthy diet is vital for oral health among children and adolescents. Dietary behaviors developing from childhood to adolescence seem to be associated with caries experience in adolescence. Dietary counseling aimed at improving dental health from childhood to adolescence should include avoiding frequent snacking, strengthening healthy eating behavior, and composing good overall diet quality.</p><p><strong>Knowledge transfer statement: </strong>Results of this longitudinal study showed how crucial a healthy diet is for oral health among growing children. Eating behaviors and enjoyment of food play also a role in maintaining good oral health. Research results can be used when planning dietary recommendations and health education for children and adolescents.</p>","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"23800844251314856"},"PeriodicalIF":2.2,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality Improvement in General Dental Practice: Situational Analysis for the United Kingdom and Germany.","authors":"C Lin, V Fehrer, L O'Malley, W Thompson, S Listl, M Lorenz, M Byrne","doi":"10.1177/23800844241306734","DOIUrl":"https://doi.org/10.1177/23800844241306734","url":null,"abstract":"<p><strong>Introduction: </strong>Quality improvement (QI) is important in ensuring standards in oral health care. Despite the growing literature on quality indicators, audit, and feedback, the perceptions and expectations of oral health professionals toward QI remain unclear. Understanding these perspectives, barriers, and facilitators is important to effectively encourage and maintain QI activities in dental practices. This is the first of 6 publications in a series titled \"Situational Analysis of QI in Oral Health Care in Europe.\"</p><p><strong>Aim: </strong>This study aimed to investigate how QI was conducted and perceived in dental practices in the United Kingdom and Germany.</p><p><strong>Methods: </strong>A situational analysis, comprising desk research and semistructured interviews, was conducted. Data collection was conducted from May to October 2023. Purposive and snowball sampling techniques were used to recruit dental practice participants in the United Kingdom and Germany. Interviews and key texts were thematically analyzed to synthesize 3 maps: a situational map, a social world map, and a positional map.</p><p><strong>Results: </strong>Eighteen participants were interviewed, comprising dentists, dental hygienists, dental therapists, dental nurses, and practice managers. The participants described 6 competing positions surrounding QI: QI activities were expressed as being worthwhile or box-ticking exercises to satisfy regulators. Some felt that QI detracted from service delivery and should not be the role of the dentist, whereas others stressed the need for a whole-team approach. Some felt that patients were important to judge quality, whereas others felt quality in dentistry required understanding of technical processes beyond the reach of patients.</p><p><strong>Conclusion: </strong>This study provided insights into how QI activities were carried out in dental practices in the United Kingdom and Germany and how it is was perceived by those working in this environment. This study offers key observations into the situations, social worlds and arenas, and positions that influence QI in dental practices.</p><p><strong>Knowledge transfer statement: </strong>The findings from this study highlight several contextual barriers and facilitators to quality improvement in general dental practice. Understanding these determinants of quality improvement is relevant for oral health teams and dental practice managers who aim to develop and implement quality improvement strategies in dental practice.</p>","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"23800844241306734"},"PeriodicalIF":2.2,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Becoming Unemployed on Affordability of Oral Health Care among Australian Adults.","authors":"G Kaur, G Tsakos, T Yap, A Karahalios, Z Chen, A Singh","doi":"10.1177/23800844241311843","DOIUrl":"https://doi.org/10.1177/23800844241311843","url":null,"abstract":"<p><strong>Introduction: </strong>Oral health care impacts of unemployment are not well understood. This is particularly important as many people, even in high-income countries, lack publicly funded oral health care, creating a financial burden for working-age individuals. This study aims to investigate the short-term effect of becoming unemployed on affordability of oral health care among working-age Australian adults.</p><p><strong>Methods: </strong>Longitudinal data from the Household, Income and Labour Dynamics in Australia Survey facilitated analysis of those employed in 2016 and examined the effect of becoming unemployed in 2017 on affordability of oral health care in 2018, adjusted for confounding with inverse probability weighting.</p><p><strong>Results: </strong>Individuals who became unemployed were 2.95 (95% CI, 1.88 to 4.63) times more likely to not receive dental treatment when needed due to a lack of affordability as compared with individuals who remained employed (<u><i>N</i></u> = 6,529). On an absolute scale, the aforementioned difference in probability was 9% (95% CI, 3% to 15%).</p><p><strong>Discussion: </strong>Becoming unemployed had a considerable and immediate negative impact on the affordability of oral health care among working-age Australian adults. Adequate welfare support services are needed to address the immediate financial hardship and consequences that may result due to unemployment.