Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia最新文献_第10页

Pediatric chronic kidney disease: blood cell count indexes as inflammation markers. 儿童慢性肾脏疾病：血细胞计数指标作为炎症标志物。

IF 1.2

Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia Pub Date : 2023-10-01 DOI: 10.1590/2175-8239-JBN-2022-0190en

Aislander Junio da Silva, Ana Cristina Dos Santos Lopes, Ana Paula Lucas Mota, Ana Cristina Simões E Silva, Luci Maria Sant'Ana Dusse, Patrícia Nessralla Alpoim

{"title":"Pediatric chronic kidney disease: blood cell count indexes as inflammation markers.","authors":"Aislander Junio da Silva, Ana Cristina Dos Santos Lopes, Ana Paula Lucas Mota, Ana Cristina Simões E Silva, Luci Maria Sant'Ana Dusse, Patrícia Nessralla Alpoim","doi":"10.1590/2175-8239-JBN-2022-0190en","DOIUrl":"10.1590/2175-8239-JBN-2022-0190en","url":null,"abstract":"Introduction: Chronic kidney disease (CKD) is defined as a progressive decline of kidney functions. In childhood, the main triggering factors are congenital anomalies of the kidneys and urinary tract (CAKUT) and glomerulopathies. Inflammatory responses present challenges for diagnosis and staging, which justifies studies on biomarkers/indexes.Aim: To define blood cell count indexes and verify their association with pediatric CKD etiology and staging. The included indexes were: Neutrophil-Lymphocyte Ratio (NLR), Derived Neutrophil-Lymphocyte Ratio (dNLR), Lymphocyte-Monocyte Ratio (LMR), Systemic Inflammation Response Index (SIRI), Aggregate Index of Systemic Inflammation (AISI), and Systemic Immune-Inflammation Index (SII).Methods: We determined the indexes in 52 pediatric CKD patients and 33 healthy controls by mathematical calculation. CKD patients were separated in five groups based on the etiology and staging: Group IA: glomerulopathies at stage 1 or 2; IB: glomerulopathies at stage 3 or 4; IIA: CAKUT at stage 1 or 2; IIB: CAKUT at stage 3 or 4; and III: stages 3 or 4 of other etiologies. In addition, we combined all patients with CKD in one group (IV). Group V was a healthy control group.Results: Lower values of LMR were observed for groups IB and IIB compared to group V (p = 0.047, p = 0.031, respectively). Increased values of SIRI were found for group III versus group V (p = 0.030). There was no difference for other indexes when the groups were compared two by two.Conclusion: The LMR and SIRI indexes showed promising results in the evaluation of inflammation, as they correlated with CKD etiologies and specially staging in these patients.","PeriodicalId":14724,"journal":{"name":"Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia","volume":" ","pages":"458-469"},"PeriodicalIF":1.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10726671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72209384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hemodialysis in Brazil: differences across geographic regions regarding demographics, laboratory parameters and drug prescription. 巴西的血液透析：不同地区在人口统计学、实验室参数和药物处方方面的差异。

IF 1.2

Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia Pub Date : 2023-10-01 DOI: 10.1590/2175-8239-JBN-2022-0169en

Fabiana Baggio Nerbass, Helbert do Nascimento Lima, Jocemir Ronaldo Lugon, Ricardo Sesso

{"title":"Hemodialysis in Brazil: differences across geographic regions regarding demographics, laboratory parameters and drug prescription.","authors":"Fabiana Baggio Nerbass, Helbert do Nascimento Lima, Jocemir Ronaldo Lugon, Ricardo Sesso","doi":"10.1590/2175-8239-JBN-2022-0169en","DOIUrl":"10.1590/2175-8239-JBN-2022-0169en","url":null,"abstract":"Introduction: Brazil has a vast territory divided into five geographic regions with important differences in sociodemographic indices. We aimed to present and compare socio-demographic characteristics, biochemical results, and drug prescription of patients on chronic hemodialysis (HD) treatment in the five geographic regions.Methods: We evaluated data from the Brazilian Dialysis Registry of all adult patients undergoing chronic HD in 2021. Variables included sociodemographic characteristics, serum levels of phosphate, calcium, and albumin, hemoglobin, urea reduction rate, and prescription of phosphate binders, erythropoietin, and intravenous iron. Data from the North and Northeast regions were combined into one group.Results: A total of 13,792 patients (57.9 ± 16.0 years old, 58.5% male, median HD vintage of 31 (11-66) months) from 73 dialysis centers were analyzed. Regional distribution was 59.5% in the Southeast; 21.7% in the South; 5.9% in the Midwest; and 12.9% in the North/Northeast. Sociodemographic features, biochemical results, and medication prescriptions differed across regions. The prevalence of elderly patients was lower in the Midwest and North/Northeast. The South region had the highest prevalence of hyperphosphatemia (41.2%) and urea reduction rate <65% (24.8%), while anemia and hypoalbuminemia were more prevalent in the Southeast, 32.7% and 11.6%, respectively.Conclusion: We found differences in socio-demographics, clinical features, and drug prescriptions across Brazilian geographic regions. Some findings reflect the socio-demographic diversity of the country, while others deserve further elucidation.","PeriodicalId":14724,"journal":{"name":"Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia","volume":" ","pages":"410-416"},"PeriodicalIF":1.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10726669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9795817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hospitalization and mortality during the pandemic in chronic hemodialysis patients and the general population in Peru. 秘鲁慢性血液透析患者和普通人群在大流行期间的住院情况和死亡率。

