IUPHAR/BPS Guide to Pharmacology CITE最新文献_第10页

Glucagon receptor family in GtoPdb v.2023.1 GtoPdb v.2023.1中胰高血糖素受体家族

IUPHAR/BPS Guide to Pharmacology CITE Pub Date : 2023-04-26 DOI: 10.2218/gtopdb/f29/2023.1

Dominique Bataille, Susan L. Chan, Philippe Delagrange, Daniel J. Drucker, Burkhard Göke, Rebecca Hills, Kelly E. Mayo, Laurence J. Miller, Roberto Salvatori, Bernard Thorens

引用次数: 0

Calcium- and sodium-activated potassium channels (KCa, KNa) in GtoPdb v.2023.1 GtoPdb v.2023.1中钙和钠活化的钾通道(KCa， KNa

IUPHAR/BPS Guide to Pharmacology CITE Pub Date : 2023-04-26 DOI: 10.2218/gtopdb/f69/2023.1

Richard Aldrich, K. George Chandy, Stephan Grissmer, George A. Gutman, Leonard K. Kaczmarek, Aguan D. Wei, Heike Wulff

引用次数: 5

Phosphodiesterases, 3',5'-cyclic nucleotide (PDEs) in GtoPdb v.2023.1 磷酸二酯酶，GtoPdb v.2023.1中的3'，5'-环核苷酸(PDEs)

IUPHAR/BPS Guide to Pharmacology CITE Pub Date : 2023-04-26 DOI: 10.2218/gtopdb/f260/2023.1

Chen Yan

引用次数: 0

Cyclic nucleotide-regulated channels (CNG) in GtoPdb v.2023.1 GtoPdb v.2023.1中的环核苷酸调节通道(CNG)

IUPHAR/BPS Guide to Pharmacology CITE Pub Date : 2023-04-26 DOI: 10.2218/gtopdb/f71/2023.1

Elvir Becirovic, Martin Biel, Stefanie Fenske, Verena Hammelmann, Franz Hofmann, U. Benjamin Kaupp

{"title":"Cyclic nucleotide-regulated channels (CNG) in GtoPdb v.2023.1","authors":"Elvir Becirovic, Martin Biel, Stefanie Fenske, Verena Hammelmann, Franz Hofmann, U. Benjamin Kaupp","doi":"10.2218/gtopdb/f71/2023.1","DOIUrl":"https://doi.org/10.2218/gtopdb/f71/2023.1","url":null,"abstract":"Cyclic nucleotide-gated (CNG) channels are responsible for signalling in the primary sensory cells of the vertebrate visual and olfactory systems. CNG channels are voltage-independent cation channels formed as tetramers. Each subunit has 6TM, with the pore-forming domain between TM5 and TM6. CNG channels were first found in rod photoreceptors [83, 120], where light signals through rhodopsin and transducin to stimulate phosphodiesterase and reduce intracellular cyclic GMP level. This results in a closure of CNG channels and a reduced ‘dark current’. Similar channels were found in the cilia of olfactory neurons [181] and the pineal gland [71]. The cyclic nucleotides bind to a domain in the C terminus of the subunit protein: other channels directly binding cyclic nucleotides include hyperolarisation-activated, cyclic nucleotide-gated channels (HCN), ether-a-go-go and certain plant potassium channels.The HCN channels are cation channels that are activated by hyperpolarisation at voltages negative to ~-50 mV. The cyclic nucleotides cyclic AMP and cyclic GMP directly bind to the cyclic nucleotide-binding domain of HCN channels and shift their activation curves to more positive voltages, thereby enhancing channel activity. HCN channels underlie pacemaker currents found in many excitable cells including cardiac cells and neurons [65, 192]. In native cells, these currents have a variety of names, such as Ih, Iq and If. The four known HCN channels have six transmembrane domains and form tetramers. It is believed that the channels can form heteromers with each other, as has been shown for HCN1 and HCN4 [2]. High resolution structural studies of CNG and HCN channels has provided insight into the the gating processes of these channels [139, 146, 140]. A standardised nomenclature for CNG and HCN channels has been proposed by the NC-IUPHAR Subcommittee on voltage-gated ion channels [108].","PeriodicalId":14617,"journal":{"name":"IUPHAR/BPS Guide to Pharmacology CITE","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135018446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parathyroid hormone receptors in GtoPdb v.2023.1 甲状旁腺激素受体在GtoPdb v.2023.1

IUPHAR/BPS Guide to Pharmacology CITE Pub Date : 2023-04-26 DOI: 10.2218/gtopdb/f53/2023.1

Alessandro Bisello, Michael Chorev, Peter A. Friedman, Tom Gardella, Rebecca Hills, Harald Jueppner, T. John Martin, Robert A. Nissenson, John Thomas Potts, Jr., Caroline Silve, Ted B. Usdin, Jean-Pierre Vilardaga

引用次数: 0

Gonadotrophin-releasing hormone receptors in GtoPdb v.2023.1 促性腺激素释放激素受体在GtoPdb v.2023.1

IUPHAR/BPS Guide to Pharmacology CITE Pub Date : 2023-04-26 DOI: 10.2218/gtopdb/f31/2023.1

