Japanese Journal of Hospital Pharmacy最新文献_第6页

Usefulness of Semi-Micro High-Performance Liquid Chromatography Using Solid-Phase Extraction in Analysis of Serum Drug Concentration. 半微高效液相色谱固相萃取在血清药物浓度分析中的应用。

Japanese Journal of Hospital Pharmacy Pub Date : 2000-01-01 DOI: 10.5649/JJPHCS1975.26.219

Kazunori Asai, Hideo Katsuta, M. Morishita, K. Takayama, T. Nagai

{"title":"Usefulness of Semi-Micro High-Performance Liquid Chromatography Using Solid-Phase Extraction in Analysis of Serum Drug Concentration.","authors":"Kazunori Asai, Hideo Katsuta, M. Morishita, K. Takayama, T. Nagai","doi":"10.5649/JJPHCS1975.26.219","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.26.219","url":null,"abstract":"A new method for the analysis of pheytoin (DPH) and carbamazepine (CBZ) in human serum described. The method involves extraction of DPH and CBZ from serum by re-used solidphase extraction (SPE) column prior to a semi-micro high-performance liquid chromatographic analysis. The chromatography for the analysis of DPH at a level of 20μg/mL was complete in 5 using a semi-micro column (C 18, 2.0mm i.d.×15cm). The sensitivity of the analysis was 3.97-fold higher than that for conventional HPLC. DPH and CBZ were extracted from serum using commercially available SPE column (Isolute C 18), and analytical recovery rate of DPH and CBZ which were added to the serum (50μL) at 2.0, 5.0, 10.0, 20.0 and 40.0μg/mL, ranged from 83.5 to 94.0% and from 86.7 to 117.1%, respectively. Excellent recovery rates of DPH and CBZ in the serum were also obtained when the same SPE column was re-used over 30-times, protein and/or albumin hardly remained in the solid-phase of the re-used SPE column. There results indicate that this new method could reduce both the time need to perform each analysis the amount of sample needed due to high sensitivity. In addition, the method also demonstrated a good cost performance. Thus, the method might be highly useful to support drug monitoring and pharmacokinetic studies.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"5 1","pages":"219-226"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86688924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Introduction and Evaluation of Communication Skill Practice as Pharmaceutical Care Training for Pharmaceutical Graduate Students in the Program as Part of the Hospital Pharmacy Course. 医院药学专业药学研究生药学服务培训中沟通技巧实践的介绍与评价。

Japanese Journal of Hospital Pharmacy Pub Date : 2000-01-01 DOI: 10.5649/JJPHCS1975.26.36

M. Nakashima, Masayo Yoshida, Masako Tsurumaru, M. Ogasawara, H. Sasaki, M. Ichikawa

引用次数: 1

Evaluation of an Automatic Dispensing Device to Prepare Disinfectants. 一种制备消毒剂的自动配药装置的评价。

Japanese Journal of Hospital Pharmacy Pub Date : 2000-01-01 DOI: 10.5649/JJPHCS1975.26.329

Kaori Tsubone, H. Yoshida, Yasuaki Ohtsubo, T. Ishimitsu, A. Kamiya

引用次数: 0

The Effect of the Mixed Witepsol Base on the Drug Release from the Zonisamide Suppository. 复方威普索尔对唑尼沙胺栓释药的影响。

Japanese Journal of Hospital Pharmacy Pub Date : 2000-01-01 DOI: 10.5649/JJPHCS1975.26.171

