Japanese Journal of Hospital Pharmacy最新文献

Assessment and Analysis of the Assessment Criteria for Meta-Analysis Articles:─ Management of Diabetes Pharmacotherapy Based on Meta-Analysis Articles ─ meta分析文章评价标准的评价与分析──基于meta分析文章的糖尿病药物治疗管理──

Japanese Journal of Hospital Pharmacy Pub Date : 2013-06-10 DOI: 10.5649/JJPHCS.39.347

Tomoka Osumi, H. Iijima

{"title":"Assessment and Analysis of the Assessment Criteria for Meta-Analysis Articles:─ Management of Diabetes Pharmacotherapy Based on Meta-Analysis Articles ─","authors":"Tomoka Osumi, H. Iijima","doi":"10.5649/JJPHCS.39.347","DOIUrl":"https://doi.org/10.5649/JJPHCS.39.347","url":null,"abstract":"meta-analysis is ranked among the highest-quality study designs, objective assessment criteria specific to meta-analysis have not been reported. As meta-analysis is complex in structure, we developed the Quality Score, which assesses the quality and format of meta-analysis. In this study, we attempted to assess the structure and quality of meta-analysis articles on type 2 diabetes. meta-analysis 2 diabetes from PubMed and the Cochrane Library. We then assessed the structure (PRISMA statement) and quality (the Quality Score) of the articles found by assigning scores. We further extracted articles above a certain level, and analyzed and organized the data with statistically significant differences. The initial search for meta-analysis articles identified 217 articles from PubMed and 25 from the Cochrane Library. Eight of the 25 articles from the Cochrane Library were also found among the articles from PubMed. Of the resultant 234 articles retrieved by the search formula, 44 were studied. The assessment score (0 – 100) for the structure (PRISMA statement) of meta-analysis was 60.2 ± 22.0 ％ (Mean ± SD), while the Quality Score was 53.0 ± 18.9 ％ . This study showed that the assessment of the quality of meta-analysis articles is linked to the assessment of the structure of the articles. In order to produce the great effect expected from diabetes medications, healthcare professionals are required to go beyond medication management and offer a wide range of therapeutic management. To do this, management priority should be given to items with secured evidence.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"6 1","pages":"347-355"},"PeriodicalIF":0.0,"publicationDate":"2013-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72655886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

ベネコートBMI-40とBMI-60との苦味マスキング効果の比較 benecat BMI-40和BMI-60苦味掩蔽效果的比较

Japanese Journal of Hospital Pharmacy Pub Date : 2000-12-10 DOI: 10.5649/JJPHCS1975.26.577

斎藤百枝美, 渡辺真知子, 暁子五十嵐, 浩尾形, 清人江戸

{"title":"ベネコートBMI-40とBMI-60との苦味マスキング効果の比較","authors":"斎藤百枝美, 渡辺真知子, 暁子五十嵐, 浩尾形, 清人江戸","doi":"10.5649/JJPHCS1975.26.577","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.26.577","url":null,"abstract":"The masking effects of BMI-40 on six kinds of bitter tasting medicines were investigated. As a result, BMI-40 alone significantly masked the bitterness of the ground Polymyxin B sulfate tablet (gPL-B). Thereafter, the masking effects of BMI-40 and flavored BMI-40 (with 10% milk cocoa+ 10% sugar) on gPL-B (a hundred thousand U/mL) were compared with those of BMI-60 and flavored BMI-60. After increasing the concentration of BMI-40 by 4%, the masking effects of BMI-40 were same as those of BMI-60 and both were below the threshold of bitterness which was reported to be 3.0 point (BMI-40: 2.5±0.3, BMI-60: 2.3±0.3). On the other hand, flavored BMI-40 was more effective than flavored BMI-60 at a 1-4% additional concentration (p<0.001), and its bitterness intensity was below the threshold (2.0±0.3-1.0±0).The mechanism of masking bitterness by using BMI-40, which contained about 50% branched dextran, was next investigated. At a 1% concentration, the rate of bitterness intensity of BMI-40 on gPL-B decreased after adding milk cocoa but not after adding sugar in comparison with that of BMI-60 (BMI-40: 42.5%, BMI-60: 64.6%).The masking effects of 3%, 5% branched dextran, which contained BMI-40 but not BMI-60, significantly increased by adding milk cocoa, while branched dextran alone was not effective.These results suggested that 1% flavored BMI-40 (with 10% milk cocoa and 10% sugar) is clinically useful for masking the bitterness of gPL-B. Furthermore, the masking mechanism of BMI-40 is also considered to be different from that of BMI-60.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"102 1","pages":"577-583"},"PeriodicalIF":0.0,"publicationDate":"2000-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75723963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

