JACC. Clinical electrophysiology最新文献

{"title":"Radiofrequency-Facilitated Left Bundle Branch Area Pacing as a Bailout Strategy in Patients With Septal Resistance.","authors":"Oriana Bastidas, Julian M Aristizabal, Luis Miguel Ruiz, Jorge E Marín, Cesar D Niño, Wilmer Borja, David Ocampo, Maria Camila Diaz-Ayala, Andres Díaz, Juan C Diaz","doi":"10.1016/j.jacep.2026.08.025","DOIUrl":"https://doi.org/10.1016/j.jacep.2026.08.025","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149136680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrograde Right Bundle Branch Block in Tachycardia Uncovering AVRT Using a Right-Sided Accessory Pathway.","authors":"Waddah Malas, Fatima M Ezzeddine","doi":"10.1016/j.jacep.2026.08.017","DOIUrl":"https://doi.org/10.1016/j.jacep.2026.08.017","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased Heart Failure Risk After Low-Voltage-Area Ablation in Patients With Paroxysmal Atrial Fibrillation.","authors":"Mizuki Ochi, Akihiro Sunaga, Hiroyuki Uematsu, Shota Kato, Hirotaka Ooka, Satoshi Kudo, Shin Okamoto, Kiyonori Nanto, Yosuke Hata, Masaya Kusuda, Wataru Ariyasu, Subaru Fujii, Masaharu Masuda","doi":"10.1016/j.jacep.2026.08.022","DOIUrl":"https://doi.org/10.1016/j.jacep.2026.08.022","url":null,"abstract":"<p><strong>Background: </strong>Extensive atrial ablation may impair atrial function; however, its impact on long-term heart failure (HF) risk remains unclear.</p><p><strong>Objectives: </strong>This study sought to evaluate the association between low-voltage area (LVA) ablation and HF outcomes after catheter ablation for paroxysmal atrial fibrillation (AF).</p><p><strong>Methods: </strong>This was a long-term follow-up analysis of the Volatile Coronary Lesion and Obstructive Nodal Atrial Fibrillation trial. A total of 398 patients were followed for up to 7 years and classified into 3 groups: no LVAs (group A), LVAs with LVA ablation (group B), and LVAs without LVA ablation (group C). The primary outcome was HF hospitalization.</p><p><strong>Results: </strong>During a median follow-up of 1,660 (735-2,555) days, HF hospitalization occurred in 21 patients. Sinus rhythm was maintained in 96% of patients, with no differences among groups (P = 0.26). Patients with LVAs had a higher incidence of HF hospitalization than those without (18% vs 3%; P < 0.001). Among patients with LVAs, HF hospitalization occurred more frequently in those undergoing LVA ablation (30% vs 6%; P = 0.01). In a competing-risk analysis accounting for all-cause death, the cumulative incidence of HF hospitalization remained significantly higher in patients undergoing LVA ablation (Gray's test, P = 0.042). Among patients who experienced HF hospitalization, most events occurred during documented sinus rhythm.</p><p><strong>Conclusions: </strong>Among patients with paroxysmal AF and LVAs, LVA ablation was associated with a higher incidence of HF hospitalization despite a high rate of sinus rhythm maintenance. Given the limited sample size and number of events, these findings should be considered exploratory and hypothesis-generating, and warrant confirmation in larger prospective studies.</p>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149136654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Interelectrode Spacing on Ventricular Tachycardia Substrate Mapping: Insights Into 3-Dimensional Characteristics of the Arrhythmogenic Substrate.","authors":"Yuto Iioka, Yuki Komatsu, Yasutoshi Shinoda, Yuichi Hanaki, Yuka Oda, Yusuke Hayashi, Yoshihiro Harano, Yuki Matsuoka, Kojiro Ogawa, Akira Kimata, Hiro Yamasaki, Miyako Igarashi, Tomoko Ishizu, Akihiko Nogami","doi":"10.1016/j.jacep.2026.08.021","DOIUrl":"https://doi.org/10.1016/j.jacep.2026.08.021","url":null,"abstract":"<p><strong>Background: </strong>Re-entrant ventricular tachycardia (VT) circuits often involve 3-dimensional activation across the endocardium, epicardium, and mid-myocardium, highlighting the importance of comprehensive substrate assessment. Wider interelectrode spacing may incorporate broader-field electrical components that are less apparent on conventional closely spaced recordings.</p><p><strong>Objectives: </strong>This study sought to investigate the electrophysiological impact of interelectrode spacing on substrate mapping and its potential implications for 3-dimensional features of VT substrate.