IF 1.2

Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia Pub Date : 2023-10-01 DOI: 10.1590/2175-8239-JBN-2022-0149en

Percy Herrera-Añazco, Moisés Apolaya Segura, Jessica Bravo-Zúñiga, Juan Lluncor Vásquez, Alvaro Taype-Rondán

{"title":"Hospitalization and mortality during the pandemic in chronic hemodialysis patients and the general population in Peru.","authors":"Percy Herrera-Añazco, Moisés Apolaya Segura, Jessica Bravo-Zúñiga, Juan Lluncor Vásquez, Alvaro Taype-Rondán","doi":"10.1590/2175-8239-JBN-2022-0149en","DOIUrl":"10.1590/2175-8239-JBN-2022-0149en","url":null,"abstract":"Background: Patients with chronic kidney disease have a higher risk of severe disease and mortality from COVID-19 than the general population.Objective: To compare hospitalization and mortality rates during the pandemic among chronic hemodialysis (HD) patients and the general population in Lima (Peru).Methods: This retrospective cohort included an assessment of the database of chronic HD patients of the health service providers of the social health insurance benefit networks of Lima and Callao between 2019 and 2021. Hospitalization and mortality rates were obtained for every 1,000 individuals, and variations in the percentages of COVID-19 cases and deaths were calculated. These rates were compared with those of the general population data and standardized by age and sex.Results: An average of 3,937 chronic HD patients were evaluated each month. Of these, 4.8% had COVID-19 and 64.97% were mild cases. The hospitalization rates per 1,000 patients were 19.5, 29.28, and 36.7 in 2019, 2020, and 2021, respectively. The mortality rates per 1,000 patients were 5.9, 9.74, and 11.49 in 2019, 2020, and 2021, respectively. When compared to the standardized general population, the peaks of both rates coincided with the plateaus of the waves during the pandemic. The hospitalization rate for COVID-19 was 12 times higher in HD patients than in the general population, and the mortality rate for COVID-19 was twice as high.Conclusion: HD patients had higher hospitalization and standardized mortality rates than the general population. Peaks in hospitalizations and mortality coincided with the plateaus of the first and second waves of the pandemic.","PeriodicalId":14724,"journal":{"name":"Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia","volume":" ","pages":"440-448"},"PeriodicalIF":1.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10726660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9823892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A silent presentation of massive staghorn calculi. 巨大鹿角形结石的无声表现。

IF 1.2

Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia Pub Date : 2023-10-01 DOI: 10.1590/2175-8239-JBN-2023-0072en

Pedro Lisboa-Gonçalves, Adriana Santos, Teresa Pina-Vaz

引用次数: 0

Impact of pretransplantation malnutrition risk on the clinical outcome and graft survival of kidney transplant patients. 移植前营养不良风险对肾移植患者临床结果和移植物存活率的影响。

IF 1.3

Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia Pub Date : 2023-10-01 DOI: 10.1590/2175-8239-JBN-2022-0150en

Marina Ribeiro de Oliveira Santos, Marcus Faria Lasmar, Evaldo Nascimento, Raquel Aparecida Fabreti-Oliveira

