Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia最新文献

{"title":"Early prediction matters: renal biomarkers in coronary artery bypass grafting.","authors":"Renata de Souza Mendes","doi":"10.1590/2175-8239-JBN-2025-E011en","DOIUrl":"10.1590/2175-8239-JBN-2025-E011en","url":null,"abstract":"","PeriodicalId":14724,"journal":{"name":"Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia","volume":"47 3","pages":"e2025E011"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12279284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Academic and professional profile and impact of graduates from the Nephrology Graduate Program at UNIFESP.","authors":"Pablo Ferraz, Nestor Schor, Gianna Mastroianni Kirsztajn","doi":"10.1590/2175-8239-JBN-2024-0178en","DOIUrl":"10.1590/2175-8239-JBN-2024-0178en","url":null,"abstract":"<p><strong>Introduction: </strong>Graduate studies in Brazil have experienced significant growth since the 1990s. Over a 40-year period, the Graduate Program in Nephrology at Unifesp has qualified 261 master's graduates, 111 doctors and 146 individuals who completed both a master's and a doctoral degree. Of these, 278 hold a degree in Medicine. Medical postgraduates were responsible for 124 master's dissertations and 243 doctoral theses completed.</p><p><strong>Objective: </strong>This study analyzed the profile and professional trajectories of graduate students from the Nephrology Graduate Program at Unifesp.</p><p><strong>Methods: </strong>The authors used the university's database to establish the graduates' profile and applied a questionnaire to identify their professional performance in academia and the job market. The graduates were divided into three groups: G1 - 1976 to 1997 (N = 127); G2 - 1998 to 2006 (N = 150); G3 - 2007 to 2015 (N = 241).</p><p><strong>Results: </strong>Regarding sex, male medical graduates were responsible for 53.6% of all completion papers; however, in the most recent period, women accounted for 61% of the works. Female participation was consistently higher among graduates from other areas, at 73.8% of the total. Among the physicians, 65.5% graduated from public universities, with the first group standing out with 73%. In the other groups, 59.5% and 59.8% came from public HEIs, respectively. The overall average income reported by master's graduates responding to the questionnaire ranged from 5 to 10 minimum wages (MW), and for doctors, above 10 MW.</p><p><strong>Conclusion: </strong>Doctoral graduates had a strong presence in academia, predominantly within the public sector.</p>","PeriodicalId":14724,"journal":{"name":"Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia","volume":"47 3","pages":"e20240178"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12259148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing kidney donor quality: the saga continues.","authors":"Tainá Veras de Sandes-Freitas","doi":"10.1590/2175-8239-JBN-2025-E013en","DOIUrl":"10.1590/2175-8239-JBN-2025-E013en","url":null,"abstract":"","PeriodicalId":14724,"journal":{"name":"Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia","volume":"47 3","pages":"e2025E013"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Brazil to the world: a journal with purpose.","authors":"José A Moura-Neto, Thyago Proença de Moraes, Miguel Carlos Riella","doi":"10.1590/2175-8239-JBN-2025-E015en","DOIUrl":"10.1590/2175-8239-JBN-2025-E015en","url":null,"abstract":"","PeriodicalId":14724,"journal":{"name":"Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia","volume":"47 3","pages":"e2025E015"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12279283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optic nerve sheath calcification in a patient with chronic kidney disease: an unusual orbital manifestation.","authors":"Lara Hemerly De Mori, Nina Ventura, Diogo Goulart Corrêa","doi":"10.1590/2175-8239-JBN-2025-0085en","DOIUrl":"10.1590/2175-8239-JBN-2025-0085en","url":null,"abstract":"","PeriodicalId":14724,"journal":{"name":"Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia","volume":"47 3","pages":"e20250085"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12208610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between the Kidney Donor Profile Index and one-year outcomes in Brazilian kidney transplant recipients of standard criteria donors.","authors":"Ana Paula Aquino de Morais, Renato Demarchi Foresto, Maria Amélia Aguiar Hazin, Bianca Cristina Cassão, Helio Tedesco-Silva, José Medina Pestana, Lúcio Requião-Moura","doi":"10.1590/2175-8239-JBN-2024-0219en","DOIUrl":"10.1590/2175-8239-JBN-2024-0219en","url":null,"abstract":"<p><strong>Introduction: </strong>The Kidney Donor Profile Index (KDPI) has not been previously validated in Brazil, thus this study aimed to investigate the association between the index and one-year outcomes in kidney transplant recipients (KTRs) of standard criteria donors (SCD).