Japanese Journal of Radiology最新文献

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Advancing the management of uterine cancer: insurance coverage for sentinel lymph node mapping with technetium-99m-labeled phytate and the potential role of lymphangiography. 推进子宫癌的管理:用锝-99m标记植酸盐进行前哨淋巴结测绘的保险范围和淋巴管造影的潜在作用。
IF 2.1 4区 医学
Japanese Journal of Radiology Pub Date : 2025-09-01 Epub Date: 2025-05-05 DOI: 10.1007/s11604-025-01795-5
Tomoki Tozawa, Kento Hatakeyama, Naoko Mori
{"title":"Advancing the management of uterine cancer: insurance coverage for sentinel lymph node mapping with technetium-99m-labeled phytate and the potential role of lymphangiography.","authors":"Tomoki Tozawa, Kento Hatakeyama, Naoko Mori","doi":"10.1007/s11604-025-01795-5","DOIUrl":"10.1007/s11604-025-01795-5","url":null,"abstract":"","PeriodicalId":14691,"journal":{"name":"Japanese Journal of Radiology","volume":" ","pages":"1550-1551"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of different breath-holding methods on scanning length and radiation dose of 320-row volumetric coronary CT angiography. 不同屏气方式对320排容积冠状动脉CT造影扫描长度和辐射剂量的影响。
IF 2.1 4区 医学
Japanese Journal of Radiology Pub Date : 2025-09-01 Epub Date: 2025-05-14 DOI: 10.1007/s11604-025-01796-4
Tian Wang, Boyu Li, Qiuli Han, Li Liao, Renbin Mo, Yufeng Miao, Rulin Xu, Wei Zhang
{"title":"Effect of different breath-holding methods on scanning length and radiation dose of 320-row volumetric coronary CT angiography.","authors":"Tian Wang, Boyu Li, Qiuli Han, Li Liao, Renbin Mo, Yufeng Miao, Rulin Xu, Wei Zhang","doi":"10.1007/s11604-025-01796-4","DOIUrl":"10.1007/s11604-025-01796-4","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to evaluate the impact of different breath-holding techniques on the scanning length and radiation dose during coronary CT angiography (CCTA).</p><p><strong>Materials and methods: </strong>A total of 210 patients with suspected coronary artery disease, who were scheduled for CCTA, were prospectively enrolled and randomly assigned to one of three breath-holding groups: Group A (end-inspiratory breath-hold), Group B (breath-holding during calm respiration), and Group C (end-expiratory breath-hold), with 70 patients in each group. The parameters recorded and analyzed included resting heart rate (during calm respiration), scanning heart rate (during breath-holding), scan length, heart rate variability, radiation dose metrics, and patient comfort levels.</p><p><strong>Results: </strong>Four patients in the end-expiratory breath-hold group (Group C) were unable to maintain breath-hold during scanning, resulting in non-diagnostic images. The remaining 206 patients successfully completed the CCTA. Across all groups, the scanning heart rate was significantly lower than the resting heart rate (P < 0.05). Follow-up assessments revealed that breath-holding during calm respiration provided the highest comfort level. Both the volume scan length and radiation dose were significantly lower in Groups B and C compared to Group A (P < 0.05), with no significant differences observed between Groups B and C (P > 0.05). The image quality in Group C was significantly lower compared to Group A and Group B (P < 0.01).</p><p><strong>Conclusion: </strong>Breath-holding during calm respiration in CCTA not only maintains the image quality, but also significantly lowers heart rate, scan length, and radiation dose, while simultaneously enhancing patient comfort and cooperation during the scan.</p>","PeriodicalId":14691,"journal":{"name":"Japanese Journal of Radiology","volume":" ","pages":"1456-1464"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Super-resolution deep learning reconstruction to evaluate lumbar spinal stenosis status on magnetic resonance myelography. 超分辨率深度学习重建评价磁共振脊髓造影腰椎管狭窄状态。
IF 2.1 4区 医学
Japanese Journal of Radiology Pub Date : 2025-09-01 Epub Date: 2025-04-23 DOI: 10.1007/s11604-025-01787-5
Koichiro Yasaka, Yusuke Asari, Yuichi Morita, Mariko Kurokawa, Taku Tajima, Hiroyuki Akai, Naoki Yoshioka, Masaaki Akahane, Kuni Ohtomo, Osamu Abe, Shigeru Kiryu
