Stability of Vitamins in the TPN Mixture at a Clinical Site.

We investigated the stability of Vitamins in a total parenteral nutrition (TPN) solution. We compared examinations at the same clinical site at two different dosage periods for the administration of Vitamins (daytime and nighttime) with the finding of a basic examination. We thus found the stability in most instances to be the same as for the basic examination of stability in numerous Vitamins reports (effect of light and temperature, trace elements, sodium sulfite). At on clinical site during the different dosage periods, the dosage at nighttime was found to be better than that observed in the daytime. We consider this influence on stability of the Vitamins to be related to the alteration of the quantity of light during the daytime. These findings suggested that the addition of Vitamins to TPN solutions should therefore be avoided whenever possible during daytime administration.