JAC-Antimicrobial Resistance最新文献

{"title":"Correction to: AMRrounds: presumed mechanisms of resistance in a case of XDR <i>Klebsiella pneumoniae</i> empyema.","authors":"","doi":"10.1093/jacamr/dlaf104","DOIUrl":"https://doi.org/10.1093/jacamr/dlaf104","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1093/jacamr/dlaf019.].</p>","PeriodicalId":14594,"journal":{"name":"JAC-Antimicrobial Resistance","volume":"7 3","pages":"dlaf104"},"PeriodicalIF":3.7,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12160008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strengthening antimicrobial stewardship in public health facilities in Malawi through a participatory epidemiology approach.","authors":"Adriano F Lubanga, Akim N Bwanali, Sibongile Kondowe, Ellen Nzima, Abgail Masi, Yaleka Njikho, Cynthia Chitule, Gracian Harawa, Steward Mudenda, Gillian Mwale, Tumaini Makole, Samuel Mpinganjira, Thomas Nyirenda, Collins Mitambo","doi":"10.1093/jacamr/dlaf103","DOIUrl":"10.1093/jacamr/dlaf103","url":null,"abstract":"<p><strong>Background: </strong>In healthcare settings, antimicrobial resistance (AMR) is largely driven by excessive use of antibiotics. Empirical prescription largely remains common due to fragile healthcare systems characterized by lack of appropriate diagnostic services. Despite limited data on the epidemiology and the burden of AMR due to the scarcity of routine microbiology facilities, it is evident that Malawi shares a heavy burden of AMR. Effectively implemented antimicrobial stewardship programmes have demonstrated successes in minimizing inappropriate antibiotic usage, and curbing the burden of AMR. However, there are limited data on how antimicrobial stewardship teams can effectively deliver their roles in hospital settings in resource limited settings, including in Malawi.</p><p><strong>Methods: </strong>Malawi's Antimicrobial Resistance National Coordinating Centre (AMRCC) in collaboration with Clinical Research Education and Management Services (CREAMS) conducted participatory workshops with hospital-based antimicrobial stewardship committees aimed at establishing drivers of resistance and antibiotic overuse in hospitals from the perspective of the committees, and co-design facility-friendly intervention against AMR. The workshops consisted of participatory discussion, sorting and design thinking exercises, utilizing principles of implementation research. All the interviews were recorded, transcribed and thematically analysed, revealing key drivers for antibiotic overuse and resistance in hospital settings. Data were analysed using thematic content analysis.</p><p><strong>Results: </strong>Key drivers of AMR included limited antibiotic formulary access, poor cross-sectoral coordination challenges between healthcare, veterinary services, government agencies and private facilities, and culturally specific barriers. The participants recommended regular training for healthcare workers on AMR and infection prevention and control (IPC), widespread dissemination of AMR findings, public awareness, introducing electronic monitoring systems and the enforcement of antibiotic restriction policies as the best measures for improving rational antimicrobial use and controlling the spread of AMR.</p><p><strong>Conclusions: </strong>Our findings underscore the complexity of the drivers for antibiotic overuse and resistance in hospital settings, as well as the need for more participatory approaches in tackling the complex challenge of AMR. The findings also signify the importance of a bottom-up approach in designing a solution for promoting antimicrobial stewardship and controlling resistance in hospital and community settings. Participatory approaches blended with principles of implementation research will help to identify contextual challenges, and help to design solutions that are people-centred, context-specific and largely accepted by all involved stakeholders.</p>","PeriodicalId":14594,"journal":{"name":"JAC-Antimicrobial Resistance","volume":"7 3","pages":"dlaf103"},"PeriodicalIF":3.7,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnitude of vancomycin-resistant <i>Enterococci</i> colonization and associated factors among people living with HIV.","authors":"Abebe Dawud, Tadesse Shume, Rajesh Sarkar, Mandie Maru, Olifan Getachew Wakjira, Ajay Kumar Prajapati, Dadi Marami, Tewodros Tesfa","doi":"10.1093/jacamr/dlaf099","DOIUrl":"10.1093/jacamr/dlaf099","url":null,"abstract":"<p><strong>Background: </strong>The limited alternatives for managing vancomycin-resistant Enterococci (VRE) have caused concern in the global community for severe infectious diseases. Therefore, the purpose of the study was to determine the magnitude of VRE colonization and associated factors among people living with HIV at Hiwot Fana Comprehensives Specialized University Hospital, Eastern Ethiopia.