JAC-Antimicrobial Resistance最新文献

{"title":"Promethazine use and QT prolongation risk during treatment with a shortened all-oral regimen for MDR/RR-TB.","authors":"Edmund Q L Shen, Letizia Trevisi, Stephane Mpinda, Allison Lahood, Llang Maama, Meseret Tamirat, Sebakeng Phate, Lawrence Oyewusi, Matthew Romo, Elna Osso, Michael L Rich, Carole D Mitnick, Kwonjune Justin Seung, Molly F Franke, Kunda Kwabisha Mikanda","doi":"10.1093/jacamr/dlag215","DOIUrl":"10.1093/jacamr/dlag215","url":null,"abstract":"<p><strong>Background: </strong>Shortened all-oral regimens for multidrug- or rifampicin-resistant tuberculosis (MDR/RR-TB) combine multiple QTc prolonging agents, including bedaquiline and delamanid, which act partly through hERG potassium channel binding. Promethazine, a first-generation antihistamine used for nausea during TB therapy, shares this mechanism. Whether adjunctive promethazine further raises the risk of clinically relevant QTc prolongation in this setting is unclear.</p><p><strong>Methods: </strong>We conducted secondary analyses from a prospective observational cohort study of patients ≥15 years in Lesotho who received a 9- to 12-month all-oral regimen (bedaquiline, linezolid, levofloxacin, clofazimine, delamanid) for pulmonary MDR/RR-TB. We modelled time-varying promethazine exposure using the Andersen-Gill formulation of Cox regression, with time-to-first grade ≥3 (>500 ms) QTc event as the outcome of interest. We conducted comparator analyses with time-varying exposure to metoclopramide, ondansetron, and episodes of nausea, dizziness, and vomiting.</p><p><strong>Results: </strong>Among 247 participants (median age 41, 63.2% living with HIV), 62 (25.1%) received promethazine. Grade ≥3 QTc prolongation occurred in 10 (4.0%). Incident clinically significant QTc prolongation was higher during promethazine-exposed than unexposed periods (7.4 versus 1.3 per 10 000 person-days; HR 7.0, 95% CI: 1.4-35.3). No comparable elevation was seen in analyses of exposure to metoclopramide (HR 1.0, 95% CI: 0.3-3.6), ondansetron, or episodes of nausea, dizziness, or vomiting (HR 1.5, 95% CI: 0.3-6.9).</p><p><strong>Conclusions: </strong>Promethazine use was associated with increased risk of clinically relevant QTc prolongation within a QTc-burdened all-oral MDR/RR-TB regimen. These findings provide preliminary evidence that clinicians may consider when selecting anti-emetics as part of MDR/RR-TB therapy with a shortened all-oral regimen and highlight the importance of evaluating adjunctive medications in DR-TB care.</p>","PeriodicalId":14594,"journal":{"name":"JAC-Antimicrobial Resistance","volume":"8 5","pages":"dlag215"},"PeriodicalIF":3.9,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13639364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Public knowledge, beliefs and behaviours related to antimicrobial resistance and antibiotics: a systematic review of studies in high-income countries.","authors":"Caoimhe Shields, Tracy Epton, Emma Berry, Laura J Sahm, Aoife Fleming, Ilias Lambrou, Rebecca Feeney, Najam Us Sahar, Mitch Dobbs, Chikondi C Kandulu, Ellen Melia, Gillian W Shorter","doi":"10.1093/jacamr/dlag213","DOIUrl":"https://doi.org/10.1093/jacamr/dlag213","url":null,"abstract":"<p><strong>Background: </strong>Antimicrobial resistance (AMR) is a growing public health concern, influenced by public behaviours. This study aimed to systematically review and synthesize qualitative and quantitative studies on public knowledge, beliefs and behaviours related to antibiotics and AMR, and explore gender differences, in high-income countries.</p><p><strong>Materials and methods: </strong>Eleven databases including Web of Science Core Collection, Medline and PsycINFO were searched for primary studies published between August 2014 and 12 June 2026. This article reports the high-income country subset of a larger global review; other results will be reported separately. We carried out a descriptive, non-meta-analytic synthesis at study- and country-level by calculating the mean, SD, median and range of the proportion of participants whose data demonstrated incorrect knowledge, misconceptions, and positive or negative behaviours. Gender differences were synthesized narratively. Qualitative data were synthesized under each outcome using deductive thematic analysis.