Israel Journal of Chemistry最新文献

Rhodium-Catalyzed Regioselective Addition of N-Hydroxyl Imides to Internal Alkynes 铑催化内炔上n -羟基亚胺的区域选择性加成

IF 2.4 4区化学

Israel Journal of Chemistry Pub Date : 2026-04-02 DOI: 10.1002/ijch.70014

Zi Liu, Bernhard Breit

引用次数: 0

Upcycling Hydrofluorocarbons to Valuable Bis(perfluoroalkyl)carbinols via Nucleophilic Fluoroalkylation 通过亲核氟烷基化将氢氟碳化合物升级为有价值的双（全氟烷基）甲醇

IF 2.4 4区化学

Israel Journal of Chemistry Pub Date : 2026-03-31 DOI: 10.1002/ijch.70015

Hiroto Iwasaki, Masashi Hattori, Norio Shibata

引用次数: 0

Crystal Facets Reactivity in Metal–Organic Frameworks 金属-有机骨架中的晶体切面反应性

IF 2.4 4区化学

Israel Journal of Chemistry Pub Date : 2026-03-31 DOI: 10.1002/ijch.70018

Emilio Borrego-Marin, Jorge A. R. Navarro

{"title":"Crystal Facets Reactivity in Metal–Organic Frameworks","authors":"Emilio Borrego-Marin, Jorge A. R. Navarro","doi":"10.1002/ijch.70018","DOIUrl":"10.1002/ijch.70018","url":null,"abstract":"Crystal facets are intrinsically defective, chemically distinct interfaces whose reactivity critically influences the function of crystalline materials. In reticular porous systems, while internal pore chemistry has been extensively engineered, growing evidence shows that chemical transformations in complex environments increasingly occur at external crystal surfaces. In this mini review, it is highlighted how the crystal facets’ reactivity can be dictated by surface functionality, particle size, defect density, or crystal morphology. Precise control of these parameters enables deliberate exposure of crystal facets, leading to enhanced crystal surface accessibility and higher reactivity. Further focus is placed on frameworks based on hemilabile bonds, whose intermediate bond strength enables dynamic yet structurally persistent crystal surfaces. In these materials, surface-confined reactions can initiate self-propagating cascade processes that extend beyond the crystal surface through controlled bond exchange, lattice degradation, and release of reactive species. This behavior transcends classical surface-limited catalysis and establishes crystal facets as active, information-bearing interfaces. Together, these insights position crystal surface reactivity as a key design parameter for developing functional materials capable of programed cascade chemistry in catalytic and biological contexts.","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":"66 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ijch.70018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147684305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Charge Regulation in Crowded Solutions of a Weak Polyelectrolyte: Steric Interactions 弱聚电解质拥挤溶液中的电荷调节：空间相互作用

IF 2.4 4区化学

Israel Journal of Chemistry Pub Date : 2026-03-31 DOI: 10.1002/ijch.70013

David Attia, Evgenee Yekymov, Rachel Yerushalmi-Rozen

{"title":"Charge Regulation in Crowded Solutions of a Weak Polyelectrolyte: Steric Interactions","authors":"David Attia, Evgenee Yekymov, Rachel Yerushalmi-Rozen","doi":"10.1002/ijch.70013","DOIUrl":"10.1002/ijch.70013","url":null,"abstract":"Weak polyelectrolytes (WPE) are used to prepare responsive materials in a variety ofapplications. When dissolved in highly crowded environments, of biorelevant media or synthetic complex fluids, that contain substantial concentrations of macromolecules, molecular assemblies, or nanoparticles, WPE exhibit deviations from the acid–base equilibrium observed in single-component solutions. In this mini review, studies of charge regulation (CR) are described in simple yet relevant model systems comprising poly (acrylic acid) (PAA) and high concentrations of non-charged micelles (Pluronic) or nonadsorbing, short chains of poly (vinyl alcohol) (PVA). Titration experiments reveal in the first mixture significant reduction in the degree of ionization of the PAA. In PAA–PVA mixtures, an unexpected increase in the degree of ionization of PAA is observed. Structural characterization of the solutions, via transmission electron microscopy and small-angle X-ray scattering, reveals that the local organization is affected by the interaction between PAA chains and the additives, leading to crowding of the micelles in one case, and crowding of the PAA chains in the other. These systems provide insights into the molecular mechanisms leading to the responsiveness of WPE and the effect of crowding on CR.","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":"66 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ijch.70013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147684306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ruppert–Prakash Reagent as a Source of Difluorocarbene: Mechanistic, Synthetic, and Practical Perspectives for Small-Ring Synthesis 鲁伯特-普拉卡什试剂作为二氟烃的来源：小环合成的机理、合成和实用前景

IF 2.4 4区化学

Israel Journal of Chemistry Pub Date : 2026-03-27 DOI: 10.1002/ijch.70012

Serhiy V. Ryabukhin, Pavel S. Nosik, Dmytro O. Leha, Dmytro M. Volochnyuk

{"title":"Ruppert–Prakash Reagent as a Source of Difluorocarbene: Mechanistic, Synthetic, and Practical Perspectives for Small-Ring Synthesis","authors":"Serhiy V. Ryabukhin, Pavel S. Nosik, Dmytro O. Leha, Dmytro M. Volochnyuk","doi":"10.1002/ijch.70012","DOIUrl":"https://doi.org/10.1002/ijch.70012","url":null,"abstract":"The Ruppert–Prakash reagent (TMSCF3) has become one of the most practical and widely used sources of difluorocarbene, enabling the efficient construction of gem-difluorocyclopropane and gem-difluorocyclopropene frameworks. Over the past decade, significant progress has been made in understanding its initiation pathways, reactivity patterns, and the factors that control reaction efficiency and safety. This review summarizes these advances, covering both mechanistic insights and the broad synthetic scope of TMSCF3-mediated transformations of alkenes, alkynes, and functionalized complex substrates, mostly leading to three- and four-membered rings. Particular attention is given to strategies that enhance practicality, including “slow addition,” catalytic approaches, and flow chemistry to enable safe handling and scale-up. The emerging structural diversity now accessible through these protocols highlights the growing importance of difluorinated small rings in modern molecular design. Together, these developments establish TMSCF3 as a cornerstone reagent for difluorocarbene chemistry, pointing toward promising opportunities for future discovery.","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":"66 2","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147615201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Use of the Legendre Transform in Chemical Thermodynamics: A Powerful Tool 勒让德变换在化学热力学中的应用：一个强大的工具