Y. Mimaki, Kenya Kawakami, Chieko Imanaka, K. Suemaru, R. Taniguchi, Kazuhide Watanabe, H. Araki, Y. Gomita

{"title":"The Effect of the Mixed Witepsol Base on the Drug Release from the Zonisamide Suppository.","authors":"Y. Mimaki, Kenya Kawakami, Chieko Imanaka, K. Suemaru, R. Taniguchi, Kazuhide Watanabe, H. Araki, Y. Gomita","doi":"10.5649/JJPHCS1975.26.171","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.26.171","url":null,"abstract":"The influences of both the mixing ratios of Witepsol as a lipophilic base and the temperature on the drug release from the zonisamide suppositories was investigated. Mixed types of zonisamide suppositories consisting of Witepsol H-15 (H) and Witepsol S-55 (S) as a lipophilic base were prepared and the release of zonisamide from a suppository was determined using the dissolution apparatus in Paddle method of JPX III. The release rate of zonisamide from the Witepsol (H: S=4: 1) suppository and Witepsol (H: S=3: 1) suppository at 4 hours after start of the release test were 66.6% and 56.5%, respectively. The former was significantly higher (p<0.05) than that of the latter. The release volume and mean dissolution time (MDT) of zonisamide from a suppository increased and decreased, respectively, according to the high mixing ratio of Witepsol H 15.The effect of low temperature (32 and 34°C) on drug release from the zonisamide suppositories was also studied using artificial membranes. The drug release properties were changed according to the mixing ratios of the two lipophilic bases and the temperature of the fluid tested. At a low temperature, the amount of released zonisamide correlated with the ratio of Witepsol S 55 in the suppository. However, the amount of the drug released from the zonisamide suppositories decreased at temperatures lower than normal body temperature. These results indicate that the ratio of Witepsol H 15 and Witepsol S 55 in suppositories was important while the temperature also influence drug absorption from the rectum with zonisamide suppositories.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"147 1","pages":"171-176"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80604106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Relationship between the Dosage of Furosemide and the Occurrence of Hyperuricemia in the Patients with Heart Failure. 心衰患者速尿用量与高尿酸血症发生的关系。

Japanese Journal of Hospital Pharmacy Pub Date : 2000-01-01 DOI: 10.5649/JJPHCS1975.26.335

T. Yae, Emiko Yae, Shiori Kishita, S. Beppu, Yumiko Tanaka, Motoki Kamura, H. Araki, Y. Gomita

{"title":"The Relationship between the Dosage of Furosemide and the Occurrence of Hyperuricemia in the Patients with Heart Failure.","authors":"T. Yae, Emiko Yae, Shiori Kishita, S. Beppu, Yumiko Tanaka, Motoki Kamura, H. Araki, Y. Gomita","doi":"10.5649/JJPHCS1975.26.335","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.26.335","url":null,"abstract":"( Received September 27, 1999 Accepted March 6, 2000 ) The purpose of this report is to clarify the relationship between the dosage of furosemide and the occurrence of hyperuricemia. 59 patients with heart failure who were treated with furosemide were analyzed retrospectively. We defined hyperuricemia to be more than 7.0mg/dL in males and 5.5mg/dL in females. Any patients with renal failure, gout, diabetes mellitus and an abnormal purine-metabolism were excluded from this investigation. The frequency of hyperuricemia was 78.0% in the 59 patients receiving furosemide. The incidence of hyperuricemia due to furosemide medication was as follows: 80% in the 20mg treated group (n=10); 81.5% in the 40mg treated group (n=27); 100% in the 60mg treated group (n =2); and 100% in the 80mg treated group (n=14) . Furthermore, in the groups receiving 20 mg, 40mg and 80mg of furosemide, the average doses of allopurinol (urate synthesis inhibitor) were 50.0•}16.7mg (mean•}SE, n=10), 88.5•}15.0mg (mean•}SE, n=26) and 130.2•}26.0mg (mean•}SE, n=10), respectively. These results indirectly suggest that the increases in the amount of furosemide correlated with the serum urate level. In conclusion, to avoid hyperuricemia, the serum urate levels should be carefully checked in","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"130 1","pages":"335-338"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86375825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Acarbose on the Lipoprotein Metabolism of Diabetes Mellitus Patients and Patient Counseling. 阿卡波糖对糖尿病患者脂蛋白代谢的影响及患者咨询。

Japanese Journal of Hospital Pharmacy Pub Date : 2000-01-01 DOI: 10.5649/JJPHCS1975.26.584