</p><p><strong>Methods: </strong>Sixty-eight high-density substrate maps from 35 patients undergoing catheter ablation for scar-related VT were retrospectively analyzed. Closely spaced (2-mm) and widely spaced (8-mm) bipolar electrograms were simultaneously acquired using a decapolar catheter and used to generate closely and widely spaced bipolar electrode maps (CEM and WEM).</p><p><strong>Results: </strong>Compared with CEM, WEM, which incorporates a greater contribution of far-field components, demonstrated higher bipolar amplitudes, a greater prevalence of multicomponent electrograms, and a lower prevalence of split potentials (all P < 0.01). Lines of block delineated by split potentials on CEM were frequently attenuated or no longer apparent on WEM because the corresponding electrograms appeared fragmented and lacked a distinct split configuration. In an exploratory analysis of 6 VTs with evaluable activation maps, activation gaps were larger with closely than widely spaced bipolar mapping (32.5% vs 20.0%; P = 0.03). In 4 VTs, widely spaced recordings identified diastolic or presystolic far-field potentials not evident with closely spaced recordings.</p><p><strong>Conclusions: </strong>Widely spaced bipolar electrograms may provide complementary functional information beyond that obtained with conventional near-field recordings by incorporating broader-field electrical components, thereby offering additional insight into the potential 3-dimensional characteristics of the arrhythmogenic substrate.</p>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abrupt Wall Thickness Transitions Amid Ischemic Re-Entrant Ventricular Tachycardia.","authors":"Edward J Ciaccio, Nicholas S Peters, Angelo B Biviano","doi":"10.1016/j.jacep.2026.07.032","DOIUrl":"https://doi.org/10.1016/j.jacep.2026.07.032","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149024808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Early Atrial Tachyarrhythmia Within the Blanking Period on Late Recurrence After Pulsed Field Ablation of Atrial Fibrillation.","authors":"Ali Dakik, Jaafar Ismail, Joe Demian, Mohamad Mdaihly, Adele Watfa, Arwa Younis, Walid Saliba, Mina Chung, Hiroshi Nakagawa, Jakub Sroubek, Justin Lee, Mandeep Bhargava, Koji Higuchi, Tyler Taigen, Thomas Callahan, Mohamed Kanj, Pasquale Santangeli, Oussama Wazni, Ayman Hussein","doi":"10.1016/j.jacep.2026.08.024","DOIUrl":"https://doi.org/10.1016/j.jacep.2026.08.024","url":null,"abstract":"<p><strong>Background: </strong>Early atrial tachyarrhythmias (ERAT) occurring during the first 3 months after atrial fibrillation (AF) ablation were not traditionally considered a treatment failure, and this defined the blanking period after thermal energy ablations. More recent data suggest that the blanking period after pulsed field ablation (PFA) is shorter. We hypothesized that the traditional concept of \"blanking period\" does not apply to PFA for AF.</p><p><strong>Objectives: </strong>This study sought to evaluate whether ERAT during the 3 months after PFA for AF predicts late recurrence and whether or not the timing of ERAT affects late recurrences.</p><p><strong>Methods: </strong>All consecutive patients undergoing PFA for AF at our institution (Feb 2024- March 2025) were enrolled in a prospective registry and followed to assess arrhythmia recurrences. ERAT was defined as atrial fibrillation or flutter lasting ≥30 seconds within 90 days. Late arrhythmia recurrences (LRAT) were defined as recurrences after 90 days.</p><p><strong>Results: </strong>Among 1,608 patients followed for 1 year, 334 (20.8%) experienced ERAT and were more likely to experience LRAT than those patients without ERAT (68.4% vs 20.3%, P < 0.001). In multivariable Cox analyses, ERAT was independently associated with LRAT (HR: 4.89; 95% CI: 4.04-5.93; P < 0.001). The risk of LRAT was consistently elevated using 30-day and 60-day ERAT timing cutoffs: ERAT ≤30 vs 31-90 days (LRAT = 70.4% vs 65.5%; P = 0.41; adjusted HR: 5.40 vs 4.34 respectively compared with no ERAT) and ERAT ≤60 vs 61-90 days (LRAT = 68.6% vs 67.1%; P = 0.88; adjusted HR: 4.91 vs 4.83 respectively) compared with no ERAT. In secondary analyses, LRAT rates were similar in ERAT patients with or without cardioversion (73% vs 66.7%, P = 0.29). Interaction testing showed no significant differences in these HRs across ERAT-timing or cardioversion subgroups (all P > 0.05). Moreover, ERAT was associated with a higher need for cardioversion (25.1% vs 7.2%, P < 0.001; HR: 1.49; 95% CI: 1.10-2.02; P = 0.008) and late arrhythmia recurrences compared with patients without ERAT.