Japanese Journal of Hospital Pharmacy最新文献_第9页

A Simple Assay for Amiodarone and Desethylamiodarone and its Clinical Application. 胺碘酮和去乙基胺碘酮的简易测定方法及其临床应用。

Japanese Journal of Hospital Pharmacy Pub Date : 1999-01-01 DOI: 10.5649/JJPHCS1975.25.28

K. Masaki, K. Ueno, M. Tsuji, K. Hiraki, M. Takada, S. Kamakura, M. Shibakawa

{"title":"A Simple Assay for Amiodarone and Desethylamiodarone and its Clinical Application.","authors":"K. Masaki, K. Ueno, M. Tsuji, K. Hiraki, M. Takada, S. Kamakura, M. Shibakawa","doi":"10.5649/JJPHCS1975.25.28","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.25.28","url":null,"abstract":"A simple reverse-phase high-performance liquid chromatographic (HPLC) assay for the measurement of amiodarone and its metabolite, desethylamiodarone in the serum was established. The ODS-2 column was used and the absorbance of the effluent from the column at 254 nm was measured. The standard curves for amiodarone and desethylamiodarone were linear up to 5μg/ml. The coefficent of variation (CV) was within 10% at a concentration of 100 ng/ml, and the CV of the intra-and interday variation was within 10% at concentrations of 0.25, 0.5 and 1μg/ml, respectively. These results suggest that the limit of detection is 100 ng/ml for amiodarone and desethylamiodarone, and this assay is thus considered to be a reliable method in clinical practice. On the other hand, the serum amiodarone and desethylamiodarone concentrations were measured in 10 inpatients who received amiodarone for at least 1 month. No significant correlation was observed between the doses and serum drug concentrations. There findings therefore suggest that TDM (Therapeutic Drug Monitoring) should be performed on anyone taking amiodarone.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"172 1","pages":"28-33"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76748366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Investigation of Pharmaceutical Equivalency in Pioneer and Generic Enteric-Coated Tablets. 先锋型和仿制型肠溶片药物等效性的研究。

Japanese Journal of Hospital Pharmacy Pub Date : 1999-01-01 DOI: 10.5649/JJPHCS1975.25.450

F. Ojima, T. Toyoguchi, T. Syoji, Y. Nakagawa

{"title":"Investigation of Pharmaceutical Equivalency in Pioneer and Generic Enteric-Coated Tablets.","authors":"F. Ojima, T. Toyoguchi, T. Syoji, Y. Nakagawa","doi":"10.5649/JJPHCS1975.25.450","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.25.450","url":null,"abstract":"In order to investigate the pharmaceutical equivalency of four propentofylline enteric-coated tablets (a pioneer preparation and 3 generic preparations), a quantitative analysis, disintegration testing and dissolution testing were all performed to evaluate them.The mean contents of propentofylline in each preparation ranged from 96 to 102%. All of the tested materials conformed to the findings for the disintegration test for enteric-coated articles in the thirteeth revised edition of Japanese Pharmacopoeia (JP). However, at the end of the disintegration test with the 1st test medium (pH 1.2), swelling was observed in one or more of the 6 tested tablets for two of the generic preparations. Although no release of propentofylline was recognized, the core of the swollen tablets had completely disintegrated inside the enteric coating film in one of the two swollen generic preparations. When doing the same test aften placing the disks in gastric fluid, the propentofylline finally dissolved in the medium after 120 min. The dissolution test was performed with a paddle (100 rpm) according to JP using a 0.05 M phosphate buffer at pHs of 6.5 and 7.2. The dissolutions were complete in less than 60 min at both pHs, and they were faster at pH 7.2 for all preparations. However, the dissolution was significantly delayed, and the 75% dissolution time was also significantly prolonged for one of the three generic preparations at both pHs when compared to the other preparations.All of the propentofylline enteric-coated preparations were acceptable based on the JP criteria, however, the pharmaceutical equivalency of the generic preparations to the pioneer preparation heve not yet been obtained. As a result, the changes between generic preparations and pioneer preparations are therefore considered to be considerable, especially ragarding enteric coated preparations","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"178 3 1","pages":"450-459"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73611794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Use of Drug Delivery Systems: Prescription Survey on Clinical Use of PGE1 in Lipid Emulsions with Aqueous Infusions. 给药系统的临床应用:PGE1在脂质乳状液水溶液输注中的临床应用处方调查。

