JACC. Clinical electrophysiology最新文献

{"title":"A Long and Winding Road to Understand and Milk the Paced QRS","authors":"Marek Jastrzębski MD, PhD","doi":"10.1016/j.jacep.2025.06.002","DOIUrl":"10.1016/j.jacep.2025.06.002","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 9","pages":"Pages 2045-2048"},"PeriodicalIF":7.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-Lead Mobile ECGs in Patients With Cardiovascular Disease","authors":"Benjamin A. Steinberg MD, MHS","doi":"10.1016/j.jacep.2025.05.026","DOIUrl":"10.1016/j.jacep.2025.05.026","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 9","pages":"Pages 2012-2013"},"PeriodicalIF":7.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breaking the Ice With Persistent Atrial Fibrillation Ablation: Is the Posterior Wall Worth the Freeze?","authors":"Jeanne du Fay de Lavallaz, Jackson J Liang","doi":"10.1016/j.jacep.2025.08.012","DOIUrl":"10.1016/j.jacep.2025.08.012","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microstructural Cardiac Alterations as a Major Cause of Sport-Related Unexplained Cardiac Arrest","authors":"Michel Haissaguerre MD, PhD , Karim Benali MD, PhD , Sebastien Knecht MD , Raphael Martins MD, PhD , Mickael Laredo MD, PhD , Jean-Marc Sellal MD, PhD , Koonlawee Nademanee MD, PhD , Tanner Carbonati BSc , Frederic Sacher MD, PhD , Sylvain Ploux MD, PhD","doi":"10.1016/j.jacep.2025.05.017","DOIUrl":"10.1016/j.jacep.2025.05.017","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 9","pages":"Pages 2071-2073"},"PeriodicalIF":7.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scar Wars","authors":"Reshma Amin MD, Sebastien Knecht MD, PhD","doi":"10.1016/j.jacep.2025.05.024","DOIUrl":"10.1016/j.jacep.2025.05.024","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 9","pages":"Pages 2001-2002"},"PeriodicalIF":7.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New ECG Morphologic Criteria for the Identification of Left Bundle Branch Capture","authors":"Óscar Cano MD, PhD ,&nbsp;Carmen Arveras MD ,&nbsp;Javier Navarrete MD ,&nbsp;Pablo Jover MD ,&nbsp;Valero Soriano MD ,&nbsp;Enrique Robles MD ,&nbsp;Josep Navarro MD ,&nbsp;Maite Izquierdo MD, PhD ,&nbsp;Joaquín Osca MD, PhD ,&nbsp;Luis Martínez-Dolz MD, PhD ,&nbsp;Pugazhendhi Vijayaraman MD","doi":"10.1016/j.jacep.2025.05.006","DOIUrl":"10.1016/j.jacep.2025.05.006","url":null,"abstract":"<div><h3>Background</h3><div>Identification of left bundle branch capture (LBBc) during left bundle branch area pacing remains challenging.</div></div><div><h3>Objectives</h3><div>This study sought to validate the utility of new simple morphologic criteria for the identification of LBBc.</div></div><div><h3>Methods</h3><div>Patients with proven LBBc based on the presence of QRS transition during decremental output pacing were included. The paced V₆ QRS upstroke/downstroke was quantitatively and qualitatively evaluated, and classified as fast or slow, with fast upstroke patterns associated with LBBc and slow upstroke patterns with left ventricular septal capture (LVSc). Additionally, the appearance of a paced QRS downstroke slurring/notching in any lead not previously present during lead penetration and/or an “M” QRS pattern in inferior leads was also considered suggestive of LBBc. Accuracy of these criteria was tested by independent evaluators using exclusively qualitative electrocardiogram morphologic features.