Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia最新文献

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The association between the Kidney Donor Profile Index and one-year outcomes in Brazilian kidney transplant recipients of standard criteria donors. 肾供者概况指数与巴西肾移植受者标准供者一年预后的关系。
IF 1.3
Ana Paula Aquino de Morais, Renato Demarchi Foresto, Maria Amélia Aguiar Hazin, Bianca Cristina Cassão, Helio Tedesco-Silva, José Medina Pestana, Lúcio Requião-Moura
{"title":"The association between the Kidney Donor Profile Index and one-year outcomes in Brazilian kidney transplant recipients of standard criteria donors.","authors":"Ana Paula Aquino de Morais, Renato Demarchi Foresto, Maria Amélia Aguiar Hazin, Bianca Cristina Cassão, Helio Tedesco-Silva, José Medina Pestana, Lúcio Requião-Moura","doi":"10.1590/2175-8239-JBN-2024-0219en","DOIUrl":"10.1590/2175-8239-JBN-2024-0219en","url":null,"abstract":"<p><strong>Introduction: </strong>The Kidney Donor Profile Index (KDPI) has not been previously validated in Brazil, thus this study aimed to investigate the association between the index and one-year outcomes in kidney transplant recipients (KTRs) of standard criteria donors (SCD).</p><p><strong>Methods: </strong>Retrospective cohort analysis including 1,943 KTRs who received kidneys from SCD between 2013 and 2017. The primary outcome was composed of death, graft loss, and 1-yr-graft function <30 mL/min/1.73m2 (eGFR, CKD-EPI). Logistic regression identified variables associated with the primary outcome, while 1-yr eGFR across KDPI strata was compared using the Kruskal-Wallis test, adjusted with the Bonferroni test.</p><p><strong>Results: </strong>Donors were 41.0 years old, 24.9% had hypertension, 47.3% died due to cerebrovascular injury, and 48.3% had the final creatinine >1.5 mg/dL; the median of KDPI was 52%. The primary outcome occurred in 14.4% of the cases, which was associated with longer dialysis duration before transplantation (p = 0.04), CMV-related events (p = 0.03), acute rejection (p < 0.001), and KDPI strata. Compared to the 1-35% KDPI stratum, the RRs for the primary outcome were significantly higher in higher KDPI strata: 1.62 (p = 0.03) for >35-50%, 2.28 (p < 0.001) for >50-85%, and 2.23 (p = 0.01) for >85%. The 1-yr eGFR was also significantly lower in KTRs with donors in higher KDPI strata (p < 0.001).</p><p><strong>Conclusion: </strong>The KDPI was independently associated with the primary outcome composed of death, graft loss, and 1-yr eGFR <30 mL/min/1.73 m2 in recipients of SCD donors. Despite not being previously validated for Brazilian donors, the KDPI was also significantly associated with 1-yr eGFR, delayed graft function, and acute rejection in those recipients.</p>","PeriodicalId":14724,"journal":{"name":"Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia","volume":"47 3","pages":"e20240219"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12282608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Position statement of the Brazilian Society of Nephrology on the refusal and discontinuation of dialysis. 巴西肾脏学会关于拒绝和停止透析的立场声明。
IF 1.3
Dirceu Reis da Silva, Fernanda Salomão Gorayeb-Polacchini, Ana Flávia Moura, Cibele Isaac Saad Rodrigues, Maurício Younes-Ibrahim, Eduardo Rocha, Marina Aline Occhiena de Oliveira Neiva, Pedro Túlio Rocha, Patrícia Ferreira Abreu, José A Moura-Neto
{"title":"Position statement of the Brazilian Society of Nephrology on the refusal and discontinuation of dialysis.","authors":"Dirceu Reis da Silva, Fernanda Salomão Gorayeb-Polacchini, Ana Flávia Moura, Cibele Isaac Saad Rodrigues, Maurício Younes-Ibrahim, Eduardo Rocha, Marina Aline Occhiena de Oliveira Neiva, Pedro Túlio Rocha, Patrícia Ferreira Abreu, José A Moura-Neto","doi":"10.1590/2175-8239-JBN-2025-0057en","DOIUrl":"10.1590/2175-8239-JBN-2025-0057en","url":null,"abstract":"<p><p>Renal failure is considered a life-limiting CONDITION that often requires Renal Replacement Therapy, such as dialysis or kidney transplantation. Dialysis can effectively relieve symptoms and prolong life, but its withdrawal results in severe complications and death. The decision to discontinue or refuse to dialysis must be made collaboratively by the patient, family, and healthcare team, considering the clinical condition, life expectancy, symptom burden, and individual preferences. This decision, involving clinical, bioethical, and legal aspects, is complex and requires