</p><p><strong>Knowledge transfer statement: </strong>Using large population-based cohort data, we established that becoming unemployed hampers the ability to afford oral health care. Our study showed that this impact occurs within a year of unemployment, highlighting how quickly unemployment can create ripple effects for oral health care utilization, cascading into a potential lack of timely treatment or preventive therapies. Our findings highlight the need for adequate welfare support policies to address the immediate financial hardship and consequences that may result due to unemployment.</p>","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"23800844241311843"},"PeriodicalIF":2.2,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical Practitioners' Views on Barriers in Collaboration with Dentists in Long-Term Care Settings.","authors":"S Tada, S M Y Koh, G K Y Lee, M L Wong","doi":"10.1177/23800844241305015","DOIUrl":"10.1177/23800844241305015","url":null,"abstract":"<p><strong>Introduction: </strong>In long-term care settings (LTCs), oral health care often remains fragmented from other geriatric care services. Medical practitioners (MPs) typically take the lead in addressing medical aspects of geriatric care plans, making it essential for them to understand the importance of oral health and to collaborate with dental professionals. However, little is known about MPs' perceptions toward oral health management in LTCs. This qualitative study aimed to gain an in-depth understanding of MPs' views on oral health management in LTCs and explore challenges in collaborating with dental professionals in Singapore.</p><p><strong>Methods: </strong>Participants were recruited using a purposive sampling strategy, initially through targeted outreach to those with experience in LTCs, followed by snowball sampling to identify additional participants until data saturation was achieved. One-to-one interviews with participants were conducted via teleconferencing using a semi-structured interview guide. The transcripts were analyzed using a hybrid (inductive and deductive) thematic analysis supported by NVivo data management software.</p><p><strong>Results: </strong>Participants (n = 13) felt that oral health care was currently not well-integrated into the existing LTC system. They frequently encountered oral health issues but arranged for dental appointments only when their patients complained of acute symptoms. Key barriers identified were (1) a cultural misconception within the eldercare community that poor oral health was an inevitable part of aging, (2) systemic barriers related to the inadequate geriatric oral health care services and infrastructure, and (3) knowledge gaps in geriatric oral health management among MPs. These factors collectively hindered effective collaboration with dental professionals in LTCs.</p><p><strong>Conclusion: </strong>Participants emphasized the lack of oral health care integration in LTCs, identifying cultural, systemic, and internal barriers. Strengthening collaboration with dental professionals in LTCs, implementing oral health education for the eldercare community, and introducing domiciliary services could address these challenges and support more effective geriatric care, with insights for similar systems globally.</p><p><strong>Knowledge transfer statement: </strong>This qualitative study highlighted a critical gap in oral health care integration within eldercare described by the MPs in this study in Singapore's long-term care settings. Although findings are context specific, they may offer insights for aging nations facing similar challenges. Overcoming misconceptions about aging and oral health, improving systems, and educating MPs are key to fostering interdisciplinary collaboration and enhancing eldercare. Addressing these barriers could improve the overall well-being of care-dependent older adults.</p>","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"23800844241305015"},"PeriodicalIF":2.2,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Microbiome and Dental Caries in Kenyan Children and Adolescents Living with HIV.","authors":"Y Wang, O Matangkasombut, A M Kemoli, G John-Stewart, S Benki-Nugent, J Slyker, G M Aldrovandi, A L Seminario","doi":"10.1177/23800844241311862","DOIUrl":"10.1177/23800844241311862","url":null,"abstract":"<p><strong>Objective: </strong>This cross-sectional study evaluates the association between the oral microbiome and the presence of untreated dental caries among Kenyan children and adolescents living with HIV (CALHIV).</p><p><strong>Methods: </strong>We collected 83 oral swab samples from CALHIV receiving medical care at Kenyatta National Hospital. We used the 16S rRNA sequencing technique on oral swab samples to profile bacterial composition. Only CALHIV with results of oral microbiome and dental examinations simultaneously were included in the further analysis. We compared the alpha and beta diversity of the oral microbiome between individuals with and without dental caries. Log-ratio LASSO regression with 2-stage estimation, 10-fold cross-validation, and adjustment for the false discovery rate was applied to select the best features that can predict caries status at the phylum level.