</p><p><strong>Results: </strong>Of 12 338 records identified, 121 were globally eligible. Thirty-three high-income country studies were included in this article (29 quantitative and 4 qualitative, with 33 252 participants). Cross-country variability was found in knowledge, beliefs and behaviours. Misunderstandings were prominent around the definition of AMR and its implications for health. Narrative gender differences were inconsistent and qualitative data were limited, but gave insight into potential drivers of behaviours.</p><p><strong>Conclusions: </strong>Despite international variations, knowledge gaps, misconceptions and counterproductive behaviours were widespread. Findings show that AMR is a system-wide issue that requires attention from all One Health stakeholders, and a unified, multi-faceted, multidisciplinary approach that can help tackle the continuing public health threat, and change behaviour to protect health.</p>","PeriodicalId":14594,"journal":{"name":"JAC-Antimicrobial Resistance","volume":"8 5","pages":"dlag213"},"PeriodicalIF":3.9,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mutations in <i>dfrA</i> and its upstream region are associated with <i>para</i>-aminosalicylic acid resistance in <i>Mycobacterium tuberculosis</i>.","authors":"Rong Zeng, Najeeb Ullah, Jing Gu, Jiao-Yu Deng","doi":"10.1093/jacamr/dlag211","DOIUrl":"https://doi.org/10.1093/jacamr/dlag211","url":null,"abstract":"<p><strong>Objectives: </strong><i>para</i>-Aminosalicylic acid is an antifolate prodrug activated in the folate biosynthesis pathway of <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>), ultimately inhibiting dihydrofolate reductase encoded by <i>dfrA</i>. Mutations in <i>dfrA</i> coding and upstream regions have not been thoroughly investigated. This study aimed to assess mutations in <i>dfrA</i> and its upstream regulatory region in clinical <i>Mtb</i> isolates.</p><p><strong>Methods: </strong>We retrieved and analysed 6547 whole-genome sequences of <i>Mtb</i> clinical isolates. We identified 29 SNPs in the <i>dfrA</i> coding region and eight mutations in the <i>thyA-dfrA</i> upstream region. The most prevalent coding mutations and upstream mutations were selected for functional evaluation using thermal stability analysis, GFP reporter assays and <i>para</i>-aminosalicylic acid drug susceptibility test (DST).</p><p><strong>Results: </strong>The coding mutations Trp142→Gly, Gln28→Leu and Arg32→Pro were analysed for protein thermal stability and <i>para</i>-aminosalicylic acid susceptibility. Gln28→Leu showed increased thermal stability relative to the WT, whereas Trp142→Gly and Arg32→Pro exhibited reduced stability. Consistently, <i>para</i>-aminosalicylic acid DST demonstrated that Gln28→Leu conferred an 8-fold increase in <i>para</i>-aminosalicylic acid resistance, while Trp142→Gly and Arg32→Pro remained phenotypically susceptible. Moreover, GFP reporter assays revealed that G70T, G59T and C48A increased promoter activity by 13-fold, 4-fold and 3-fold, respectively, whereas the remaining mutations showed no significant effect. Findings were verified by <i>para</i>-aminosalicylic acid DST, where G70T, G59T and C48A showed <i>para</i>-aminosalicylic acid resistance compared with WT.</p><p><strong>Conclusions: </strong>By integrating genomic analysis with functional assays of thermal stability, promoter activity and drug susceptibility, this study demonstrated that mutations in <i>dfrA</i> coding and upstream regulatory regions contribute to <i>para</i>-aminosalicylic acid resistance in <i>Mtb</i> clinical isolates.</p>","PeriodicalId":14594,"journal":{"name":"JAC-Antimicrobial Resistance","volume":"8 5","pages":"dlag211"},"PeriodicalIF":3.9,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Characterization of isavuconazole pharmacokinetics and pharmacodynamics in a real-life cohort.","authors":"","doi":"10.1093/jacamr/dlag214","DOIUrl":"https://doi.org/10.1093/jacamr/dlag214","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1093/jacamr/dlag071.].