IF 2.4 4区化学

Israel Journal of Chemistry Pub Date : 2026-03-27 DOI: 10.1002/ijch.70010

Renato Veríssimo de Oliveira, Luiz Daniel Alves Rios, Norberto de Kássio Vieira Monteiro

引用次数: 0

Biodegradation of Tissue Separation Spacer Implant 组织分离垫片植入物的生物降解

IF 2.4 4区化学

Israel Journal of Chemistry Pub Date : 2026-03-27 DOI: 10.1002/ijch.70005

Muhammad Abd El-haq, Awanish Kumar, Yuval Ramot, Abraham Nyska, Abraham J. Domb

{"title":"Biodegradation of Tissue Separation Spacer Implant","authors":"Muhammad Abd El-haq, Awanish Kumar, Yuval Ramot, Abraham Nyska, Abraham J. Domb","doi":"10.1002/ijch.70005","DOIUrl":"https://doi.org/10.1002/ijch.70005","url":null,"abstract":"The biodegradation of inflated spacers made of PLCL 70:30 (poly(L-lactide-co-ε-caprolactone)) is investigated. This spacer is intended to temporarily position the anterior rectal wall away from the prostate during radiotherapy of prostate cancer. When inflated with phosphate buffer solution, this spacer implant creates space in the anterior rectum, thereby reducing radiation-induced damage. The mechanical stability of such inflated biodegradable systems over time is highly compromised, and their stability is uncertain due to continuous hydrolysis of the polymer material and imbalance with the muscular pressure that constantly acts on the inflated implant. Herein, detailed in vitro and in vivo degradation data of the inflated spacer are reported and correlated with its stability under a constant mechanical pressure that impersonates the pressure created by the anterior rectum on the spacers. The mechanical and physicochemical test results have a direct correlation with the degradation profile of the PLCL material. Mechanical testing demonstrates spacer inflation for at least 13 weeks.","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":"66 2","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ijch.70005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147615200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorinated Poly(Aryl Ether) Superacidic Ionomers 氟化聚芳基醚超酸性离聚物

IF 2.4 4区化学

Israel Journal of Chemistry Pub Date : 2026-02-15 DOI: 10.1002/ijch.70011

Ying Chang, Chulsung Bae

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Porous Nanocellulose-Reinforced Polyacrylamide Hybrid Hydrogels for Tissue Engineering 用于组织工程的多孔纳米纤维素增强聚丙烯酰胺杂化水凝胶

IF 2.4 4区化学

Israel Journal of Chemistry Pub Date : 2026-02-12 DOI: 10.1002/ijch.70006

Amir Rudich, Idan Carmon, Daniel Voignac, Shylee Belsey, Ido Simon, Alexander Greenberg, Nardi Caspi, Mona Dvir-Ginzberg, Oded Shoseyov

{"title":"Porous Nanocellulose-Reinforced Polyacrylamide Hybrid Hydrogels for Tissue Engineering","authors":"Amir Rudich, Idan Carmon, Daniel Voignac, Shylee Belsey, Ido Simon, Alexander Greenberg, Nardi Caspi, Mona Dvir-Ginzberg, Oded Shoseyov","doi":"10.1002/ijch.70006","DOIUrl":"https://doi.org/10.1002/ijch.70006","url":null,"abstract":"Hydrogels emerge as promising scaffolds in tissue engineering due to their high water content and tunable mechanical and structural properties. However, balancing biocompatibility with mechanical strength remains a key challenge, especially when introducing porosity, which is crucial for cell population of the scaffold structure, subsequent proliferation and efficient mass transfer of nutrients and waste. Herein, a macroporous hydrogel scaffold composed of polyacrylamide (PAAM) and nanocellulose is presented, in which porosity is introduced via CO2 generation from sodium bicarbonate decomposition during polymerization. This approach enables tunable pore architecture with minimal compromise to structural integrity, maintaining high resilience under mechanical deformation. Building on prior work demonstrating enhanced mechanical performance and cytocompatibility through nanocellulose reinforcement, this hydrogel system is now explored for cartilage tissue engineering. In vitro studies with human chondrocytes demonstrate enhanced cell adhesion, proliferation, and infiltration in scaffolds with intermediate porosity (≈300 μm), correlating with improved swelling dynamics. The hydrogel's resilience, tunable porosity, and cytocompatibility suggest its strong potential as a customizable scaffold for regenerating load-bearing, extracellular matrix-rich tissues such as cartilage.","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":"66 2","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ijch.70006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146176443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Discovery on Metal-Free Construction of S-Aryl Phosphorothioate Diesters s -芳基硫代磷酸二酯无金属结构的新发现

IF 2.4 4区化学

Israel Journal of Chemistry Pub Date : 2026-01-28 DOI: 10.1002/ijch.70008

Jayshree Nandkumar Solanke, Savita Gat, Rambabu Dandela, Vasudevan Dhayalan

引用次数: 0