Japanese Journal of Hospital Pharmacy最新文献_第5页

Preparation of Sodium Polystyrene Sulfonate Suspension Enema for Treatment of Hyperkalemia. 聚苯磺酸钠悬浮液灌肠治疗高钾血症的制备。

Japanese Journal of Hospital Pharmacy Pub Date : 2000-01-01 DOI: 10.5649/JJPHCS1975.26.380

K. Ohsawa, M. Ohtani, S. Kariya, Tohru Shinohara, K. Uchino, Kunji Mita, H. Matsuura, K. Akimoto, H. Kawahara, N. Hashimoto, K. Yakumaru, T. Rikihisa

{"title":"Preparation of Sodium Polystyrene Sulfonate Suspension Enema for Treatment of Hyperkalemia.","authors":"K. Ohsawa, M. Ohtani, S. Kariya, Tohru Shinohara, K. Uchino, Kunji Mita, H. Matsuura, K. Akimoto, H. Kawahara, N. Hashimoto, K. Yakumaru, T. Rikihisa","doi":"10.5649/JJPHCS1975.26.380","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.26.380","url":null,"abstract":"Enemas of sodium polystyrene sulfonate (SPS) in 20% sorbitol (20% Sor) have regularly been administered by an irrigator for the treatment of hyperkalemia. However, intestinal necrosis, which may be caused by the high osmolality of Sor, has been reported in some patients who received enemas of SPS in Sor.We prepared several SPS suspensions using a 5% glucose solution containing methyl cellulose (MC), hydroxypropyl cellulose (HP) or Avicel RC 591 NF (AB) as a vehicle, and examined the physicochemical properties (dispersibility, osmotic pressure, viscosity and dropping time from irrigator) of each suspension. Among the suspensions tested, the 1% ABG suspension, which was prepared as follows; SPS was suspended in 5% glucose solution containing 1% AB by mixing at 5, 000 rpm for 3 min on a homo mixer, showed the best results. The 1% ABG suspension was isotonic with physiological fluid. A predominant dispersibility of SPS, a low viscosity and a short dropping time from the irrigator were all obtained using this-suspension. The suspension was quite stable for at least 90 days at room temperature.In uremic rats which were made by performing a bilateral nephrectomy, the occurrence of intestinal necrosis and the effect on the serum level of potassium were investigated after the rectal administration of SPS suspensions. No significant pathological changes were noted in rats receiving a 1% ABG suspension. In addition, the 1% ABG suspension caused a significant decrease in the serum level of potassium from the control level.These results suggest that the 1% ABG suspension for enemas of SPS can be useful in the treatment of hyperkalemia.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"25 1","pages":"380-387"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84512802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Studies on Factor Affecting Pharmacokinetics of Cilostazol and Pharmacokinetics-Pharmacodynamics Analysis Based Platelet Aggregation. 西洛他唑药动学影响因素及基于血小板聚集的药动学-药效学分析研究。

Japanese Journal of Hospital Pharmacy Pub Date : 2000-01-01 DOI: 10.5649/JJPHCS1975.26.264

S. Ishida, Megumi Morii, K. Ueno, M. Takada, T. Sakata, A. Okamoto, J. Kobayashi, O. Monta, Nobutatu Koizumi, Y. Sasako, M. Shibakawa

引用次数: 2

Development and Applications of Initial Dosage Setting of Cibenzoline in Consideration of the Cases of Adverse Reaction Induced by Cibenzoline on Clinical Services in a Hospital. 考虑到苯并啉在临床服务中引起的不良反应，苯并啉初始剂量设定的制定与应用。

Japanese Journal of Hospital Pharmacy Pub Date : 2000-01-01 DOI: 10.5649/JJPHCS1975.26.239

Y. Maeda, T. Konishi, K. Omoda, Y. Takeda, H. Fujii, I. Kanazawa, S. Eno, S. Tsukiai

{"title":"Development and Applications of Initial Dosage Setting of Cibenzoline in Consideration of the Cases of Adverse Reaction Induced by Cibenzoline on Clinical Services in a Hospital.","authors":"Y. Maeda, T. Konishi, K. Omoda, Y. Takeda, H. Fujii, I. Kanazawa, S. Eno, S. Tsukiai","doi":"10.5649/JJPHCS1975.26.239","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.26.239","url":null,"abstract":"Adverse reactions induced by cibenzoline at this hospital showed the trough value of cibenzoline at the time to be above 400ng/mL. In these cases, by adjusting the trough values to 150-230ng/mL and also by reducing the cibenzoline dosage, the effects of cibenzoline could thus be maintained while adverse reactions were avoided. Therefore, the relationship between the trough value based on cibenzoline dosage and the creatinine clearance in 19 cases who took cibenzoline was examined. In order to adjust trough level to 150-250ng/mL as the goal concentration based on the relation formula, the recommended dosage of cibenzoline and the creatinine clearance were calculated. The utility of an initial dosage setting according to the combination a recommended dosage of cibenzoline and the creatinine clearance nomogram reported by Nielsen et al. was examined in 9 cases.As a result, using this nomogram, the percentage of the goal concentration thus significantly increased, while the percentage of hypoglycemia significantly decreased. Accordingly, the nomogram of cibenzoline prepared in our hospital was thus concluded to be clinically acceptable.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"38 1","pages":"239-249"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85209466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A Questionnaire Study on Health Foods for Cancer Patients. 癌症患者保健食品的问卷调查研究

