Elenice Andrade Milhomem Ayoub, Maria Helena Vaisbich, Daniel Ribeiro Rocha, Bruno Pellozo Cerqueira, Ana Cristina Carvalho de Matos, Igor Gouveia Pietrobom, Ita Pfeferman Heilberg
{"title":"Nephrocalcinosis: unveiling renal tubulopathies in the genomic era.","authors":"Elenice Andrade Milhomem Ayoub, Maria Helena Vaisbich, Daniel Ribeiro Rocha, Bruno Pellozo Cerqueira, Ana Cristina Carvalho de Matos, Igor Gouveia Pietrobom, Ita Pfeferman Heilberg","doi":"10.1590/2175-8239-JBN-2025-0225en","DOIUrl":"10.1590/2175-8239-JBN-2025-0225en","url":null,"abstract":"<p><strong>Introduction: </strong>The diagnosis of nephrocalcinosis (NC) is challenging due to difficulties in radiologic detection, clinical heterogeneity, and its broad etiological spectrum that includes both genetic and non-genetic causes. This study aimed to uncover, in a pioneering manner, the distinct NC etiologies in a Brazilian cohort according to age of onset.</p><p><strong>Methods: </strong>This retrospective cross-sectional study was based on 96 medical records of outpatients (66 adults and 30 children) with NC, who had followed a comprehensive investigation.</p><p><strong>Results: </strong>Distal renal tubular acidosis was the leading cause of NC in both children (43.3%) and adults (22.7%), followed by other tubulopathies mostly in children (36.7%), and primary hyperparathyroidism in adults (19.7%). Pediatric patients exhibited more electrolyte disorders (47%), failure to thrive (50%), and sensorineural hearing loss (23%) than adults. Conversely, adults presented more associated nephrolithiasis (73%), low back pain (42%), and lower estimated glomerular filtration rate than children (85 versus 106 mL/min/1.73m2). According to phenotype, genetic suspicion had been raised in 96.7% of children and 57.6% of adults. Nevertheless, the availability of genetic tests was low in the whole cohort.</p><p><strong>Conclusion: </strong>This study represents a novel contribution to the national scientific landscape, revealing a limited access to genetic tests for patients with nephrocalcinosis, likely due to cost and availability constraints in the public healthcare system, and showed that a clinically oriented laboratory protocol may provide more precise indications. Notably, a phenotype suggestive of monogenic disease among 57.6% of adults with NC justifies the need for more frequent genetic investigations in this group.</p>","PeriodicalId":14724,"journal":{"name":"Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia","volume":"48 2","pages":"e20250225"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12857816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146085871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Celso Souza de Moraes-Júnior, Natalia Orihuela, Natália Maria da Silva Fernandes, Laura Cortes Sanabria, Luciane Senra de Souza Braga, Pablo Amair, Uriel Winik, Angelica Viviana Manchinelli, Marta Susana Adragna, Eliseo Antonio Guzmán, Cristina Vallve, Roger Ayala Ferrari, Rodrigo José Álvarez, Hernán Jaramillo Mendoza, Viviane Calice-Silva, Erwin Iván Campos, Raul Plata-Cornejo, Regulo Valdes, Ricardo Silvariño, Harold David Alvarez, Rosana Chaud, Alejandro Concepción Orozco, Gustavo Lorenzo Moretta, José Carolino Divino-Filho
{"title":"Cost elements to be considered in estimates for microcosting studies in peritoneal dialysis (PD) therapy in Latin America.","authors":"Celso Souza de Moraes-Júnior, Natalia Orihuela, Natália Maria da Silva Fernandes, Laura Cortes Sanabria, Luciane Senra de Souza Braga, Pablo Amair, Uriel Winik, Angelica Viviana Manchinelli, Marta Susana Adragna, Eliseo Antonio Guzmán, Cristina Vallve, Roger Ayala Ferrari, Rodrigo José Álvarez, Hernán Jaramillo Mendoza, Viviane Calice-Silva, Erwin Iván Campos, Raul Plata-Cornejo, Regulo Valdes, Ricardo Silvariño, Harold David Alvarez, Rosana Chaud, Alejandro Concepción Orozco, Gustavo Lorenzo Moretta, José Carolino Divino-Filho","doi":"10.1590/2175-8239-JBN-2025-0202en","DOIUrl":"10.1590/2175-8239-JBN-2025-0202en","url":null,"abstract":"<p><strong>Introduction: </strong>The main tools for making clinical decisions based on efficient use of resources are economic evaluation studies that allow the assessment of both the costs and benefits of different therapeutics, with appropriate guidelines for preparing reports. This study aimed to develop a checklist of consumable cost elements to be considered in estimates for micro-costing studies in peritoneal dialysis (PD).