Investigation of the Effect of the Coexistence of Surfactant on the Release Behavior of Diethylhexyl Phthalate from the Polyvinyl Chloride Tubing.

Abstract

The release behavior of diethylhexyl phthalate (DEHP, a plasticizer of polyvinyl chloride) from polyvinyl chloride (PVC) tubing caused by the coexistence of such surfactants as polysorbate 80 and polyoxyethylene castor oil (Tween 80 and HCO 60, a solubilizer for water insoluble drugs, respectively) in various solutions was investigated. The concentration of released DEHP increased as the concentration of Tween 80 increased. As the drip rate accelerated, the concentration of the released DEHP diminished. Based on a comparison of the release behaviors of DEHP observed in the solutions containing surfactant alone and a commercial injection, they were found to be compatible together. These results suggest that it is become feasible to predict the concentration of dissolved DEHP based on the concentration of the surfactant and the drip rate.