JACC. Clinical electrophysiology最新文献

{"title":"Who Gets the Most Benefit From the Marshall Plan?","authors":"Michael Fletcher, Jason G Andrade","doi":"10.1016/j.jacep.2026.08.012","DOIUrl":"https://doi.org/10.1016/j.jacep.2026.08.012","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149038589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-Specific Temporal Trends in the Incidence of Heart Failure Among Patients With Atrial Fibrillation: A Population-Based Study.","authors":"Jia-Yi Huang, Wen-Li Gu, Ran Guo, Jing-Nan Zhang, Hao-Chen Xuan, Christopher Tze-Wei Tsang, Hai-Yue Yang, An-Ping Cai, Xin-Li Li, Gregory Y H Lip, Kai-Hang Yiu","doi":"10.1016/j.jacep.2026.08.014","DOIUrl":"https://doi.org/10.1016/j.jacep.2026.08.014","url":null,"abstract":"<p><strong>Background: </strong>Although there is evidence linking women to a higher risk of ischemic stroke in AF, it remains uncertain whether there are sex differences in the hazards of HF.</p><p><strong>Objectives: </strong>This study sought to evaluate sex differences in the temporal trend of incident heart failure (HF) among patients with atrial fibrillation (AF).</p><p><strong>Methods: </strong>Using a territory-wide clinical registry in Hong Kong, patients newly diagnosed with AF between 1997 and 2021 were studied. Annual incidence rate (IR) and incidence rate ratio were estimated by Poisson regression analysis. Multivariate adjusted Fine-Gray regression models were performed to examine the subdistribution hazard ratio between women and HF, accounting for all-cause mortality as a competing event.</p><p><strong>Results: </strong>We included 130,132 individuals with newly diagnosed AF (median age: 76.6 years; IQR: 60.4-92.8; 48.6% female). Between 1997 and 2021, the annual IR (per 1000 person-years) of HF declined from 69.6 to 16.7 in women and from 44.5 to 13.7 in men over the years. Women maintained a higher IR than men for the entire follow-up period (IR: 25.3 vs 19.3 per 1000 person-years) and were associated with a higher risk of HF than men (incidence rate ratio [95% CI]: 1.34 [1.31-1.37]). When compared with men, women were older at the time of diagnosis of AF, had higher baseline CHA₂DS₂-VASc scores, and were more likely to be prescribed reduced doses of direct oral anticoagulants.</p><p><strong>Conclusions: </strong>Despite an overall decrease in the risk of HF among AF patients over two decades of follow-up, women retained elevated residual adjusted HF risk after full adjustment for time-varying comorbidities.</p>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149038561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac Radioablation: When Evidence Challenges Enthusiasm.","authors":"Jesus Almendral, Maria Teresa Barrio-Lopez","doi":"10.1016/j.jacep.2026.07.029","DOIUrl":"https://doi.org/10.1016/j.jacep.2026.07.029","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149038274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left Stellate Ganglion Pulsed Radiofrequency Suppresses Ischemic Ventricular Arrhythmias: A Translational Study.","authors":"Zhou Xu, Shu Yang, Xiaokai Zhou, Jiawei Li, Xiaoyu Xu, Wenjie Liu, Chengzong Li, Chang Cui, Minglong Chen","doi":"10.1016/j.jacep.2026.08.019","DOIUrl":"https://doi.org/10.1016/j.jacep.2026.08.019","url":null,"abstract":"<p><strong>Background: </strong>Cardiac sympathetic hyperactivity originating from the left stellate ganglion (LSG) drives ischemic ventricular arrhythmias (VAs). Stellate ganglion block provides only transient relief, whereas surgical denervation is invasive and irreversible. A minimally invasive approach with potentially sustained effects is needed.</p><p><strong>Objectives: </strong>This study sought to investigate whether pulsed radiofrequency (PRF) of the LSG-a nonthermal neuromodulatory technique-safely suppresses ischemic VAs, and to characterize its mechanism using integrated neural and cardiac transcriptomics.</p><p><strong>Methods: </strong>Safety was first assessed in healthy rats (n = 15) randomized to control, LSG-PRF (42 °C, 2 Hz, 20 milliseconds), or surgical LSG excision. In a rat myocardial infarction (MI) model (n = 24; Sham, MI, MI + PRF), cardiac sympathetic nerve activity, programmed electrical stimulation, echocardiography, and histology were evaluated, complemented by bulk RNA-seq of the LSG and single-cell RNA-seq of cardiac tissue. Translational feasibility was tested in 4 patients with drug-refractory electrical storm using ultrasound-guided LSG-PRF.</p><p><strong>Results: </strong>In contrast to LSG excision, PRF produced only transient Horner's syndrome and did not cause hypotension. In MI rats, PRF reduced cardiac sympathetic nerve activity, attenuated ventricular tachycardia/ventricular fibrillation inducibility and duration on programmed stimulation, lowered serum norepinephrine and angiotensin II, improved left ventricular function, and reduced myocardial fibrosis. LSG transcriptomics showed down-regulation of inflammation- and sprouting-related genes including S100a9 and Ngf. Single-cell analysis of the infarcted heart revealed attenuation of a proinflammatory Grik2⁺ Schwann cell subset, with computationally inferred reductions in neuro-immune signaling. In all 4 patients, no sustained ventricular tachycardia recurrence was observed during a median follow-up of 12 months.</p><p><strong>Conclusions: </strong>LSG-PRF is a minimally invasive neuromodulatory strategy associated with suppression of sympathetic hyperactivity and post-MI VAs, accompanied by attenuated ganglionic inflammation and modulated cardiac neuro-immune signaling. Preliminary clinical experience supports feasibility and warrants prospective trials.</p>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conduction System Pacing in Children: Not Just Little Adults?","authors":"Jeremy P Moore","doi":"10.1016/j.jacep.2026.08.015","DOIUrl":"https://doi.org/10.1016/j.jacep.2026.08.015","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149038277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding the Scope of Permissible Exercise in Arrhythmogenic Cardiomyopathy.","authors":"Bruce B Lerman, Jim W Cheung","doi":"10.1016/j.jacep.2026.08.013","DOIUrl":"https://doi.org/10.1016/j.jacep.2026.08.013","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149038551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When Less Can Be More in Cardioneuroablation.","authors":"Piotr Futyma","doi":"10.1016/j.jacep.2026.08.004","DOIUrl":"10.1016/j.jacep.2026.08.004","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148990009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolution in Functional Mapping for Ventricular Tachycardia: Can We Focus Better on the Target?","authors":"Henry H Hsia","doi":"10.1016/j.jacep.2026.07.036","DOIUrl":"10.1016/j.jacep.2026.07.036","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148989973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjuvant Ablation for PeRsistent AtrIal FibrillAtion Using Dual ENergy LatticE Tip Catheter: ARIADNE-Randomized Clinical Trial Acute Results.","authors":"Stavros E Mountantonakis, James K Gabriels, Haisam Ismail, Kostantinos P Letsas, Michalis Efremidis, Ourania Kariki, Subbaro Choudry, Nicholas Skipitaris, Andrew Krumerman, Kristie M Coleman","doi":"10.1016/j.jacep.2026.08.016","DOIUrl":"https://doi.org/10.1016/j.jacep.2026.08.016","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149038200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When the VT Lies Between the Struts: Left Coronary Cusp Tachycardia After TAVR.","authors":"Jesús Diz-Díaz, Teba González-Ferrero, Carlos Álvarez-Ortega, Rafael Peinado","doi":"10.1016/j.jacep.2026.08.007","DOIUrl":"https://doi.org/10.1016/j.jacep.2026.08.007","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148990024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}