Japanese Journal of Hospital Pharmacy最新文献_第4页

Preparation and Trial Use of a Database of Medicated Syrups for Assistance in Drug Dispensing. 协助配药的药用糖浆数据库的准备和试用。

Japanese Journal of Hospital Pharmacy Pub Date : 2000-01-01 DOI: 10.5649/jjphcs1975.26.612

K. Hasegawa, F. Komada, Y. Saitoh

{"title":"Preparation and Trial Use of a Database of Medicated Syrups for Assistance in Drug Dispensing.","authors":"K. Hasegawa, F. Komada, Y. Saitoh","doi":"10.5649/jjphcs1975.26.612","DOIUrl":"https://doi.org/10.5649/jjphcs1975.26.612","url":null,"abstract":"We prepared a database (689 KB) on 113 medicated syrups using Microsoft Access to quickly search information primarily concerning potential incompatibilities when dispensing medicated syrups. This database contains and allows access to data concerning 16 items such as trade names, compositions, additives, incompatibilities, and the recommended doses collected from interview forms, package inserts, in-housedocuments, and from the literature. It can also accurately calculate the pediatric dose based on the adult dose. The size of this database is 906 KB including the basic data of Microsoft Excel (226 KB) prepared for facilities that do not possess Microsoft Access so that the entire database can be used as a simple database that utilizes the filter function of Microsoft Excel and, with file conversion, can also be used on Windows CE and Macintosh systems. Moreover, these basic data are also available to a large number of people via the LAN and Internet when converted to FileMaker Pro 5. As a result of the use of this database, a mean of 0.9 cases of absolute incompatibilities and a mean of 1.8 cases of possible incompatibilities per item were revealed in the 113 items, and 64 items were found to contain phydroxybenzoic esters as additives, which have been suggested to have a possible side effect of inducing asthma attacks. The data on the dosage for children were missing in 26 items (about 23%). Furthermore, we investigated the rate of prescriptions including medicated syrups at two pharmacies. The rates at pharmacy A and B were about 11% and 2%, respectively. Thirty four % and 82% of the prescribed medicines included medicated syrups at pharmacy A and B. Sixty three % of the prescriptions for pediatrics patients included 3 or more medicated syrups. This database is thus considered to be useful for both preparing and evaluating prescriptions for medicated syrups, their dispensing, and also as a source for educating patients.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"21 1","pages":"612-624"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90581396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Survey of Clinical Trials in Patients with Rheumatoid Arthritis. 类风湿关节炎患者临床试验调查。

Japanese Journal of Hospital Pharmacy Pub Date : 2000-01-01 DOI: 10.5649/JJPHCS1975.26.418

Mitsuru Kato, H. Okada, S. Takenaka, Y. Takakuwa, Noriko Mitsutake, T. Mitsui

{"title":"Survey of Clinical Trials in Patients with Rheumatoid Arthritis.","authors":"Mitsuru Kato, H. Okada, S. Takenaka, Y. Takakuwa, Noriko Mitsutake, T. Mitsui","doi":"10.5649/JJPHCS1975.26.418","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.26.418","url":null,"abstract":"A survey regarding understanding the images and demands of clinical trials was carried out on 177 ambulatory patients with rheumatoid arthritis at Aichi Medical University Hospital in April 1999. 72.3% of the study patients did not have a sufficient understanding of the clinical trials, while 27.7% of the patients did have a sufficient understanding. A total of 8.5%, of the patients had previous experience as trial subjects in clinical trials while 19.2% of the patients did not. In addition, 11.3% of the patients would take part of their own free will while 7.9% of the patients would refuse to take part in the trial. Many patients have an image that clinical trials are similar to experiments on humans. However, none of the patients with experience as subjects regretted their previous involvement in such trials. The reasons are clear why patients do not want to participate in clinical trials, since many people do not have a sufficient understanding of the effects of investigational drugs, are worried about the side effects of such drugs, and also have a general feeling of anxiety about such trials. These concerns have created a new role for hospital pharmacists as a CRC (Clinical Research Coordinator) to assist in the clinical trial process through medication counseling.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"282 1","pages":"418-426"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76808281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmaceutical Study of Allopurinol Gargle Containing Glycerin. 含甘油别嘌呤醇含漱液的药学研究。

Japanese Journal of Hospital Pharmacy Pub Date : 2000-01-01 DOI: 10.5649/JJPHCS1975.26.145