</p><p><strong>Results: </strong>Of the 70 participants with both oral health data and oral microbiome data available, 66% had dental caries. The group with dental caries had higher Chao 1 alpha diversity (P = 0.046) but not beta diversity. Log-ratio LASSO regression had a higher ratio of paired features proteobacteria/SR1 (P = 0.0067), Euryarchaeota/SR1 (P = 0.0074), Acidobacteria/SR1 (P = 0.0079), and Fusobacteria/SR1 (P = 0.0125) at the phylum level and was significantly associated with a lower prevalence of untreated dental caries. A higher abundance of SR1 together with certain bacteria was associated with a higher prevalence of untreated dental caries.</p><p><strong>Conclusions: </strong>This is the first study to analyze the oral microbiome of CALHIV and untreated dental caries in a cohort that had received medical care since their first years of life. While this study provides information about the paired feature selection for dental caries in CALHIV on ART using cross-validation, SR1 may interact with other bacteria to increase the prevalence of untreated dental caries. Longitudinal microbiome data and samples from multiple sites in the oral cavity will be essential for understanding and confirming these findings.</p><p><strong>Knowledge transfer statement: </strong>The results of this study can help clinicians understand how SR1 interacts with other bacteria that may increase the prevalence of untreated dental caries in children and adolescents living with HIV and on long-term antiretroviral therapy. Furthermore, these findings may provide valuable insights for future research, informing longitudinal microbiome data and sampling from various sites in the oral cavity.</p>","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"23800844241311862"},"PeriodicalIF":2.2,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to Socioeconomic Position and Oral Health in Chinese Older Adults: A Life Course Approach.","authors":"","doi":"10.1177/23800844251320407","DOIUrl":"https://doi.org/10.1177/23800844251320407","url":null,"abstract":"","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"23800844251320407"},"PeriodicalIF":2.2,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Chronic Temporomandibular Disorders on Fatigue and Daily Life: A Qualitative Phenomenological Study.","authors":"W Safour, R Hovey","doi":"10.1177/23800844241302064","DOIUrl":"https://doi.org/10.1177/23800844241302064","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic temporomandibular disorders (TMDs) affect a notable portion of the population, with a prevalence of 5% to 12%. These conditions often lead individuals to adopt a soft-food diet to manage pain, but such dietary adjustments can inadvertently cause nutritional deficiencies. This issue may be compounded by medications used to manage TMD symptoms, which can contribute to fatigue and reduced daily functioning. In addition, TMD encompasses not only pain but also functional disorders, such as joint locking, which can further affect the individual's quality of life.</p><p><strong>Aim: </strong>This study aimed to delve into the lived experiences of individuals with chronic TMDs, focusing specifically on how their condition affected their daily activities including dietary habits and interactions within social settings.</p><p><strong>Materials and methods: </strong>This study used interpretative phenomenological analysis (IPA) with semi-structured interviews with participants referred from specialists in Montreal, Canada, who were diagnosed with TMDs for at least 6 mo. The interviews were transcribed verbatim and analyzed to uncover the nuanced challenges faced by individuals living with TMDs.</p><p><strong>Results: </strong>Six participants were interviewed. The thematic analysis identified 4 main themes: (1) limited functioning and energy levels highlighting fatigue and frustration by TMDs; (2) communication challenges due to pain, affecting professional roles and social interactions; (3) impact on social and professional life necessitating adjustments and accommodations; and (4) seeking medical assistance such as medications and physiotherapy, reflecting proactive approaches to managing TMDs' symptoms.</p><p><strong>Discussion: </strong>The findings demonstrated the wide effects and complex needs of individuals enduring chronic TMD. These effects attributed to TMD medications causing fatigue and impairing daily activity levels suggest a need for comprehensive care approaches that address both physical and psychological dimensions.</p><p><strong>Conclusion: </strong>The multifaceted effects of chronic TMDs on individuals' lives highlighted the necessity for integrated health care approaches that address diverse aspects of well-being. By incorporating patient perspectives and experiences into clinical practice, health care providers can enhance treatment outcomes and quality of life for TMDs' patients.</p><p><strong>Knowledge transfer statement: </strong>This study highlighted the daily challenges faced by individuals with temporomandibular disorders (TMDs), emphasizing the importance of tailored interventions to improve their quality of life. These insights can inform health care providers in developing holistic approaches to address the multifaceted needs of TMD patients, ultimately leading to improved health outcomes.</p>","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"23800844241302064"},"PeriodicalIF":2.