JDR Clinical & Translational Research最新文献

{"title":"Nocturnal Autonomic Nervous System Dynamics and Chronic Painful Temporomandibular Disorders.","authors":"J C Nickel, Y M Gonzalez, Y Wu, D Choi, H Liu, L R Iwasaki","doi":"10.1177/23800844251325226","DOIUrl":"10.1177/23800844251325226","url":null,"abstract":"<p><strong>Objective: </strong>Chronic pain associated with temporomandibular disorders (TMDs) may reflect dynamic autonomic nervous system (ANS) effects. This pilot observational study tested the hypotheses that Characteristic Pain Intensity (CPI) scores correlated with 1) amplitude, 2) duration, and 3) power densities (amplitude/duration) of nocturnal ultradian cycling of the sympathetic and parasympathetic arms of the ANS.</p><p><strong>Materials and methods: </strong>In accordance with institutional review board oversight and Strengthening the Reporting of Observational Studies in Epidemiology guidelines, adult subjects gave informed consent, completed Axis I and II components of Diagnostic Criteria for TMD (DC-TMD), and were trained in research protocols to record nocturnal heart rate data. Subjects were assigned to ± pain groups based on CPI scores (0 = no pain, >0 = pain). Nocturnal ultradian cycling of sympathetic and parasympathetic activities was characterized using heart rate variability measures of the percentage of the absolute value of the low-frequency power component (ms²) and normal-to-normal sinus node depolarizations >50 ms compared to total number (pNN50, %), respectively. Peaks and valleys of ultradian cycling were identified, where cycle amplitudes and durations were quantified, and sympathetic/parasympathetic power densities were calculated. The hypotheses were tested by nonparametric correlations and regression analyses, where significance was defined by <i>P</i> < 0.05.</p><p><strong>Results: </strong>Of 32 individuals screened and enrolled, 18 females and 11 males completed all study protocols. Subjects produced 87 nighttime electrocardiogram recordings with an average duration of 7.7 ± 1.0 h. CPI scores ranged from 0 to 70 and were significantly higher (<i>P</i> = 0.032) in females (30 ± 25) than in males (10 ± 17). Nocturnal ultradian sympathetic cycling in females compared to males showed significantly higher amplitudes (<i>P</i> = 0.011) and lower durations (<i>P</i> = 0.048). CPI scores were correlated with nocturnal cycling amplitude and duration (all |<i>R</i>| ≥ 0.80) and the log of sympathetic/parasympathetic power densities (<i>R</i>² = 0.89).</p><p><strong>Conclusion: </strong>Characteristic Pain Intensity scores were correlated with amplitudes, durations, and power densities of nocturnal ANS ultradian cycling.Knowledge Transfer Statement:Chronic myofascial pain may reflect autonomic nervous system (ANS) activity. Characteristic Pain Intensity scores of subjects were correlated with power densities of ANS ultradian cycling during sleep. Future research is needed to detect sex differences in ANS power densities in subjects with chronically painful temporomandibular disorders.</p>","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"237-244"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13082565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cascade of Care in Pediatric Oral Health: A Cross-sectional Study to Assess Care Utilization.","authors":"D Bahdila, H Alhazmi, A S Alfarsi, L Y Alzahrani, A I Koumu, R H Alshaikh, S O Khalifa, Z S Natto","doi":"10.1177/23800844251347914","DOIUrl":"10.1177/23800844251347914","url":null,"abstract":"<p><strong>Introduction: </strong>The cascade of care (COC) approach assesses key stages in care, including screening, diagnosis, treatment, and control. It has been applied to communicable and noncommunicable diseases but is yet to be used in oral health.</p><p><strong>Objectives: </strong>To adapt the COC framework for pediatric oral health and apply it in a cross-sectional study of schoolchildren in Jeddah, Saudi Arabia, to assess dental needs, diagnosis, treatment, and follow-up.</p><p><strong>Methods: </strong>A 2-stage process was used to first adapt the 4-step COC model for pediatric dental needs and to produce a survey questionnaire. Stratified random sampling was then used to recruit children in grades 4 to 6 in primary schools in Jeddah, Saudi Arabia, from October 2023 to January 2024. Parents completed COC questions, and children completed dental examinations. Descriptive statistics and multilevel logistic regression models were used to assess outcomes, including unmet dental needs in context.