JAMA Pediatrics最新文献

{"title":"Role of Biomarkers in Acute Brain Injury During ECMO Support.","authors":"Roberto Lorusso,Eddy Fan","doi":"10.1001/jamapediatrics.2026.0387","DOIUrl":"https://doi.org/10.1001/jamapediatrics.2026.0387","url":null,"abstract":"","PeriodicalId":14683,"journal":{"name":"JAMA Pediatrics","volume":"17 1","pages":""},"PeriodicalIF":26.1,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147495011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep Health Dimensions From Wearables and Transdiagnostic Mental Health in Young Adolescents.","authors":"Rebecca E Cooper,Amanda E Baker,Allysa D Quick,Lan Yu,Raul Gonzalez,Duncan B Clark,Dana L McMakin,Adriane M Soehner,Maria Jalbrzikowski,Meredith L Wallace","doi":"10.1001/jamapediatrics.2026.0335","DOIUrl":"https://doi.org/10.1001/jamapediatrics.2026.0335","url":null,"abstract":"ImportanceSleep behavior markedly shifts in adolescence, increasing vulnerability to mental health disorders. Although sleep health is understood to be multidimensional, adolescent-specific sleep health dimensions have not been empirically validated and their relevance to transdiagnostic mental health outcomes is unknown.ObjectiveTo identify sleep health dimensions using Fitbit devices in a large sample of young adolescents and assess concurrent and prospective associations between sleep health dimensions and transdiagnostic mental health outcomes.Design, Setting, and ParticipantsMulticenter longitudinal cohort study using data from 3393 participants in the Adolescent Brain Cognitive Development (ABCD) Study (Data Release 5.1, collected 2018-2020), including early adolescents (ages 11-13 years) within the US. Exploratory factor analysis (EFA) was used to identify sleep health dimensions and confirmatory factor analysis (CFA) to confirm the factor structure in an independent subsample. Linear mixed-effects models were used to test concurrent and prospective associations between sleep dimensions and mental health outcomes at 1-year follow-up. Statistical analysis was conducted from January to November 2025.ExposuresObjective sleep data collected for up to 21 (range, 7-21) days, using wearable Fitbit devices.Main Outcomes and MeasuresTransdiagnostic mental health outcomes assessed via the Child Behavior Checklist and Brief Problem Monitor (internalizing and externalizing symptoms), Prodromal Questionnaire-Brief Child Version (psychoticlike symptoms), and 10-item Mania Scale (mania symptoms).ResultsThe 3393 participants (49% female; median age, 12 years) were split into EFA and CFA subsamples. Six sleep factors were identified using EFA: irregularity, timing, social jetlag, duration, weekend oversleep, and continuity. CFA confirmed this factor structure. All variables loaded strongly (≥0.64) onto at least 1 factor (factor 1 loadings, 0.64-0.98; factor 2, 0.96-0.98; factor 3, 0.95-0.97; factor 4, -0.86 to 1.01; factor 5, 0.68-0.93; factor 6, 0.82-0.94). Greater sleep irregularity was associated with transdiagnostic mental health symptoms cross-sectionally, but not prospectively (β, 0.06 [95% CI, 0.02-0.10] to 0.12 [95% CI, 0.08-0.16]). Shorter duration was associated with total, internalizing, externalizing, and attention symptoms cross-sectionally (β, -0.06 [95% CI, -0.10 to -0.01] to -0.11 [95% CI, -0.15 to -0.06]) and total, attention, and psychotic symptoms 1 year later.Conclusions and RelevanceIn this study, wearable Fitbit data provide empirical support for multidimensional frameworks of sleep health in adolescence. Although effect sizes were small, sleep irregularity and duration emerged as key dimensions with relevance to mental health. These findings establish a foundation for future investigations, including examining within-person patterns of the 6 dimensions, extending to older adolescence, investigating associations with other health outc","PeriodicalId":14683,"journal":{"name":"JAMA Pediatrics","volume":"37 1","pages":""},"PeriodicalIF":26.1,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147495012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generative