</p><p><strong>Conclusions: </strong>After PFA for AF, atrial tachyarrhythmias at any time within the first 3 months, regardless of timing or need for cardioversion, strongly predict late recurrence and warrant increased monitoring intensity in the early postablation period.</p>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149136662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Programmed Ventricular Stimulation for Risk Stratification in Nonischemic Cardiomyopathy With Preserved or Mildly Reduced LVEF.","authors":"Piotr Gardziejczyk, Yuichiro Sagawa, Arian Afzalian, Alireza Oraii, Michael Stuckey, Rajat Deo, Sanjay Dixit, Andrew E Epstein, Gustavo S Guandalini, Balaram Krishna J Hanumanthu, Matthew C Hyman, Ramanan Kumareswaran, David Lin, Timothy M Markman, Maiwand Mirwais, Saman Nazarian, Michael P Riley, Robert D Schaller, Vincent See, Poojita Shivamurthy, Gregory E Supple, Cory M Tschabrunn, David J Callans, David S Frankel, Fermin C Garcia, Francis E Marchlinski, Andres Enriquez","doi":"10.1016/j.jacep.2026.08.011","DOIUrl":"10.1016/j.jacep.2026.08.011","url":null,"abstract":"<p><strong>Background: </strong>A substantial proportion of sudden cardiac deaths occur in patients with nonischemic cardiomyopathy (NICM) and left ventricular ejection fraction (LVEF) ≥40% who do not meet current criteria for implantable cardioverter-defibrillator (ICD) implantation.</p><p><strong>Objectives: </strong>This study sought to evaluate programmed ventricular stimulation (PVS) for arrhythmic risk stratification in patients with NICM, cardiac magnetic resonance-confirmed myocardial scar, and LVEF ≥40%.</p><p><strong>Methods: </strong>Consecutive patients with NICM, LVEF ≥40%, late gadolinium enhancement on cardiac magnetic resonance, and frequent premature ventricular complexes (PVCs; >5%) or nonsustained ventricular tachycardia who underwent PVS at a tertiary center (2014-2025) were included. The primary outcome was a major arrhythmic event (MAE): sustained ventricular tachycardia/fibrillation, appropriate ICD therapy, or sudden cardiac death.</p><p><strong>Results: </strong>Among 182 patients (median aged 62 years; 33% women), PVS was positive in 45 (25%). Over a median 3.5-year follow-up, MAE occurred in 13 of 45 PVS-positive (29%) vs 2 of 137 PVS-negative patients (1.5%; P < 0.001), yielding a negative predictive value of 98.5%. Additional MAE predictors included multifocal PVCs/nonsustained ventricular tachycardia (HR: 6.6; 95% CI: 1.8-24.4), family history of sudden cardiac death (HR: 16.7; 95% CI: 4.5-62.3), QRS ≥100 milliseconds (HR: 5.2; 95% CI: 1.4-19.2), and LVEF ≤50% (HR: 4.4; 95% CI: 1.4-13.4; all P < 0.05). A noninvasive risk score incorporating these 4 variables yielded an optimism-corrected C-statistic of 0.892 (95% CI: 0.805-0.957).</p><p><strong>Conclusions: </strong>PVS represents a useful tool for risk stratification of arrhythmic events in patients with NICM, myocardial scar and preserved or mildly reduced LVEF, identifying those who may benefit from primary prevention ICD implant.</p>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149024784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric Catecholaminergic Polymorphic Ventricular Tachycardia: Clinical Characteristics, Genetic Spectrum, and Outcomes in a Multicenter Cohort.","authors":"Merve Maze Aydemir, Mustafa Nalbant, Mehmet Karacan, Ülkü Aydin, Gülhan Tunca Şahin, Aylin Demirel Başgöze, Sertaç Haydin, Murat Akkuş, Murat Hanözü, Mehmet Zeki Günlüoğlu, Recep Şiyar Balik, Hasan Candaş Kafali, Celal Akdeniz, Yakup Ergül, Volkan Tuzcu","doi":"10.1016/j.jacep.2026.08.020","DOIUrl":"https://doi.org/10.1016/j.jacep.2026.08.020","url":null,"abstract":"<p><strong>Background: </strong>Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare inherited arrhythmia with a high risk of life-threatening ventricular arrhythmias in childhood.</p><p><strong>Objectives: </strong>This study sought to characterize pediatric CPVT and evaluate contemporary therapeutic outcomes, including left cardiac sympathetic denervation (LCSD) and bilateral cardiac sympathetic denervation (BCSD).