</div></div><div><h3>Results</h3><div>115 patients with proven LBBc were included. Mean V₆ QRS upstroke duration during LBBc was significantly shorter than during LVSc (34.6 ± 10.1 ms vs 63.2 ± 12.1 ms; <em>P</em> &lt; 0.001). A paced V₆ upstroke/downstroke ratio &lt;1 had a sensitivity and specificity of 0.97 and 0.95 for the identification of LBBc. A slurred/notched QRS downstroke or “M” pattern in inferior leads was present in 91.1% during LBBc in baseline narrow QRS patients with inferior paced QRS axis, with sensitivity and specificity being 0.91 and 0.87, respectively. Using exclusively qualitative criteria, independent evaluators were able to identify the correct capture pattern in 87% of LBBc and 89% of LVSc cases, with diagnostic accuracy being significantly lower among dilated cardiomyopathy patients: 70.4% vs 93%; <em>P</em> = 0.004.</div></div><div><h3>Conclusions</h3><div>Simple electrocardiogram morphologic criteria can accurately identify LBBc during left bundle branch area pacing in patients with baseline narrow QRS and/or without cardiomyopathy.</div></div>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 9","pages":"Pages 2031-2044"},"PeriodicalIF":7.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144496662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single Access Assist Snare Technique for Challenging Leadless Pacemaker Retrieval","authors":"James E. Ip MD","doi":"10.1016/j.jacep.2025.04.031","DOIUrl":"10.1016/j.jacep.2025.04.031","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 9","pages":"Pages 2083-2087"},"PeriodicalIF":7.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Role of Human Epicardial Adipocyte–Derived SPARCL1 in Postoperative Atrial Fibrillation Following Cardiovascular Surgery","authors":"Taisuke Harada MD ,&nbsp;Hidekazu Kondo MD, PhD ,&nbsp;Masaki Takahashi MD ,&nbsp;Hirochika Yamasaki MD ,&nbsp;Masayuki Takano MD, PhD ,&nbsp;Hiroki Sato MD, PhD ,&nbsp;Yumi Ishii MD, PhD ,&nbsp;Ichitaro Abe MD, PhD ,&nbsp;Akira Fukui MD, PhD ,&nbsp;Hidefumi Akioka MD, PhD ,&nbsp;Tetsuji Shinohara MD, PhD ,&nbsp;Yasushi Teshima MD, PhD ,&nbsp;Kunio Yufu MD, PhD ,&nbsp;Tetsuya Uemura MD ,&nbsp;Kyoko Kawano MD, PhD ,&nbsp;Shigeru Naono MD, PhD ,&nbsp;Kazuhiro Ueno MD ,&nbsp;Kenshi Yoshimura MD ,&nbsp;Takayuki Kawashima MD, PhD ,&nbsp;Takashi Shuto MD, PhD ,&nbsp;Naohiko Takahashi MD, PhD","doi":"10.1016/j.jacep.2025.05.008","DOIUrl":"10.1016/j.jacep.2025.05.008","url":null,"abstract":"<div><h3>Background</h3><div>Postoperative atrial fibrillation (POAF) is associated with short- and long-term morbidity and mortality. However, the ability of the epicardial adipocyte to regulate POAF remains poorly understood.</div></div><div><h3>Objectives</h3><div>The authors investigated the possible role of human epicardial adipocyte–derived adipokines in the regulation of the myocardial redox state and POAF.</div></div><div><h3>Methods</h3><div>The authors prospectively studied 274 patients who underwent scheduled open-heart surgery. Finally, 149 patients without known atrial fibrillation were enrolled and divided into POAF and non-POAF groups. Epicardial adipose tissue biopsies and isolated preadipocytes were used to explore the important secretable adipokines associated with POAF.</div></div><div><h3>Results</h3><div>POAF occurred in 53 (35.6%) patients. Genome-wide expression profiling of background-matched differentiated preadipocytes representing the POAF or non-POAF groups and quantitative polymerase chain reaction validation as a biological replicate using all cohort samples revealed that only <em>SPARCL1</em> was significantly downregulated in the POAF group. <em>SPARCL1</em> messenger RNA expression in differentiated preadipocytes correlated with SPARCL1 protein concentration in the preadipocyte culture medium. SPARCL1 attenuated angiotensin II–induced oxidative stress in neonatal rat myocytes. Coculture of human induced pluripotent stem cell–derived atrial cardiomyocyte with the differentiated preadipocyte revealed that the preadipocytes derived from non-POAF patients suppressed myocardial oxidative stress. Low <em>SPARCL1</em> expression in human epicardial differentiated preadipocytes was associated with a higher risk of long-term adverse cardiovascular events after surgery.