</p>","PeriodicalId":14594,"journal":{"name":"JAC-Antimicrobial Resistance","volume":"8 5","pages":"dlag214"},"PeriodicalIF":3.9,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13621177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149080798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The guidance ratio: a measure of post-diagnostic antibiotic decision-making.","authors":"Kalle Garpvall, Alex Aljundi, Anna Dahl, Ellinor Sterky, Joachim Luthander, Susanne Sütterlin","doi":"10.1093/jacamr/dlag195","DOIUrl":"10.1093/jacamr/dlag195","url":null,"abstract":"<p><strong>Background: </strong>Scalable measures that capture post-diagnostic antibiotic decisions are lacking. We developed and validated the guidance ratio (GR), a registry-based measure of post-diagnostic antibiotic decision-making.</p><p><strong>Methods: </strong>We conducted a retrospective multi-centre validation study of the GR and discontinuation ratio (DR), two registry-based indicators of post-diagnostic antibiotic decision-making in paediatric febrile urinary tract infection. Prescribing outcomes were classified using rule-based algorithms and compared with manually classified outcomes from medical record review. Indicator performance was evaluated against medical record data used as the reference standard.</p><p><strong>Results: </strong>Among 909 episodes, the GR identified guided treatment with a sensitivity of 0.78 and specificity of 1.00. Although registry-based estimates underestimated absolute values, they closely tracked temporal prescribing patterns. Calibration substantially improved agreement with manually classified outcomes.</p><p><strong>Conclusions: </strong>The GR captured clinically meaningful prescribing patterns and may support scalable monitoring of post-diagnostic antibiotic decision-making in stewardship programmes.</p>","PeriodicalId":14594,"journal":{"name":"JAC-Antimicrobial Resistance","volume":"8 4","pages":"dlag195"},"PeriodicalIF":3.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13529414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148874079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of medical and dental education on student antimicrobial resistance literacy in Croatia.","authors":"Caroline Othilie Dedekam Pederssen, Son Lam Pham, Paula Žugec, Jan Homolak, Ivana Šutej, Roger Junges","doi":"10.1093/jacamr/dlag183","DOIUrl":"10.1093/jacamr/dlag183","url":null,"abstract":"<p><strong>Background and objectives: </strong>Antimicrobial resistance is a pressing public health concern in Croatia, where antibiotic consumption exceeds the European average. Assessing the impact of education on antimicrobial resistance literacy among future prescribers is a priority, yet parallel evidence from both medicine and dentistry remains limited. Here we evaluated the effect of curriculum-based education on antimicrobial resistance literacy among Croatian medical and dental students across all study years.</p><p><strong>Methods: </strong>We used a cross-sectional survey to assess dental and medical students' attitudes towards antibiotics and antimicrobial resistance. Domains included perceptions, knowledge, confidence to prescribe and educational interest. Descriptive statistics were used coupled with statistical testing for comparison across study years.</p><p><strong>Results: </strong>A total of 692 responses were collected. Antimicrobial resistance was selected as one of the top global priorities by both medical and dental students. While AMR was broadly recognized as a global challenge, significant knowledge gains across study years were more pronounced in dental than in medical students, particularly from year 1 to subsequent years. Over 58% of final-year medical students reported feeling patient-imposed pressure to prescribe antibiotics. For fifth- and sixth-year students, a marked difference in patient communication was observed as >60% of medical students reported discussing antimicrobial resistance with patients very often, compared with only 10% of dental students.</p><p><strong>Conclusions: </strong>We showed a positive effect of education throughout the study years in both medicine and dentistry, with more evident effects in the latter. High reported pressures to prescribe coupled with a gap in communication practices were observed.