</p><p><strong>Results: </strong>A total of 783 schoolchildren from 11 primary schools were included in the cross-sectional study. The largest loss of care occurred at the treatment stage, where 41.3% of those who had visited a dentist and were diagnosed had completed their treatment. Children who had not visited a dentist in >12 mo were less likely to be diagnosed, complete treatment, or receive follow-up care when compared with those who had seen a dentist within 12 mo ( <u>P</u> < 0.05).</p><p><strong>Conclusion: </strong>This study is the first to adapt and apply the COC framework in pediatric oral health. The total unmet dental need was high, particularly for children visiting the dentist for symptomatic reasons (i.e., pain or extraction). This model lays the groundwork for more targeted assessments at national or subnational levels.Knowledge Transfer Statement:This is the first time that the cascade of care (COC) approach has been adapted and applied in a pediatric oral health case study in Jeddah, Saudi Arabia, to understand gaps in children's dental care. It showed how the COC can highlight where systems might be underperforming and where additional data are needed. Introducing the COC framework in pediatric oral health could improve data collection across key stages of care, such as access, diagnosis, treatment, and follow-up.</p>","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"245-256"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors and Barriers to Prenatal Dental Care among Pregnant Women in 2 Regions of China.","authors":"Q Jing, H Yang, Y Chen, X Cao, L Shi, L Ma, K Wan, D Zhang","doi":"10.1177/23800844251338766","DOIUrl":"10.1177/23800844251338766","url":null,"abstract":"<p><strong>Introduction: </strong>Maintaining oral health during pregnancy is essential for women's health, yet awareness of and access to dental care among pregnant women in China remain limited.</p><p><strong>Objectives: </strong>We aim to assess the knowledge, attitudes, and dental care-seeking behaviors of pregnant women in 2 regions of China and identify the key factors predicting prenatal dental care utilization.</p><p><strong>Methods: </strong>Data were collected via an online survey from pregnant women recruited through convenience sampling at 2 hospitals in Beijing municipality and Haikou city, Hainan province. The survey included knowledge, attitudes, and sociopsychological factors that may influence dental care utilization. Principal component analysis and multivariate logistic regression were applied to assess the roles of knowledge and attitudes in prenatal dental care utilization.</p><p><strong>Results: </strong>A total of 248 participants completed the survey. Among them, 39.92% consulted a dentist when experiencing dental issues, while 63.31% consulted any health care professional, including dentists and obstetricians. Participants from Hainan were significantly less likely to consult a dentist as compared with those from Beijing (odds ratio [OR], 0.01; 95% CI, 0.00 to 0.40). Regular dental care before pregnancy (principal component 1) was associated with lower odds of consulting a dentist (OR, 0.58; 95% CI, 0.37 to 0.92) and any health care professional (OR, 0.56; 95% CI, 0.35 to 0.92). Perceived severity of untreated dental issues (principal component 6) increased the odds of consulting a dentist (OR, 1.69; 95% CI, 1.22 to 2.33) and a health care professional (OR, 1.66; 95% CI, 1.21 to 2.30).</p><p><strong>Conclusion: </strong>Geographic location and perceptions regarding dental care during pregnancy significantly influenced dental care-seeking behaviors among pregnant women. Women in less developed regions such as Hainan sought less dental care, while those aware of untreated dental risks were more likely to seek treatment. These findings highlight the importance of targeted interventions to address regional disparities and gaps in knowledge.Knowledge Transfer Statement:This study highlights key factors influencing prenatal dental care utilization among pregnant women in China, emphasizing regional disparities and the impact of knowledge and perceptions on care-seeking behaviors. Women in less developed regions, such as Hainan, were significantly less likely to consult a dentist or other health care professional as compared with women in Beijing. In addition, prior regular dental care was associated with lower odds of seeking treatment during pregnancy, and awareness of the severity of untreated dental issues increased the likelihood of seeking care. These findings underscore the need for targeted interventions to improve oral health education and access to prenatal dental care, particularly in underserved areas.