{"title":"Impact of pretransplantation malnutrition risk on the clinical outcome and graft survival of kidney transplant patients.","authors":"Marina Ribeiro de Oliveira Santos, Marcus Faria Lasmar, Evaldo Nascimento, Raquel Aparecida Fabreti-Oliveira","doi":"10.1590/2175-8239-JBN-2022-0150en","DOIUrl":"10.1590/2175-8239-JBN-2022-0150en","url":null,"abstract":"Background: The prevalence of malnourished patients before transplantation and the influence of malnutrition on graft and patient outcomes remain underestimated, despite being associated with higher postoperative morbidity and mortality. This study aimed to develop an easy nutritional screening tool and evaluate the impact of nutritional status on clinical outcome, graft survival (GS) and mortality risk in kidney transplant patients (KTP).Methods: In this retrospective cohort study including 451 KTP, we developed a score by using anthropometric, clinical, and laboratory measures performed in the pretransplant evaluation. The patients were stratified into 3 groups according to the final score: G1 (0 or 1 point)=low risk, G2 (2 to 4 points)=moderate risk, and G3 (>5 points)=high risk of malnutrition. The patients were monitored after transplantation at least 1 to 10 years.Results: Stratifying the 451 patients based on the pretransplant risk score, G1, G2, and G3 were composed of 90, 292, and 69 patients, respectively. Patients from G1 maintained the lowest serum creatinine levels at hospital discharge when compared with others (p = 0.012). The incidence of infection in the patients from G3 was higher than patients from G1 and G2 (p = 0.030). G3 recipients showed worse GS than G1 patients (p = 0.044). G3 patients showed almost threefold higher risk for graft loss (HR 2.94, 95% CI 1.084-7.996).Conclusions: KTP with higher malnutrition risk score were associated with worse outcomes and GS. The nutritional screening tool is easy to be used in clinical practice to evaluate the patient in preparation for kidney transplant.","PeriodicalId":14724,"journal":{"name":"Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia","volume":" ","pages":"470-479"},"PeriodicalIF":1.3,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10726658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9826960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Malnutrition before kidney transplantation: how to assess it and what is the impact? 肾移植前营养不良：如何评估营养不良及其影响？

IF 1.2

Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia Pub Date : 2023-10-01 DOI: 10.1590/2175-8239-JBN-2023-E014en

Miguel Moyses Neto, Anderson Marliere Navarro, Marcio Dantas

引用次数: 0

Substance used in the ripening of fruits can cause kidney damage and water and electrolytic disorders. 水果成熟过程中使用的物质会导致肾脏损伤、水分和电解质紊乱。

IF 1.3

Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia Pub Date : 2023-10-01 DOI: 10.1590/2175-8239-JBN-2023-E009en

Talita Rojas Sanches, Lúcia Andrade

引用次数: 0

Frailty and chronic kidney disease: associations and implications. 虚弱与慢性肾病：关联与影响。

IF 1.3

Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia Pub Date : 2023-10-01 DOI: 10.1590/2175-8239-JBN-2022-0117en

Luv Bansal, Ashish Goel, Amitesh Agarwal, Rahul Sharma, Rajarshi Kar, Alpana Raizada, Rhea Wason, Raghav Gera

{"title":"Frailty and chronic kidney disease: associations and implications.","authors":"Luv Bansal, Ashish Goel, Amitesh Agarwal, Rahul Sharma, Rajarshi Kar, Alpana Raizada, Rhea Wason, Raghav Gera","doi":"10.1590/2175-8239-JBN-2022-0117en","DOIUrl":"10.1590/2175-8239-JBN-2022-0117en","url":null,"abstract":"Introduction: Frailty and its association with chronic kidney disease (CKD) has been established previously. The present study examined this association further by studying the distribution of frailty among groups defined by different stages of the disease. It also identified associated health deficits and explored their association with estimated glomerular filtration rate (eGFR) and urine albumin creatinine ratio (UACR).Methods: A cross-sectional survey was conducted on 90 non-dialysis dependent CKD Stage 1-4 patients, recruited in three stratified groups of 30 participants each based on the stage of disease. Frailty was assessed using Fried's frailty criteria and associated health deficits were recorded using a pre-determined list. Depression was screened using a 4-point depression scale.Results: 21.1% of the participants were frail and 43.3% were pre-frail. The proportion of frailty in CKD groups A (Stages 1 and 2), B (Stage 3a), and C (Stages 3b and 4) was 10%, 13.3%, and 40%, respectively. The association of health deficits including co-morbidities, physical parameters, mental status, daily activities, etc. with UACR, eGFR, and CKD stages was not statistically significant. Nearly one in two frail participants was depressed compared with 14% among non-frail participants.Conclusion: The skewed distribution of 21% frail subjects identified in our study indicates an association between frailty and advancing kidney disease. Frail individuals had a lower eGFR, higher UACR, were more likely to be depressed, and had higher count of health deficits and poorer performance on Barthel Index of Activities of Daily Living and WHOQOL. Early identification of depression would improve care in these patients.","PeriodicalId":14724,"journal":{"name":"Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia","volume":" ","pages":"401-409"},"PeriodicalIF":1.3,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10726667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9474637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reduction of estimated glomerular filtration rate after COVID-19-associated acute kidney injury. COVID-19 相关急性肾损伤后估计肾小球滤过率降低。

