JAMA Pediatrics最新文献

{"title":"Addressing Inequities in Breastfeeding and Beyond.","authors":"Cristina R Fernández, Valerie J Flaherman","doi":"10.1001/jamapediatrics.2024.6807","DOIUrl":"https://doi.org/10.1001/jamapediatrics.2024.6807","url":null,"abstract":"","PeriodicalId":14683,"journal":{"name":"JAMA Pediatrics","volume":" ","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Blood Pressure Tracks-Salty and Secondary Causes-Reply.","authors":"Yaxing Meng, Olli T Raitakari, Costan G Magnussen","doi":"10.1001/jamapediatrics.2025.0045","DOIUrl":"https://doi.org/10.1001/jamapediatrics.2025.0045","url":null,"abstract":"","PeriodicalId":14683,"journal":{"name":"JAMA Pediatrics","volume":" ","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SARS-CoV-2 Infection and Childhood Islet Autoimmunity.","authors":"Gregory J Walker, Kylie-Ann Mallitt, Maria E Craig, Pat Ashwood, Simon C Barry, James D Brown, Joanna Caguicla, Elizabeth A Davis, Emma E Hamilton-Williams, Leonard C Harrison, Aveni Haynes, Tony Huynh, Guinevere Martin, Kelly J McGorm, Grant Morahan, Zin Naing, Helena Oakey, Megan A S Penno, Andrea Sevendal, Richard O Sinnott, Georgia Soldatos, Rebecca L Thomson, Jason Tye-Din, Peter J Vuillermin, Emily J Ward, John M Wentworth, Peter G Colman, Jennifer J Couper, Ki Wook Kim, William D Rawlinson","doi":"10.1001/jamapediatrics.2024.6848","DOIUrl":"10.1001/jamapediatrics.2024.6848","url":null,"abstract":"","PeriodicalId":14683,"journal":{"name":"JAMA Pediatrics","volume":" ","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11877402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ATP1A3 Variants, Variably Penetrant Short QT Intervals, and Lethal Ventricular Arrhythmias","authors":"Mary E. Moya-Mendez, Minu-Tshyeto Bidzimou, Padmapriya Muralidharan, Zhushan Zhang, Jordan E. Ezekian, Robin M. Perelli, Lauren E. Parker, Lyndsey Prange, April Boggs, Jeffrey J. Kim, Taylor S. Howard, Tarah A. Word, Xander H. T. Wehrens, Gabriela Reyes Valenzuela, Roberto Caraballo, Giacomo Garone, Federico Vigevano, Sarah Weckhuysen, Charissa Millevert, Monica Troncoso, Mario Matamala, Simona Balestrini, Sanjay M. Sisodiya, Josephine Poole, Claudio Zucca, Eleni Panagiotakaki, Maria T. Papadopoulou, Sébile Tchaicha, Marta Zawadzka, Maria Mazurkiewicz-Bełdzińska, Carmen Fons, Jennifer Anticona, Elisa De Grandis, Ramona Cordani, Livia Pisciotta, Sergiu Groppa, Sandra Paryjas, Francesca Ragona, Elena Mangia, Tiziana Granata, Andrey Megvinov, Mirjana Pavlicek, Kevin Ess, Christine Q. Simmons, Alfred L. George, Rosaria Vavassori, Mohamad A. Mikati, Andrew P. Landstrom","doi":"10.1001/jamapediatrics.2024.6832","DOIUrl":"https://doi.org/10.1001/jamapediatrics.2024.6832","url":null,"abstract":"ImportanceAlternating hemiplegia of childhood (AHC) is a disorder that can result from pathogenic variants in <jats:italic>ATP1A3</jats:italic>-encoded sodium-potassium adenosine triphosphatase alpha 3 (ATP1A3). While AHC is primarily a neurologic disease, some individuals experience sudden unexplained death (SUD) potentially associated with cardiac arrhythmias.ObjectiveTo determine the impact of <jats:italic>ATP1A3</jats:italic> variants on cardiac electrophysiology and whether lethal ventricular arrhythmias are associated with SUD in patients with AHC.Design, Setting, and ParticipantsIn this international, multicenter case-control study from 12 centers across 10 countries, patients with AHC were grouped by <jats:italic>ATP1A3</jats:italic> variant status (positive vs negative) and into subgroups with the most common AHC variants (D801N, E815K, G947R, and other). A healthy control cohort was established for comparison. Blinded, manual measurements of QT intervals and corrected QT interval (QTc) were performed independently by 2 pediatric cardiac electrophysiologists. Induced pluripotent stem cell cardiomyocytes were derived from patients with AHC who were positive for the D801N variant of <jats:italic>ATP1A3</jats:italic> (iPSC-CM<jats:sup>D801N</jats:sup> cells). Data analysis was performed from April to June 2022.ExposurePresence of <jats:italic>ATP1A3</jats:italic> variant.Main Outcomes and MeasuresThe primary outcome was QTc. Outcomes, including survival, were abstracted and variants were mapped on cryogenic electron microscopy structure maps. iPSC-CM<jats:sup>D801N</jats:sup> cells were used to validate ventricular repolarization and arrhythmic susceptibility in vitro.ResultsAmong the 222 individuals included (148 with AHC and 74 control), the mean (SD) age at diagnostic electrocardiography was 11.0 (9.4) years and 119 (54%) were female. The