</p><p><strong>Method: </strong>A cross-sectional study was conducted among 260 patients on anti-retroviral therapy (ART) who attended the ART clinic from 10 April to 10 May 2022. A structured questionnaire was used to gather information. The stool sample was collected and processed by standard microbiological techniques. The Bile Esculin Azide Agar and blood agar were used to isolate <i>Enterococci</i> species (spp.). The antimicrobial susceptibility testing of the isolates was performed using the Kirby-Bauer disk diffusion technique on the Mueller-Hinton agar plate. Data were analysed using Statistical Package for the Social Sciences 25 software. The chi-square (<i>χ</i> ²) test was used to determine the strength of the association. A <i>P</i>-value of  ≤ 0.05 was considered statistically significant.</p><p><strong>Result: </strong>Out of the 260 participants, colonization of <i>Enterococcus</i> spp. from stool specimens were observed among 68 (26.2%). Of these, five were VRE. Multidrug resistance was noted in 60 (88.2%) of the <i>Enterococcus</i> spp. isolates. Previous antibiotic treatment was significantly associated with VRE (<i>χ</i> ² = 7.063, <i>P</i>-value = 0.009).</p><p><strong>Conclusion: </strong>VRE must be regularly monitored for antimicrobial susceptibility testing and surveillance to prevent the spread of antibiotic resistance.</p>","PeriodicalId":14594,"journal":{"name":"JAC-Antimicrobial Resistance","volume":"7 3","pages":"dlaf099"},"PeriodicalIF":3.7,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic diversity of clinically relevant bacterial pathogens from an acute care hospital in Suva, Fiji.","authors":"Jane Hawkey, Michael J Loftus, Amitesh Prasad, Timoci Vakatawa, Vinita Prasad, Litia Tudravu, Katherine Pragastis, Jessica Wisniewski, Taylor Harshegyi-Hand, Luke Blakeway, Andrew J Stewardson, Adam W Jenney, Anton Y Peleg","doi":"10.1093/jacamr/dlaf058","DOIUrl":"10.1093/jacamr/dlaf058","url":null,"abstract":"<p><strong>Objectives: </strong>Antimicrobial resistance (AMR) is a global health threat, with third-generation cephalosporin-resistant (3GCR) and carbapenem-resistant infections of particular concern. There is currently a lack of genomic data on AMR organisms in the Pacific region.</p><p><strong>Methods: </strong>We aimed to address this gap by examining the genetic diversity of a collection of 788 Gram-negative and Gram-positive clinical isolates collected between July 2020 and October 2022 from a single hospital in Suva, Fiji. We sampled sensitive and resistant isolates, focusing on 3GCR and carbapenem-resistant Gram-negatives, and methicillin-resistant <i>Staphylococcus</i> and vancomycin-resistant <i>Enterococcus</i>.</p><p><strong>Results: </strong>We detected 29 distinct species across 12 different genera. Amongst Gram-negative genomes, <i>Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii</i> and <i>Pseudomonas aeruginosa</i> were the most common. Carbapenem resistance was mostly detected in <i>A. baumannii</i> ST2 and <i>P. aeruginosa</i> ST773, with both STs carrying NDM-1 and showing evidence of transmission within Fiji. Carbapenem resistance was relatively rare amongst the Enterobacterales; however, we observed evidence of transmission of OXA-232-carrying <i>K. pneumoniae</i> ST395 and NDM-7 <i>E. coli</i> ST410. For Gram-positive bacteria, <i>Staphylococcus aureus</i> ST1 was the dominant clone, and phylogenetic analysis revealed a single clade harbouring the majority of Fijian genomes, with close relationships to genomes from neighbouring Samoa. <i>Enterococcus</i> was relatively rare, with only 22 genomes detected.</p><p><strong>Conclusions: </strong>This study provides crucial genomic data on AMR organisms in Fiji, highlighting the diversity of resistant species in the region. Local transmission of four carbapenem-resistant clones within Fiji was observed, underscoring the importance of local spread of these resistant strains.</p>","PeriodicalId":14594,"journal":{"name":"JAC-Antimicrobial Resistance","volume":"7 3","pages":"dlaf058"},"PeriodicalIF":3.7,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic use without prescription among children aged under 5 years in low- and middle-income countries: a systematic review and meta-analysis.","authors":"Segenet Zewdie, Assefa Andargie Kassa, Mekonen Melkie Bizuneh, Tegenu Chanie Tesfaye, Ashagrachew Tewabe Yayehrad","doi":"10.1093/jacamr/dlaf093","DOIUrl":"10.1093/jacamr/dlaf093","url":null,"abstract":"<p><strong>Background: </strong>Antimicrobial resistance as a result of inappropriate use of antibiotics is one of the top global public health threats. This systematic review and meta-analysis aimed to assess the prevalence of antibiotic use without prescription among children aged under 5 years in low- and middle-income countries (LMICs).