Investigative ophthalmology & visual science最新文献

{"title":"Erratum in: Cellular-Level Visualization of Retinal Pathology in Multiple Sclerosis With Adaptive Optics.","authors":"","doi":"10.1167/iovs.66.12.36","DOIUrl":"10.1167/iovs.66.12.36","url":null,"abstract":"","PeriodicalId":14620,"journal":{"name":"Investigative ophthalmology & visual science","volume":"66 12","pages":"36"},"PeriodicalIF":4.7,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12448147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RP1 Dual-AAV Gene Therapy Preserves Retinal Structure and Ameliorates Photoreceptor Degeneration in a Murine Model of Retinitis Pigmentosa.","authors":"Fanfei Liu, Qiqi Li, Jing Su, Jiamei Fu, Xiaoyi Wu, Qiuxia Xu, Chengda Ren, Xiu Jin, Li Song, Fang Lu, Yang Yang","doi":"10.1167/iovs.66.12.29","DOIUrl":"10.1167/iovs.66.12.29","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to develop and compare dual-adeno-associated virus (AAV) gene therapy utilizing protein trans-splicing versus mRNA trans-splicing to restore RP1 expression, and to evaluate their safety and efficacy in rescuing photoreceptor degeneration in a mouse model of RP1-associated retinitis pigmentosa (RP).</p><p><strong>Methods: </strong>By screening various split sites within the RP1 sequence in combination with different inteins or adopting mRNA trans-splicing binding sequences, we generated several plasmid pairs capable of reconstituting RP1 in vitro. Next, we conducted dual-AAV gene therapy via subretinal injection in RP1-/- mice. We validated the RP1 protein reconstitution in vivo by Western blotting. To assess the safety and efficacy of dual-AAV systems in RP1-/- mice, retinal structure was evaluated by histological analysis and transmission electron microscopy (TEM), and visual function was assessed by electroretinography (ERG) and visually guided behavioral tests at 1 and 6 months post-treatment.</p><p><strong>Results: </strong>The protein trans-splicing dual-AAV system achieved 72.35% of wild-type RP1 expression levels, significantly outperforming the mRNA trans-splicing approach (37.84%) at 1 month post-treatment. Both dual-AAV gene therapies preserved photoreceptor morphology and restored retinal function. The protein trans-splicing dual-AAV system exhibited higher ERG amplitudes and better performance in the water maze than the mRNA trans-splicing system.</p><p><strong>Conclusions: </strong>Our study demonstrates protein trans-splicing mediated dual-AAV gene therapy as a promising strategy for RP1-associated RP, offering potential therapeutic avenue for patients with RP.</p>","PeriodicalId":14620,"journal":{"name":"Investigative ophthalmology & visual science","volume":"66 12","pages":"29"},"PeriodicalIF":4.7,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrogen Sulfide-Preconditioned Mesenchymal Stem Cells Attenuate Ferroptosis in Corneal Alkali Burn via the AMPK/Nrf2/HO-1 Pathway in an IL-10-Dependent Manner.","authors":"Mingxiong Chen, Yilin Jiang, Hanrui Yu, Haolan Qi, Xiaoqi Li, Junyi Wang, An Wang, Zhao Li, Qun Wang, Yifei Huang, Liqiang Wang","doi":"10.1167/iovs.66.12.58","DOIUrl":"10.1167/iovs.66.12.58","url":null,"abstract":"<p><strong>Purpose: </strong>We aimed to investigate whether hydrogen sulfide (H2S)-preconditioned mesenchymal stem cells (MSCs) could enhance the anti-ferroptotic effects in a murine model of corneal alkali burn.</p><p><strong>Methods: </strong>MSCs were treated with various concentrations of GYY4137 (an H2S donor) and Western blot was used to detect the expression of IL-10 and cleaved-caspase-3. Slit-lamp photography and hematoxylin and eosin (H&E) staining were used to observe corneal structure after receiving a single subconjunctival injection of H2S-MSCs. Quantitative PCR (QPCR) or Western blot were used to detect the expression of pro-inflammatory cytokines, ferroptosis-regulatory molecules (SLC7A11, GPX4, 4-HNE, and FTH1) and AMPK/Nrf2/HO-1 pathway on day 7 after corneal injury. A co-culture model of human corneal epithelial cells (HCECs) and MSCs was used to investigate the anti-ferroptotic effects of MSCs.