cohort with AHC consisted of 148 largely unrelated probands (mean [SD] age at diagnostic electrocardiography, 11.5 [10.5] years). Of these, 123 individuals were <jats:italic>ATP1A3</jats:italic> genotype positive, including 35 (28%) with the D801N variant, 21 (17%) with the E815K variant, 8 (7%) with the G947R variant, and 8 (7%) with a loss-of-function variant. Probands with the D801N variant had shorter mean (SD) QTcs (381.8 [36.6] milliseconds; 24 [69%] with QTc <370 milliseconds) compared with those who had the E815K variant (393.6 [43.1] milliseconds; <jats:italic>P</jats:italic> = .001; 4 [19%] with QTC <370 milliseconds), the G947R variant (388.4 [26.5] milliseconds; <jats:italic>P</jats:italic> = .02; 1 [13%] with QTc <370 milliseconds), a loss-of-function variant (403.0 [33.5] milliseconds; <jats:italic>P</jats:italic> < .001; 1 [13%] with QTc <370 milliseconds), all other variants (387.8 [37.1] milliseconds; <jats:italic>P</jats:italic> < .001; 44 [86%] with QTc <370 milliseconds), and healthy controls (415.4 [21.0] m","PeriodicalId":14683,"journal":{"name":"JAMA Pediatrics","volume":"29 1","pages":""},"PeriodicalIF":26.1,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rates of Population-Level Child Sexual Abuse After a Community-Wide Preventive Intervention","authors":"Jennie G. Noll, Johnny Felt, Justin Russotti, Kate Guastaferro, Sunshine Day, Zachary Fisher","doi":"10.1001/jamapediatrics.2024.6824","DOIUrl":"https://doi.org/10.1001/jamapediatrics.2024.6824","url":null,"abstract":"ImportanceChild sexual abuse (CSA) impacts 15% of girls and 8% of boys worldwide, incurring high public costs and devastating consequences for survivors. US incidence rates have stagnated over the past 15 to 20 years, signaling a dire need for innovation in primary prevention. In 2024, the US Preventive Services Task Force reported that there is insufficient evidence for the effectiveness of child abuse preventive strategies, and none have shown decreases in incidence rates at the population level.ObjectiveTo test whether a coordinated, community-wide preventive intervention could significantly reduce population-level incidence rates of CSA.Design, Setting, and ParticipantsThis population cohort study used synthetic control methods with a counterfactual condition and CSA incidence data from a statewide child welfare information system. Participants included a population-based sample in the state of Pennsylvania.InterventionFrom 2018 through 2020, the state of Pennsylvania launched a 3-pronged CSA prevention intervention in 5 counties that included: (1) exposing 5% of the adult population (approximately 72 000) to online and in-person trainings with an accompanying countywide media campaign, (2) delivering a psychoeducation program to 100% of second-grade students (approximately 17 000), and (3) providing parent training to 100% of parents served by the child welfare system (approximately 300). Intervention counties were a priori matched to 1 of 5 control counties based on population size and preintervention CSA rates.Main Outcomes and MeasuresAggregate rates of both substantiated and unsubstantiated CSA reports were examined across intervention and control counties for 5 preintervention years and 3 postintervention years.ResultsWithin 1 year of intervention launch, CSA reports were significantly reduced in intervention counties, as compared with control counties for both substantiated (average treatment of the treated [ATT] = −17.22; 95% CI, −34.15 to −4.20) and unsubstantiated reports (ATT = −36.04; 95% CI, −74.40 to −3.88).ConclusionsIn this evaluation of a place-based, coordinated, countywide intervention, reports of both substantiated and unsubstantiated CSA were shown to be significantly reduced at the population level.","PeriodicalId":14683,"journal":{"name":"JAMA Pediatrics","volume":"8 1","pages":""},"PeriodicalIF":26.1,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Levels of Satisfaction and Regret Are Far From Settled.","authors":"Joanne Sinai, Chan Kulatunga-Moruzi, Sarah Jorgensen","doi":"10.1001/jamapediatrics.2025.0004","DOIUrl":"https://doi.org/10.1001/jamapediatrics.2025.0004","url":null,"abstract":"","PeriodicalId":14683,"journal":{"name":"JAMA Pediatrics","volume":" ","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breastfeeding Support Provided by Lactation Consultants","authors":"Curtis J. D’Hollander, Victoria A. McCredie, Elizabeth M. Uleryk, Michaela Kucab, Rosella M. Le, Ofri Hayosh, Charles D. G. Keown-Stoneman, Catherine S. Birken, Jonathon