</p>","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"280-292"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nothing to Hide: The Merits of Open Data in Dental Research.","authors":"N S Jakubovics, F Schwendicke, V Muirhead, J Feine","doi":"10.1177/23800844251407686","DOIUrl":"10.1177/23800844251407686","url":null,"abstract":"","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"104-106"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146009623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implicit Racial Bias in Oral Health: A Scoping Review of Students' and Providers' Perceptions.","authors":"P Martin, K Rafia, M Minter-Jordan, E P Tranby, P D Edouard, R Taylor, L J Heaton","doi":"10.1177/23800844251338167","DOIUrl":"10.1177/23800844251338167","url":null,"abstract":"<p><strong>Introduction: </strong>Implicit bias is a form of unconscious bias that can affect judgment, decisions, and behaviors.</p><p><strong>Objectives: </strong>This scoping review examined what scientific literature exists about implicit bias demonstrated by dental/dental hygiene students and providers and, when possible, how these implicit biases are associated with patients' oral health outcomes.</p><p><strong>Methods: </strong>This scoping review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR). This review included English-language PubMed peer-reviewed studies meeting inclusion criteria, published through October 2023, measuring the implicit bias of dental/dental hygiene students or professionals and how such bias can affect patient oral health outcomes.</p><p><strong>Results: </strong>A total of 363 records were found. After removing duplicates (<i>n</i> = 114) and title screening (<i>n</i> = 60), 54 abstracts were screened, 24 reports were assessed, and 10 were included in the final review. Implicit bias was assessed using the Implicit Association Test (IAT), Brief IAT (BIAT), and Color-Blind Racial Attitudes Scale (CoBRAS). BIAT scores revealed a pro-White unconscious racial bias in clinical decision-making among dental professionals, and additional IAT results suggested implicit racial preferences for European Americans over African Americans; non-White participants showed more positive implicit preferences toward African Americans in comparison with White participants. Studies using CoBRAS suggest moderate levels of color-blind racial attitudes among students and professionals, indicating an unawareness of racism and a need to further understand the implications of bias on patient outcomes.</p><p><strong>Conclusion: </strong>Despite small sample sizes and a lack of racial/ethnic diversity that limit their generalizability, the included studies provide evidence for implicit racial bias held by some dental/dental hygiene students and professionals that may affect the oral health outcomes of patients. Training to increase awareness of and reduce implicit bias among those providing oral health care is an important first step to providing a more equitable health care system for all patients.Knowledge Transfer Statement:Despite small sample sizes and a lack of racial/ethnic diversity that limit their generalizability, the included studies provide evidence for implicit racial bias held by some dental/dental hygiene students and professionals that may affect the oral health outcomes of patients. Training to increase awareness of and reduce implicit bias among those providing oral health care is an important first step to providing a more equitable health care system for all patients.</p>","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"149-158"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12967376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers and Facilitators for Accessing Oral Health Care for Ukrainian Newcomers to Nova Scotia.","authors":"H Doucette, Y Tylchak, S Saad, V D'Souza","doi":"10.1177/23800844251352395","DOIUrl":"10.1177/23800844251352395","url":null,"abstract":"<p><strong>Introduction: </strong>The war in Ukraine has resulted in a mass exodus of Ukrainians fleeing their country and seeking resettlement in many countries, including Canada. There is a lack of literature, particularly qualitative, that explores past experiences with oral health care in the country of origin for newcomers and the experience of access and utilization of oral health care once in Canada. The increase in Ukrainian newcomers to Canada requires an exploration of barriers and facilitators to oral health care access to inform policy.