M. Myotoku, Kazunori Shimomura, Hisayuki Haji, T. Nishino

{"title":"Pharmaceutical Study of Allopurinol Gargle Containing Glycerin.","authors":"M. Myotoku, Kazunori Shimomura, Hisayuki Haji, T. Nishino","doi":"10.5649/JJPHCS1975.26.145","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.26.145","url":null,"abstract":"One of the side effects of cancer chemotherapy is the occurrence of stomatitis. Many studies have shown the effectiveness of a 0.1% allopurinol gargle for treating such stomatitis. Allopurinol gargle develops crystalline deposition a few days after preparation, and therefore it should befreshly prepared each time before use.We developed a prescription that delays crystalline deposition by adding glycerin to allopurinol gargle.Sterile allopurinol gargle (sterile ALT) was prepared by crushing allopurinol tablets, and then glycerin was added at various concentrations.The dissolved amount after 30 days was 0.65±0.05 mg/mL in sterile ALT without glycerin (sterile G0-ALT), 0.75±0.01 mg/mL in sterile ALT containing 1% glycerin (sterile G1-ALT), 0.79±0.03 mg/mL in sterile ALT containing 3% glycerin (sterile G 3-ALT), 0.89±0.06 mg/mL in sterile ALT containing 5% glycerin (sterile G 5-ALT), and 0.98±0.01 mg/mL in sterile ALT containing 10% glycerin (sterile G 10-ALT). The dissolved amount increased with the glycerin concentration.Allopurinol crystal deposition was observed after 2 days in sterile G 0-ALT, after 3 days in sterile G 1-ALT, after 6 days in sterile G 3-ALT, and after 10 days in sterile G 5-ALT, but could not be detected even after 30 days in sterile G 10-ALT.In tests of the sensation tastes during use in normal subjects, similar results were obtained between sterile G 10-ALT and sterile G 0-ALT. The xanthine oxidase (XOD) inhibitory activity was also similar between the two gargles.These results show that sterile G 10-ALT can be preserved for 30 days at 25°C, and its effects and sensation during use are similar to those of a prescription not containing glycerin.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"8 1","pages":"145-156"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82865830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between Serum Trough Concentrations of Cibenzoline and Fasting Blood Glucose Levels in Inpatiens Received Cibenzoline Therapy. 苯并啉治疗住院患者血药谷浓度与空腹血糖的关系

Japanese Journal of Hospital Pharmacy Pub Date : 2000-01-01 DOI: 10.5649/JJPHCS1975.26.304

K. Ueno, Megumi Morii, S. Ishida, A. Tamamura, Kana Matsumoto, Ayumi Oda, M. Takada, S. Kamakura, M. Shibakawa

引用次数: 0

Evaluation of Medline Utility for the Retrieval of Case Reports of Drug Adverse Effects. Medline对药物不良反应病例报告检索的效用评价。

Japanese Journal of Hospital Pharmacy Pub Date : 2000-01-01 DOI: 10.5649/JJPHCS1975.26.27

J. Hamada, T. Orii, E. Negishi, Yasuhiko Yamada, Hitoshi Sato, T. Iga

{"title":"Evaluation of Medline Utility for the Retrieval of Case Reports of Drug Adverse Effects.","authors":"J. Hamada, T. Orii, E. Negishi, Yasuhiko Yamada, Hitoshi Sato, T. Iga","doi":"10.5649/JJPHCS1975.26.27","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.26.27","url":null,"abstract":"Database usage was evaluated regarding the retrieval of drug-induced adverse effect case reports. A search of case reports was performed using the on-line Medline (Ovid). Forty case reports were extracted from “Reactions” (adis INTERNATIONAL) used as secondary literature on adverse effects. From the original titles and abstracts, the name of the drugs and adverse effects were translated into Japanease and used to search data sets. After 6 pharmacists received a 30-minute explanation on how to use Medline since they had no previous experience in using Medline at the time of this study, the accessibility to the original case reports was examined and evaluated for their hitting rates. The hitting rates of the original data were 40-75%, and the data was divided into high-rate and low-rate groups. A major cause of a low hitting rate was that the “explode” function was not utilized to extend the terms of adverse effects. As a result, the “explode” function was found to be an important factor in effectively using Medline, especially when terms are not adequately chosen to retrieve case reports on adverse effects.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"29 1","pages":"27-35"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74805956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Contribution of Hospital Pharmacists to Countermeasures for Intrahospital Infectionin of the Tuberculosis. Epidemic Research on Tuberculin Reaction in the General Hospital Staffs. 医院药师对防治院内感染的贡献。综合医院职工结核菌素反应的流行病学研究。

