JAMA PediatricsPub Date : 2025-03-03DOI: 10.1001/jamapediatrics.2025.0007
Carlos Blanco, Nora D Volkow
{"title":"Opportunities and Needs to Advance Prevention of Substance Use Disorders.","authors":"Carlos Blanco, Nora D Volkow","doi":"10.1001/jamapediatrics.2025.0007","DOIUrl":"https://doi.org/10.1001/jamapediatrics.2025.0007","url":null,"abstract":"","PeriodicalId":14683,"journal":{"name":"JAMA Pediatrics","volume":" ","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JAMA PediatricsPub Date : 2025-03-01DOI: 10.1001/jamapediatrics.2024.5539
Steven M Levy
{"title":"Caution Needed in Interpreting the Evidence Base on Fluoride and IQ.","authors":"Steven M Levy","doi":"10.1001/jamapediatrics.2024.5539","DOIUrl":"10.1001/jamapediatrics.2024.5539","url":null,"abstract":"","PeriodicalId":14683,"journal":{"name":"JAMA Pediatrics","volume":" ","pages":"231-234"},"PeriodicalIF":24.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JAMA PediatricsPub Date : 2025-03-01DOI: 10.1001/jamapediatrics.2024.5594
Laura Widman, Reina Evans-Paulson, Anne J Maheux, Jordyn McCrimmon, Julia Brasileiro, Claire D Stout, Aaron Lankster, Sophia Choukas-Bradley
{"title":"Identifying the Strongest Correlates of Condom Use Among US Adolescents: A Systematic Review and Meta-Analysis.","authors":"Laura Widman, Reina Evans-Paulson, Anne J Maheux, Jordyn McCrimmon, Julia Brasileiro, Claire D Stout, Aaron Lankster, Sophia Choukas-Bradley","doi":"10.1001/jamapediatrics.2024.5594","DOIUrl":"10.1001/jamapediatrics.2024.5594","url":null,"abstract":"<p><strong>Importance: </strong>Condoms are effective at preventing sexually transmitted infections and pregnancy; however, only 52% of sexually active US adolescents used a condom at last intercourse.</p><p><strong>Objective: </strong>To examine (1) the association between 36 psychosocial variables and adolescent condom use to determine the strongest correlates of condom use behavior across the literature, (2) heterogeneity of these effects, and (3) the moderating roles of age, gender/sex, race/ethnicity, sexual orientation, and year of study.</p><p><strong>Data sources: </strong>A systematic search was conducted of studies published between January 2000 and February 2024 using Medline, CINAHL, PsycINFO, and Communication Source databases, plus relevant review articles and unpublished data.</p><p><strong>Study selection: </strong>Studies were included if they (1) were observational studies of US adolescents (mean sample age <19 years), (2) included adolescent reports of condom use behavior and a correlate of interest, and (3) were available in English after January 2000.</p><p><strong>Data extraction and synthesis: </strong>Investigators extracted data on participant characteristics, study methods, settings, correlates, condom use outcomes, and study quality. Correlation coefficients and 95% CIs were computed from studies and meta-analyzed using random-effects models.</p><p><strong>Main outcomes and measures: </strong>The primary outcome was adolescent-reported condom use behavior.</p><p><strong>Results: </strong>A total of 249 studies with 283 independent samples (251 713 adolescents; weighted mean age, 16.2 years) were synthesized. Twenty-three correlates were significantly associated with adolescent condom use. The correlates of condom use with the largest weighted mean effects were condom use at first sex (Pearson r = 0.47; 95% CI, 0.36-0.56), condom use intentions (Pearson r = 0.42; 95% CI, 0.35-0.48), and condom communication with a partner (Pearson r = 0.41; 95% CI, 0.29-0.52). Safer sex knowledge-a primary focus of many sex education efforts-was not significantly associated with condom use (Pearson r = -0.03; 95% CI, -0.10 to 0.05). Most effects (24 of 31 [77%]) were statistically significantly heterogeneous; age, gender/sex, sexual orientation, and year of study explained heterogeneity in only a few effects.</p><p><strong>Conclusions and relevance: </strong>This systematic review and meta-analysis identified the strongest and weakest correlates of adolescent condom use across nearly 25 years of research. These results can be used to refine sexual behavior theory and guide more targeted evidence-based intervention efforts for adolescents.</p>","PeriodicalId":14683,"journal":{"name":"JAMA Pediatrics","volume":" ","pages":"273-281"},"PeriodicalIF":24.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JAMA PediatricsPub Date : 2025-03-01DOI: 10.1001/jamapediatrics.2024.5311