a collective understanding of the process. Withdrawal to dialysis presents a challenge for nephrologists and the healthcare team due to the lack of clear guidelines, which can compromis the safety of the process and the patient's dignity. In this position statement, the Brazilian Society of Nephrology recommends a process for dialysis withdrawal or refusal, including identifying eligible patients, applying prognostic assessment tools, shared decision-making, advance care planning, and offering dialysis alternatives. The decision must be consensual, allowing adequate time for reflection, and healthcare services must provide comprehensive management of physical, psychological, social, and spiritual symptoms, as well as end-of-life care. Proper documentation in medical records is essential to ensure process transparency. Therefore, refusal or withdrawal to dialysis should be an informed decision that respects individual autonomy and balances clinical, bioethical, spiritual, and legal considerations.</p>","PeriodicalId":14724,"journal":{"name":"Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia","volume":"47 3","pages":"e20250057"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12360398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychiatric disorders in chronic hemodialysis patients in a clinic in Bahia: the influence of the COVID-19 pandemic. 巴伊亚州一家诊所慢性血液透析患者的精神障碍:COVID-19大流行的影响
IF 1.3
Daniela de Queiroz Moura Landim, Melina Pinheiro Gomes de Souza, Lianna Gabriella Dantas, Ana Flávia Moura, José A Moura-Neto, José Andrade Moura Júnior, Constança Margarida Sampaio Cruz
{"title":"Psychiatric disorders in chronic hemodialysis patients in a clinic in Bahia: the influence of the COVID-19 pandemic.","authors":"Daniela de Queiroz Moura Landim, Melina Pinheiro Gomes de Souza, Lianna Gabriella Dantas, Ana Flávia Moura, José A Moura-Neto, José Andrade Moura Júnior, Constança Margarida Sampaio Cruz","doi":"10.1590/2175-8239-JBN-2024-0147en","DOIUrl":"10.1590/2175-8239-JBN-2024-0147en","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic Kidney Disease is associated, due to several factors linked to the disease, with a high rate of psychiatric disorders. With the COVID-19 pandemic, evidence suggests an increase in the already high prevalence of these disorders in chronic kidney patients. It is assumed that early diagnosis of psychiatric disorders can contribute to the development of treatment strategies, reducing the morbidity and mortality caused by the disorders.</p><p><strong>Objective: </strong>To determine the prevalence of psychiatric disorders in hemodialysis patients, evaluating the association of COVID-19 and some variables with the occurrence of these disorders.</p><p><strong>Methodology: </strong>Cross-sectional study carried out in a nephrology clinic in Bahia, in 2023. The sample consisted of 119 patients chosen by simple randomization. Patients were evaluated by the Mini International Neuropsychiatric Interview, an internationally validated interview.</p><p><strong>Results: </strong>Sixty-two patients (52.1%) had at least one psychiatric disorder. The most common were Generalized Anxiety Disorder (GAD) (42%) and Major Depressive Episode (MDE) (18.5%). There was no association between COVID-19 diagnosis and any psychiatric disorder. Among the 58 patients who had COVID-19, men had a lower chance of developing some disorder (OR = 0.30; 95% CI [0.10-0.91]), as did patients with >5 years of treatment (OR = 0.17; 95% CI [0.05-0.61]).</p><p><strong>Conclusions: </strong>The prevalence of psychiatric disorders is high. Among patients who had COVID-19, women had more psychiatric disorders, as well as, specifically, more GAD, and patients who had more than 5 years of treatment had a significantly lower chance of developing some psychiatric disorder.</p>","PeriodicalId":14724,"journal":{"name":"Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia","volume":"47 3","pages":"e20240147"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute kidney disease in patients with COVID-19. A prospective, multicenter, multinational study in Latin America. COVID-19患者的急性肾病拉丁美洲前瞻性、多中心、多国研究。
IF 1.3
Raúl Lombardi, Alejandro Ferreiro, Yanissa Venegas, Mariana Pereira, Cristina Carlino, Rolando Claure-Del Granado, Daniela Ponce, Daniel Molina, Agustina Zinoveev