</p><p><strong>Objective: </strong>To explore the barriers and facilitators to oral health care experienced by Ukrainian newcomers during resettlement in Nova Scotia, Canada.</p><p><strong>Methods: </strong>This study used a narrative qualitative methodology. Adult Ukrainian newcomers who arrived in Canada after the Russian invasion in 2022 were recruited via social media and through recruitment flyers advertised at the Immigrant Services Association of Nova Scotia. They were interviewed between February 17 and July 1, 2023, in the Ukrainian language. The interviews were audio recorded, transcribed, and analyzed via inductive and deductive line-by-line coding per the thematic analysis method. Codes were grouped to form categories and themes.</p><p><strong>Results: </strong>Participants identified facilitators to oral health care that included friends and family, social networks, and information provided through the workplace. Barriers to access included cost, referral process, location and wait times for specialists, language, and lack of understanding the oral health care and dental insurance systems in Canada.</p><p><strong>Conclusion: </strong>Ukrainian newcomers to Nova Scotia face several barriers to oral health care access. Interventions to address these barriers should be considered to ensure equitable access to oral health care services during the resettlement process.Knowledge Transfer Statement:The results of this study may be used to inform policy to facilitate timely access to oral health care for Ukrainian newcomers. The findings may also guide professionals when providing oral health care services to Ukrainian newcomers. Addressing the barriers and maximizing the facilitators to oral health care services for this population could help to improve access to oral health care services and oral health outcomes.</p>","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"168-180"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12967390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parents' Views on Access to Dental Care and the Interim Canada Dental Benefit.","authors":"A Menon, V Cruz de Jesus, J I Virtanen, R J Schroth","doi":"10.1177/23800844251323169","DOIUrl":"10.1177/23800844251323169","url":null,"abstract":"<p><strong>Introduction: </strong>Canada's national health insurance historically excluded dental care until the introduction of the Interim Canada Dental Benefit (CBD) in October 2022. This represented a paradigm shift toward enhancing dental care accessibility for children younger than 12 y from lower-income families. This study investigated parents' perspectives on access to oral health care and the Interim CDB.</p><p><strong>Methods: </strong>The Strategic Counsel for Health Canada collected data from participants across Canada using an online survey administered in March 2023. Data were administered to parents of children younger than 12 y with a household income less than $90,000. The survey included 45 questions covering demographics, barriers to accessing dental care, and awareness of the Interim CBD. Paired/overlap <i>t</i> test for means and paired/overlap <i>z</i> test for percentages were performed, with statistical significance set at <i>P</i> ≤ 0.05.</p><p><strong>Results: </strong>A total of 2,203 participants completed the survey, with a response rate of 65%. Most participants expressed concerns about the costs (90.9%) and accessibility (80.9%) of dental care, indicated that regular dental visits for children are important (97.2%), and would take their children more frequently to dental appointments if they had extra money (79.9%). Some of the barriers preventing regular dental visits for children included the costs of service and transportation and lack of insurance. Most parents supported the Interim CDB (87%), with the greatest support coming from the provinces of Manitoba and Saskatchewan (90.4%).</p><p><strong>Conclusion: </strong>This research underscores the imperative for ongoing evaluation and policy refinement to ensure the Canadian Dental Care Plan (CDCP) effectively addresses the nuanced needs of Canadian families, fostering a more inclusive and accessible dental care system. Parents' concerns regarding dental care and their support for the Interim CDB signal a clear mandate for improving program outreach and accessibility through the CDCP.Knowledge Transfer Statement:This study showed the significant concerns reported by survey participants about dental care affordability in Canada and the highly positive perception of the Interim Canada Dental Benefit (CDB). This supports the necessity of programs such as the CDB and Canadian Dental Care Plan, which are crucial for the success of a policy intervention. Concern about accessing dental services, despite the availability of insurance, indicates ongoing barriers to dental care, suggesting areas for future policy refinements.