Japanese Journal of Hospital Pharmacy Pub Date : 1999-01-01 DOI: 10.5649/JJPHCS1975.25.393

B. Hino, Y. Kurosaki, K. Yamauchi, K. Kamiya, H. Araki, Y. Gomita, N. Goto, M. Masada, H. Kawasaki

{"title":"Clinical Use of Drug Delivery Systems: Prescription Survey on Clinical Use of PGE1 in Lipid Emulsions with Aqueous Infusions.","authors":"B. Hino, Y. Kurosaki, K. Yamauchi, K. Kamiya, H. Araki, Y. Gomita, N. Goto, M. Masada, H. Kawasaki","doi":"10.5649/JJPHCS1975.25.393","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.25.393","url":null,"abstract":"As DDS drugs with various drug delivery functions are often prescribed under in conbination with a widerange of concurrent drug therapies, drug information closely related to its clinical usage is required to guarantee the appropriate multiple pharmaceutical functions of DDS drugs: We surveyed the actual concurrent therapy of lipo-PGE1 (Palux® inj. and Liple®), a targeting-type DDS, with various aqueous infusions at both Okayama University Hospital and Fukui Medical School Hospital. The term of the survey, which was done by evaluating the prescription records, and the total number of prescriptions were 14 months and 1, 005 prescriptions, respectively. Lipo-PGE1 was scarcely administered without any concurrently prescribed infusions. Although lipo-PGE1 was mostly diluted with Glucose Injection or Isotonic Sodium Chloride Solution, some electrolyte infusions were also concurrently prescribed with Lipo-PGE1 in some cases. The magnification of the dilution and the administration route seemed to be related each other. The data revealed in this report ave considered to be useful for a clinical usage-based assessment system to obtain further information guaranteeing the drug delivery function of Lipo-PGE1 from both a pharmaceutical and pharmacodynamic viewpoint one word.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"38 1","pages":"393-398"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84308785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Diabetes on Theophylline Disposition in the Rat. 糖尿病对大鼠茶碱代谢的影响。

Japanese Journal of Hospital Pharmacy Pub Date : 1999-01-01 DOI: 10.5649/JJPHCS1975.25.603

A. Takahashi, K. Saito, Y. Takizawa, R. Murata

引用次数: 1

Compatibility of Sodium Ferrous Citrate Improved-Granules in Combination with Other Preparations. 柠檬酸亚铁钠改良颗粒与其它制剂的配伍性。

Japanese Journal of Hospital Pharmacy Pub Date : 1999-01-01 DOI: 10.5649/jjphcs1975.25.176

Y. Arai, T. Nakane, A. Kubota, N. Mizushima, T. Shibata

{"title":"Compatibility of Sodium Ferrous Citrate Improved-Granules in Combination with Other Preparations.","authors":"Y. Arai, T. Nakane, A. Kubota, N. Mizushima, T. Shibata","doi":"10.5649/jjphcs1975.25.176","DOIUrl":"https://doi.org/10.5649/jjphcs1975.25.176","url":null,"abstract":"Sodium Ferrous Citrate formulatio, Ferromia®granule was originally supplied as film-coated granules. However, some problems have been pointed out with this formulation regarding awkwardness in handling and unpleasantness during consumption.Therefore, corrigent was added while the film conting was removed in order to improve it.We investigated influence of changing the formilative method, and carry out the incompatibility test and hygroscopic test on 29 powders which can be admixed together. Furthermore, we also carried out a ferrous ion dissolution test on 11 powders which are likely to have an ionic interaction with iron. As a result, the modified granuls were incompatible when combined with ascorbic acid powder, Cinal ®granule, sodium bicarbonate and fblic acid powder (10%).The modified granules demonstrated no water-vapor sorption at 25°C, 75% RH at 30 days. Hygroscopicity was not considered to be related to incompatibility, and no noticeable difference was found due to the modification of the formulation.In the compounding the sample, dissolution property demonstrated only a slight difference in the ferrous ion elution.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"11 1","pages":"176-186"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82525794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stability of Vitamins in the TPN Mixture at a Clinical Site. TPN混合物中维生素在临床的稳定性。