Japanese Journal of Hospital Pharmacy Pub Date : 2000-01-01 DOI: 10.5649/JJPHCS1975.26.524

Mutsunobu Yoshioka, Kouichi Masaki, N. Kitada, Y. Ogawa, T. Tuji, M. Watari, K. Nagasawa, N. Ohnishi, T. Yokoyama, Kazuo Kuroda

引用次数: 0

The Evaluation of Transdermal Nitrate Tape Preparations on their Side Effects for Skin Irritation, Efficacies and Costs. The Determination of Water Permeability and Exfoliation of Stratum Corneum. 硝酸根透皮贴制剂对皮肤刺激的副作用、疗效和成本的评价。角质层透水性及剥落的测定。

Japanese Journal of Hospital Pharmacy Pub Date : 2000-01-01 DOI: 10.5649/JJPHCS1975.26.510

N. Hayase, M. Koeda, T. Awaya, C. Hara, Yasunori Yamashita, Kuniko Yamamoto, Y. Itagaki, K. Matubara

{"title":"The Evaluation of Transdermal Nitrate Tape Preparations on their Side Effects for Skin Irritation, Efficacies and Costs. The Determination of Water Permeability and Exfoliation of Stratum Corneum.","authors":"N. Hayase, M. Koeda, T. Awaya, C. Hara, Yasunori Yamashita, Kuniko Yamamoto, Y. Itagaki, K. Matubara","doi":"10.5649/JJPHCS1975.26.510","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.26.510","url":null,"abstract":"In recent years, transdermal tape preparations have been widely used for numerous patients. A major problem related to the use of such tape is skin irritation. This adverse event is considered to be due to the impermeability of water through the tape material during adhesion and the occurrence of skin, eruption after its removal. As a result, the water permeability of the tape materials and the amounts of stratum comeum stripped from the skin were studied on five transdermal nitrate tape preparations. The water permeability of the preparation, in which the polyester membrane was used for the backing body, depends on the membrane thickness: a thinner membrane has a higher water permeability. The highest permeability was detected in the Antup® preparation. On the other hand, the amount of stratum comeum stripped from the skin was significantly lower when the new Frandol tape S® preparation was applied. According to these results and other drug information such as the cost of the preparation, we evaluated the quality of these products based on decision analysis criteria. This evaluation thus accurately indicated the effectiveness, safety and cost of the product. As a result, the highest score was obtained by the new Frandol tape S® preparation among the five tested products. This product showed the lowest amount of stratum comeum and the low incidence of side effects. In other words, new Frandol tape S® appears to be the most cost-beneficial transdermal nitrate tape preparation. The method used in this study was thus shown to be useful for the selection of the safest and most effective transdermal tape preparation.","PeriodicalId":14621,"journal":{"name":"Japanese Journal of Hospital Pharmacy","volume":"41 1","pages":"510-517"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84856523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of Plasma Panipenem Concentration in Neonates by High-Performance Liquid Chromatography. 高效液相色谱法测定新生儿血浆帕尼培南浓度。

Japanese Journal of Hospital Pharmacy Pub Date : 2000-01-01 DOI: 10.5649/JJPHCS1975.26.505

H. Kokubun, Toshimi Kimura, S. Murase, S. Shimada, H. Kubo, M. Matsumoto, M. Nowatari, N. Matsuura

引用次数: 1

A Study for the Side Effect of Iron Products. 铁制品的副作用研究。

Japanese Journal of Hospital Pharmacy Pub Date : 2000-01-01 DOI: 10.5649/JJPHCS1975.26.323

E. Usami, H. Shibata, M. Mizuno, Y. Seyama

引用次数: 0

Investigation of the Effect of the Coexistence of Surfactant on the Release Behavior of Diethylhexyl Phthalate from the Polyvinyl Chloride Tubing. 表面活性剂共存对聚氯乙烯管中邻苯二甲酸二乙己酯释放行为影响的研究。

Japanese Journal of Hospital Pharmacy Pub Date : 2000-01-01 DOI: 10.5649/JJPHCS1975.26.471

E. Muramatsu, T. Hanawa, Masahiko Suzuki, Mutsuko Tanaka, K. Kawano, S. Nakajima

引用次数: 8