{"title":"Super-resolution deep learning reconstruction to evaluate lumbar spinal stenosis status on magnetic resonance myelography.","authors":"Koichiro Yasaka, Yusuke Asari, Yuichi Morita, Mariko Kurokawa, Taku Tajima, Hiroyuki Akai, Naoki Yoshioka, Masaaki Akahane, Kuni Ohtomo, Osamu Abe, Shigeru Kiryu","doi":"10.1007/s11604-025-01787-5","DOIUrl":"10.1007/s11604-025-01787-5","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate whether super-resolution deep learning reconstruction (SR-DLR) of MR myelography-aided evaluations of lumbar spinal stenosis.</p><p><strong>Material and methods: </strong>In this retrospective study, lumbar MR myelography of 40 patients (16 males and 24 females; mean age, 59.4 ± 31.8 years) were analyzed. Using the MR imaging data, MR myelography was separately reconstructed via SR-DLR, deep learning reconstruction (DLR), and conventional zero-filling interpolation (ZIP). Three radiologists, blinded to patient background data and MR reconstruction information, independently evaluated the image sets in terms of the following items: the numbers of levels affected by lumbar spinal stenosis; and cauda equina depiction, sharpness, noise, artifacts, and overall image quality.</p><p><strong>Results: </strong>The median interobserver agreement in terms of the numbers of lumbar spinal stenosis levels were 0.819, 0.735, and 0.729 for SR-DLR, DLR, and ZIP images, respectively. The imaging quality of the cauda equina, and image sharpness, noise, and overall quality on SR-DLR images were significantly better than those on DLR and ZIP images, as rated by all readers (p < 0.001, Wilcoxon signed-rank test). No significant differences were observed for artifacts on SR-DLR against DLR and ZIP.</p><p><strong>Conclusions: </strong>SR-DLR improved the image quality of lumbar MR myelographs compared to DLR and ZIP, and was associated with better interobserver agreement during assessment of lumbar spinal stenosis status.</p>","PeriodicalId":14691,"journal":{"name":"Japanese Journal of Radiology","volume":" ","pages":"1427-1433"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12396975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
STAT image reporting in a large-scale cohort: types, frequency, and insights from the Tohoku Medical Megabank Brain MRI Study. 大规模队列中的STAT图像报告:类型、频率和来自Tohoku医学超级库脑MRI研究的见解。
IF 2.1 4区 医学
Japanese Journal of Radiology Pub Date : 2025-09-01 Epub Date: 2025-05-15 DOI: 10.1007/s11604-025-01800-x
Naoko Mori, Shunji Mugikura, Yuto Abe, Atsushi Hozawa, Nobuo Fuse, Masayuki Yamamoto
{"title":"STAT image reporting in a large-scale cohort: types, frequency, and insights from the Tohoku Medical Megabank Brain MRI Study.","authors":"Naoko Mori, Shunji Mugikura, Yuto Abe, Atsushi Hozawa, Nobuo Fuse, Masayuki Yamamoto","doi":"10.1007/s11604-025-01800-x","DOIUrl":"10.1007/s11604-025-01800-x","url":null,"abstract":"","PeriodicalId":14691,"journal":{"name":"Japanese Journal of Radiology","volume":" ","pages":"1413-1416"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12397134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of LI-RADS CT/MRI Radiation Treatment Response Assessment Version 2024: a study after transarterial radioembolization for hepatocellular carcinoma. LI-RADS CT/MRI放射治疗反应评估版2024的应用:经动脉放射栓塞治疗肝癌后的研究。
IF 2.1 4区 医学
Japanese Journal of Radiology Pub Date : 2025-09-01 Epub Date: 2025-04-16 DOI: 10.1007/s11604-025-01785-7
Jaeseung Shin, Sunyoung Lee, Ja Kyung Yoon, Kyowon Gu, Sun-Young Baek, Dong-Ho Hyun, Gyoung Min Kim, Jong Yun Won
{"title":"Application of LI-RADS CT/MRI Radiation Treatment Response Assessment Version 2024: a study after transarterial radioembolization for hepatocellular carcinoma.","authors":"Jaeseung Shin, Sunyoung Lee, Ja Kyung Yoon, Kyowon Gu, Sun-Young Baek, Dong-Ho Hyun, Gyoung Min Kim, Jong Yun Won","doi":"10.1007/s11604-025-01785-7","DOIUrl":"10.1007/s11604-025-01785-7","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the performance of the LI-RADS CT/MRI Radiation Treatment Response Assessment (TRA) version 2024 (v2024) after transarterial radioembolization (TARE) for hepatocellular carcinoma (HCC) with that of the LI-RADS CT/MRI TRA version 2017 (v2017).</p><p><strong>Methods: </strong>This retrospective study included patients with HCC treated with TARE followed by hepatic surgery between November 2012 and April 2023 at two tertiary referral centers. Each treated lesion was assigned an LI-RADS treatment response (LR-TR) category based on a consensus reading of three radiologists using both v2024 and v2017. The sensitivity and specificity of the two TRA versions were compared using the McNemar test, with histopathology as a reference standard.