Japanese Journal of Hospital Pharmacy Pub Date : 1999-01-01 DOI: 10.5649/JJPHCS1975.25.40

Y. Wakiya, A. Saiki, N. Kondou, M. Masada

引用次数: 0

Development and Utilization of the Database of Problem List from Pharmaceutical Care Records Concerned with Problems and Assessments on Pharmacotherapy in Wards. Proposal to Use and Develop Jointly the Database of Problem List from Pharmaceutical Care Records. 药学服务记录问题清单数据库的开发与利用、病区药物治疗问题及评价。建议共同利用和开发药学服务记录问题清单数据库。

Japanese Journal of Hospital Pharmacy Pub Date : 1999-01-01 DOI: 10.5649/JJPHCS1975.25.53

Mariko Asahi, Noriaki Kakimoto, J. Nishigami, R. Matsushita, F. Ichimura

引用次数: 0

Questionnaire Survey about the Side Effects of Drugs in the Multiple Medical Institutions. 多家医疗机构药品不良反应问卷调查。

Japanese Journal of Hospital Pharmacy Pub Date : 1999-01-01 DOI: 10.5649/JJPHCS1975.25.440

Y. Koike, K. Uno, Manabu Abe, M. Tsugita, M. Tobita, K. Kajiwara, K. Toyama, H. Kawase, N. Yohkoh, Mayumi Sasahara, Miho Takahashi, K. Ono, Youko Sutoh, S. Maruyama, Kazuhiko Nagai

引用次数: 1

Survey of Drug Information Leaflet in Ranitidine Use for Outpatients. Switch OTC. 门诊患者使用雷尼替丁药品信息单张调查。开关场外。

Japanese Journal of Hospital Pharmacy Pub Date : 1999-01-01 DOI: 10.5649/JJPHCS1975.25.690

N. Takami, Ayumi Sakiya, K. Moriwaki, Masahiro Tamasiro

引用次数: 0

Study of a Scale for Discriminating the Self-Regulation of Medication to Select the Correct Menu of Individualized Medication Consultation. 辨别性用药自律量表在个体化用药咨询中选择正确菜单的研究。

Japanese Journal of Hospital Pharmacy Pub Date : 1999-01-01 DOI: 10.5649/JJPHCS1975.25.138

N. Iihara, T. Tsukamoto, S. Morita

{"title":"Study of a Scale for Discriminating the Self-Regulation of Medication to Select the Correct Menu of Individualized Medication Consultation.","authors":"N. Iihara, T. Tsukamoto, S. Morita","doi":"10.5649/JJPHCS1975.25.138","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.25.138","url":null,"abstract":"The purpose of this study is to establish the methodology of individualized medication consultation. We studied a Scale for Discriminating the Self-Regulation of Medication, which was an instrument of discriminating whether a patient was more likely to do a self-regulation of medication. Items of this scale are composed of principal factors related to self-regulation ofmedication age, degree of understanding common information for medication, and the patient's concept of what is important in taking medicines without anxiety. These items were extracted by multivariate analysis. For this analysis, we interviewed 73 patients. About 85 percent of subjects were discriminated correctly with this scale.This scale enables us: 1) to classify patients according to the discriminant values, where we can select the menu of consultation based on the classification, 2) to understand the reasons why a patient does self-regulation of medication. Consequently, it becomes easier to make an individualized medication consultation plan. To establish and validate this scale, further assessment is needed more in patients with various diseases.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"53 1","pages":"138-148"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81234904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0