Rachel G Greenberg, Wes Rountree, Mary Allen Staat, Elizabeth P Schlaudecker, Brenda Poindexter, Andrea Trembath, Matthew Laughon, Marek S Poniewierski, Rachel L Spreng, Karen R Broder, A Patricia Wodi, Oidda Museru, E Gloria Anyalechi, Paige L Marquez, Emily A Randolph, Samia Aleem, Ryan Kilpatrick, Emmanuel B Walter
{"title":"Apnea After 2-Month Vaccinations in Hospitalized Preterm Infants: A Randomized Clinical Trial.","authors":"Rachel G Greenberg, Wes Rountree, Mary Allen Staat, Elizabeth P Schlaudecker, Brenda Poindexter, Andrea Trembath, Matthew Laughon, Marek S Poniewierski, Rachel L Spreng, Karen R Broder, A Patricia Wodi, Oidda Museru, E Gloria Anyalechi, Paige L Marquez, Emily A Randolph, Samia Aleem, Ryan Kilpatrick, Emmanuel B Walter","doi":"10.1001/jamapediatrics.2024.5311","DOIUrl":"10.1001/jamapediatrics.2024.5311","url":null,"abstract":"<p><strong>Importance: </strong>Preterm infants are recommended to receive most vaccinations at the same postnatal age as term infants. Studies have inconsistently observed an increased risk for postvaccination apnea in preterm infants.</p><p><strong>Objective: </strong>To compare the proportions of hospitalized preterm infants with apnea and other adverse events in the 48 hours after 2-month vaccinations vs after no vaccinations.</p><p><strong>Design, setting, and participants: </strong>This randomized, open-label clinical trial took place at 3 US neonatal intensive care units between August 2018 and October 2021. Infants between 6 and 12 weeks' postnatal age who were born at less than 33 weeks' gestational age and were eligible to receive 2-month vaccines were included.</p><p><strong>Intervention: </strong>Infants were randomized 1:1 to vaccinated (received vaccines within 12 hours of randomization) or unvaccinated (no vaccines received during the study period) groups. Cardiorespiratory data were collected during the 48 hours after vaccination or randomization (unvaccinated group).</p><p><strong>Main outcomes and measures: </strong>The primary outcome was apnea, defined as a respiration pause greater than 20 seconds or a respiration pause greater than 15 seconds with associated bradycardia less than 80 beats per minute. Other outcomes included the number and duration of apnea episodes, serious adverse events, respiratory support escalation, and receipt of positive pressure ventilation.</p><p><strong>Results: </strong>Of 223 randomized infants (117 female; median [range] gestational age, 27.6 [23.0-32.9] weeks), 107 (48%) were vaccinated, and 116 (52%) were unvaccinated. For 2 infants in the vaccinated group, the primary outcome was unable to be assessed. The proportion of infants with 1 or more apnea event was 25 of 105 (24%) in the vaccinated group vs 12 of 116 (10%) in the unvaccinated group (adjusted odds ratio, 2.70; 95% CI, 1.27 to 5.73; P = .01). The mean number of apneic episodes did not significantly differ (model point estimate of difference, 0.54; 95% CI, -0.12 to 1.21) between the vaccinated (2.72) and unvaccinated (2.00) groups. The mean duration of apneic episodes did not significantly differ (model point estimate of difference, 4.6; 95% CI, -5.4 to 14.7) between the vaccinated (27.7) and unvaccinated (32.3) groups. No serious adverse events occurred during the 48-hour monitoring period. Other outcomes were not significantly different between groups.</p><p><strong>Conclusions and relevance: </strong>In hospitalized preterm infants, the odds of apnea within 48 hours were higher after 2-month vaccinations vs after no vaccinations. The similar number and duration of apneic events and lack of serious adverse events suggest that current vaccination recommendations for hospitalized preterm infants are appropriate. Neonatal clinicians should continue providing evidence-based anticipatory guidance about postvaccination apnea risk.</p><p><s","PeriodicalId":14683,"journal":{"name":"JAMA Pediatrics","volume":" ","pages":"246-254"},"PeriodicalIF":24.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11877207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JAMA PediatricsPub Date : 2025-03-01DOI: 10.1001/jamapediatrics.2024.6161
Scott P Oltman, Elizabeth E Rogers, Laura L Jelliffe-Pawlowski
{"title":"Queries on Sudden Infant Death Syndrome-Reply.","authors":"Scott P Oltman, Elizabeth E Rogers, Laura L Jelliffe-Pawlowski","doi":"10.1001/jamapediatrics.2024.6161","DOIUrl":"10.1001/jamapediatrics.2024.6161","url":null,"abstract":"","PeriodicalId":14683,"journal":{"name":"JAMA Pediatrics","volume":" ","pages":"352-353"},"PeriodicalIF":24.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}