{"title":"Acute kidney disease in patients with COVID-19. A prospective, multicenter, multinational study in Latin America.","authors":"Raúl Lombardi, Alejandro Ferreiro, Yanissa Venegas, Mariana Pereira, Cristina Carlino, Rolando Claure-Del Granado, Daniela Ponce, Daniel Molina, Agustina Zinoveev","doi":"10.1590/2175-8239-JBN-2024-0154en","DOIUrl":"10.1590/2175-8239-JBN-2024-0154en","url":null,"abstract":"<p><strong>Introduction: </strong>Acute kidney disease (AKD) is defined as functional and/or structural abnormalities of kidneys with health implications and a duration of ≤90 days. This study aimed to evaluate AKD as a more appropriate approach to these conditions for which we used a cohort of COVID-19 patients in whom kidney impairment is expressed by proteinuria and/or loss of function.</p><p><strong>Methods: </strong>Observational, prospective, longitudinal, multinational cohort study conducted across five Latin American countries. Adult patients with diagnosis of COVID-19 were included. Upon hospital admission, urinalysis or urine strip test was performed. If protein was not detected, a follow-up search was conducted five days later. Patients were classified in four AKD categories: non-kidney disease, proteinuria only, acute kidney injury (AKI) only, and proteinuria and AKI.</p><p><strong>Results: </strong>Three hundred and sixty patients were included. AKD was present in 273 (75.8%), of whom 142 (52.0%) had only proteinuria, 11 (4.1%) had AKI without proteinuria, and 120 (43.9%) had both proteinuria and AKI. Overall, proteinuria with or without AKI was present in 262 patients (72.8%). AKI with or without proteinuria occurred in 131 patients (36.4%). AKI was mainly severe, non-oliguric, and hospital-acquired. In-hospital mortality increased with the severity of AKD: non-kidney disease 9.5%, proteinuria only 22.8%, AKI only 56.7%, and proteinuria plus AKI 53.0% (p = 0.001).</p><p><strong>Conclusions: </strong>Our data endorse a comprehensive approach based on the concept of AKD. This integrative approach, encompassing the structural and functional continuum of AKI, AKD, and CKD, enables timely interventions and the implementation of preventive and therapeutic strategies.</p>","PeriodicalId":14724,"journal":{"name":"Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia","volume":"47 3","pages":"e20240154"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12448115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Urinary and serum biomarkers of renal injury in coronary artery bypass grafting: a prospective evaluation with new biomarkers'. 冠状动脉旁路移植术中肾损伤的尿液和血清生物标志物:新生物标志物的前瞻性评价。
IF 1.3
Antônio Felipe Leite Simão, Gdayllon Cavalcante Meneses, Lia Cavalcante Cezar, Letícia Machado de Araújo, Alice Maria Costa Martins, Heraldo Guedis Lobo Filho, Bruna Viana Barroso Martins, Geraldo Bezerra da Silva Júnior, Elizabeth De Francesco Daher, José Glauco Lobo Filho
{"title":"Urinary and serum biomarkers of renal injury in coronary artery bypass grafting: a prospective evaluation with new biomarkers'.","authors":"Antônio Felipe Leite Simão, Gdayllon Cavalcante Meneses, Lia Cavalcante Cezar, Letícia Machado de Araújo, Alice Maria Costa Martins, Heraldo Guedis Lobo Filho, Bruna Viana Barroso Martins, Geraldo Bezerra da Silva Júnior, Elizabeth De Francesco Daher, José Glauco Lobo Filho","doi":"10.1590/2175-8239-JBN-2024-0173en","DOIUrl":"10.1590/2175-8239-JBN-2024-0173en","url":null,"abstract":"<p><strong>Introduction: </strong>Cardiopulmonary bypass (CPB) for coronary artery bypass grafting (CABG) often causes kidney dysfunction and increases morbidity and mortality.</p><p><strong>Aims: </strong>To evaluate the effects of CPB on kidney structures of patients submitted to CABG using serum and urinary biomarkers.</p><p><strong>Methods: </strong>This prospective study included patients who underwent CABG over a 14-month period. Data related to clinical, surgical, and laboratory were collected. The glomerular filtration rate was estimated using the CKD-EPI equation. The urinary biomarkers trialed were nephrin, KIM-1, MCP-1, Syndecan-1, and NGAL.</p><p><strong>Results: </strong>Out of 30 patients enrolled, 22 were assessed. The mean age was 65 years and most were male. During CABG, the On-pump group had increased urinary nephrin (p = 0.007) and urinary (p = 0.036) and serum NGAL (p = 0.030) levels compared to the Off-pump group. Moreover, intraoperatively, in the On-Pump clusters, the urinary NGAL was correlated with the decrease of glomerular filtration rate in the first 48 hours after CABG (Rho = - 0.838, p = 0.009). There was no statistical difference in clinical and surgical aspects between groups according to use of CBP during CABG.