H. Sasaki, Tohru Asayama, Saburo Kanai, M. Kurokawa, Y. Miyashita, K. Shirai

{"title":"Effect of Acarbose on the Lipoprotein Metabolism of Diabetes Mellitus Patients and Patient Counseling.","authors":"H. Sasaki, Tohru Asayama, Saburo Kanai, M. Kurokawa, Y. Miyashita, K. Shirai","doi":"10.5649/JJPHCS1975.26.584","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.26.584","url":null,"abstract":"The effects of an α-glucosidase inhibitor, acarbose on serum lipoproteins as well as hemoglobin A1c were studied in type 2 diabetes mellitus patients. Furthermore, the improving rates of hemoglobin A1c and serum lipoproteins were compared between the patients with and those without patient-counseling by a pharmacist.Acarbose was administered to 55 poor control type 2 diabetes mellitus patients for 4 months. Overall, the level of HbA1c was reduced by 1.55%. The reduction in patients with patient counseling (PC, n=17) was 2.1% while that in patients without such counseling (non-PC, n=38) was 1.05%(p<0.01). Total cholesterol and triglyceride levels were reduced in total by 7.7%, 21.8%, respectively, but the rate of decrease was significantly larger in PC than in non-PC patients (8.8% vs 5.3% for total cholesterol, 29.3% vs 10.1% for triglyceride, both p< 0.001). The Midband, which migrated between VLDL and LDL on polyacrylamide disc electrophoresis disappeared in 45% of the patients, and the Midband of PC disappeared in 60% of the patients, whereas the same rate for non-PC was 35%.These results suggested that the delayed glucose absorption by acarbose in type 2 diabetes mellitus improved the serum lipoproteins as well as the blood glucose level, and that patient counseling by a pharmacist significantly improved the efficacy of this agent.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"115 1","pages":"584-591"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79358013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Malabsorption of Calcium Due to the Increase of Intragastric pH Caused by Coadministration Famotidine. 共给法莫替丁引起胃内pH升高引起钙吸收不良。

Japanese Journal of Hospital Pharmacy Pub Date : 2000-01-01 DOI: 10.5649/jjphcs1975.26.451

Mayumi Kioka, Hajime Tanaka, N. Kubo, Y. Nakai

引用次数: 0

Stability of the Powdered Dosage Form Prepared by Unsealing the Capsules. II. Investigation of Hygroscopicity and Discoloration of the Powdery Contents of Clorazepate Dipotassium Capsule. 开封胶囊制粉状剂型的稳定性。2氯硝泽酸双钾胶囊粉末含量的吸湿性和变色性研究。

Japanese Journal of Hospital Pharmacy Pub Date : 2000-01-01 DOI: 10.5649/jjphcs1975.26.339

T. Hanawa, T. Ohta, T. Tsuchiya, R. Ikoma, Tomomi Uchida, F. Kimura, Masahiko Suzuki, S. Nakajima

引用次数: 0

A Case Report of Phenytoin Intoxication Identified with Capillary Electrophoresis. 毛细管电泳鉴定苯妥英中毒1例。

Japanese Journal of Hospital Pharmacy Pub Date : 2000-01-01 DOI: 10.5649/JJPHCS1975.26.110

K. Makino, Y. Matsunaga, Y. Nakao, Y. Kataoka, R. Oishi

{"title":"A Case Report of Phenytoin Intoxication Identified with Capillary Electrophoresis.","authors":"K. Makino, Y. Matsunaga, Y. Nakao, Y. Kataoka, R. Oishi","doi":"10.5649/JJPHCS1975.26.110","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.26.110","url":null,"abstract":"A 2-year and 5-month old male child was admitted to our hospital, deu to signs of antiepileptic drug intoxication. He had been administered zonisamide and valproic acid for the treatment of epilepsy. One day after taking the medicines prepared in an outside pharmacy according to the doctor's prescription, he showed ataxia. The serum valproic acid concentration was within the normal therapeutic range, when measured using the fluorescence polarization immunoassay method (FPIA). We assayed the zonisamide concentration in patient serum using the capillary electrophoresis method. The peak of zonisamide was very low, but another extremely high peak was found. This peak was identified as phenytoin based on the migration time and absorption spectrum. We therefore concluded that the patient fell into phenytoin intoxication by taking a large amount of phenytoin that had been incorrectly prepared. The capillary electrophoresis method appears to be useful for therapeutic drug monitoring, especially in drug intoxication, because of its specificity of separation, simultaneous determination, speed of analysis, and small injection volume.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"59 1","pages":"110-115"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88364858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum Hydroxyzine Concentrations and Toxic Symptom in Acute Intoxication Patients. 急性中毒患者血清羟嗪浓度与中毒症状。

Japanese Journal of Hospital Pharmacy Pub Date : 2000-01-01 DOI: 10.5649/JJPHCS1975.26.13

K. Koyama, T. Kikuno, H. Kagami, Shinichiro Yamamoto, K. Ichikizaki, Nobuko Ogasawara, Y. Aono, N. Tamura

引用次数: 0