Brain tissue biomarker impact bone age in central precocious puberty more than hormones: a quantitative synthetic magnetic resonance study.

IF 2.1 4区医学

Japanese Journal of Radiology Pub Date : 2025-09-01 Epub Date: 2025-05-02 DOI:10.1007/s11604-025-01792-8

Shuang-Shuang Zhong, Feng-Yun Zou, Ya-Yin Deng, Bo-Ya Yin, Xiang Zhou, Xiao-Wen Luo, Li-Shan Shen, Qing-Ling Li, Ruo-Mi Guo

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引用次数: 0

Abstract

Objective: To investigate which brain tissue component volume (BTCV) biomarkers may be more effective than hormones in influencing bone age development in central precocious puberty (CPP).

Methods: This retrospective study included 84 children with CPP and 84 controls. Data on cranial synthetic magnetic resonance (SyMR), X-ray bone age, and three hormones were collected. BTCVs-myelin content (MyC), white matter (WM), gray matter (GM), cerebrospinal fluid (CSF), and non-WM/GM/MyC/CSF (NoN)-were obtained from SyMRI. A deep learning model assessed Tanner-Whitehouse III (TW3) bone age scores (TW3-RUS, TW3-Carpal). We evaluated the correlation between BTCVs, bone age scores, luteinizing hormone (LH), LH after gonadotropin-releasing hormone (GnRH) stimulation, and follicle-stimulating hormone (FSH).

Results: Children with CPP had lower MyC, WM, and GM than controls. The TW3-RUS score did not correlate with BTCVs or hormones. The TW3-Carpal score was positively correlated with MyC (r = 0.397, P < 0.001) but not with WM, GM, CSF, NoN, or hormones. The regression model showed a positive correlation between the TW3-Carpal score and MyC (β = 0.077, P < 0.001), while LH correlated with GM and NoN (β = - 16.66, P = 0.019; β = 24.62, P = 0.019).

Conclusion: The TW3-Carpal score in CPP positively correlates with MyC, while two TW3 scores do not correlate with hormone levels, suggesting myelin has a greater impact on bone age development than hormones. MyC may serve as a potential biomarker in BTCVs for CPP.

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脑组织生物标志物对中枢性性早熟患者骨年龄的影响大于激素：一项定量合成磁共振研究。

目的：探讨哪些脑组织成分体积（BTCV）生物标志物可能比激素更有效地影响中心性性早熟（CPP）的骨龄发育。方法：回顾性研究84例CPP患儿和84例对照组。采集颅骨合成磁共振（SyMR）、x线骨龄及三种激素的数据。btcvs -髓磷脂含量（MyC），白质（WM），灰质（GM），脑脊液（CSF）和非WM/GM/MyC/CSF (NoN)-通过SyMRI获得。深度学习模型评估Tanner-Whitehouse III （TW3）骨龄评分（TW3- rus, TW3- carpal）。我们评估了BTCVs、骨龄评分、促黄体生成素（LH）、促性腺激素释放激素（GnRH）刺激后的LH和促卵泡激素（FSH）之间的相关性。结果：CPP患儿MyC、WM、GM均低于对照组。TW3-RUS评分与BTCVs或激素无关。TW3- carpal评分与MyC呈正相关（r = 0.397， P）结论：CPP中TW3- carpal评分与MyC呈正相关，而两个TW3评分与激素水平无关，提示髓磷脂对骨龄发育的影响大于激素。MyC可能作为btcv中潜在的CPP生物标志物。

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来源期刊

Japanese Journal of Radiology Medicine-Radiology, Nuclear Medicine and Imaging

自引率

4.80%

发文量

133

期刊介绍： Japanese Journal of Radiology is a peer-reviewed journal, officially published by the Japan Radiological Society. The main purpose of the journal is to provide a forum for the publication of papers documenting recent advances and new developments in the field of radiology in medicine and biology. The scope of Japanese Journal of Radiology encompasses but is not restricted to diagnostic radiology, interventional radiology, radiation oncology, nuclear medicine, radiation physics, and radiation biology. Additionally, the journal covers technical and industrial innovations. The journal welcomes original articles, technical notes, review articles, pictorial essays and letters to the editor. The journal also provides announcements from the boards and the committees of the society. Membership in the Japan Radiological Society is not a prerequisite for submission. Contributions are welcomed from all parts of the world.