</p>","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"257-269"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12967379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benefit-Cost Analysis of Noninvasive Early Childhood Caries Interventions among Latvian Children.","authors":"I Maldupa, S E Uribe, O Sļepcova, E Senakola, A Brinkmane, T M Nguyen, N Innes, R Mariño","doi":"10.1177/23800844251332888","DOIUrl":"10.1177/23800844251332888","url":null,"abstract":"<p><strong>Objectives: </strong>Analyze the benefit-cost analysis of noninvasive early childhood caries (ECC) management in Latvian preschoolers versus placebo, from a health care perspective, over 12 mo.</p><p><strong>Methods: </strong>Randomized, blinded, placebo-controlled trial (September 2020-August 2022) at Riga Stradins University, Latvia. A factorial trial was conducted with 3 interventions (placebo, silver diamine fluoride [SDF], Tiefenfluorid) and 2 recall intervals (none: 1 and 6 mo: 2), all including behavioral modification. The 6 strategies were placebo (P1, P2), SDF (SDF1, SDF2), and Tiefenfluorid (TF1, TF2). Probabilistic sensitivity analysis was calculated from the health care perspective. Costs associated with each ECC management program and associated treatments were identified and measured. Incremental benefit-cost ratios (IBCRs) were calculated to determine the margin by which each program was more beneficial than P1 (comparator). The primary outcome measure used for economic evaluation was health care complications averted, defined as teeth with pulp involvement due to dental caries. The economic costs associated with health care complications averted were quantified in monetary terms as benefits.</p><p><strong>Results: </strong>All alternative strategies were more effective than the comparator in averting health care complications and dental caries lesions. Over 12 mo, SDF2, TF2, and P2 were dominant interventions, yielding an IBCR of -0.98, -0.80, and -0.70, respectively. SDF1 and TF1 had an IBCR of 2.95 and 10.67, respectively, rending these interventions economically beneficial but with lower return on investment.</p><p><strong>Conclusion: </strong>Biannual SDF applications (SDF2) were the most cost-effective for ECC, significantly outperforming Tiefenfluorid^® (TF2) and placebo (P2). TF2 and P2 slightly improved over placebo (P1) due to additional behavioral modification and counseling. Implementing SDF2 in Latvia would likely reduce health care complications and costs.Knowledge Transfer Statement:This study compared 5 noninvasive early childhood caries management strategies with a placebo \"no treatment\" group over a 12-mo period. The primary outcome measure was health care complications averted, quantified in monetary terms. The results showed that the 6-monthly applications of SDF and fluoride varnish demonstrated cost savings compared with the placebo group. The study recommends implementing SDF and fluoride varnish into routine clinical practice to reduce health care complications and associated costs.</p>","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"195-203"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood Lead Exposure and the Risk of Dental Caries in Permanent Teeth: The Cincinnati Lead Study.","authors":"M R Amin, B P Lanphear, R W Hornung, G E Watson, R J Billings, D T Kopycka-Kedzierawski, M Dock, L Brown, K N Dietrich","doi":"10.1177/23800844251339089","DOIUrl":"10.1177/23800844251339089","url":null,"abstract":"<p><strong>Introduction: </strong>Dental caries is a significant public health problem in the United States. The evidence on the association between lead exposure and dental caries is conflicting because the impact of childhood lead exposure on the prevalence of caries in young adults has not been evaluated in prospective cohort studies.</p><p><strong>Objective: </strong>To assess the association of prenatal and postnatal childhood lead exposure with dental caries in young adults living in Cincinnati, Ohio, United States.