「創薬ボランティアのしおり」,「被験者管理票」の利用と治験コーディネーター業務 “创新药物志愿者指南”，“受试者管理票”的利用和试验协调工作

Japanese Journal of Hospital Pharmacy Pub Date : 2000-10-10 DOI: 10.5649/JJPHCS1975.26.542

西原茂樹, 二神幸次郎, 定金典明, 井上真由美, 豊田倫子, 三村瞳, 荒木博陽, 裕五味田

引用次数: 1

Hemodializability of Pimobendan and Its Active Metabolite, UD-CG 212, in Patients with Congestive Heart Failure Undergoing Hemodialysis 匹莫苯丹及其活性代谢物d - cg212在充血性心力衰竭血液透析患者中的血液透析作用

Japanese Journal of Hospital Pharmacy Pub Date : 2000-08-10 DOI: 10.5649/JJPHCS1975.26.438

Masaaki Takahashi, M. Hanaoka, S. Shimada, M. Nomura, H. Echizen

引用次数: 0

An Investigation into the Current Management for Patients with Long-Term Withdrawal Periods from Drugs 长期停药患者的管理现状调查

Japanese Journal of Hospital Pharmacy Pub Date : 2000-08-10 DOI: 10.5649/JJPHCS1975.26.432

M. Isawa, K. Yamazaki, K. Hattori, Ai Takahashi, K. Tada, F. Tsuchiya, E. Nakashima

引用次数: 0

Stability of Morphine Hydrochloride in a Total Parenteral Nutrient Solution 盐酸吗啡在全肠外营养液中的稳定性

Japanese Journal of Hospital Pharmacy Pub Date : 2000-06-10 DOI: 10.5649/JJPHCS1975.26.316

T. Chikuma, Takeshi Shinoda, K. Taguchi, T. Ebihara, A. Tanaka, K. Kushida

引用次数: 0

Preparation and Evaluation of Heat-sensitive Melting Gel 热敏熔融凝胶的制备与评价

Japanese Journal of Hospital Pharmacy Pub Date : 2000-06-10 DOI: 10.5649/JJPHCS1975.26.250