</p><p><strong>Methods: </strong>Retrospective cohort analysis including 1,943 KTRs who received kidneys from SCD between 2013 and 2017. The primary outcome was composed of death, graft loss, and 1-yr-graft function <30 mL/min/1.73m2 (eGFR, CKD-EPI). Logistic regression identified variables associated with the primary outcome, while 1-yr eGFR across KDPI strata was compared using the Kruskal-Wallis test, adjusted with the Bonferroni test.</p><p><strong>Results: </strong>Donors were 41.0 years old, 24.9% had hypertension, 47.3% died due to cerebrovascular injury, and 48.3% had the final creatinine >1.5 mg/dL; the median of KDPI was 52%. The primary outcome occurred in 14.4% of the cases, which was associated with longer dialysis duration before transplantation (p = 0.04), CMV-related events (p = 0.03), acute rejection (p < 0.001), and KDPI strata. Compared to the 1-35% KDPI stratum, the RRs for the primary outcome were significantly higher in higher KDPI strata: 1.62 (p = 0.03) for >35-50%, 2.28 (p < 0.001) for >50-85%, and 2.23 (p = 0.01) for >85%. The 1-yr eGFR was also significantly lower in KTRs with donors in higher KDPI strata (p < 0.001).</p><p><strong>Conclusion: </strong>The KDPI was independently associated with the primary outcome composed of death, graft loss, and 1-yr eGFR <30 mL/min/1.73 m2 in recipients of SCD donors. Despite not being previously validated for Brazilian donors, the KDPI was also significantly associated with 1-yr eGFR, delayed graft function, and acute rejection in those recipients.</p>","PeriodicalId":14724,"journal":{"name":"Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia","volume":"47 3","pages":"e20240219"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12282608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychiatric disorders in chronic hemodialysis patients in a clinic in Bahia: the influence of the COVID-19 pandemic.","authors":"Daniela de Queiroz Moura Landim, Melina Pinheiro Gomes de Souza, Lianna Gabriella Dantas, Ana Flávia Moura, José A Moura-Neto, José Andrade Moura Júnior, Constança Margarida Sampaio Cruz","doi":"10.1590/2175-8239-JBN-2024-0147en","DOIUrl":"10.1590/2175-8239-JBN-2024-0147en","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic Kidney Disease is associated, due to several factors linked to the disease, with a high rate of psychiatric disorders. With the COVID-19 pandemic, evidence suggests an increase in the already high prevalence of these disorders in chronic kidney patients. It is assumed that early diagnosis of psychiatric disorders can contribute to the development of treatment strategies, reducing the morbidity and mortality caused by the disorders.</p><p><strong>Objective: </strong>To determine the prevalence of psychiatric disorders in hemodialysis patients, evaluating the association of COVID-19 and some variables with the occurrence of these disorders.</p><p><strong>Methodology: </strong>Cross-sectional study carried out in a nephrology clinic in Bahia, in 2023. The sample consisted of 119 patients chosen by simple randomization. Patients were evaluated by the Mini International Neuropsychiatric Interview, an internationally validated interview.</p><p><strong>Results: </strong>Sixty-two patients (52.1%) had at least one psychiatric disorder. The most common were Generalized Anxiety Disorder (GAD) (42%) and Major Depressive Episode (MDE) (18.5%). There was no association between COVID-19 diagnosis and any psychiatric disorder. Among the 58 patients who had COVID-19, men had a lower chance of developing some disorder (OR = 0.30; 95% CI [0.10-0.91]), as did patients with >5 years of treatment (OR = 0.17; 95% CI [0.05-0.61]).</p><p><strong>Conclusions: </strong>The prevalence of psychiatric disorders is high. Among patients who had COVID-19, women had more psychiatric disorders, as well as, specifically, more GAD, and patients who had more than 5 years of treatment had a significantly lower chance of developing some psychiatric disorder.</p>","PeriodicalId":14724,"journal":{"name":"Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia","volume":"47 3","pages":"e20240147"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypertension in Latin America and the Caribbean: an analysis of recent progress and remaining challenges.","authors":"Andrea Pio de Abreu","doi":"10.1590/2175-8239-JBN-2024-0245en","DOIUrl":"10.1590/2175-8239-JBN-2024-0245en","url":null,"abstract":"<p><p>This narrative review aims to present the current information on cardiovascular diseases, focusing on hypertension (HT) and associated comorbidities in Latin American and Caribbean (LAC) countries, and compare successful global studies on the subject. LAC countries have unique characteristics, including high socioeconomic inequality and unequal access to health and urban infrastructure. At the same time, urbanization and economic growth have contributed to the proliferation of unhealthy lifestyles. HT is the primary risk factor for cardiovascular morbidity and mortality, affecting between 20 and 40% of the population in this region. It is of utmost importance to address the alarmingly low rates of awareness, treatment, and control of HT. This is further compounded by the rising prevalence of