L. Maguire","doi":"10.1001/jamapediatrics.2024.6810","DOIUrl":"https://doi.org/10.1001/jamapediatrics.2024.6810","url":null,"abstract":"ImportanceBreast milk offers numerous health benefits, yet breastfeeding recommendations are met less than half of the time in high-income countries.ObjectiveTo evaluate the effect of lactation consultant (LC) interventions on breastfeeding, maternal breastfeeding self-efficacy, and infant growth compared to usual care.Data SourcesThe Cochrane Central Register of Controlled Trials, MEDLINE, Embase, CINAHL, Scopus, Web of Science, and the gray literature were searched for articles published between January 1985 and July 2024. The search took place on July 10, 2024, and data analysis was performed from July to August 2024.Study SelectionRandomized clinical trials of LC interventions in high-income countries published in any language were eligible for inclusion.Data Extraction and SynthesisData extracted included study design, participant and intervention characteristics, and outcome data. To account for studies that reported outcomes at multiple time points, effect estimates were pooled with 3-level correlated and hierarchical effects models. Meta-regression was performed for clinically important characteristics, such as the time point when the outcome was measured, intervention intensity, and participant income.Main Outcomes and MeasuresThe primary outcome was stopping exclusive breastfeeding. Secondary outcomes included stopping any breastfeeding, exclusive breastfeeding and any breastfeeding duration, maternal breastfeeding self-efficacy, infant overweight and obesity, and infant growth.ResultsThe search yielded 6476 records, of which 40 studies were included involving 8582 participants. Studies were published between 1992 and 2024, and most studies (n = 22) were conducted in the US. Compared to usual care, LC interventions reduced the risk of stopping exclusive breastfeeding (risk ratio [RR], 0.96; 95% CI, 0.94-0.99) and any breastfeeding (RR, 0.92; 95% CI, 0.87-0.96) and increased any breastfeeding duration by 3.63 weeks (95% CI, 0.13-7.12). There was weak evidence that LC interventions increased exclusive breastfeeding duration (mean difference [MD], 1.44 weeks; 95% CI, −2.73 to 5.60), maternal breastfeeding self-efficacy (MD, 2.83; 95% CI, −1.23 to 6.90), or the risk of infant overweight and obesity (RR, 1.52; 95% CI, 0.94-2.46). Meta-regression showed that LC interventions were more effective at reducing the risk for stopping exclusive breastfeeding (<jats:italic>P</jats:italic> = .01) and any breastfeeding (<jats:italic>P</jats:italic> &amp;amp;lt; .001) the earlier that breastfeeding was measured in the postpartum period. LC interventions with a higher intensity (ie, number of LC visits) were more effective at reducing the risk for stopping any breastfeeding (<jats:italic>P</jats:italic> = .04).Conclusions and RelevanceAccording to the results of this systematic review and meta-analysis, LC interventions are a promising intervention for improving exclusive breastfeeding and any breastfeeding in high-income countries.","PeriodicalId":14683,"journal":{"name":"JAMA Pediatrics","volume":"34 1","pages":""},"PeriodicalIF":26.1,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Error in Table.","authors":"","doi":"10.1001/jamapediatrics.2025.0192","DOIUrl":"10.1001/jamapediatrics.2025.0192","url":null,"abstract":"","PeriodicalId":14683,"journal":{"name":"JAMA Pediatrics","volume":" ","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11877400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Blood Pressure Tracks-Salty and Secondary Causes.","authors":"Federico Bernardo Rossi, Giulio Cabrelle, Giacomo Rossitto","doi":"10.1001/jamapediatrics.2025.0048","DOIUrl":"https://doi.org/10.1001/jamapediatrics.2025.0048","url":null,"abstract":"","PeriodicalId":14683,"journal":{"name":"JAMA Pediatrics","volume":" ","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Child and Neighborhood-Level Factors and Violent Reinjury Among Children With Firearm Injuries","authors":"Samaa Kemal, Matt Hall, Michelle L. Macy, Joel A. Fein, Clemens Noelke, Karen M. Sheehan, Jay G. Berry","doi":"10.1001/jamapediatrics.2024.6842","DOIUrl":"https://doi.org/10.1001/jamapediatrics.2024.6842","url":null,"abstract":"This cross-sectional study assesses the association between Child Opportunity Index and revisits for violent reinjury among children within 1 year of an index firearm-related injury.","PeriodicalId":14683,"journal":{"name":"JAMA Pediatrics","volume":"66 1","pages":""},"PeriodicalIF":26.1,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}