</p><p><strong>Conclusion: </strong>CBP procedure used during CABG was associated with relevant effects on kidney structure, such as podocyte and tubular injury. Urinary NGAL was able to predict an impairment of glomerular filtration 48 hours after CABG.</p>","PeriodicalId":14724,"journal":{"name":"Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia","volume":"47 3","pages":"e20240173"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12279285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hypertension in Latin America and the Caribbean: an analysis of recent progress and remaining challenges. 拉丁美洲和加勒比的高血压:对最近进展和仍然存在的挑战的分析。
IF 1.3
Andrea Pio de Abreu
{"title":"Hypertension in Latin America and the Caribbean: an analysis of recent progress and remaining challenges.","authors":"Andrea Pio de Abreu","doi":"10.1590/2175-8239-JBN-2024-0245en","DOIUrl":"10.1590/2175-8239-JBN-2024-0245en","url":null,"abstract":"<p><p>This narrative review aims to present the current information on cardiovascular diseases, focusing on hypertension (HT) and associated comorbidities in Latin American and Caribbean (LAC) countries, and compare successful global studies on the subject. LAC countries have unique characteristics, including high socioeconomic inequality and unequal access to health and urban infrastructure. At the same time, urbanization and economic growth have contributed to the proliferation of unhealthy lifestyles. HT is the primary risk factor for cardiovascular morbidity and mortality, affecting between 20 and 40% of the population in this region. It is of utmost importance to address the alarmingly low rates of awareness, treatment, and control of HT. This is further compounded by the rising prevalence of patients with metabolic disorders. Obesity and HT are two pivotal drivers of the cardio-renal disease continuum because patients with uncontrolled cardiovascular risk in mid-life are likely to be at increased risk of clinical cardiovascular and chronic kidney disease in old age. A series of recommended actions include developing population-wide prevention and control programs, implementing opportunistic screening, and using out-of-office blood pressure measurements. It is imperative that primary care and treatment adherence are reinforced. Moreover, accessibility and optimal distribution of efficacious, cost-effective antihypertensive medications are of paramount importance. Insights from high-income countries should be effectively conveyed to LAC countries, respecting the particularities of the regions involved.</p>","PeriodicalId":14724,"journal":{"name":"Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia","volume":"47 3","pages":"e20240245"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12227124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of real-world kidney outcomes with predicted outcomes at the time of diagnosis and post-biopsy in a cohort of children with IgA nephropathy. 在IgA肾病儿童队列中,真实肾脏预后与诊断时和活检后预测预后的比较
IF 1.3
Mafalda Félix Cabral, Inês Martins, Miguel Pereira, Gonçalo Vale, Madalena Almeida Borges, Maria Soto-Maior Costa, Fernando Caeiro, Mário Góis, Helena Sousa, Telma Francisco, Gisela Neto, Margarida Abranches, Rute Baeta Baptista
{"title":"Comparison of real-world kidney outcomes with predicted outcomes at the time of diagnosis and post-biopsy in a cohort of children with IgA nephropathy.","authors":"Mafalda Félix Cabral, Inês Martins, Miguel Pereira, Gonçalo Vale, Madalena Almeida Borges, Maria Soto-Maior Costa, Fernando Caeiro, Mário Góis, Helena Sousa, Telma Francisco, Gisela Neto, Margarida Abranches, Rute Baeta Baptista","doi":"10.1590/2175-8239-JBN-2024-0260en","DOIUrl":"10.1590/2175-8239-JBN-2024-0260en","url":null,"abstract":"<p><strong>Introduction: </strong>IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis, with a variable clinical course. This study aimed to evaluate real-world kidney outcomes in children with IgAN and compare these with predictions from the International IgAN Prediction Tool for children (IIgAN-PT).</p><p><strong>Methods: </strong>A single-center, longitudinal retrospective study was conducted on pediatric patients diagnosed with IgAN from 2010 to 2022. Data on clinical, laboratory, and histological parameters were analyzed. The IIgAN-PT score was calculated for each patient at biopsy and one year after biopsy. The primary outcome was a composite endpoint of ≥30% eGFR decrease or progression to end stage kidney disease (ESKD).