</p><p><strong>Results: </strong>A total of 46 (mean age, 56.2 years; 39 men) patients with 46 TARE-treated lesions (23 with incomplete [< 100%] necrosis) were included. The distribution of categories based on v2024 was as follows: LR-TR Nonviable, 52.2% (24/46); LR-TR Nonprogressing, 39.1% (18/46); and LR-TR Viable, 8.7% (4/46). While no category change was noted for LR-TR Nonviable lesions, 16 lesions classified as LR-TR Viable in v2017 were recategorized as LR-TR Nonprogressing in v2024. For predicting histopathologically incomplete necrosis, the LR-TR Viable or Nonprogressing categories of v2024 and the LR-TR Viable or Equivocal categories of v2017 showed equivalent high sensitivity (87.0%; 20/23; 95% confidence interval [CI]: 67.9, 95.5) and specificity (91.3%; 21/23; 95% CI 73.2, 97.6) (all P > 0.99).</p><p><strong>Conclusion: </strong>While applying the updated radiation TRA v2024 resulted in recategorization, its diagnostic performance in predicting tumor viability was comparable to that of TRA v2017.</p>","PeriodicalId":14691,"journal":{"name":"Japanese Journal of Radiology","volume":" ","pages":"1498-1508"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Qualitative and quantitative CT analyses of the solid component in lung adenocarcinoma for predicting invasiveness. 肺腺癌固体成分的定性和定量CT分析预测侵袭性。
IF 2.1 4区 医学
Japanese Journal of Radiology Pub Date : 2025-09-01 Epub Date: 2025-05-25 DOI: 10.1007/s11604-025-01794-6
Yoshie Kunihiro, Fumi Kameda, Taiga Kobayashi, Masahiro Tanabe, Ryoko Morooka, Toshiki Tanaka, Yoshinobu Hoshii, Tsuneo Matsumoto, Katsuyoshi Ito
{"title":"Qualitative and quantitative CT analyses of the solid component in lung adenocarcinoma for predicting invasiveness.","authors":"Yoshie Kunihiro, Fumi Kameda, Taiga Kobayashi, Masahiro Tanabe, Ryoko Morooka, Toshiki Tanaka, Yoshinobu Hoshii, Tsuneo Matsumoto, Katsuyoshi Ito","doi":"10.1007/s11604-025-01794-6","DOIUrl":"10.1007/s11604-025-01794-6","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the CT findings of lung adenocarcinoma with solid components and to determine the difference between adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA) with invasive adenocarcinoma (IAC).</p><p><strong>Materials and methods: </strong>A total of 54 cases were included in this study. The diagnoses of lung adenocarcinoma consisted of AIS or MIA (n = 20) and IAC (n = 34). The following factors were evaluated on CT images: part-solid nodule or solid nodule, presence of air bronchogram, air space, calcification within the tumor, presence of interstitial pneumonia and emphysema, diameters of the tumor and solid component, and CT values of the solid component. The volume and CT number histograms, including the 50th, 75th, and 100th percentiles of solid component were obtained using a software program. The CT criteria were compared between AIS, MIA, and IAC, and an indicator of differentiation was considered.</p><p><strong>Results: </strong>Part-solid nodules were observed more frequently in AIS and MIA (85.0%) than in IAC (55.9%). All criteria for quantitative analysis showed significant differences between AIS or MIA and IAC, and the diameter of the solid component in the mediastinal window was an indicator of differentiation (p = 0.0006; odds ratio, 1.4; 95% confidence interval, 1.2-1.8).</p><p><strong>Conclusion: </strong>The diameter of the solid component on the mediastinal window was considered an indicator of differentiation between AIS, MIA, and IAC.</p><p><strong>Condensed abstract: </strong>Quantitative data of solid component, including both manual measurements and evaluation using CT software, are correlated with pathological invasiveness. Diameter of the solid component in the mediastinal window would be an indicator of IAC.</p>","PeriodicalId":14691,"journal":{"name":"Japanese Journal of Radiology","volume":" ","pages":"1489-1497"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12397110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of amyloid PET positivity using machine learning on 18F-FDG PET images. 在18F-FDG PET图像上使用机器学习评估淀粉样蛋白PET阳性。