</p><p><strong>Methods: </strong>This retrospective multicenter study included 92 pediatric patients with CPVT from 3 tertiary centers in Türkiye between 2012 and 2025. Arrhythmic events included aborted cardiac arrest, sudden cardiac death, appropriate implantable cardioverter-defibrillator shocks, arrhythmic syncope, and ventricular tachycardia. Paired preprocedural and postprocedural event rates were compared in patients with an adequate preprocedural observation period.</p><p><strong>Results: </strong>Median age at symptom onset was 9.25 years (IQR: 5.88-12.0), and median age at diagnosis was 11.6 years (IQR: 8.64-14.41). Among 87 genetically tested patients, 74 (85.1%) had a pathogenic or likely pathogenic variant; ryanodine receptor 2 and calsequestrin 2 variants were identified in 41 (47.1%) and 24 (27.6%), respectively. Fifty patients underwent sympathetic denervation (LCSD, n = 25; BCSD, n = 25). In the paired cohort (n = 35), median arrhythmic event rate decreased from 3.20 events/year (IQR: 1.74-8.76) before LCSD/BCSD to 0.00 events/year (IQR: 0.00-1.35) during the first 2 postprocedural years (P < 0.001). First 2-year event rates did not differ significantly between procedures. Seven patients died; documented treatment nonadherence was present in all.</p><p><strong>Conclusions: </strong>LCSD/BCSD was associated with a substantial reduction in arrhythmic burden, but observational treatment allocation and center-specific management preclude conclusions regarding comparative effectiveness. Sustained treatment adherence remains essential.</p>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stellate Ganglion Block Reduces the Incidence of Postoperative Atrial Fibrillation After Coronary Artery Bypass Grafting.","authors":"Shunping Tian, Chao Chen, Wei Liang, Jiajia Yin, Wei Zhou, Meng Wang, Shantian Feng, Xun Pu, Zhi Xing, Jianyou Zhang, Zhuan Zhang","doi":"10.1016/j.jacep.2026.07.006","DOIUrl":"https://doi.org/10.1016/j.jacep.2026.07.006","url":null,"abstract":"<p><strong>Background: </strong>Postoperative atrial fibrillation (POAF) is associated with sympathetic overactivity. Stellate ganglion is a potential target for intervention.</p><p><strong>Objectives: </strong>The aim of this study was to examine the efficacy of preemptive left stellate ganglion block (SGB) in reducing POAF in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass.</p><p><strong>Methods: </strong>Patients were randomized to the SGB group or the control group. The primary endpoint was the incidence of POAF within 5 days postoperatively. Secondary endpoints included POAF-associated characteristics and recovery indicators.</p><p><strong>Results: </strong>A total of 124 patients underwent initial randomization, with 108 in modified intention-to-treat and 98 in per-protocol analysis. In modified intention-to-treat analysis, POAF occurred in 18.5% of the SGB group and 44.4% of the control group (OR: 0.288; 95% CI: 0.106-0.731; P = 0.007). Per-protocol analysis yielded consistent results. SGB group showed significantly lower POAF burden, shorter duration of first POAF episode, fewer POAF episodes and antiarrhythmic treatments, decreased C-reactive protein, interleukin-6, high-sensitivity cardiac troponin T, and creatine kinase-MB on certain postoperative time points, and decreased postoperative hospitalization than the control group (all P < 0.05). Exploratory subgroup analyses suggested that the association between SGB pretreatment and lower POAF incidence was more pronounced among patients without diabetes (OR: 0.10; 95% CI: 0.019-0.480; P = 0.004) and those at lower baseline risk of POAF (OR: 0.10; 95% CI: 0.005-0.642; P = 0.040).</p><p><strong>Conclusions: </strong>In patients undergoing coronary artery bypass grafting with cardiopulmonary bypass, preemptive left SGB was associated with a reduced incidence of POAF within 5 postoperative days. Exploratory subgroup analyses suggested a potentially greater association among patients without diabetes and those at lower risk of POAF.</p>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149038639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative Signal Processing to Distinguish Juvenile Anterior T-Wave Inversion From ARVC-Related T-Wave Inversion.","authors":"Mark Abela, Nicolai Spicher, Philip Hempel, Sebastian Schmale Ing, Ardan M Saguner, Victor Schweiger, Firat Duru, Corinna Brunckhorst, Aaron Baggish, David Niederseer","doi":"10.1016/j.jacep.2026.08.018","DOIUrl":"https://doi.org/10.1016/j.jacep.2026.08.018","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149008272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}