</p><p><strong>Results: </strong>Among 23 patients (57% male, median age at biopsy 13.8 years), MEST-C scores showed M1 in 87%, E1 in 22%, S1 in 39%, T1/2 in 13%, and C1 in 26%. During a median 3.1-year follow-up, 26% reached the primary outcome, while the median predicted risk based on IIgAN-PT was 6.5%. Additionally, 57% experienced eGFR decline (annual median decline of 5.6 mL/min/1.73 m2). Application of the updated IIgAN-PT one-year post-biopsy (n = 13) resulted in a median predicted risk of 1.79%, while 23% met the primary outcome.</p><p><strong>Conclusion: </strong>The observed eGFR decline or progression to ESKD was higher than predicted, highlighting the need for early diagnosis, monitoring, and treatment. Small-scale studies like ours underscore the importance of early intervention and may inform the design of larger studies to improve the predictive ability of the IIgAN-PT tool in diverse clinical settings.</p>","PeriodicalId":14724,"journal":{"name":"Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia","volume":"47 3","pages":"e20240260"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12448116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145053664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IgA nephropathy in children: how much can we trust prognostic tools? 儿童IgA肾病:我们能在多大程度上信任预后工具?
IF 1.3
Maria Goretti Moreira Guimarães Penido, Nilzete Liberato Bresolin, Oreste Ferra-Neto
{"title":"IgA nephropathy in children: how much can we trust prognostic tools?","authors":"Maria Goretti Moreira Guimarães Penido, Nilzete Liberato Bresolin, Oreste Ferra-Neto","doi":"10.1590/2175-8239-JBN-2025-E012en","DOIUrl":"10.1590/2175-8239-JBN-2025-E012en","url":null,"abstract":"","PeriodicalId":14724,"journal":{"name":"Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia","volume":"47 3","pages":"e2025E012"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12442730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiovascular-kidney-metabolic Syndrome: a current and urgent concept. 心血管-肾-代谢综合征:一个当前和紧迫的概念。
IF 1.3
Andrea Pio de Abreu, Luciano Ferreira Drager, Madson Queiroz Almeida, Luiz Aparecido Bortolotto, Heno Ferreira Lopes
{"title":"Cardiovascular-kidney-metabolic Syndrome: a current and urgent concept.","authors":"Andrea Pio de Abreu, Luciano Ferreira Drager, Madson Queiroz Almeida, Luiz Aparecido Bortolotto, Heno Ferreira Lopes","doi":"10.1590/2175-8239-JBN-2024-0277en","DOIUrl":"10.1590/2175-8239-JBN-2024-0277en","url":null,"abstract":"<p><p>The concept of cardiovascular-kidney-metabolic health is based on the idea of a multifaceted interaction among several cardiovascular, renal, and meta-bolic factors. Alterations in this complex interaction have a significant impact on morbidity and mortality. The ramifications of poor cardiovascular-kidney-metabolic health are far-reaching, with a notable clinical impact. A considerable proportion of the population is affected by precarious cardiovascular, renal, and metabolic health, and indivi-duals with adverse social determinants of health endure an even greater burden. To this end, it is essential to develop an approach that incorporates metabolic staging and prioritizes lifelong prevention. Equally imperative is integrating the social determinants of health into care models for Cardiovascular-kidney-metabolic syndrome, facilitating patient-centered interdisciplinary care. The American Heart Association (AHA) provides guidelines on the definition, staging, paradigms, and holistic approaches to the management of patients with this syndrome. Furthermore, it offers a comprehensive framework for effectively and equitably improving the cardiovascular, kidney, and metabolic health of the population.</p>","PeriodicalId":14724,"journal":{"name":"Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia","volume":"47 2","pages":"e20240277"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
C3 glomerulonephritis associated with monoclonal gammopathy of renal significance: a diagnostic and therapeutic challenge. C3肾小球肾炎与肾脏单克隆性伽玛病相关:诊断和治疗的挑战。
IF 1.3
Bárbara Beirão, Mariana Freitas, Natália Silva, Patrícia Ferraz, Catarina Prata, Teresa Morgado
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