</p><p><strong>Methods: </strong>We examined 206 predominately African American participants aged 16 to 22 y in the Cincinnati Lead Study, a prospective cohort study measuring prenatal and postnatal blood lead levels from the maternal, neonatal, and postnatal periods (from 3-78 mo of age) for dental caries. Caries experience was quantified as the number of decayed, missing, and filled teeth (DMFT) and surfaces (DMFS) in permanent teeth. The impact of average childhood blood lead levels on stimulated and unstimulated salivary flow rate was also assessed.</p><p><strong>Results: </strong>A significant positive association between average childhood blood lead levels and DMFS and DMFT was observed in young adults. A 2-fold increase in DMFS between 6 and 15 µg/dL, followed by a downturn at the highest blood lead quintile (P < 0.05), was observed. Statistically significant covariates were the number of sealants present, lactobacilli count in saliva, and maternal high school education. When adjusted for mutans streptococci, ever smoking, flossing, and the number of adults and children living in the household, the average childhood blood lead levels were associated with reduced salivary flow rate.</p><p><strong>Conclusions: </strong>Childhood blood lead levels were associated with an increased DMFS/DMFT in young adulthood.Knowledge Transfer Statement:The results of this study support the need for continued reduction in lead exposure-especially in low- and middle-income countries-to further reduce the risk of dental caries in permanent teeth.</p>","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"215-225"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Autologous Concentrated Growth Factor in Regenerative Dentistry: A Systematic Review and Meta-Analysis.","authors":"A A Alshirah, M H Elnaem, Z Al-Ani, F Alzahrani, M Almasri, P A McCarron","doi":"10.1177/23800844251325532","DOIUrl":"10.1177/23800844251325532","url":null,"abstract":"<p><strong>Introduction: </strong>Concentrated growth factor (CGF), a novel autologous platelet concentrate, has gained substantial interest for its potential role in managing oral diseases. The objective of this study is to evaluate the effectiveness of CGF in regenerative dentistry.</p><p><strong>Methods: </strong>A systematic search was performed across MEDLINE, OVID, Scopus, Cochrane Library, Google Scholar, Web of Science, and Elsevier for publications between July 1, 2013, and July 1, 2023. Only randomized clinical trials were included. The quality of the methodology was assessed using the Cochrane Risk of Bias Tool. Data were analyzed using RevMan 5.4 software.</p><p><strong>Results: </strong>In 3 trials treating periodontal intrabony defects, CGF combined with bone grafts showed significant superiority over bone grafts alone (<i>P</i> < .00001), with a mean reduction of 1.41 mm in intrabony defect depth and a mean gain of 0.55 mm in clinical attachment level (<i>P</i> = 0.002). For gingival recession in 5 trials, CGF combined with coronally advanced flap (CAF) was more effective than CAF alone, resulting in a mean increase in keratinized tissue width of 0.41 mm and a mean increase in gingival thickness of 0.26 mm (<i>P</i> < 0.00001). However, CGF combined with CAF was less effective than connective tissue graft (CTG) combined with CAF, showing a mean difference in root coverage of -15.09% and a mean difference in gingival thickness of -0.50 mm (<i>P</i> < 0.0001). In alveolar ridge preservation, sinus elevation, guided bone regeneration, dental implant procedures, and postextraction healing, CGF gave better values in clinical practice.</p><p><strong>Conclusions: </strong>CGF enhances regenerative surgery outcomes for periodontal intrabony defects. Combined with CAF, CGF improves therapeutic efficacy for gingival recession, although less so than CTG with CAF. CGF shows promise in various regenerative dentistry areas. However, the absence of meta-analysis and low-quality assessments in many studies necessitates further high-quality research.Knowledge Transfer Statement:The use of concentrated growth factors (CGFs) in regenerative dentistry, within the limitation of low-quality studies, shows promising benefits in treating periodontitis infrabony defects, gingival recession, guided bone regeneration, dental implant alveolar ridge preservation, sinus elevation, and third molar extraction. Future research should focus on high-quality studies and explore combining CGF with grafting materials to enhance therapeutic outcomes in oral surgery.</p>","PeriodicalId":14783,"journal":{"name":"JDR Clinical & Translational Research","volume":" ","pages":"133-148"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12967397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}