</p><p><strong>Results: </strong>Under the stimulation of 1 µmol/L GYY4137 for 48 hours, MSCs showed enhanced expression of IL-10. Furthermore, H2S pretreatment suppressed hydrogen peroxide (H2O2)- or serum deprivation-induced MSC apoptosis in vitro. On days 7 and 14 post-treatment, corneal opacity was ameliorated and corneal structure was more regular in the H2S-MSC group. H2S-MSC effectively attenuated ferroptosis in the cornea and HCECs by upregulating the expression of SLC7A11 and GPX4, while suppressing the level of 4-HNE and FTH1. Meanwhile, H2S-MSC activated AMPK/Nrf2/HO-1 pathway in vitro and in vivo. Knockdown of IL-10 via siRNA attenuated the inhibitory effects of H2S-MSC on erastin-induced ferroptosis in HCECs.</p><p><strong>Conclusions: </strong>H2S preconditioning augmented the anti-inflammatory and anti-ferroptotic effects of MSCs via activation of the AMPK/Nrf2/HO-1 pathway in an IL-10-dependent way, offering a novel strategy for corneal alkali burn treatment.</p>","PeriodicalId":14620,"journal":{"name":"Investigative ophthalmology & visual science","volume":"66 12","pages":"58"},"PeriodicalIF":4.7,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment of an Advanced In Vitro Model for Pseudoexfoliation Syndrome and Glaucoma.","authors":"Sai Pulasani, Matthias Zenkel, Robert Lämmer, Anselm Jünemann, Andreas Gießl, Klaus Korn, Friedrich E Kruse, Francesca Pasutto, Ursula Schlötzer-Schrehardt","doi":"10.1167/iovs.66.12.61","DOIUrl":"10.1167/iovs.66.12.61","url":null,"abstract":"<p><strong>Purpose: </strong>Pseudoexfoliation (PEX) glaucoma is caused by progressive accumulation of abnormal fibrillar aggregates in aqueous humor outflow tissues. The current lack of effective models for PEX research, replicating the key feature of PEX material production, represents a critical gap in understanding the molecular pathomechanisms and identifying specific therapeutic targets. We have developed an advanced in vitro model using stromal fibroblasts from iridectomy specimens of PEX glaucoma patients with an appropriate genetic background.</p><p><strong>Methods: </strong>Peripheral iridectomy specimens were obtained from patients with PEX glaucoma (n = 35) during routine trabeculectomy. Stromal fibroblasts were enriched from heterogenous cell cultures. Extracellular matrix formation was stimulated and modulated in two- and three-dimensional (3D) spheroid cultures by TGF-β1, Ficoll 400, all-trans-retinoic acid (ATRA), and curcumin. Cell cultures were analyzed by immunocytochemistry, transmission electron microscopy and qPCR. Immortalized cell lines (n = 4) were generated by SV40 large T-antigen transfection.</p><p><strong>Results: </strong>Fibroblasts carrying the high-risk haplotype of LOXL1 (lysyl oxidase-like 1) expressed PEX-relevant matrix components and assembled an elastic fibrillar network, particularly upon treatment with TGF-β1 and the macromolecular crowding agent Ficoll 400. In 3D spheroid cultures, the presence of typical fibrillar PEX aggregates could be demonstrated by electron microscopy. Matrix production could be effectively suppressed by ATRA and curcumin. Similar to primary cells, immortalized cell lines formed 3D spheroids and expressed PEX-relevant matrix components including typical fibrillar aggregates.</p><p><strong>Conclusions: </strong>This advanced in vitro model, which recapitulates the hallmark of PEX syndrome/glaucoma, may provide a useful, easy-to-handle platform for studying disease mechanisms, assessing the impact of genetic and external factors, and exploring effects of targeted therapies for PEX-associated fibrosis.