L. Heitman, A. IJzerman, C. McArdle, Adam J Pawson

{"title":"Gonadotrophin-releasing hormone receptors in GtoPdb v.2023.1","authors":"L. Heitman, A. IJzerman, C. McArdle, Adam J Pawson","doi":"10.2218/gtopdb/f31/2023.1","DOIUrl":"https://doi.org/10.2218/gtopdb/f31/2023.1","url":null,"abstract":"GnRH1 and GnRH2 receptors (provisonal nomenclature [39], also called Type I and Type II GnRH receptor, respectively [85]) have been cloned from numerous species, most of which express two or three types of GnRH receptor [85, 84, 114]. GnRH I (p-Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) is a hypothalamic decapeptide also known as luteinizing hormone-releasing hormone, gonadoliberin, luliberin, gonadorelin or simply as GnRH. It is a member of a family of similar peptides found in many species [85, 84, 114] including GnRH II (pGlu-His-Trp-Ser-His-Gly-Trp-Tyr-Pro-Gly-NH2 (which is also known as chicken GnRH-II). Receptors for three forms of GnRH exist in some species but only GnRH I and GnRH II and their cognate receptors have been found in mammals [85, 84, 114]. GnRH1 receptors are expressed by pituitary gonadotrophs, where they mediate the effects of GnRH on gonadotropin hormone synthesis and secretion that underpin central control of mammalian reproduction. GnRH analogues are used in assisted reproduction and to treat steroid hormone-dependent conditions [58]. Notably, agonists cause desensitization of GnRH-stimulated gonadotropin secretion and the consequent reduction in circulating sex steroids is exploited to treat hormone-dependent cancers of the breast, ovary and prostate [58]. GnRH1 receptors are selectively activated by GnRH I and all lack the COOH-terminal tails found in other GPCRs. GnRH2 receptors do have COOH-terminal tails and (where tested) are selective for GnRH II over GnRH I. GnRH2 receptors are expressed by some primates but not by humans [88]. Phylogenetic classifications divide GnRH receptors into three [85] or five groups [130] and highlight examples of gene loss through evolution, with humans retaining only one ancient gene. The structure of the GnRH1 receptor in complex with elagolix has been elucidated [133].","PeriodicalId":14617,"journal":{"name":"IUPHAR/BPS Guide to Pharmacology CITE","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80331581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Angiotensin receptors in GtoPdb v.2023.1 血管紧张素受体在GtoPdb v.2023.1

IUPHAR/BPS Guide to Pharmacology CITE Pub Date : 2023-04-26 DOI: 10.2218/gtopdb/f6/2023.1

Wayne Alexander, K. Bernstein, K. Catt, M. de Gasparo, Khuraijam Dhanachandra Singh, S. Eguchi, E. Escher, T. Goodfriend, M. Horiuchi, L. Hunyady, A. Husain, T. Inagami, S. Karnik, Jacqueline R. Kemp, W. Thomas, P. Timmermans, Kalyan C. Tirupula, Hamiyet Unal, T. Unger, P. Vanderheyden

引用次数: 0

Glycoprotein hormone receptors in GtoPdb v.2023.1 GtoPdb v.2023.1中糖蛋白激素受体

IUPHAR/BPS Guide to Pharmacology CITE Pub Date : 2023-04-26 DOI: 10.2218/gtopdb/f30/2023.1

S. Costagliola, J. Dias, M. Gershengorn, Adam J. Pawson, D. Segaloff, A. Themmen, G. Vassart

引用次数: 0

ABCG subfamily in GtoPdb v.2023.1

IUPHAR/BPS Guide to Pharmacology CITE Pub Date : 2023-04-26 DOI: 10.2218/gtopdb/f155/2023.1

I. Kerr

引用次数: 0

Voltage-gated calcium channels (CaV) in GtoPdb v.2023.1 GtoPdb v.2023.1中的电压门控钙通道(CaV)

IUPHAR/BPS Guide to Pharmacology CITE Pub Date : 2023-04-26 DOI: 10.2218/gtopdb/f80/2023.1

W. Catterall, Edward Perez-Reyes, Terrance P. Snutch, Joerg Striessnig

{"title":"Voltage-gated calcium channels (CaV) in GtoPdb v.2023.1","authors":"W. Catterall, Edward Perez-Reyes, Terrance P. Snutch, Joerg Striessnig","doi":"10.2218/gtopdb/f80/2023.1","DOIUrl":"https://doi.org/10.2218/gtopdb/f80/2023.1","url":null,"abstract":"Ca2+ channels are voltage-gated ion channels present in the membrane of most excitable cells. The nomenclature for Ca2+channels was proposed by [131] and approved by the NC-IUPHAR Subcommittee on Ca2+ channels [72]. Most Ca2+ channels form hetero-oligomeric complexes. The α1 subunit is pore-forming and provides the binding site(s) for practically all agonists and antagonists. The 10 cloned α1-subunits can be grouped into three families: (1) the high-voltage activated dihydropyridine-sensitive (L-type, CaV1.x) channels; (2) the high- to moderate-voltage activated dihydropyridine-insensitive (CaV2.x) channels and (3) the low-voltage-activated (T-type, CaV3.x) channels. Each α1 subunit has four homologous repeats (I-IV), each repeat having six transmembrane domains (S1-S6) and a pore-forming region between S5 and S6. Voltage-dependent gating is driven by the membrane spanning S4 segment, which contains highly conserved positive charges that respond to changes in membrane potential. All of the α1-subunit genes give rise to alternatively spliced products. At least for high-voltage activated channels, it is likely that native channels comprise co-assemblies of α1, β and α2-δ subunits. The γ subunits have not been proven to associate with channels other than the α1s skeletal muscle Cav1.1 channel. The α2-δ1 and α2-δ2 subunits bind gabapentin and pregabalin.","PeriodicalId":14617,"journal":{"name":"IUPHAR/BPS Guide to Pharmacology CITE","volume":"271 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86727520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0