</p><p><strong>Methods: </strong>To identify primary studies a comprehensive search of databases was conducted from PubMed, Scopus and HINARI. Observational studies conducted among children ≤5 years old and published in the English language were included. After screening, data were extracted using a checklist. Heterogeneity was assessed using forest plots, Cochran's <i>Q</i> test and <i>I</i> ². The random effects meta-analysis model was employed to pool the prevalence of antibiotic use without prescription among under-5 children in LMICs. Subgroup analysis and meta-regression were performed to identify the sources of heterogeneity. Publication bias was assessed using funnel plots with Egger's test.</p><p><strong>Findings: </strong>The review was conducted of 12 cross-sectional studies with a combined sample size of 8773 participants. The pooled prevalence of antibiotic use without prescription among under-5 children in LMICs was 33.27% (95% CI, 27.37%-39.18%; <i>P</i> < 0.0001) with high heterogeneity (<i>I</i> ² = 97.21%, <i>P</i> <i><</i> 0.001). The pooled estimates were higher among studies from Africa (39.85%; 95% CI, 35.61%-44.09%) compared with studies from South America (28.59%; 95% CI, 24.17%-33.01%).</p><p><strong>Conclusions: </strong>The pooled prevalence of antibiotic use without prescription among under-5 children in LMICs is high. This implies that the WHO in collaboration with the nations should develop different strategies to improve the regulatory system in LMICs and prevent the use of antibiotics without prescription among under-5 children.</p>","PeriodicalId":14594,"journal":{"name":"JAC-Antimicrobial Resistance","volume":"7 3","pages":"dlaf093"},"PeriodicalIF":3.7,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nurse prescribing for selected UTIs in Spain: a challenging step forward.","authors":"Enrique Castro-Sánchez, Aina Huguet-Torres, Aina María Yáñez-Juan, Miquel Bennasar-Veny","doi":"10.1093/jacamr/dlaf102","DOIUrl":"10.1093/jacamr/dlaf102","url":null,"abstract":"<p><p>This paper examines the implications of Spain's recent legislative reform enabling nurses to prescribe antibiotics for uncomplicated urinary tract infections (UTIs) in women, positioning it as a critical development in antimicrobial stewardship (AMS) and nursing practice. The paper aims to assess how this policy aligns with international models of nurse prescribing, evaluating its potential to enhance workforce flexibility, and identifying some challenges and opportunities regarding its implementation. While this reform may reduce pressures on general practitioners and optimize primary care delivery, it raises questions regarding diagnostic accuracy, restricted formularies and the need for rigorous surveillance. The viewpoint highlights the importance of robust training in diagnostic and clinical reasoning, regular updates to antibiotic formularies and comprehensive auditing mechanisms to ensure safe and effective prescribing. Additionally, we explore broader considerations, such as professional incentives and inter-professional collaboration, essential for the sustained impact of nurse prescribing. By centring the discussion on nursing leadership in AMS, we highlight an underexplored area of policy implementation, with implications for other countries considering similar reforms.</p>","PeriodicalId":14594,"journal":{"name":"JAC-Antimicrobial Resistance","volume":"7 3","pages":"dlaf102"},"PeriodicalIF":3.7,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial resistance trends of methicillin-resistant <i>Staphylococcus aureus</i> in Norway from 2008 to 2017.","authors":"Torunn Gresdal Rønning, Hege Enger, Jan Egil Afset, Christina Gabrielsen Ås","doi":"10.1093/jacamr/dlaf094","DOIUrl":"10.1093/jacamr/dlaf094","url":null,"abstract":"<p><strong>Objectives: </strong>The purpose of this study was to analyse nationwide trends in antimicrobial susceptibility and molecular epidemiology of all MRSA strains in Norway over a 10-year period.</p><p><strong>Materials and methods: </strong>All cases of MRSA in Norway from 2008 to 2017 were included, limited to the first case per year per individual (<i>n</i> = 15 200). Strains were confirmed as MRSA with PCR and genotyped using <i>spa</i>-typing. Antimicrobial susceptibility data and epidemiological data were collected from the Norwegian MRSA reference laboratory and the Norwegian Surveillance System for Communicable Diseases, respectively.