IF 1.2

Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia Pub Date : 2023-10-01 DOI: 10.1590/2175-8239-JBN-2022-0179en

Gabrielle Accioly Omena Bento, Vivian Larissa Tenório Leite, Rodrigo Peixoto Campos, Flora Braga Vaz, Elizabeth De Francesco Daher, Daniella Bezerra Duarte

{"title":"Reduction of estimated glomerular filtration rate after COVID-19-associated acute kidney injury.","authors":"Gabrielle Accioly Omena Bento, Vivian Larissa Tenório Leite, Rodrigo Peixoto Campos, Flora Braga Vaz, Elizabeth De Francesco Daher, Daniella Bezerra Duarte","doi":"10.1590/2175-8239-JBN-2022-0179en","DOIUrl":"10.1590/2175-8239-JBN-2022-0179en","url":null,"abstract":"Introduction: Acute Kidney Injury (AKI), a frequent manifestation in COVID-19, can compromise kidney function in the long term. We evaluated renal function after hospital discharge of patients who developed AKI associated with COVID-19.Methods: This is an ambidirectional cohort. eGFR and microalbuminuria were reassessed after hospital discharge (T1) in patients who developed AKI due to COVID-19, comparing the values with hospitalization data (T0). P < 0.05 was considered statistically significant.Results: After an average of 16.3 ± 3.5 months, 20 patients were reassessed. There was a median reduction of 11.5 (IQR: -21; -2.1) mL/min/1.73m2 per year in eGFR. Forty-five percent of patients had CKD at T1, were older, and had been hospitalized longer; this correlated negatively with eGFR at T1. Microalbuminuria was positively correlated with CRP at T0 and with a drop in eGFR, as well as eGFR at admission with eGFR at T1.Conclusion: There was a significant reduction in eGFR after AKI due to COVID-19, being associated with age, length of hospital stay, CRP, and need for hemodialysis.","PeriodicalId":14724,"journal":{"name":"Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia","volume":" ","pages":"488-494"},"PeriodicalIF":1.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10726661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9618536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A spurious elevation of serum creatinine level in a patient with Crohn's disease without histologic kidney damage: a case report and review of the literature. 克罗恩病患者血清肌酸酐水平的虚假升高而无组织学肾损伤：一例病例报告和文献综述。

IF 1.2

Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia Pub Date : 2023-10-01 DOI: 10.1590/2175-8239-JBN-2023-0071en

Sul A Lee, Gearoid Michael McMahon

{"title":"A spurious elevation of serum creatinine level in a patient with Crohn's disease without histologic kidney damage: a case report and review of the literature.","authors":"Sul A Lee, Gearoid Michael McMahon","doi":"10.1590/2175-8239-JBN-2023-0071en","DOIUrl":"10.1590/2175-8239-JBN-2023-0071en","url":null,"abstract":"Patients with inflammatory bowel disease (IBD) are prone to develop kidney injury. Renal involvement in IBD patients is usually diagnosed by the measurement of serum creatinine and the estimation of the glomerular filtration rate. We describe a patient with IBD who presented with large fluctuations in his serum creatinine level (~3.0-fold) without significant histologic abnormalities and with a normal cystatin C level. This appears to be related to a high-protein diet and intermittent fasting. Even though the impact of a high-protein diet on mild elevations of the serum creatinine level has been described, large fluctuations in serum creatinine from diet alone, as seen in this case, have never been reported, raising the question about the potential contribution of inflamed bowel on gut absorption or metabolism of creatinine. This case highlights the importance of a detailed history, including the dietary habits, when encountering a patient with increased serum creatinine level, and careful interpretation of serum creatinine in a patient with a creatinine high-protein diet or underlying IBD.","PeriodicalId":14724,"journal":{"name":"Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia","volume":" ","pages":"497-501"},"PeriodicalIF":1.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10726663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71481549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0