IF 2.1 4区 医学
Japanese Journal of Radiology Pub Date : 2025-09-01 Epub Date: 2025-05-02 DOI: 10.1007/s11604-025-01789-3
Takahiro Yamada, Yuichi Kimura, Shogo Watanabe, Aya Watanabe, Misa Honda, Takashi Nagaoka, Mitsutaka Nemoto, Kohei Hanaoka, Hayato Kaida, Yasuyuki Kojita, Minoru Yamada, SungWoon Im, Atsushi Kono, Kazunari Ishii
{"title":"Evaluation of amyloid PET positivity using machine learning on <sup>18</sup>F-FDG PET images.","authors":"Takahiro Yamada, Yuichi Kimura, Shogo Watanabe, Aya Watanabe, Misa Honda, Takashi Nagaoka, Mitsutaka Nemoto, Kohei Hanaoka, Hayato Kaida, Yasuyuki Kojita, Minoru Yamada, SungWoon Im, Atsushi Kono, Kazunari Ishii","doi":"10.1007/s11604-025-01789-3","DOIUrl":"10.1007/s11604-025-01789-3","url":null,"abstract":"<p><strong>Background: </strong>Since the approval of disease-modifying drugs for Alzheimer's disease, the demand for amyloid positron emission tomography (PET) scans, which are crucial for determining treatment eligibility, is expected to increase significantly. We thus investigated the ability of an algorithm to predict amyloid accumulation from <sup>18</sup>F-fluorodeoxyglucose (FDG)-PET images for use in amyloid PET screening.</p><p><strong>Methods: </strong>We analyzed the images of 194 subjects with cognitive disorders who had undergone brain FDG-PET, amyloid PET using Pittsburgh compound-B (<sup>11</sup>C-PiB), and MRI scans at Kindai University Hospital between 2011 and 2018. Among them, 108 subjects showed positive amyloid accumulation; the other 86 did not. For the 108 positive cases, the input values were the region of interest-based calculated from the automatic anatomical labeling template, which divides the brain into 120 regions, and applied to the anatomically standardized FDG-PET images of each subject. We then used a support vector machine (SVM) machine learning algorithm and conducted a tenfold cross-validation to assess the algorithm's accuracy for predicting amyloid accumulation from FDG-PET images.</p><p><strong>Results: </strong>We observed 81.5% accuracy, 78.5% sensitivity, 84.6% specificity, and an area under the curve (AUC) of 0.846 during training. The validation results for the trained model revealed 85.9% accuracy, 88.4% sensitivity, 81.0% specificity, and an AUC of 0.918.</p><p><strong>Conclusion: </strong>These results indicate that the performance of our algorithm to predict amyloid accumulation from <sup>18</sup>FDG-PET images is adequate for use in amyloid PET scan screenings.</p>","PeriodicalId":14691,"journal":{"name":"Japanese Journal of Radiology","volume":" ","pages":"1541-1549"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MRI-pathologic correlation in tubulocystic renal cell carcinoma. 肾小管囊性细胞癌的mri病理相关性。
IF 2.1 4区 医学
Japanese Journal of Radiology Pub Date : 2025-09-01 Epub Date: 2025-05-09 DOI: 10.1007/s11604-025-01778-6
Yuto Sakano, Takashi Koyama, Kenji Notohara
{"title":"MRI-pathologic correlation in tubulocystic renal cell carcinoma.","authors":"Yuto Sakano, Takashi Koyama, Kenji Notohara","doi":"10.1007/s11604-025-01778-6","DOIUrl":"10.1007/s11604-025-01778-6","url":null,"abstract":"","PeriodicalId":14691,"journal":{"name":"Japanese Journal of Radiology","volume":" ","pages":"1552-1555"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The potential of CT colonography for colorectal cancer screening in Japan. 日本CT结肠镜筛查结直肠癌的潜力。
IF 2.1 4区 医学
Japanese Journal of Radiology Pub Date : 2025-09-01 Epub Date: 2025-05-10 DOI: 10.1007/s11604-025-01798-2
Kenichi Utano, Masato Aizawa, Noriyuki Isohata, Yuka Utano, Shungo Endo, Kazutomo Togashi