</p><p><strong>Results: </strong>Despite an increase in MRSA cases, antimicrobial resistance rates remained stable throughout the study period. The most common susceptibility profile of the MRSA strains was resistance to cefoxitin alone (41.4%), while co-resistance (58.6%) was observed most commonly for erythromycin (31.0%), tetracycline (25.3%) and ciprofloxacin/norfloxacin (21.6%). Notably, associations were identified between specific resistance patterns and clinical variables, including higher resistance rates among healthcare-associated MRSA, particularly in older adults and nursing home residents. Geographic associations were also observed, linking specific resistance profiles to strains acquired in North America, Africa and Asia.</p><p><strong>Conclusions: </strong>The findings highlight a complex landscape of MRSA resistance in a low-prevalence country, characterized by a diverse genotypic population and stable longitudinal trends in resistance rates. However, the prevalence of co-resistance to one or more antibiotics among Norwegian MRSA strains was high and increasing. This study thus underscores the importance of continuous surveillance and adherence to antimicrobial guidelines.</p>","PeriodicalId":14594,"journal":{"name":"JAC-Antimicrobial Resistance","volume":"7 3","pages":"dlaf094"},"PeriodicalIF":3.7,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12141746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resistance mechanisms and tedizolid susceptibility in clinical isolates of linezolid-resistant bacteria in Japan.","authors":"Ryosuke Shoji, Masayuki Maeda, Kozue Yamaguchi, Takahiro Takuma, Rintaro On, Kazuhisa Ugajin, Daisuke Okatomi, Kunihiko Fukuchi, Issei Tokimatsu, Keiko Ishino","doi":"10.1093/jacamr/dlaf097","DOIUrl":"10.1093/jacamr/dlaf097","url":null,"abstract":"<p><strong>Objectives: </strong>Studies combining linezolid resistance mechanisms and tedizolid susceptibility in linezolid-resistant clinical isolates are scarce. This study investigated the linezolid resistance mechanisms and tedizolid susceptibility of linezolid-resistant strains isolated clinically in Japan.</p><p><strong>Methods: </strong>We analysed 25 linezolid-resistant strains of <i>Enterococcus faecium</i> and <i>Enterococcus faecalis</i> isolated from Japanese hospitals between 2015 and 2021. MICs of linezolid and tedizolid were determined using the agar plate dilution method. Each 23S rRNA copy was amplified by PCR, sequenced and analysed for mutations. The linezolid resistance genes <i>cfr</i>, <i>poxtA</i>, <i>optrA</i>, <i>fexA</i> and <i>fexB</i> were also detected by PCR.</p><p><strong>Results: </strong>Drug susceptibility tests revealed that five linezolid-resistant <i>E. faecium</i> isolates had low (≤1 mg/L) tedizolid MICs. Resistance mechanisms included the G2576T mutation in 23S rRNA, the T2504A mutation and the resistance genes <i>optrA</i>, <i>fexA</i> and <i>fexB</i>. The T2504A mutation was identified in one <i>E. faecium</i> isolate, which exhibited linezolid and tedizolid MICs of 64 and 32 mg/L, respectively.</p><p><strong>Conclusions: </strong>Some linezolid-resistant isolates demonstrated low (≤1 mg/L) tedizolid MICs. To determine whether tedizolid susceptibility testing should be performed on linezolid-resistant isolates, more linezolid-resistant isolates should be collected and tested for tedizolid MICs. Tedizolid MICs were 2-3 doubling dilutions lower than linezolid MICs. The results of this study suggest that future research should investigate whether the T2504A mutation contributes to tedizolid resistance. To our knowledge, this is the first study to report tedizolid susceptibility in <i>E. faecium</i> with the T2504A mutation and in isolate harbouring this mutation.</p>","PeriodicalId":14594,"journal":{"name":"JAC-Antimicrobial Resistance","volume":"7 3","pages":"dlaf097"},"PeriodicalIF":3.7,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12130435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clonal dissemination and persistence of Carbapenem-resistant <i>bla</i> _KPC-2 harbouring <i>Klebsiella pneumoniae</i> ST307 in a Tertiary Hospital in the Republic of Korea.","authors":"Eunkyung Shin, Dong-Yeop Lee, Min Kyeong Kim, Jaeil Yoo, Ji-Yeon Hyeon, Junyoung Kim","doi":"10.1093/jacamr/dlaf090","DOIUrl":"10.1093/jacamr/dlaf090","url":null,"abstract":"<p><strong>Objectives: </strong>We investigated the epidemiological patterns of carbapenem-resistant, <i>bla</i> _KPC-2 harbouring <i>Klebsiella pneumoniae</i> (<i>K. pneumoniae</i>) ST 307 isolates in a tertiary hospital in South Korea between 2019 and 2021 and compared them to isolates collected from 25 hospitals through a nationwide survey, using whole genome sequencing and phylogenetic analysis.