</p>","PeriodicalId":14594,"journal":{"name":"JAC-Antimicrobial Resistance","volume":"8 4","pages":"dlag183"},"PeriodicalIF":3.9,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13526504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Online education resources for antimicrobial stewardship in Ethiopia: an educational resource review.","authors":"Mikiyas G Teferi, Kebron W Aweke, Gelila S Kassa, Selamawit Z Tadesse, Elias Gashaw Endegnanew, Eden Haile Hagos, Biruk T Mengistie, Chernet T Mengistie, Demmelash Gezahegn Nigatu, Eskedar Ferdu Azerefegne","doi":"10.1093/jacamr/dlag193","DOIUrl":"10.1093/jacamr/dlag193","url":null,"abstract":"<p><strong>Background: </strong>Antimicrobial stewardship (AMS) in Ethiopia requires practical and scalable educational resources that can support healthcare workers in resource-limited settings. Online resources may help strengthen stewardship knowledge and implementation, but their value depends on accessibility, contextual relevance and practical utility.</p><p><strong>Objectives: </strong>To identify and appraise online AMS educational resources relevant to Ethiopia and to assess their potential contribution to AMS education and implementation.</p><p><strong>Methods: </strong>We conducted a targeted education resource review of six publicly accessible online AMS resources. Targeted searches combined antimicrobial stewardship (AMS) and antimicrobial resistance (AMR) education terms with Ethiopia, low- and middle-income country settings, toolkit, training, online course, massive open online course (MOOC), OpenWHO, FutureLearn, CDC, BSAC and WHO. Resources were evaluated for accessibility, educational design, contextual appropriateness, implementation utility and complementarity.</p><p><strong>Results: </strong>The Ethiopian national practical guide had the strongest implementation relevance because of its close alignment with local stewardship priorities and facility-level needs. WHO- and course-based resources added structured learning and broader programmatic support. Across resources, common limitations included dependence on internet connectivity, limited offline usability and insufficient locally contextualized case-based learning.</p><p><strong>Conclusions: </strong>The included resources offer complementary value for AMS education in Ethiopia, but no single resource is sufficient on its own. A blended, context-adapted approach that integrates national guidance with selected online educational resources is likely to provide the greatest educational and system-level benefit.</p>","PeriodicalId":14594,"journal":{"name":"JAC-Antimicrobial Resistance","volume":"8 4","pages":"dlag193"},"PeriodicalIF":3.9,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13522844/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vancomycin-associated acute kidney injury in patients with moderate CKD: a multicentre retrospective cohort study.","authors":"Liujing Miao, Xingyun Hou, Yuzhu Wang, Chengchun Zuo, Jie Li, Qianzhou Lv, Xiaoyu Li, Kunming Pan","doi":"10.1093/jacamr/dlag173","DOIUrl":"10.1093/jacamr/dlag173","url":null,"abstract":"<p><strong>Background: </strong>Vancomycin, as a first-line treatment for methicillin-resistant staphylococcus aureus infections, is notably nephrotoxic. Research on vancomycin nephrotoxicity in patients with moderate chronic kidney disease (CKD) is still lacking. This study aims to investigate the incidence of vancomycin-associated acute kidney injury (VA-AKI) in patients with moderate CKD and to identify associated risk factors in this specific population.</p><p><strong>Methods: </strong>This was a multicentre, retrospective, cohort study from China. Patients with estimated glomerular filtration rate (eGFR) ˂90 mL/(min·1.73 m²) who received vancomycin from January 2009 to December 2024 were included. For patients with moderate CKD and eGFR ˂60 mL/(min·1.73 m²), multivariate logistic regression analysis was used to identify the independent risk factors for VA-AKI and the prognosis of VA-AKI patients.</p><p><strong>Results: </strong>A total of 3844 patients were included, and 1194 patients had moderate CKD. The incidence of VA-AKI in patients with moderate CKD was 19.1% (228/1194). The risk of VA-AKI increased significantly with the progression of CKD stages (<i>P</i> = 0.003). Cardiac insufficiency (OR 1.816, 95% CI 1.320-2.500, <i>P</i> < 0.001), ICU admission (OR 2.018, 95% CI 1.449-2.810, <i>P</i> < 0.001), and duration of vancomycin therapy (OR 1.482, 95% CI 1.071-2.051, <i>P</i> = 0.018) were significantly and independently associated with VA-AKI in patients with moderate CKD.