</div></div><div><h3>Conclusions</h3><div>These findings suggested that the SPARCL1, derived from epicardial differentiated preadipocytes, may be an important paracrine adipokine that regulates POAF and subsequent cardiovascular outcomes by improving myocardial redox state.</div></div>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 9","pages":"Pages 1951-1967"},"PeriodicalIF":7.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Cavotricuspid Isthmus Ablation With a Single Pulsed-Field Application Using the PulseSelect System","authors":"Ding-Sen Huang MD ,&nbsp;Chun-Ting Shih MD ,&nbsp;Yung-Lung Chen MD","doi":"10.1016/j.jacep.2025.05.016","DOIUrl":"10.1016/j.jacep.2025.05.016","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 9","pages":"Pages 2100-2102"},"PeriodicalIF":7.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Prior Exercise Practice on Disease Characteristics in Desmoplakin-Related Arrhythmogenic Left Ventricular Cardiomyopathy","authors":"Camille Jean MD ,&nbsp;Anne-Laure Laprérie MD ,&nbsp;Béatrice Guyomarch MSc ,&nbsp;Amaury Guédon MD ,&nbsp;Adeline Goudal PharmD ,&nbsp;Flore Morio MD ,&nbsp;Lara Marteau MD ,&nbsp;Sabine Pattier MD ,&nbsp;Dimitri Grimault MD ,&nbsp;Sébastien Schmitt MD ,&nbsp;Sophie Clero RN ,&nbsp;Imen Fellah PhD ,&nbsp;Aurélie Thollet PhD ,&nbsp;Jean-Noël Trochu MD, PhD ,&nbsp;Vincent Probst MD, PhD ,&nbsp;Nicolas Piriou MD","doi":"10.1016/j.jacep.2025.05.007","DOIUrl":"10.1016/j.jacep.2025.05.007","url":null,"abstract":"<div><h3>Background</h3><div><span><span>The harmful effects of high-intensity (HI) and long duration (LD) exercise have been reported in arrhythmogenic right ventricular cardiomyopathy, including in asymptomatic </span>genetic<span> variant carriers. However, the impact of exercise remains unclear in desmoplakin (</span></span><em>DSP</em><span>) gene variant carriers at risk of arrhythmogenic left ventricular cardiomyopathy (ALVC).</span></div></div><div><h3>Objectives</h3><div>The goal of this study was to assess the relationship between HI and LD exercise and the risk of developing an ALVC phenotype and its severity in DSP variant carriers.</div></div><div><h3>Methods</h3><div>In a monocentric retrospective study, patients with DSP pathogenic or likely pathogenic variant were interviewed about their exercise practice before genetic or disease diagnosis. HI and LD exercise were defined as having practiced at least one sport with an intensity ≥6 METs and ≥2.5 hours/week, respectively. We studied the association of HI and LD exercise practice with the risk of ALVC phenotype occurrence at diagnosis.</div></div><div><h3>Results</h3><div>A total of 85 patients were included (mean age 39 ± 19 years; 49% female). Sixty-nine percent had practiced HI exercise and 66% LD exercise. The rate of patients with an ALVC phenotype at time of diagnosis did not differ between patients having practiced HI and LD exercise and those who had not (71% vs 65% [<em>P</em> = 0.60] and 70% vs 69% [<em>P</em> = 0.95]). The distribution of prior calculated exercise dose was not different between patients with vs those without ALVC phenotype at diagnosis (<em>P</em> = 0.57).</div></div><div><h3>Conclusions</h3><div>Prior exercise intensity, duration, and cumulated lifetime dose were not associated with an increased risk of developing an ALVC phenotype at the time of diagnosis in DSP variant carriers.</div></div>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 9","pages":"Pages 1923-1932"},"PeriodicalIF":7.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}