</p><p><strong>Methods: </strong>Whole genome sequences of 25 isolates from hospital GB2 and 45 isolates from 25 other hospitals were analysed for antibiotic resistance gene profiles, virulence gene profiles, plasmid replicons, and phylogenetic relationships.</p><p><strong>Results: </strong>Core genome single nucleotide polymorphism (cgSNP)-based phylogenetic analysis categorized the 70 isolates into three distinct groups and 13 subgroups, supported by high bootstrap values and low SNP differences. Subgroup 1 comprised the 18 isolates from GB2 collected over 3 years, suggesting long-term persistence and repeated outbreaks within GB2. Region-specific dissemination was indicated by several subgroups containing isolates from different hospitals within the same province. Subgroup 7 comprised isolates from multiple provinces and years, suggesting potential long-distance transmission via patient transfers or community reservoirs. All isolates carried multiple β-lactam resistance genes; <i>bla</i> _CTX-M-15 was observed in 67 isolates (89.3%) and the OXA variants in 70 isolates (93.3%). None of the isolates carried the <i>rmpA/rmpA2</i> or <i>magA</i> genes, while 58 of the 70 (82.9%) harboured yersiniabactin-encoding genes.</p><p><strong>Conclusions: </strong>Our findings reveal both clonal persistence within a tertiary hospital and region-specific dissemination of <i>bla</i> _KPC-2 producing <i>K. pneumoniae</i> ST307 across South Korea. These results highlight the importance of continuous nationwide surveillance and genomic analysis to implement effective infection control measures to mitigate further dissemination.</p>","PeriodicalId":14594,"journal":{"name":"JAC-Antimicrobial Resistance","volume":"7 3","pages":"dlaf090"},"PeriodicalIF":3.7,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, practices, educational needs and hospital engagement in Infection Prevention and Control (IPC) among Italian healthcare workers and students: results from a national multicentre survey.","authors":"Francesco Di Gennaro, Francesco Vladimiro Segala, Roberta Papagni, Elda De Vita, Giacomo Guido, Luisa Frallonardo, Alessandra Vigna, Monica Fiorella, Davide Capruzzi, Marinella Cibelli, Annunziata Ilenia Ritacco, Luigi Pisani, Francesca De Palo, Pietro Locantore, Alessandra Tolin, Federica Penco, Marianna Meschiari, Rita Murri, Massimo Fantoni, Cristina Mussini, Annalisa Saracino","doi":"10.1093/jacamr/dlaf081","DOIUrl":"10.1093/jacamr/dlaf081","url":null,"abstract":"<p><strong>Objective: </strong>This study assesses the knowledge, practices, educational needs and hospital engagement in IPC among healthcare workers (HCWs) and students in Italy.</p><p><strong>Methods: </strong>A national cross-sectional observational study was conducted from April to July 2024. Participants completed a validated questionnaire based on WHO and CDC guidelines. Four outcomes were evaluated: (i) knowledge of IPC, (ii) self-reported compliance, (iii) satisfaction with education and (iv) hospital engagement in IPC.</p><p><strong>Results: </strong>Among respondents (<i>n</i> = 1063, 67.75% female) significant gaps in IPC knowledge were noted, with only 66.1% correctly identifying key hand hygiene moments. Compliance was low, with only 43.3% always adhering to hand hygiene rules. Satisfaction with IPC education was also low (28%). While alcohol-based hand gel was widely available (84.2%), only 36.6% received formal hand hygiene training before onboarding.Multivariate analysis revealed that female HCWs had higher IPC knowledge [adjusted odds ratio (aOR) 1.55, 95% CI: 1.04-2.31] and better compliance (aOR 1.72, 95% CI: 1.01-2.92). Younger HCWs demonstrated greater knowledge and satisfaction. Surgical ward staff, despite greater education satisfaction, exhibited lower IPC knowledge (aOR 0.53, 95% CI: 0.32-0.87). Nurses and health assistants received more hospital IPC training (aOR 1.59, 95% CI: 1.04-2.46; aOR 5.83, 95% CI: 1.94-18.89, respectively). Finally, the presence of a hospital IPC team positively correlated with all outcomes, including higher IPC knowledge (aOR 2.68, 95% CI: 1.79-4.05) and adherence (aOR 3.4, 95% CI: 1.92-6.3).</p><p><strong>Conclusion: </strong>The study reveals substantial gaps in IPC knowledge, practices and education among Italian HCWs, emphasizing the urgent need for effective targeted interventions that require robust institutional support.</p>","PeriodicalId":14594,"journal":{"name":"JAC-Antimicrobial Resistance","volume":"7 3","pages":"dlaf081"},"PeriodicalIF":3.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}