Japanese Journal of Hospital Pharmacy Pub Date : 2000-01-01 DOI: 10.5649/JJPHCS1975.26.95

Hiroko Takahashi, Y. Kudo, Kazuhiko Kanno, K. Saito, T. Ogasawara, Masahiro Matsumoto, K. Yoshinaga

{"title":"A Questionnaire Study on Health Foods for Cancer Patients.","authors":"Hiroko Takahashi, Y. Kudo, Kazuhiko Kanno, K. Saito, T. Ogasawara, Masahiro Matsumoto, K. Yoshinaga","doi":"10.5649/JJPHCS1975.26.95","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.26.95","url":null,"abstract":"There are many health foods presently available. Some health foods are sold with the sales message \"a medicine for cancer\", so a lot of patients pay a large amount of money for them. Therefore we carried out a questionnaire survey which was given to patients to find out how many patients take health foods. For comparison purposes we did the same survey on diabetics and patients suffering from chronic illnesses like hepatitis and hypertensions, and then we analysed the differences among disease. In addition, we also checked out the safety of health foods. The ratio of taking health foods was especialy high for cancer patients, and they also spent a lot of money on them. There are several reports about adverse reactions of health foods and interactions between medicines and health foods. In addition health foods are often sold with the sales message that they act like a medicine. For these reasons, we have to provide information on the safety, interactions, effects and prices of such health foods with patients and doctors. This remains an important task as pharmaeists which has to be confronted in the future.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"95 1","pages":"95-101"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77216713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Bactericidal Effects of Disinfectants on Clinical Isolates from the Hospital. (Report 4). 消毒剂对医院临床分离菌的杀菌效果。(4)报告。

Japanese Journal of Hospital Pharmacy Pub Date : 2000-01-01 DOI: 10.5649/JJPHCS1975.26.652

Takeshi Mori, Nobuo Shimizu, Masafumi Ohnishi, S. Sanada, Y. Koda, Masaharu Inoue, S. Kurono, H. Okada

{"title":"Bactericidal Effects of Disinfectants on Clinical Isolates from the Hospital. (Report 4).","authors":"Takeshi Mori, Nobuo Shimizu, Masafumi Ohnishi, S. Sanada, Y. Koda, Masaharu Inoue, S. Kurono, H. Okada","doi":"10.5649/JJPHCS1975.26.652","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.26.652","url":null,"abstract":"At our hospital, we have been conducting experiments on the time course of bactericidal effectiveness of disinfectants against clinically isolated bacterial strains. In the present study, we investigated the following commonly used disinfectants; chlorhexidine gluconate (CHG), benzalkonium chloride (BAC), povidone iodine (PVP-I) and alkyl diaminoethylglycine hydrochloride (ADG). The results showed that PVP-I exhibited the greatest bactericidal effect among these disinfectants with a bactericidal time of within 20 seconds for both gram-positive and gramnegative bacteria. CHG, BAC and ADG appeared to have a relatively delayed bactericidal time against gram-positive bacteria and 7 of 9 strains tended to show resistance to these disinfectants. These findings point to the need to add ethanol in order to ensure the effectiveness of disinfec tion when using these agents. Furthermore, these disinfectants showed only poor bactericidal effectiveness at low concentrations against gram-negative bacteria, thus indicating that caution is needed when determining the appropriate concentration levels. Moreover, since our results for BAC and PVP-I differ from those described in our previous reports, extreme care is thus called for when determining the concentration levels and exposure times due to intrinsic bacterial factors and the time course of bactericidal effectiveness.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"11 1","pages":"652-658"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84090982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Patient Compliance Instruction Using TDM. Noncompliance Problems in Children with Epilepsy and its Solution. 患者使用TDM的依从性指导。儿童癫痫不遵医嘱问题及其解决方法。

Japanese Journal of Hospital Pharmacy Pub Date : 2000-01-01 DOI: 10.5649/JJPHCS1975.26.280

Masayuki Morita, Tatsuo Saito, M. Toyoshima, Yuji Shirai, K. Sano, Yasunobu Sato, M. Murofushi, Sayaka Matsuyama, Tomomi Uchiyama, Akemi Muroya