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Intraoral Fluoride Retention in Older Adults: A Randomized Crossover Study.","authors":"J Baez-Polan, T E Danciu, D Sweier, C González-Cabezas, M Fontana, L M A Tenuta","doi":"10.1177/23800844241252816","DOIUrl":"10.1177/23800844241252816","url":null,"abstract":"<p><strong>Introduction: </strong>Previous studies have shown that a calcium prerinse can increase intraoral fluoride retention from a fluoride rinse. To explore the potential of this approach to control root caries, we assessed intraoral fluoride bioavailability after a calcium prerinse in older adults with normal to low salivary flow rates.</p><p><strong>Methods: </strong>In a 2-period crossover trial (NCT04239872), 20 participants (65-80 y old), with low or normal salivary flow rate, rinsed for 1 min with a 0.05% NaF mouth rinse (226 ppm F, F only) or with this rinse immediately after a 1-min rinse with 150 mM calcium lactate (Ca→F). Dental biofilm and saliva samples were collected before and up to 2 h after the rinse(s). Fluoride concentrations in saliva (whole and clarified) and dental biofilm (fluid and solid phases) were blindly determined. Data were statistically analyzed by a mixed-effects model for the effect of treatment, time, and their interaction (<i>α</i> = 5%).</p><p><strong>Results: </strong>The Ca→F group resulted in significantly higher fluoride concentrations in all variables analyzed, for almost all of the collection time points. The effect was greater in the biofilm solids and whole saliva (compatible with the formation of calcium fluoride deposits) and still significant (<i>P</i> < 0.001) after 2 h in the biofilm fluid and clarified saliva, suggesting that fluoride stored in insoluble particles was released, increasing free fluoride.</p><p><strong>Conclusion: </strong>The use of a calcium prerinse before a fluoride rinse was able to prolong intraoral fluoride bioavailability in older adults.</p><p><strong>Knowledge transfer statement: </strong>A calcium prerinse increased intraoral fluoride bioavailability in older individuals. This approach could be used to improve root caries control without the need to increase the fluoride concentration in dental products.</p>","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"16-23"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11653333/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141320886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Putative Causal Associations between Diet and Periodontal Disease Susceptibility.","authors":"X X Ying, Y Hou, X Zheng, J X Ma, M L Wu, M Liu, X Y Liu, K L Zhang","doi":"10.1177/23800844241247485","DOIUrl":"10.1177/23800844241247485","url":null,"abstract":"<p><strong>Introduction: </strong>Dietary factors may play an important role in periodontal health. However, current evidence from observational studies remains inconclusive.</p><p><strong>Objective: </strong>This study aimed to investigate the causal relationships between dietary exposures and periodontal disease risks using Mendelian randomization analysis.</p><p><strong>Methods: </strong>Large-scale genome-wide association study summary statistics for 20 dietary factors were obtained from the MRC-IEU consortium. Multivariable and univariable 2-sample Mendelian randomization analyses were performed to assess the causal effects of each dietary exposure on 6 periodontal outcomes, including gingivitis and periodontitis.</p><p><strong>Results: </strong>Genetically predicted higher dried fruit intake was significantly associated with reduced risks of acute gingivitis (odds ratio [OR]: 0.02; 95% confidence interval [CI]: 0.00-0.42; <i>P</i> = 0.01) and bleeding gums (OR: 0.96; 95% CI: 0.93-0.99; <i>P</i> = 0.01). Higher fresh fruit and water intake showed protective effects against chronic gingivitis (OR: 0.18; 95% CI: 0.04-0.91; <i>P</i> = 0.04 and OR: 0.15; 95% CI: 0.04-0.53; <i>P</i> = 0.00) and bleeding gums (OR: 0.95; 95% CI: 0.92-0.981; <i>P</i> = 0.00 and OR: 0.98; 95% CI: 0.96-0.99; <i>P</i> = 0.02). Alcohol intake frequency and processed meat intake were risk factors for bleeding gums (OR: 1.01; 95% CI: 1.00-1.02; <i>P</i> = 0.01 and OR: 1.05; 95% CI: 1.01-1.08; <i>P</i> = 0.00) and painful gums (OR: 1.01; 95% CI: 1.00-1.01; <i>P</i> = 0.00 and OR: 1.02; 95% CI: 1.01-1.03; <i>P</i> = 0.00). Most of the causal relationships between genetic predisposition to the specified dietary factors and periodontal diseases remained statistically significant (P < 0.05) after adjusting for genetic risks associated with dentures, smoking, and type 2 diabetes in multivariable Mendelian randomization models.</p><p><strong>Conclusions: </strong>The findings suggest potential protective effects of higher fruit and water intake against gingivitis and other periodontal problems, while alcohol and processed meat intake may increase the risks of periodontal disease. Our study provides preliminary causal evidence on the effects of diet on periodontal health and could inform prevention strategies targeting dietary habits to improve oral health.</p><p><strong>Knowledge transfer statement: </strong>This study suggests that fruit and water intake may protect against periodontal disease, while alcohol and processed meats increase risk, informing dietary guidelines to improve oral health.</p>","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"44-53"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11653277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140858992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}