</p>","PeriodicalId":14620,"journal":{"name":"Investigative ophthalmology & visual science","volume":"66 12","pages":"61"},"PeriodicalIF":4.7,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Ocular Microbiomes of Children and Their Siblings and Parents.","authors":"Xiangtian Ling, Yuzhou Zhang, Christine H T Bui, Hei-Nga Chan, Pancy O S Tam, Yu Peng, Xiu Juan Zhang, Charlene C Yim, Ka Wai Kam, Wai Kit Chu, Patrick Ip, Alvin L Young, Stephen Kwok-Wing Tsui, Clement C Tham, Chi Pui Pang, Li Jia Chen, Jason C Yam","doi":"10.1167/iovs.66.12.59","DOIUrl":"10.1167/iovs.66.12.59","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to investigate the association of ocular microbiomes between children and their parents and siblings.</p><p><strong>Methods: </strong>An observational study was conducted at family units, involving 114 children and 131 parents, with conjunctival swab samples collected and analyzed using 16S rDNA high-throughput sequencing. Comparative analyses, diversity indexes, and distance measures were used to assess microbial community differences.</p><p><strong>Results: </strong>Children's ocular microbiomes are more similar to their parents than unrelated adults (P < 0.001 for both Bray-Curtis and Jensen-Shannon distances). Additionally, children's ocular microbiomes exhibited greater similarities with their siblings than with unrelated children (P < 0.001). However, couples who lived in the same family showed no more similarity in the composition of their ocular microbiota than did unrelated individuals (Bray-Curtis distance P = 0.7; Jensen-Shannon distance P = 0.47). Four genera, Aquabacterium, Corynebacterium, Staphylococcus and Streptococcus, were highly shared between parental and children's ocular microbiomes (>70% shared rate). A relatively weak correlation was observed between the age of child and the similarity comparing child's and adults' microbiomes. The interquartile range of parental contribution to a child's ocular microbiome was 11.2% (first quartile) to 33.0% (third quartile), suggesting a substantial majority attributable to unknown factors.</p><p><strong>Conclusions: </strong>Children's ocular microbiome is associated with that of their siblings and their parents, with this association showing a small tendency to increase with the age of the children. These findings highlight the importance of considering familial and environmental contexts in future microbiological research.</p>","PeriodicalId":14620,"journal":{"name":"Investigative ophthalmology & visual science","volume":"66 12","pages":"59"},"PeriodicalIF":4.7,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ebbinghaus Illusion Distortions in Amblyopia: Impairments of Visual Size Processing and Interocular Integration.","authors":"Changwu Tan, Xi Wang, Tong Liu, Longqian Liu, Alexandre Reynaud","doi":"10.1167/iovs.66.12.54","DOIUrl":"10.1167/iovs.66.12.54","url":null,"abstract":"<p><strong>Purpose: </strong>The perceived size of an object can be manipulated by its surroundings. In the current study, we wanted to investigate whether amblyopic patients have normal object size perception and how their perception is affected by abnormal interocular interactions.</p><p><strong>Methods: </strong>Sixteen adult amblyopes and 16 controls participated in this experiment. We measured the Ebbinghaus illusion magnitude with large and small inducers under one binocular, two monocular, and four dichoptic viewing configurations. Exploratory factor analysis was used to extract common structures and underlying mechanisms in different conditions.</p><p><strong>Results: </strong>The mean Ebbinghaus illusion magnitude in amblyopia was smaller with large inducers (F1,30 = 5.874, P = 0.021) and larger with small inducers (F1,30 = 5.814, P = 0.022) than in controls. For the small-inducer geometry, the interaction effect between groups and viewing configurations (F6,180 = 4.472, P < 0.001) was significant. Compared to the control population, the exploratory factor analysis in amblyopia extracted three more factors mainly accounting for dichoptic viewing configurations.</p><p><strong>Conclusions: </strong>Amblyopes tended to overestimate the object size relative to controls in the Ebbinghaus illusion, thereby amplifying it in the small-inducer geometry and diminishing it in the large-inducer geometry. Our factor analysis revealed a limited interocular transfer of the Ebbinghaus illusion in amblyopia, suggesting a defective mechanism in local binocular integration circuitry.