</p><p><strong>Methods: </strong>Four stages were conducted, followed by data analysis and interpretation. Three stages were carried out to develop the direct cost elements questionnaire: 1st - designing the first version of the checklist; 2nd - evaluating and expanding it using the Delphi method; 3rd - conducting two expert panels; and 4th - applying the questionnaire to professionals from 18 Latin American countries. Inclusion criteria: professionals with at least one year of clinical and/or administrative experience in PD. A discrete probability distribution adjustment was performed. Distribution lots were considered according to the category of cost elements for each country. The maximum likelihood estimation method was applied, and the statistical classification of the adjustments was assessed using the Akaike Information Criterion.</p><p><strong>Results: </strong>A total of 596 questionnaires, comprising seven dimensions and 41 elements, were validated. From the results of each batch, it was possible to segment the elements into three choice options, with the probability of evaluating an element as very important, thus allowing for the classification of the cost elements.</p><p><strong>Conclusion: </strong>The checklist favors more equitable economic dimensioning in comparative studies, making it possible to compare economic values in PD across countries, while considering the appropriate cost elements.</p>","PeriodicalId":14724,"journal":{"name":"Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia","volume":"48 2","pages":"e20250202"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12885495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ana Catarina Oliveira, Maria Inês Vasconcelos Bessa, Roberto Silva
{"title":"A rare overlap: an image of ANCA-associated glomerulonephritis superimposed on membranous nephropathy.","authors":"Ana Catarina Oliveira, Maria Inês Vasconcelos Bessa, Roberto Silva","doi":"10.1590/2175-8239-JBN-2025-0308en","DOIUrl":"10.1590/2175-8239-JBN-2025-0308en","url":null,"abstract":"","PeriodicalId":14724,"journal":{"name":"Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia","volume":"48 2","pages":"e20250308"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147491119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
John Dotis, Charalampos Antachopoulos, Vasiliki Karava, Athina Papadopoulou, Nikoleta Printza
{"title":"Moraxella peritoneal dialysis-related infections: a systematic review.","authors":"John Dotis, Charalampos Antachopoulos, Vasiliki Karava, Athina Papadopoulou, Nikoleta Printza","doi":"10.1590/2175-8239-JBN-2025-0246en","DOIUrl":"10.1590/2175-8239-JBN-2025-0246en","url":null,"abstract":"<p><strong>Introduction: </strong>Moraxella species, although infrequent in peritoneal dialysis (PD)-associated infections, are established pathogens. Moraxella catarrhalis is recognized as a cause of upper and lower respiratory tract infections and is increasingly associated with β-lactamase production. The role of Moraxella species in PD-related infections warrants further investigation.</p><p><strong>Methods: </strong>A comprehensive search of PubMed and Google Scholar was conducted for cases of PD-associated infections caused by Moraxella. Inclusion criteria required a diagnosis of peritonitis or exit-site infection confirmed by culture. Demographic data, clinical presentation, microbiological identification, antimicrobial resistance, therapeutic regimens, and outcomes were analyzed.</p><p><strong>Results: </strong>Fourteen cases of Moraxella-related peritonitis in PD patients were identified between 1987 and 2024 from 13 studies, with no reports of exitsite infections. The mean age was 56 years; diabetic nephropathy was the most common underlying condition (four cases). M. catarrhalis (n = 6) and Moraxella osloensis (n = 5) were the most frequent pathogens. The most commonly reported methods were bacterial growth in culture media, followed by species identification using biochemical profiling or automated systems (n = 10), and advanced confirmatory techniques. Clinical presentation included abdominal pain, fever, and clouding of the dialysis fluid. Most isolates were susceptible to cephalosporins, aminoglycosides, and fluoroquinolones. The majority of patients (86%) retained their catheters after appropriate treatment, usually with intraperitoneal cephalosporins, achieving complete symptom resolution within a few days. Overall prognosis was favorable, with no mortality.