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New Frontiers in Gas Phase Chemistry and Catalysis. Celebrating the 80th Birthday of Helmut Schwarz 气相化学和催化的新前沿。庆祝赫尔穆特·施瓦茨80岁生日
IF 3.2 4区 化学
Israel Journal of Chemistry Pub Date : 2023-07-31 DOI: 10.1002/ijch.202300106
Yitzhak Apeloig, Sason Shaik
{"title":"New Frontiers in Gas Phase Chemistry and Catalysis. Celebrating the 80th Birthday of Helmut Schwarz","authors":"Yitzhak Apeloig,&nbsp;Sason Shaik","doi":"10.1002/ijch.202300106","DOIUrl":"10.1002/ijch.202300106","url":null,"abstract":"<p>Helmut Schwarz is a great scientist and a statesman who has made important fundamental contributions to chemistry as a science, and to the globalization of chemistry when he served as the Vice President of the German Research Foundation and subsequently as the President of the Alexander von Humboldt (AvH) Foundation.</p>","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ijch.202300106","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41493648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mode-Selective Vibrational-Tunneling Dynamics in the N=2 Triad of the Hydrogen-Bonded (HF)2 Cluster 氢键(HF)2簇N=2三元组的模式选择振动隧穿动力学
IF 3.2 4区 化学
Israel Journal of Chemistry Pub Date : 2023-07-31 DOI: 10.1002/ijch.202300092
Michael Hippler, Lars Oeltjen, Martin Quack
{"title":"Mode-Selective Vibrational-Tunneling Dynamics in the N=2 Triad of the Hydrogen-Bonded (HF)2 Cluster","authors":"Michael Hippler,&nbsp;Lars Oeltjen,&nbsp;Martin Quack","doi":"10.1002/ijch.202300092","DOIUrl":"10.1002/ijch.202300092","url":null,"abstract":"<p>Rovibrationally resolved spectra of the <i>N</i><sub>j</sub>=2<sub>2</sub>, <i>K</i><sub>a</sub>=0←1 transition and of the <i>N</i><sub>j</sub>=2<sub>3</sub>, <i>K</i><sub>a</sub>=0←0 and <i>K</i><sub>a</sub>=1←0 transitions of the hydrogen-bonded (HF)<sub>2</sub> have been measured in the near infrared range near 1.3 μm by cw-diode laser cavity ring-down spectroscopy in a pulsed supersonic slit jet expansion. The spectroscopic assignment and analysis provided an insight into the dynamics of these highly-excited vibrational states, in particular concerning the predissociation of the hydrogen bond and the tunneling process of the hydrogen bond switching. Together with our previously analyzed spectra of the <i>N</i><sub>j</sub>=2<sub>1</sub> and <i>N</i><sub>j</sub>=2<sub>2</sub> components, the mode-specific dynamics in all three components of this triad can now be compared. In the <i>N</i>=2 triad, the HF-stretching vibration is excited by two quanta with similar excitation energy, but the quanta are distributed in three different ways, which has a distinct influence on the dynamics. The observed band centers and tunneling splittings are in agreement with our recent calculations on the (HF)<sub>2</sub> potential energy hypersurface SO-3, resolving the long-standing discussion about the symmetry ordering of polyad levels in this overtone region. The results are also discussed in relation to the general questions of non-statistical reaction dynamics of polyatomic molecules and clusters and in relation to quasi-adiabatic channel above barrier tunneling.</p>","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ijch.202300092","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45969633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Catalytic Main-Group Metal Complexes of Phosphine-Based Pincer Ligands 膦基钳配体的催化主族金属配合物
IF 3.2 4区 化学
Israel Journal of Chemistry Pub Date : 2023-07-28 DOI: 10.1002/ijch.202300082
Dr. Michael Montag, Prof. David Milstein