</p>","PeriodicalId":14620,"journal":{"name":"Investigative ophthalmology & visual science","volume":"66 12","pages":"54"},"PeriodicalIF":4.7,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantifying Choriocapillaris Flow Deficits in Diabetic Retinopathy Using Projection-Resolved OCT Angiography.","authors":"Jie Wang, Tristan Hormel, Dong-Wouk Park, Shazib Haq, Steve Bailey, David Huang, Thomas S Hwang, Yali Jia","doi":"10.1167/iovs.66.12.13","DOIUrl":"10.1167/iovs.66.12.13","url":null,"abstract":"<p><strong>Purpose: </strong>To quantify choriocapillaris (CC) flow deficits using projection-resolved optical coherence tomographic angiography (PR-OCTA) and to evaluate whether they are correlated with diabetic retinopathy (DR).</p><p><strong>Methods: </strong>In this retrospective study, OCTA scans covering a range of DR severities were acquired. Shadowing artifacts caused by hard exudates, large inner retinal vessels, and vitreous floaters were detected, along with the retinal fluid area. The CC deficit ratio (percentage of deficit area) was measured and compared with shadowing artifacts and area beneath retinal fluid excluded to assess the effect of these confounding features. The Spearman correlation between the CC deficit ratio and disease severity was calculated, as well as the diagnostic performance (area under the receiver operating characteristic curve).</p><p><strong>Results: </strong>One hundred eighty-three participants were enrolled in this study. We found a significant positive correlation between age and CC deficit ratio in normal controls (Pearson correlation, P = 0.02). There was no significant difference in deficit ratio between measurements excluding only shadows and those excluding both shadows and the area beneath the fluid (Mann-Whitney U-test, P = 0.81). The CC deficit ratio was positively correlated with DR severity (Spearman correlation, P < 0.01). It was significantly higher in nonproliferative DR and PDR patients compared to normal controls (Tukey HSD, P < 0.01) but not in those with diabetes without DR. The proposed CC deficit segmentation method achieved high repeatability with an intraclass correlation coefficient of 0.92.</p><p><strong>Conclusions: </strong>The CC deficit ratio measured by the proposed method correlates with the presence and severity of DR.</p>","PeriodicalId":14620,"journal":{"name":"Investigative ophthalmology & visual science","volume":"66 12","pages":"13"},"PeriodicalIF":4.7,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144992414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cystoid Macular Edema in Non-Syndromic Retinitis Pigmentosa: Associations With Causative Genes in a Large Cohort.","authors":"Francesco Testa, Marianthi Karali, Rosa Boccia, Danila Pisani, Luciana Damiano, Antonio Nicolò, Emanuele Madonna, Luigi De Rosa, Raffaella Colucci, Antonella De Benedictis, Valentina Di Iorio, Paolo Melillo, Sandro Banfi, Francesca Simonelli","doi":"10.1167/iovs.66.12.5","DOIUrl":"10.1167/iovs.66.12.5","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the prevalence of cystoid macular edema (CME) in relation to the disease-causing genes in a large cohort of genetically defined patients with non-syndromic retinitis pigmentosa (RP).</p><p><strong>Methods: </strong>Spectral-domain optical coherence tomography (SD-OCT) imaging has been retrospectively reviewed in order to assess the presence of CME over the disease course in a cohort of 580 patients with a clinical and genetic diagnosis of non-syndromic RP.