</p><p><strong>Conclusions: </strong>The incidence of VA-AKI in patients with moderate CKD is slightly higher than that in mixed populations (general, unselected hospitalized cohorts). This study indicates that the risk of VA-AKI increases with the severity of CKD staging. Heart failure, ICU admission, and duration of vancomycin therapy may result in a higher risk of VA-AKI occurrence.</p>","PeriodicalId":14594,"journal":{"name":"JAC-Antimicrobial Resistance","volume":"8 4","pages":"dlag173"},"PeriodicalIF":3.9,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13522842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In vitro</i> activity of ceftaroline against clinical isolates of Gram-positive bacteria in paediatric patients: ATLAS programme 2018-2023.","authors":"Pattarachai Kiratisin, Alona Kuraieva, Eric Utt, Susanna Esposito","doi":"10.1093/jacamr/dlag179","DOIUrl":"10.1093/jacamr/dlag179","url":null,"abstract":"<p><strong>Objectives: </strong>This study evaluated the antimicrobial activity of ceftaroline and comparator antimicrobials against clinical isolates of Gram-positive bacteria (GPB) from paediatric patients globally and in Africa/Middle East (AfME), Asia-Pacific (APAC), Europe and Latin America (LATAM) as part of the Antimicrobial Testing Leadership and Surveillance programme between 2018 and 2023.</p><p><strong>Methods: </strong>Susceptibility and minimum inhibitory concentrations of all organisms were determined using broth microdilution methodology for ceftaroline and comparators from Clinical and Laboratory Standards Institute (CLSI) and European Committee on Antimicrobial Susceptibility Testing (EUCAST) breakpoints.</p><p><strong>Results: </strong>Overall and across regions, <i>Staphylococcus aureus</i> (CLSI/EUCAST, ≥99.0%) and methicillin-resistant <i>S. aureus</i> (CLSI, ≥95.6%) demonstrated high susceptibility to ceftaroline. High susceptibility to daptomycin, linezolid, teicoplanin, tigecycline (from the FDA), trimethoprim/sulfamethoxazole and vancomycin was demonstrated against these isolates for both breakpoints. Globally and across regions, for <i>Streptococcus pneumoniae</i> (CLSI/EUCAST, 93.3%-100%) and penicillin-intermediate <i>S. pneumoniae</i> (CLSI/EUCAST, 100%), high susceptibility to ceftaroline was observed. For penicillin-resistant <i>S. pneumoniae</i>, higher susceptibility to ceftaroline following the CLSI (96.5%-100%) than EUCAST (74.4%-88.7%) was observed except in LATAM. High susceptibility to linezolid, levofloxacin, tigecycline and vancomycin was demonstrated against these isolates across regions from both breakpoints, whereas, for ceftriaxone, higher susceptibility following the CLSI than EUCAST was observed. For β-haemolytic streptococci, high susceptibility to ceftaroline was observed (CLSI, 100%). High susceptibility to linezolid, penicillin and vancomycin was demonstrated against these isolates from both breakpoints.</p><p><strong>Conclusions: </strong>Ceftaroline demonstrated potent activity against key GPB. This study significantly contributes to the limited current information on paediatric antimicrobial resistance patterns across AfME, APAC, Europe and LATAM.</p>","PeriodicalId":14594,"journal":{"name":"JAC-Antimicrobial Resistance","volume":"8 4","pages":"dlag179"},"PeriodicalIF":3.9,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13522833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Exploring UK medical schools' perception and intent for teaching on antimicrobial resistance and stewardship.","authors":"Rachel J Grainger, Niall T Stevens, Hilary Humphreys, Fidelma Fitzpatrick","doi":"10.1093/jacamr/dlag187","DOIUrl":"10.1093/jacamr/dlag187","url":null,"abstract":"","PeriodicalId":14594,"journal":{"name":"JAC-Antimicrobial Resistance","volume":"8 4","pages":"dlag187"},"PeriodicalIF":3.9,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13519043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148840179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}