{"title":"Catalytic Main-Group Metal Complexes of Phosphine-Based Pincer Ligands","authors":"Dr. Michael Montag,&nbsp;Prof. David Milstein","doi":"10.1002/ijch.202300082","DOIUrl":"10.1002/ijch.202300082","url":null,"abstract":"<p>Pincer ligand complexes, which appeared nearly five decades ago, have provided a valuable platform for the study of fundamental chemical processes and the development of efficient catalysts for many chemical transformations. These complexes have usually contained transition metal atoms or ions, and their respective pincer ligands have often featured phosphine donor groups, which strongly coordinate to the metal center and allow its steric and electronic properties to be fine-tuned. The increasing need to develop cost-effective and sustainable catalytic processes has driven the search for main-group metals as alternatives to commonly-used transition metals. In this review, we show that despite the inherent mismatch between phosphines, which are soft Lewis bases, and main-group metal ions, which are hard Lewis acids, a series of well-defined phosphine-based pincer complexes containing Li(I), Na(I), K(I), Mg(II), Ca(II), Zn(II) and Al(III) have been reported, which have proven to be active catalysts for industrially-relevant transformations.</p>","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ijch.202300082","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42251490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent Advances in Electrochemical, Ni-Catalyzed C−C Bond Formation 电化学、镍催化的C−C键形成的最新进展
IF 3.2 4区 化学
Israel Journal of Chemistry Pub Date : 2023-07-27 DOI: 10.1002/ijch.202300089
Mareena C. Franke, Daniel J. Weix
{"title":"Recent Advances in Electrochemical, Ni-Catalyzed C−C Bond Formation","authors":"Mareena C. Franke,&nbsp;Daniel J. Weix","doi":"10.1002/ijch.202300089","DOIUrl":"10.1002/ijch.202300089","url":null,"abstract":"<p>Nickel-catalyzed cross-electrophile coupling (XEC) is an efficient method to form carbon-carbon bonds and has become an important tool for building complex molecules. While XEC has most often used stoichiometric metal reductants, these transformations can also be driven electrochemically. Electrochemical XEC (<i>e</i>XEC) is attractive because it can increase the greenness of XEC and this potential has resulted in numerous advances in recent years. The focus of this review is on electrochemical, Ni-catalyzed carbon-carbon bond forming reactions reported since 2010 and is categorized by the type of anodic half reaction: sacrificial anode, sacrificial reductant, and convergent paired electrolysis. The key developments are highlighted and the need for more scalable options is discussed.</p>","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ijch.202300089","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42512491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Off/on Switching of Electric Current as a Strategy for One-Pot Synthesis of Bromoarylpyridines by Cross-Coupling/ C−H Bromination 电流开关作为交叉耦合/C−H溴化一锅合成溴酰基吡啶的策略
IF 3.2 4区 化学
Israel Journal of Chemistry Pub Date : 2023-07-24 DOI: 10.1002/ijch.202300087
Yamato Hirota, Takaya Fujie, Takuya Kochi, Fumitoshi Kakiuchi
{"title":"Off/on Switching of Electric Current as a Strategy for One-Pot Synthesis of Bromoarylpyridines by Cross-Coupling/ C−H Bromination","authors":"Yamato Hirota,&nbsp;Takaya Fujie,&nbsp;Takuya Kochi,&nbsp;Fumitoshi Kakiuchi","doi":"10.1002/ijch.202300087","DOIUrl":"10.1002/ijch.202300087","url":null,"abstract":"<p>An “OFF/ON” electric current switching protocol was developed as a new strategy for one-pot organic synthesis. Suzuki-Miyaura coupling of 2-bromopyridines with arylboronic acids in an electrochemical cell was performed without applying an electric current, and subsequently, the Pd-catalyzed electrochemical C−H bromination was conducted using the already-present Pd catalyst to obtain 2-(2-bromoaryl)pyridines as products. The one-pot synthesis of bromoarenes can also be achieved without adding an external Br source in the second step. Furthermore, an OFF/ON/OFF two-times switching protocol also realized the formation of an N-containing teraryl derivative.</p>","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ijch.202300087","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46433381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Direct Electrooxidative Selenylamination of Alkynes: Access to 3-Selenylindoles 炔的直接电氧化硒基层合:获得3‐硒基lindoles