AI in Adolescence—A Developmental Framework","authors":"Cindy H. Liu, Tiffany Yip","doi":"10.1001/jamapediatrics.2026.0032","DOIUrl":"https://doi.org/10.1001/jamapediatrics.2026.0032","url":null,"abstract":"This Viewpoint describes the engagement of generative artificial intelligence (AI) as a relational partner among adolescents and how to set research priorities in order to pay immediate attention to the developmental risks and benefits.","PeriodicalId":14683,"journal":{"name":"JAMA Pediatrics","volume":"126 1","pages":""},"PeriodicalIF":26.1,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147461803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coding Error in Dataset of Study of Behavior Problems in Low-Income Young Children Screened in Pediatric Primary Care.","authors":"Robert T Ammerman","doi":"10.1001/jamapediatrics.2026.0272","DOIUrl":"https://doi.org/10.1001/jamapediatrics.2026.0272","url":null,"abstract":"","PeriodicalId":14683,"journal":{"name":"JAMA Pediatrics","volume":"26 1","pages":""},"PeriodicalIF":26.1,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147465493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Effectiveness of Antihypertensive Medications in Children With Chronic Kidney Disease.","authors":"Michelle R Denburg,Amy J Goodwin Davies,Mitchell G Maltenfort,Mark M Mitsnefes,Joseph T Flynn,Alicia M Neu,Bradley P Dixon,Dorey A Glenn,Caroline A Gluck,Lyndsay A Harshman,Chryso P Katsoufis,Mary B Leonard,Zubin J Modi,Cynthia G Pan,Hiren P Patel,Larry T Patterson,Priya S Verghese,Amy C Wilson,Aneta Jovanovska,Rebecca Levondosky,Mark Levondosky,Kimberley Dickinson,Kaleigh Wieand,Hanieh Razzaghi,Lu Li,Yong Chen,Christopher B Forrest, ","doi":"10.1001/jamapediatrics.2026.0207","DOIUrl":"https://doi.org/10.1001/jamapediatrics.2026.0207","url":null,"abstract":"ImportanceHypertension is a major modifiable factor for kidney function decline in chronic kidney disease (CKD). Comparative trials of antihypertensive medications in pediatric CKD are lacking.ObjectiveTo evaluate the comparative effectiveness of renin-angiotensin-aldosterone system inhibition (RAASi) vs calcium channel blockade (CCB), the most widely used first-line antihypertensive treatment approaches in pediatric CKD, on preservation of kidney function.Design, Setting, and ParticipantsUsing target trial emulation methods, this comparative-effectiveness study emulated a pragmatic, open-label clinical trial using electronic health record data from the Preserving Kidney Function in Children with CKD (PRESERVE) study from January 2009 through December 2020. Thirteen health care institutions from 5 PCORnet Clinical Research Networks were represented. Children and adolescents aged 2 to 20.9 years with CKD stage 2-4 and systolic blood pressure higher than the 90th percentile or with a hypertension diagnosis who initiated treatment with RAASi or CCB were included. Exclusion criteria included kidney replacement therapy, renal artery stenosis, malignancy, and pregnancy. Data analysis was completed in July 2025.ExposuresIncident RAASi or CCB treatment. Randomization was emulated by propensity score weighting to balance groups on sociodemographic factors, institution, year, CKD etiology, proteinuria, CKD stage, obesity, health care use, medications, comorbidities, and blood pressure control (percentage of time at greater than the 90th percentile).Main Outcomes and MeasuresThe primary outcome was progression to kidney replacement therapy within 2 years of follow-up, ascertained through linkage with the United States Renal Data System. The secondary outcome was a composite of kidney replacement therapy, 50% decline in estimated glomerular filtration rate, or estimated glomerular filtration rate less than 15 mL/min/1.73 m2. Cox proportional hazards regression with propensity score stratification was used to estimate adjusted hazard ratios (aHRs) in the intention-to-treat analysis. Adjusted analyses also compared systolic blood pressure control within 2 years of follow-up.ResultsOf 2762 children and adolescents, 1757 