H. Endo, Yoshiteru Watanabe, M. Matsumoto, Shoichi Shirotake

{"title":"Preparation and Evaluation of Heat-sensitive Melting Gel","authors":"H. Endo, Yoshiteru Watanabe, M. Matsumoto, Shoichi Shirotake","doi":"10.5649/JJPHCS1975.26.250","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.26.250","url":null,"abstract":"The aim of the present study was to prepare a heat-sensitive melting gel using κ-carrageenan and gelatin as the gelation agents. The two agents have similar melting points (40-50°C for κ-carrageenan and 20-30°C for gelatin). When mixed together, they have a coexisting grid structure, which is favorable for the preparation of a gel with a melting temperature close to the human body temperature. Gel preparation showed a clearly different melting behavior from that of many other compounds and began to soften significantly below its melting temperature.κ-carrageenan at 0.5% may thus be the preferred concentration because preparations having a melting temperature just below the human body temperature are easy to chew, with a rapidly decreasing viscosity. We studied the plasma concentrations of acetaminophen as a function of time after the oral administration of a bulk powder or gel preparation of acetaminophen to rabbits after overnight fasting. A comparison of the AUC for both oral and intravenous administration indicated the bioavailability of acetaminophen gel to be about 90%. The heat-sensitive acetaminophen melting gel prepared using κ-carrageenan and gelatin thus shows promise for clinical use because of its favorable physicochemical and pharmaceutical characteristics.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"9 1","pages":"250-258"},"PeriodicalIF":0.0,"publicationDate":"2000-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88390880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Studies on Hospital Pharmaceutical Manufacturing (VI) Cost Comparison of Six Times versus Twice Per Year Preparations of 1% Methylene Blue Injection by a Cost Saving Analysis 1%亚甲蓝注射液6次/年配制与2次/年配制的医院制药厂成本比较及成本节约分析

Japanese Journal of Hospital Pharmacy Pub Date : 2000-04-10 DOI: 10.5649/JJPHCS1975.26.164

Moemi Saito, Machiko Watanabe, M. Hoshi, T. Mikawa, H. Yoshida, K. Edo

{"title":"Studies on Hospital Pharmaceutical Manufacturing (VI) Cost Comparison of Six Times versus Twice Per Year Preparations of 1% Methylene Blue Injection by a Cost Saving Analysis","authors":"Moemi Saito, Machiko Watanabe, M. Hoshi, T. Mikawa, H. Yoshida, K. Edo","doi":"10.5649/JJPHCS1975.26.164","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.26.164","url":null,"abstract":"For the purpose of determining the shelf life of 1% Methylene Blue (MB) injection, its stability was investigated under 4 storage conditions for 30 weeks. The content of MB in 1% MB injection started to decrease at 5°C in the dark 4 weeks after preparation, but no significant differences were observed under three other storage conditions (at room temperature (22.0±0.5°C) and at 40°C in the dark and at room temperature (22.0±0.5°C) in 1000 Lux fluorescent light) for 30 weeks. According to these results, we changed the shelf life of 1% MB injection from 2 to 6 months and the frequency of preparation from six times to twice/year. The unit cost before and after the change of shelf life was compared. One unit cost calculated according to materials costs and labor costs was ¥2, 738.6 during the 1993-1995 period (six times preparations/year), while it was ¥1, 545.9 during the 1996-1998 period (twice preparations/year). A cost savings of ¥1, 192.7/ampule (43.6%) was produced by changing the frequency of preparation from six times to twice/year. In addition, the discard cost for 1% MB injection past its shelf life was estimated. A discard cost saving of ¥85, 766.8/year (75.2%) was achieved by changing the frequency of preparation from six times to twice/year. Furthermore, the working hours were reduced by 9.58 hours/man/year and it allowed pharmacists to utilize the extra time gained by changing the frequency to other work.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"8 1","pages":"164-170"},"PeriodicalIF":0.0,"publicationDate":"2000-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77887850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

個別化に対応した薬剤管理指導用「お薬説明書」作成システムの構築构建针对个体化的药物管理指导用“药品说明书”制作系统

Japanese Journal of Hospital Pharmacy Pub Date : 2000-04-10 DOI: 10.5649/JJPHCS1975.26.177

恵子新迫, 良子石塚, 博子若杉, 和伸高柳, 亨橋田, 高弘二見, 雅弘石津, 賢一乾

引用次数: 1

Construction and Evaluation of Common Guidelines for Recommended Dosage and Directions for the Use of Drugs in the Hospital 医院药品推荐用量和使用说明通用指南的构建与评价

Japanese Journal of Hospital Pharmacy Pub Date : 2000-04-10 DOI: 10.5649/JJPHCS1975.26.157

Mitsuru Machida, K. Sagawa, S. Murase, H. Kagaya, Haruko Kuzuyama, S. Shimada

引用次数: 0