IF 3.2 4区 化学
Israel Journal of Chemistry Pub Date : 2023-07-24 DOI: 10.1002/ijch.202300088
Balati Hasimujiang, Yong Zeng, Shifeng Zou, Kaihui Zhong, Lebin Su, Xinwei Hu, Zhixiong Ruan
{"title":"Direct Electrooxidative Selenylamination of Alkynes: Access to 3-Selenylindoles","authors":"Balati Hasimujiang,&nbsp;Yong Zeng,&nbsp;Shifeng Zou,&nbsp;Kaihui Zhong,&nbsp;Lebin Su,&nbsp;Xinwei Hu,&nbsp;Zhixiong Ruan","doi":"10.1002/ijch.202300088","DOIUrl":"10.1002/ijch.202300088","url":null,"abstract":"<p>A novel metal- and oxidant-free electrooxidative selenylamination of <i>o</i>-aminophenacetylenes with diselenides for achieving 3-selenylindoles has been developed with moderate to excellent yield. The reaction proceeded smoothly with a broad substrate scope and highly functional group tolerance. The synthetic practicality of this innovative approach was demonstrated by its easy scalability. Moreover, mechanistic studies revealed that an in-situ generated selenium cation might be the key intermediate for the electrochemical selenocyclization process.</p>","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47827821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial Siderophores with a Trihydroxamate-DOTAM Scaffold Deliver Iron and Antibiotic Cargo into the Bacterial Pathogen Escherichia coli 具有三羟肟酸盐-DOTAM支架的人工Siderophores将铁和抗生素货物输送到细菌病原体大肠杆菌中
IF 3.2 4区 化学
Israel Journal of Chemistry Pub Date : 2023-07-19 DOI: 10.1002/ijch.202300057
Isabell Schneider, Verena Fetz, Hans-Peter Prochnow, Mark Brönstrup
{"title":"Artificial Siderophores with a Trihydroxamate-DOTAM Scaffold Deliver Iron and Antibiotic Cargo into the Bacterial Pathogen Escherichia coli","authors":"Isabell Schneider,&nbsp;Verena Fetz,&nbsp;Hans-Peter Prochnow,&nbsp;Mark Brönstrup","doi":"10.1002/ijch.202300057","DOIUrl":"10.1002/ijch.202300057","url":null,"abstract":"<p>Infections with multidrug-resistant Gram-negative bacteria constitute a silent pandemic threat that is increasing globally. A major technical and scientific hurdle hampering the development of efficient antibiotics against Gram-negative species is the low permeability of their outer membrane that prevents the entry of most small molecules into the cells. This can be overcome by targeting active iron transport systems of the pathogens in a Trojan-Horse strategy that makes use of drug-loaded artificial siderophores. While we utilized catechols as iron-binding motifs in previous work, this study reports the design, synthesis and characterization of siderophores with a DOTAM scaffold that was substituted with three hydroxamate arms allowing for a hexacoordination of iron. Their iron-chelating capabilities were shown colorimetrically, and the ability of compound <b>1</b> to deliver iron into <i>Escherichia coli</i> in a chelation-specific manner was proven by a growth recovery assay. A covalent siderophore-ciprofloxacin conjugate exerted antibiotic effects against <i>E. coli</i>, albeit it was less potent than the free drug. The study qualifies artificial DOTAM siderophores with hydroxamate binders as scaffolds for bacterial Trojan Horses. This contribution for honoring my mentor Helmut Schwarz echoes two motifs of my work with him: Hydroxylamin, the topic of my first paper ever, and the fascinating properties of iron ions, studied in the gas phase during my Ph.D. Thesis, became a core subject of our current chemical biology research on antiinfectives.</p>","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ijch.202300057","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47724761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of Naphthoquinone Derivatives Non‐Covalently Modified Graphene Nanosheets in Asymmetric Supercapacitors 萘醌衍生物非共价修饰石墨烯纳米片在不对称超级电容器中的应用