</p><p><strong>Conclusion: </strong>Moraxella species, although rare, should be considered in the differential diagnosis of PD-associated infections. Identification using advanced techniques allows effective treatment and favorable outcomes, often without the need for catheter removal.</p>","PeriodicalId":14724,"journal":{"name":"Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia","volume":"48 2","pages":"e20250246"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12987636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147457511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mediating effect of cardiorespiratory fitness on the relationship between inspiratory muscle strength and quality of life in people on hemodialysis.","authors":"Júlia Garcia de Castro Pereira, Inara Caroline Marcelino Martins, Cecília Alves Macedo, Joyce Noelly Vitor Santos, Elisângela Andrade Assis Madeira, Vanessa Gomes Brandão Rodrigues, Maria Cecília Sales Mendes Prates, Frederico Lopes Alves, Emílio Henrique Barroso Maciel, Vanessa Pereira Lima, Henrique Silveira Costa, Vanessa Amaral Mendonça, Pedro Henrique Scheidt Figueiredo","doi":"10.1590/2175-8239-JBN-2025-0175en","DOIUrl":"10.1590/2175-8239-JBN-2025-0175en","url":null,"abstract":"<p><strong>Introduction: </strong>Patients undergoing hemodialysis often exhibit inspiratory muscle weakness, which has been associated with a reduced health-related quality of life (HRQoL). However, the extent to which this relationship is mediated by cardiorespiratory fitness remains unclear.</p><p><strong>Objective: </strong>To evaluate the mediating effect of cardiorespiratory fitness on the association between inspiratory muscle strength and HRQoL in hemodialysis patients.</p><p><strong>Methods: </strong>Cross-sectional study in which hemodialysis patients underwent assessment of inspiratory muscle strength by measuring Maximum Inspiratory Pressure (MIP), cardiorespiratory fitness by the Incremental Shuttle Walk Test (ISWT), and HRQoL by measuring the physical, mental, and general health component summary scores of the Kidney Disease Quality of Life questionnaire (KDQOL-SF). Simple mediation analyses were performed using the PROCESS macro (version 3.5) for SPSS, with HRQoL as the dependent variable, MIP as the independent variable, and cardiorespiratory fitness as the mediating variable.</p><p><strong>Results: </strong>64 individuals, 67.2% male, with a mean age of 48.1 years (95%CI 44.3-51.9), were evaluated. Cardiorespiratory fitness exerted a partial mediating effect on the association between MIP and PCS (β = 0.14; 95%CI: 0.02-0.27), resulting in a 6% reduction in PCS variance explained by MIP (6% of R2). The mediating proportion was 32.5%. There was no association between MIP and the mental component, and cardiorespiratory fitness did not mediate the relationship between MIP and the general component of HRQoL (β = 0.13; p = 0.350).</p><p><strong>Conclusion: </strong>In the sample studied, the association between inspiratory muscle strength and the physical aspects of HRQoL is partially mediated by cardiorespiratory fitness. However, this mediating effect was not observed for the mental or general aspects of HRQoL.</p>","PeriodicalId":14724,"journal":{"name":"Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia","volume":"48 2","pages":"e20250175"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13004158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147485806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Márcia Alvarenga da Trindade, Ana Elizabeth Prado Lima Figueiredo, Carlos Eduardo Poli-de-Figueiredo
{"title":"Translation, cross-cultural adaptation, and validation of the Integrated Palliative Care Outcome Scale Renal (IPOS-Renal) for Brazilian Portuguese.","authors":"Márcia Alvarenga da Trindade, Ana Elizabeth Prado Lima Figueiredo, Carlos Eduardo Poli-de-Figueiredo","doi":"10.1590/2175-8239-JBN-2025-0133en","DOIUrl":"10.1590/2175-8239-JBN-2025-0133en","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic Kidney Disease (CKD) is associated with a high symptom burden. In Brazil, there is no specific instrument to assess symptoms in CKD patients receiving palliative care. The Integrated Palliative Care Outcome Scale Renal (IPOS-Renal) has been translated and validated in 13 languages.