patients with metabolic disorders. Obesity and HT are two pivotal drivers of the cardio-renal disease continuum because patients with uncontrolled cardiovascular risk in mid-life are likely to be at increased risk of clinical cardiovascular and chronic kidney disease in old age. A series of recommended actions include developing population-wide prevention and control programs, implementing opportunistic screening, and using out-of-office blood pressure measurements. It is imperative that primary care and treatment adherence are reinforced. Moreover, accessibility and optimal distribution of efficacious, cost-effective antihypertensive medications are of paramount importance. Insights from high-income countries should be effectively conveyed to LAC countries, respecting the particularities of the regions involved.</p>","PeriodicalId":14724,"journal":{"name":"Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia","volume":"47 3","pages":"e20240245"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12227124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary and serum biomarkers of renal injury in coronary artery bypass grafting: a prospective evaluation with new biomarkers'.","authors":"Antônio Felipe Leite Simão, Gdayllon Cavalcante Meneses, Lia Cavalcante Cezar, Letícia Machado de Araújo, Alice Maria Costa Martins, Heraldo Guedis Lobo Filho, Bruna Viana Barroso Martins, Geraldo Bezerra da Silva Júnior, Elizabeth De Francesco Daher, José Glauco Lobo Filho","doi":"10.1590/2175-8239-JBN-2024-0173en","DOIUrl":"10.1590/2175-8239-JBN-2024-0173en","url":null,"abstract":"<p><strong>Introduction: </strong>Cardiopulmonary bypass (CPB) for coronary artery bypass grafting (CABG) often causes kidney dysfunction and increases morbidity and mortality.</p><p><strong>Aims: </strong>To evaluate the effects of CPB on kidney structures of patients submitted to CABG using serum and urinary biomarkers.</p><p><strong>Methods: </strong>This prospective study included patients who underwent CABG over a 14-month period. Data related to clinical, surgical, and laboratory were collected. The glomerular filtration rate was estimated using the CKD-EPI equation. The urinary biomarkers trialed were nephrin, KIM-1, MCP-1, Syndecan-1, and NGAL.</p><p><strong>Results: </strong>Out of 30 patients enrolled, 22 were assessed. The mean age was 65 years and most were male. During CABG, the On-pump group had increased urinary nephrin (p = 0.007) and urinary (p = 0.036) and serum NGAL (p = 0.030) levels compared to the Off-pump group. Moreover, intraoperatively, in the On-Pump clusters, the urinary NGAL was correlated with the decrease of glomerular filtration rate in the first 48 hours after CABG (Rho = - 0.838, p = 0.009). There was no statistical difference in clinical and surgical aspects between groups according to use of CBP during CABG.</p><p><strong>Conclusion: </strong>CBP procedure used during CABG was associated with relevant effects on kidney structure, such as podocyte and tubular injury. Urinary NGAL was able to predict an impairment of glomerular filtration 48 hours after CABG.</p>","PeriodicalId":14724,"journal":{"name":"Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia","volume":"47 3","pages":"e20240173"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12279285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular-kidney-metabolic Syndrome: a current and urgent concept.","authors":"Andrea Pio de Abreu, Luciano Ferreira Drager, Madson Queiroz Almeida, Luiz Aparecido Bortolotto, Heno Ferreira Lopes","doi":"10.1590/2175-8239-JBN-2024-0277en","DOIUrl":"10.1590/2175-8239-JBN-2024-0277en","url":null,"abstract":"<p><p>The concept of cardiovascular-kidney-metabolic health is based on the idea of a multifaceted interaction among several cardiovascular, renal, and meta-bolic factors. Alterations in this complex interaction have a significant impact on morbidity and mortality. The ramifications of poor cardiovascular-kidney-metabolic health are far-reaching, with a notable clinical impact. A considerable proportion of the population is affected by precarious cardiovascular, renal, and metabolic health, and indivi-duals with adverse social determinants of health endure an even greater burden. To this end, it is essential to develop an approach that incorporates metabolic staging and prioritizes lifelong prevention. Equally imperative is integrating the social determinants of health into care models for Cardiovascular-kidney-metabolic syndrome, facilitating patient-centered interdisciplinary care. The American Heart Association (AHA) provides guidelines on the definition, staging, paradigms, and holistic approaches to the management of patients with this syndrome. Furthermore, it offers a comprehensive framework for effectively and equitably improving the cardiovascular, kidney, and metabolic health of the population.</p>","PeriodicalId":14724,"journal":{"name":"Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia","volume":"47 2","pages":"e20240277"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}