{"title":"Patient Compliance Instruction Using TDM. Noncompliance Problems in Children with Epilepsy and its Solution.","authors":"Masayuki Morita, Tatsuo Saito, M. Toyoshima, Yuji Shirai, K. Sano, Yasunobu Sato, M. Murofushi, Sayaka Matsuyama, Tomomi Uchiyama, Akemi Muroya","doi":"10.5649/JJPHCS1975.26.280","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.26.280","url":null,"abstract":"Noncompliance with drug therapy was suspected based on the results of therapeutic drug monitoring (TDM) in two 3-and 4-year-old children with epilepsy. An analysis of the data for both children showed the serum concentration of the antiepileptic drugs estimated from individual parameters to deviate remarkably from those established based on population parameters, and that the difference between these values varied after each measurement.After a careful evaluation of patient compliance according to the results of TDM, it was revealed the dosage due to the fact that mother had not realized her inaccurate dosage while another mother admitted that she had reduced the dosage due to the fact that her child refused to take the drug. The time needed to correct the noncompliance after its discovery using TDM was 3 months in the case of inaccurate dosage, and 12 months in the case where the child had refused to take the drug, by means of compliance education and training given to the mothers once -a-month at the outpatient clinic.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"294 1","pages":"280-286"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77180797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thermodynamics Study on Solubility Change in Injection Admixing and Preparation of the Incompatibility Estimation Table. 注射掺合中溶解度变化的热力学研究及不相容评定表的编制。

Japanese Journal of Hospital Pharmacy Pub Date : 2000-01-01 DOI: 10.5649/JJPHCS1975.26.359

T. Itoh, M. Kawai

{"title":"Thermodynamics Study on Solubility Change in Injection Admixing and Preparation of the Incompatibility Estimation Table.","authors":"T. Itoh, M. Kawai","doi":"10.5649/JJPHCS1975.26.359","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.26.359","url":null,"abstract":"We examined the solubility change in injection admixing using thermodynamics. During our investigation, information regarding solubility, as described on the package insert, was utilized as reference data.The solubility of a compound in water is determined by the balance of the force which promotes dissolution and the force which prevents dissolution. Enthalpy of hydration, entropy of sublimation and dissociation are forces which all promote dissolution. Ionic lattice energy, entropy of hydration, Van der Waals force, and the generation of hydrophobic bond are forces which prevent dissolution. If the force which prevents dissolution is larger than the force which promotes dissolution, then a compound will not dissolve in water even if it is an ionic compound. Therefore, the generation of a hydrophobic bond and the aggregation of a polyvalent cation and polyvalent anion are considered to be important factors in the formation of insoluble ionic compounds.The incompatibility estimation table was prepared by classifying the injection formulation into six groups (anionic insoluble compound, anionic soluble compound, cationic insoluble compound, cationic soluble compound, nonionic insoluble compound, and noncationic nonanionic soluble compound). A rapid chemical evaluation of injection admixing is possible by using of the incompatibility estimation table.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"38 1","pages":"359-368"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82948886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacokinetics and Clinical Pharmacological Effects of Propofol. 异丙酚的药代动力学及临床药理作用。

Japanese Journal of Hospital Pharmacy Pub Date : 2000-01-01 DOI: 10.5649/JJPHCS1975.26.1

Sachiyo Funakoshi, T. Konishi, Y. Maeda, Hiroyuki Yamato, M. Yamasaki, S. Tsukiai, I. Nakagawa

引用次数: 0

Investigation of the Appropriate Use of Antiseptics with Cotton Swabs. 用棉签适当使用消毒剂的调查。

Japanese Journal of Hospital Pharmacy Pub Date : 2000-01-01 DOI: 10.5649/JJPHCS1975.26.647

Y. Yoshida, Y. Enomoto, Yuki Hasumi, M. Makimura

{"title":"Investigation of the Appropriate Use of Antiseptics with Cotton Swabs.","authors":"Y. Yoshida, Y. Enomoto, Yuki Hasumi, M. Makimura","doi":"10.5649/JJPHCS1975.26.647","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.26.647","url":null,"abstract":"To determine their most appropriate use for medical purposes, we investigated the method for preparing antiseptic-containing cotton swabs. We measured the amount of antiseptic solution contained in a cotton swab according to the water-absorbency method for absorbent cotton as described in detail in the Japanese Pharmacopoeia.We tested three antiseptic agents which are frequently used in hospitals: povidone-iodine, benzalkonium chloride and chlorhexidine gluconate. Since the weight of cotton swabs from various manufacturers differed significantly, the amount of water or antiseptic solution contained in each swab was also different.Based on the results of these measurements, we additionally evaluated the amount in each solution-containing cotton swab prepared in a medical setting. Judging from the volume of nonabsorbed antiseptic solution, we found that the actual amount used was slightly less than 90% of the calculated amount.It therefore seems that the excessive use of antiseptic agents might be avoided, and health expenditures thus can be reduced, if we could make a manual for preparing antiseptic-containing cotton swabs based on the present results, and thereafter prepare them according to the instructions of the manual at hospitals.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"26 1","pages":"647-651"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74462756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Milk on Dissolution of Theophylline Sustained-Release Preparations. 牛奶对茶碱缓释制剂溶出度的影响。

Japanese Journal of Hospital Pharmacy Pub Date : 2000-01-01 DOI: 10.5649/JJPHCS1975.26.550

A. Takahashi, K. Saito, R. Murata, Yorihisa Tanaka

引用次数: 1