</p><p><strong>Objective: </strong>To translate, cross-culturally adapt, and validate the IPOS-renal for Brazilian Portuguese.</p><p><strong>Methods: </strong>A methodological study conducted in eight phases: conceptual definition, forward translation, back-translation, expert review, cognitive interviews, proofreading, psychometric testing, and final reporting. A total of 153 stage 5 CKD patients were assessed with the IPOS-renal and the Edmonton Symptom Assessment System (ESAS-r) between February and March 2024. Instruments were reapplied after 15 days in 95 patients.</p><p><strong>Results: </strong>The scale demonstrated internal consistency, reliability, temporal stability, and convergent validity with the ESAS-r. The most prevalent symptoms were drowsiness (44%), difficulty walking (44%), fatigue/lack of energy (43%), and pain (36%). Less frequent symptoms included dyspnea (7%), diarrhea (14%), and vomiting (14%). Unbearable symptoms intensity was rare, including emotional symptoms (5%), difficulty sleeping (3%), and fatigue/lack of energy (3%). Symptom intensity varied, being severe for pain (24-25%) and drowsiness (21%); and moderate for difficulty walking (25%) and fatigue/lack of energy (22%).</p><p><strong>Conclusion: </strong>The Brazilian Portuguese version of the IPOS- renal is valid, reliable, and suitable for identifying biopsychosocial symptoms in stage 5 CKD patients receiving palliative care.</p>","PeriodicalId":14724,"journal":{"name":"Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia","volume":"48 2","pages":"e20250133"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12810525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145989502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Peritoneal dialysis catheter implantation: technical aspects, challenges, and current perspectives.","authors":"Domingos Candiota Chula, Rodrigo Peixoto Campos, Ricardo Portiolli Franco, Henrique Carrascossi, Viviane Calice-Silva","doi":"10.1590/21758239-JBN-2025-0267en","DOIUrl":"10.1590/21758239-JBN-2025-0267en","url":null,"abstract":"<p><p>The success of peritoneal dialysis (PD) depends on securing a functional, safe, and durable peritoneal access. Over recent decades, important advances in catheter design and insertion techniques have been consolidated, with the Tenckhoff catheter remaining the most widely used. Nevertheless, the prevalence of PD in Brazil remains limited, hindered by technical and logistical barriers to catheter placement, as well as by delays between indication and procedure. This review critically examines the main approaches to establishing PD access, with emphasis on technical aspects, clinical outcomes, and complications. Conventional surgery provides direct visualization of the peritoneal cavity in a simple and safe manner, whereas percutaneous methods, particularly those guided by ultrasonography and fluoroscopy, shorten hospitalization and broaden applicability when performed by nephrologists. Comparative evidence shows that percutaneous approaches achieve low rates of infectious and mechanical complications, with satisfactory catheter survival, while videolaparoscopic placement appears to yield superior results among the most frequently adopted techniques, despite greater technical and logistical complexity. Study heterogeneity limits definitive conclusions, underscoring the need for robust randomized clinical trials. Systematic use of imaging guidance may improve technical accuracy, while the active involvement of nephrologists in the procedure is crucial for reducing delays, optimizing outcomes, and expanding PD utilization. Standardization of practices and wider adoption of minimally invasive techniques represent promising avenues for strengthening PD as a therapeutic modality.</p>","PeriodicalId":14724,"journal":{"name":"Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia","volume":"48 2","pages":"e20250267"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12928706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147276051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The APOL1 gene and kidney transplantation: a review article.","authors":"Melissa Gaspar Tavares, Lúcio Requião-Moura, Luísa Queiroga, Helio Tedesco Silva Junior, José Osmar Medina Pestana","doi":"10.1590/21758239-JBN-2025-0093en","DOIUrl":"10.1590/21758239-JBN-2025-0093en","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic kidney disease (CKD) is a global public health problem and kidney transplantation is the treatment of choice for patients with stage 5 (G5) CKD. Kidney transplant survival at the end of the first year exceeds 95%, and at 5 years, it approaches 90%. However, the decline in the estimated glomerular filtration rate (eGFR) over the years remains a challenge. The rate of eGFR decline is attributed to several factors and has recently been attributed to the presence of APOL1 gene variants.