C3 glomerulonephritis associated with monoclonal gammopathy of renal significance: a diagnostic and therapeutic challenge.

IF 1.3 Q3 UROLOGY & NEPHROLOGY
Bárbara Beirão, Mariana Freitas, Natália Silva, Patrícia Ferraz, Catarina Prata, Teresa Morgado
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引用次数: 0

Abstract

C3 glomerulopathy represents a heterogeneous group of glomerulopathies characterized by hyperactivity of the alternative complement pathway. Although the pathophysiology is incompletely understood, an association between this disease and monoclonal gammopathies is increasingly recognized, especially in older individuals. There is still some uncertainty regarding the best treatment for patients with monoclonal gammopathy-associated C3 glomerulopathy. However, recent evidence suggests that myeloma-targeted therapies are associated with improved renal outcomes compared with conservative or conventional immunosuppressive therapies. This case report describes the clinical course and long-term follow-up of a patient with monoclonal gammopathy-associated C3 glomerulonephritis treated with myeloma-targeted therapy.

C3肾小球肾炎与肾脏单克隆性伽玛病相关:诊断和治疗的挑战。
C3肾小球病是一种异质性肾小球病,其特征是补体通路异常活跃。尽管病理生理学尚不完全清楚,但人们越来越认识到这种疾病与单克隆γ病之间的联系,特别是在老年人中。单克隆伽玛病相关C3肾小球病变的最佳治疗方案仍存在一些不确定性。然而,最近的证据表明,与保守或传统的免疫抑制治疗相比,骨髓瘤靶向治疗与肾脏预后改善相关。本病例报告描述了一例单克隆伽玛病相关C3肾小球肾炎患者接受骨髓瘤靶向治疗的临床过程和长期随访。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.20
自引率
16.70%
发文量
208
审稿时长
16 weeks
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