</p><p><strong>Results: </strong>Over the course of the disease, 179 patients (30.9%) developed CME in at least one eye. Based on the patients' genotypes, we found a statistically significant difference in CME prevalence according to the inheritance pattern (P < 0.001), with autosomal dominant forms being more frequently associated with CME (51.4%), followed by autosomal recessive forms (28.1%), but CME was rarely observed in X-linked RP (7.5%). By analyzing the most recurrent causative genes, we found the highest prevalence of CME in patients with autosomal dominant RP forms due to variants in RHO (58.2%), PRPF8 (72.7%), and PRPF3 (75.0%), whereas the lowest prevalence was observed in X-linked cases with mutations in RP2 (3.4%) and RPGR (8.8%).</p><p><strong>Conclusions: </strong>This study revealed a strong association of CME with the underlying causative gene in non-syndromic RP in the largest genotyped cohort so far reported, adding new insights in the etiopathogenesis of CME in RP. Our findings emphasize the importance of SD-OCT morphological assessments of RP patients both to improve disease management and to better explore genotype-phenotype correlations.</p>","PeriodicalId":14620,"journal":{"name":"Investigative ophthalmology & visual science","volume":"66 12","pages":"5"},"PeriodicalIF":4.7,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12410279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prevalence of Myopia in Finnish Conscripts Has not Increased in Recent Decades and Is Lower Than in Many East and Southeast Asian Countries.","authors":"Olavi Pärssinen, Marja-Liisa Franssila, Klaus Nordhausen, Mika Mattinen, Roope Sovelius, Markku Kauppinen, Jukka Moilanen, Niko Setälä, Ian Morgan","doi":"10.1167/iovs.66.12.10","DOIUrl":"10.1167/iovs.66.12.10","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to determine the prevalence of myopia among Finnish conscripts and to identify the factors associated with its occurrence in Finland.</p><p><strong>Methods: </strong>A total of 1694 conscripts (mean age: 19.3 ± 1.55 years) participated in the study. Refraction was performed on 1522 participants under tropicamide-induced cycloplegia. The final analyses included 1286 male conscripts who had completed the Finnish schooling system. A structured questionnaire collected data about education, time spent doing near work, smartphone use, and outdoor time. Univariate analyses and multivariate logistic regression models were used to determine the factors associated with myopia.</p><p><strong>Results: </strong>The overall prevalence of myopia was 23.5%, of which 0.4% had high myopia (SE ≤ -6 D). The main factors associated with myopia included (adjusted odds ratio; 95% confidence interval) near work time (1.184; 1.113-1.259), time spent outdoors (0.823; 0.754-0.895), and basic schooling versus higher education (1.256; 0.796-1.988). Among the higher-educated group, increased smartphone use was associated with a higher prevalence of myopia, whereas in the other educational groups, no association could be established.</p><p><strong>Conclusions: </strong>The prevalence of myopia among Finnish conscripts was relatively low, and high myopia was rare compared to the rates reported in many East and Southeast Asian countries. Higher education, prolonged near work, reduced time outdoors, and increased smartphone use (in the higher-educated group) were factors associated with myopia prevalence. The reduced educational pressure may be attributed to the lower prevalence of myopia among Finnish conscripts compared to many East and Southeast Asian countries, where myopia is much more prevalent.</p>","PeriodicalId":14620,"journal":{"name":"Investigative ophthalmology & visual science","volume":"66 12","pages":"10"},"PeriodicalIF":4.7,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12410276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum in: Characterization of the Retinal Circulation of the Mouse.","authors":"","doi":"10.1167/iovs.66.12.15","DOIUrl":"10.1167/iovs.66.12.15","url":null,"abstract":"","PeriodicalId":14620,"journal":{"name":"Investigative ophthalmology & visual science","volume":"66 12","pages":"15"},"PeriodicalIF":4.7,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12429679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}