IF 3.2 4区 化学
Israel Journal of Chemistry Pub Date : 2023-07-12 DOI: 10.1002/ijch.202300043
Lijie Hou, C. Kong, Zhongai Hu, Yanxia Han, Bowan Wu
{"title":"Application of Naphthoquinone Derivatives Non‐Covalently Modified Graphene Nanosheets in Asymmetric Supercapacitors","authors":"Lijie Hou, C. Kong, Zhongai Hu, Yanxia Han, Bowan Wu","doi":"10.1002/ijch.202300043","DOIUrl":"https://doi.org/10.1002/ijch.202300043","url":null,"abstract":"","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46615834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DNA-Encoded Libraries and Their Application to RNA DNA编码文库及其在RNA中的应用
IF 3.2 4区 化学
Israel Journal of Chemistry Pub Date : 2023-07-10 DOI: 10.1002/ijch.202300073
Xueyi Yang, Dr. Jessica L. Childs-Disney, Prof. M. Paegel, Prof. Matthew D. Disney
{"title":"DNA-Encoded Libraries and Their Application to RNA","authors":"Xueyi Yang,&nbsp;Dr. Jessica L. Childs-Disney,&nbsp;Prof. M. Paegel,&nbsp;Prof. Matthew D. Disney","doi":"10.1002/ijch.202300073","DOIUrl":"10.1002/ijch.202300073","url":null,"abstract":"<p>The functional roles of structured RNAs in the regulation of biological processes, and hence RNA's potential as an effective therapeutic target, have only recently been appreciated. Robust and high-throughput methods that identify potent RNA ligands are critical to the development of chemical probes and therapeutics. DNA-encoded libraries (DEL) technology has emerged as a powerful tool for protein ligand discovery, and its ability to generate large, custom-tailored, and novel chemical space offers unprecedented opportunities to discover the rules of RNA ligand design. In this review, we discuss the basic principles of DEL selection, current progress on the application of DEL to RNA targets, and the outlook of targeting RNA by DEL.</p>","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ijch.202300073","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41687737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Calix[5]arene Self-Folding Cavitands: A New Family of Bio-Inspired Receptors with Enhanced Induced Fit Behavior 杯形[5]芳烃自折叠空腔:具有增强诱导契合行为的生物激发受体新家族
IF 2.3 4区 化学
Israel Journal of Chemistry Pub Date : 2023-07-06 DOI: 10.1002/ijch.202300077
Rubén Álvarez-Yebra, Ricard López-Coll, Núria Clos-Garrido, Dr. David Lozano, Dr. Agustí Lledó
{"title":"Calix[5]arene Self-Folding Cavitands: A New Family of Bio-Inspired Receptors with Enhanced Induced Fit Behavior","authors":"Rubén Álvarez-Yebra,&nbsp;Ricard López-Coll,&nbsp;Núria Clos-Garrido,&nbsp;Dr. David Lozano,&nbsp;Dr. Agustí Lledó","doi":"10.1002/ijch.202300077","DOIUrl":"10.1002/ijch.202300077","url":null,"abstract":"<p>Self-folding cavitands represent the quintessential form of bioinspired synthetic receptors, featuring deep hydrophobic cavities that engage in host-guest chemistry reminiscent of that operating in biomolecules. Although remarkable proof-of-concept applications have been reported, the narrow and rigid spaces of the legacy resorcin[4]arene derived hosts constitute a liability towards the development of specific applications in catalysis, sensing or sequestration. While notable efforts to expand the size of the cavities have been reported, the development of confined spaces reproducing the highly adaptable nature of biological receptors is a largely unaddressed issue. This review summarizes the development of a new family of calix[5]arene derived self-folding cavitands displaying enhanced induced fit and conformational selection phenomena. Our approach capitalizes on hydrogen bonding preorganization rather than the covalent restriction approaches customary of conventional supramolecular chemistry.</p>","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ijch.202300077","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41986278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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