initiated RAASi (median [IQR] age, 13.1 [9.2-15.5] years; 897 [51.1%] male) and 1005 initiated CCB (median [IQR] age, 12.6 [8.4-15.3] years; 500 [49.8%] male). In adjusted analyses, RAASi was associated with reduced risk of both kidney replacement therapy (aHR, 0.58; 95% CI, 0.40-0.84, P = .004) and the secondary composite outcome (aHR, 0.67; 95% CI, 0.53-0.83). Systolic blood pressure control was better with RAASi than CCB (29% vs 39% of time >90th percentile).Conclusions and RelevanceIn this comparative-effectiveness study, RAASi was associated with lower risk of CKD progression and better blood pressure control compared to CCB. Findings support first-line use of RAASi for antihypertensive treatment in pediatric CKD.","PeriodicalId":14683,"journal":{"name":"JAMA Pediatrics","volume":"20 1","pages":""},"PeriodicalIF":26.1,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147465491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Missed Opportunities for Human Papillomavirus Vaccination Before Sexual Debut Among Adolescents","authors":"Brian P. Jenssen, Priyani Sharma, Mary Kate Kelly, Maura Powell, Alexander G. Fiks, Stephanie L. Mayne","doi":"10.1001/jamapediatrics.2026.0090","DOIUrl":"https://doi.org/10.1001/jamapediatrics.2026.0090","url":null,"abstract":"This cross-sectional study examines factors associated with missed opportunities to vaccinate adolescents for human papillomavirus before sexual debut, using survey data linked to vaccination records within a large pediatric network.","PeriodicalId":14683,"journal":{"name":"JAMA Pediatrics","volume":"13 1","pages":""},"PeriodicalIF":26.1,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147461804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital Media, Attention Fracking, and Youth Mental Health","authors":"D. Graham Burnett, James D. Sargent","doi":"10.1001/jamapediatrics.2026.0055","DOIUrl":"https://doi.org/10.1001/jamapediatrics.2026.0055","url":null,"abstract":"This Viewpoint discusses the correlation between increasing social media and device usage, the underlying business model of the attention economy, and declines in youth mental health and proposes solutions to address this.","PeriodicalId":14683,"journal":{"name":"JAMA Pediatrics","volume":"81 1","pages":""},"PeriodicalIF":26.1,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147462190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"JAMA Pediatrics Peer Reviewers in 2025.","authors":"","doi":"10.1001/jamapediatrics.2026.0385","DOIUrl":"https://doi.org/10.1001/jamapediatrics.2026.0385","url":null,"abstract":"","PeriodicalId":14683,"journal":{"name":"JAMA Pediatrics","volume":" ","pages":"e260385"},"PeriodicalIF":18.0,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147467902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Annual Trends in Unmet Health Care Needs Among Children With Autism Spectrum Disorder","authors":"Tingxuan Wang, James D. Lee, Wen Zhang","doi":"10.1001/jamapediatrics.2026.0046","DOIUrl":"https://doi.org/10.1001/jamapediatrics.2026.0046","url":null,"abstract":"This survey study identifies the prevalence of unmet medical, dental, vision, hearing, mental, and general health care needs of autistic children from 2016 to 2023.","PeriodicalId":14683,"journal":{"name":"JAMA Pediatrics","volume":"1 1","pages":""},"PeriodicalIF":26.1,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147462189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The US Advisory Committee on Immunization Practices Dismantled","authors":"Mark C. Navin, Lainie F. Ross","doi":"10.1001/jamapediatrics.2026.0415","DOIUrl":"https://doi.org/10.1001/jamapediatrics.2026.0415","url":null,"abstract":"This Viewpoint discusses the dismissal of vaccine recommendations from medical professional groups, including the US Advisory Committee on Immunization Practices.","PeriodicalId":14683,"journal":{"name":"JAMA Pediatrics","volume":"36 1","pages":""},"PeriodicalIF":26.1,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147462158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}