</p><p><strong>Discussion: </strong>The risk variants G1 and G2 of the APOL1 gene are related to CKD. Evidence suggests that kidneys from deceased donors carrying APOL1 risk variants have worse kidney graft survival. The presence of risk variants in living donors also confers worse long-term outcomes after donation. Novel therapies targeted to inhibit APOL1 protein function have not yet been tested in the transplant population. Proteomic studies continue to advance, using increasingly refined techniques to analyze APOL1 isoforms, their receptors, metabolites, agonists, and potential blockers.</p><p><strong>Conclusion: </strong>Risk variants have a significant impact on the understanding of CKD and kidney transplantation. Research on these variants in potential living donors should better guide donor selection and decision-making regarding donation.</p>","PeriodicalId":14724,"journal":{"name":"Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia","volume":"48 2","pages":"e20250093"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12923211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146226781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thyago Proença de Moraes, Caio Pellizzari, Paulo Ricardo Gessolo Lins, Viviane Calice-Silva
{"title":"Current approaches to prescription and optimization of peritoneal dialysis: a practical review.","authors":"Thyago Proença de Moraes, Caio Pellizzari, Paulo Ricardo Gessolo Lins, Viviane Calice-Silva","doi":"10.1590/2175-8239-JBN-2025-0288en","DOIUrl":"10.1590/2175-8239-JBN-2025-0288en","url":null,"abstract":"<p><p>Peritoneal dialysis (PD) is an established form of kidney replacement therapy that offers patients the possibility of homebased treatment with significant flexibility and autonomy. Despite its advantages, many physicians in training and those just starting their clinical practice feel uncertain when prescribing PD, given the technical aspects, individualized adjustments, and the variety of modalities available. This manuscript provides a practical and didactic overview of how to prescribe PD, focusing on both continuous ambulatory peritoneal dialysis (CAPD) and automated peritoneal dialysis (APD). The discussion begins with the fundamental principles of solute and fluid transport, followed by step-by-step guidance on prescription elements such as dialysate volume, dwell time, number of exchanges, glucose concentration, and the use of icodextrin. Special attention is given to differences between CAPD and APD, highlighting the strengths and limitations of each approach in terms of clearance, ultrafiltration, and patient lifestyle. By combining theoretical background with clinical examples, this teaching resource aims to bridge the gap between guideline recommendations and bedside practice. Ultimately, the article seeks to empower clinicians to prescribe PD with confidence, improve patient-centered decision-making, and foster broader adoption of this therapy, which remains underutilized despite its well-documented clinical and social benefits.</p>","PeriodicalId":14724,"journal":{"name":"Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia","volume":"48 2","pages":"e20250288"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13262985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148239313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gianna Mastroianni-Kirsztajn, Michelle T Passos Riguetti, Juliana Mansur Siliano
{"title":"Anti-PLA2R antibodies: implications for therapeutic planning and the prediction of remission in membranous nephropathy.","authors":"Gianna Mastroianni-Kirsztajn, Michelle T Passos Riguetti, Juliana Mansur Siliano","doi":"10.1590/2175-8239-JBN-2026-E009en","DOIUrl":"10.1590/2175-8239-JBN-2026-E009en","url":null,"abstract":"","PeriodicalId":14724,"journal":{"name":"Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia","volume":"48 2","pages":"e2026E009"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13120714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}