{"title":"The potential of CT colonography for colorectal cancer screening in Japan.","authors":"Kenichi Utano, Masato Aizawa, Noriyuki Isohata, Yuka Utano, Shungo Endo, Kazutomo Togashi","doi":"10.1007/s11604-025-01798-2","DOIUrl":"10.1007/s11604-025-01798-2","url":null,"abstract":"<p><p>Colorectal cancer remains a leading cause of mortality worldwide, and early detection is essential for improving outcomes. CT colonography (CTC) has emerged as a promising alternative to optical colonoscopy for colorectal cancer screening. This article explores the potential of CTC in Japan, focusing on quality control, patient acceptability, complications, and its role in screening programs. CTC has demonstrated high sensitivity and specificity for detecting colorectal polyps, with its diagnostic performance comparable to colonoscopy for lesions ≥ 10 mm. Techniques such as fecal tagging and dual-position imaging significantly enhance diagnostic accuracy. However, the variability in diagnostic outcomes underscores the need for rigorous interpretation training and quality control. The American College of Radiology recommends training with at least 50 cases verified by colonoscopy. Despite its advantages, the adoption of CTC in Japan remains limited due to low awareness among medical professionals, a shortage of trained radiologists, and the absence of specific guidelines endorsing its use. Patient acceptability for CTC is high due to its non-invasive nature, shorter examination time, and reduced bowel preparation requirements compared to colonoscopy. Nonetheless, complications such as bowel perforation, albeit rare, necessitate careful risk assessment. While CTC has been recognized in the U.S. and Europe for screening and diagnostic follow-up, its integration into Japan's colorectal cancer screening guidelines is crucial to expand its utilization. To maximize the benefits of CTC, efforts must focus on standardizing methodologies, establishing quality indicators, and generating robust evidence on mortality reduction and cost-effectiveness.</p>","PeriodicalId":14691,"journal":{"name":"Japanese Journal of Radiology","volume":" ","pages":"1417-1426"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12397183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brain tissue biomarker impact bone age in central precocious puberty more than hormones: a quantitative synthetic magnetic resonance study. 脑组织生物标志物对中枢性性早熟患者骨年龄的影响大于激素:一项定量合成磁共振研究。
IF 2.1 4区 医学
Japanese Journal of Radiology Pub Date : 2025-09-01 Epub Date: 2025-05-02 DOI: 10.1007/s11604-025-01792-8
Shuang-Shuang Zhong, Feng-Yun Zou, Ya-Yin Deng, Bo-Ya Yin, Xiang Zhou, Xiao-Wen Luo, Li-Shan Shen, Qing-Ling Li, Ruo-Mi Guo
{"title":"Brain tissue biomarker impact bone age in central precocious puberty more than hormones: a quantitative synthetic magnetic resonance study.","authors":"Shuang-Shuang Zhong, Feng-Yun Zou, Ya-Yin Deng, Bo-Ya Yin, Xiang Zhou, Xiao-Wen Luo, Li-Shan Shen, Qing-Ling Li, Ruo-Mi Guo","doi":"10.1007/s11604-025-01792-8","DOIUrl":"10.1007/s11604-025-01792-8","url":null,"abstract":"<p><strong>Objective: </strong>To investigate which brain tissue component volume (BTCV) biomarkers may be more effective than hormones in influencing bone age development in central precocious puberty (CPP).</p><p><strong>Methods: </strong>This retrospective study included 84 children with CPP and 84 controls. Data on cranial synthetic magnetic resonance (SyMR), X-ray bone age, and three hormones were collected. BTCVs-myelin content (MyC), white matter (WM), gray matter (GM), cerebrospinal fluid (CSF), and non-WM/GM/MyC/CSF (NoN)-were obtained from SyMRI. A deep learning model assessed Tanner-Whitehouse III (TW3) bone age scores (TW3-RUS, TW3-Carpal). We evaluated the correlation between BTCVs, bone age scores, luteinizing hormone (LH), LH after gonadotropin-releasing hormone (GnRH) stimulation, and follicle-stimulating hormone (FSH).</p><p><strong>Results: </strong>Children with CPP had lower MyC, WM, and GM than controls. The TW3-RUS score did not correlate with BTCVs or hormones. The TW3-Carpal score was positively correlated with MyC (r = 0.397, P < 0.001) but not with WM, GM, CSF, NoN, or hormones. The regression model showed a positive correlation between the TW3-Carpal score and MyC (β = 0.077, P < 0.001), while LH correlated with GM and NoN (β = - 16.66, P = 0.019; β = 24.62, P = 0.019).</p><p><strong>Conclusion: </strong>The TW3-Carpal score in CPP positively correlates with MyC, while two TW3 scores do not correlate with hormone levels, suggesting myelin has a greater impact on bone age development than hormones. MyC may serve as a potential biomarker in BTCVs for CPP.</p>","PeriodicalId":14691,"journal":{"name":"Japanese Journal of Radiology","volume":" ","pages":"1531-1540"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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