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引用次数: 0
摘要
维生素D (VDR)、Pregnane X (PXR)和组成型雄甾烷(CAR)受体(命名由NC-IUPHAR核激素受体小组委员会同意[501,1])是核受体NR1I家族的成员，它们与类视黄醇X受体家族的成员形成异源二聚体。尽管高浓度的胆汁酸和胆汁色素可以激活PXR和CAR，但PXR和CAR可被一系列外源性化合物激活，没有确定的内源性生理激动剂。
1I. Vitamin D receptor-like receptors in GtoPdb v.2023.1
Vitamin D (VDR), Pregnane X (PXR) and Constitutive Androstane (CAR) receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [50, 1]) are members of the NR1I family of nuclear receptors, which form heterodimers with members of the retinoid X receptor family. PXR and CAR are activated by a range of exogenous compounds, with no established endogenous physiological agonists, although high concentrations of bile acids and bile pigments activate PXR and CAR [50].
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