JACC. Clinical electrophysiology最新文献

{"title":"The Reappraisal of Neuropeptide Y as Biomarker and Therapeutic Target in Arrhythmic Disorders","authors":"Tania Zaglia PhD , Olujimi A. Ajijola MD, PhD","doi":"10.1016/j.jacep.2025.01.012","DOIUrl":"10.1016/j.jacep.2025.01.012","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 4","pages":"Pages 664-666"},"PeriodicalIF":8.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and Clinical Management of Supraventricular Arrhythmias in Patients With Catecholaminergic Polymorphic Ventricular Tachycardia","authors":"Brett C. Austin MD ,&nbsp;Gurukripa N. Kowlgi MBBS ,&nbsp;Raquel Almeida Lopes Neves MD ,&nbsp;Konstantinos C. Siontis MD ,&nbsp;J. Martijn Bos MD, PhD ,&nbsp;John R. Giudicessi MD, PhD ,&nbsp;Michael J. Ackerman MD, PhD","doi":"10.1016/j.jacep.2024.11.018","DOIUrl":"10.1016/j.jacep.2024.11.018","url":null,"abstract":"<div><h3>Background</h3><div>Smaller studies suggest supraventricular arrhythmias (SVAs) are common in patients with catecholaminergic polymorphic ventricular tachycardia (CPVT).</div></div><div><h3>Objectives</h3><div>This study aimed to determine the incidence, type, and clinical management of SVAs observed within a large, single-center cohort of CPVT cases.</div></div><div><h3>Methods</h3><div>The electronic medical records of 206 patients (51% female; average age at diagnosis 21 ± 17 years) diagnosed clinically with CPVT between January 2000 and September 2023 were reviewed for electrocardiographic evidence of SVAs, including atrial fibrillation (AF), atrial flutter (AFL), atrial tachycardia (AT), and supraventricular tachycardia. SVAs were considered clinically significant when sustained for &gt;30 seconds, with or without symptoms, ultimately necessitating clinical evaluation. SVA type, symptoms, and therapeutic efficacy were assessed.</div></div><div><h3>Results</h3><div>Overall, 17 (8.3%) of 206 patients had evidence of an SVA (AF/AFL in 8, AT in 9, and supraventricular tachycardia in 1 [1 patient experienced both AT and AF/AFL]). The median age at SVA diagnosis was 28 years (Q1-Q3: 16-34 years). A total of 11 (65%) of 17 patients were symptomatic, 3 (27%) of whom experienced inappropriate shocks. All patients were trialed on antiarrhythmics. Owing to drug failure, intolerance, or patient/provider preference; 5 (29%) of 17 patients with SVAs underwent radiofrequency ablation. Notably, over a median follow-up duration of 11 months (Q1-Q3: 5-45 months), 1 SVA recurrence was observed in a patient treated medically.</div></div><div><h3>Conclusions</h3><div>In comparison with prior studies, the incidence of SVAs in this large, single-center CPVT cohort was substantially lower (8.3% vs 26%-35%). Although a larger multicenter study is needed to confirm, this study suggests that radiofrequency ablation durably treats CPVT-associated SVAs.</div></div>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 4","pages":"Pages 792-800"},"PeriodicalIF":8.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical Ablation of Atrial Fibrillation and the Fine Balancing Act of Neuromodulation in Cardiology","authors":"Robert Lemery MD, MA","doi":"10.1016/j.jacep.2025.01.008","DOIUrl":"10.1016/j.jacep.2025.01.008","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 4","pages":"Pages 789-791"},"PeriodicalIF":8.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"JACC: Clinical Electrophysiology 2024 Young Author Achievement Award Winner","authors":"Kalyanam Shivkumar MD, PhD (Editor-in-Chief, JACC: Clinical Electrophysiology)","doi":"10.1016/j.jacep.2025.02.002","DOIUrl":"10.1016/j.jacep.2025.02.002","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 4","pages":"Pages 873-874"},"PeriodicalIF":8.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postablation Arrhythmogenic Channels Predict Atrial Fibrillation Recurrence","authors":"Mariona Regany-Closa MSc ,&nbsp;Josep Pomes MSc ,&nbsp;Elena Arbelo MD, PhD ,&nbsp;Jean-Baptiste Guichard MD, PhD ,&nbsp;Andreu Porta-Sanchez MD, PhD ,&nbsp;Eduard Guasch MD, PhD ,&nbsp;Josep Brugada MD, PhD ,&nbsp;Ivo Roca-Luque MD, PhD ,&nbsp;Lluís Mont MD, PhD ,&nbsp;Till F. Althoff MD","doi":"10.1016/j.jacep.2024.12.006","DOIUrl":"10.1016/j.jacep.2024.12.006","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 4","pages":"Pages 823-826"},"PeriodicalIF":8.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Results of ICE-Guided Isolation of the Superior Vena Cava With Pulsed Field Ablation","authors":"Nicola Pierucci MD ,&nbsp;Vincenzo Mirco La Fazia MD ,&nbsp;Sanghamitra Mohanty MD ,&nbsp;Marco Schiavone MD ,&nbsp;Brandon Doty MD ,&nbsp;Kirollos Gabrah DO ,&nbsp;Domenico G. Della Rocca MD ,&nbsp;J. David Burkhardt MD ,&nbsp;Amin Al-Ahmad MD ,&nbsp;Luigi Di Biase MD ,&nbsp;Michela Casella MD, PhD ,&nbsp;Antonio Dello Russo MD, PhD ,&nbsp;Devi Nair MD ,&nbsp;Moussa Mansour MD ,&nbsp;Claudio Tondo MD, PhD ,&nbsp;Andrea Natale MD","doi":"10.1016/j.jacep.2024.11.009","DOIUrl":"10.1016/j.jacep.2024.11.009","url":null,"abstract":"<div><h3>Background</h3><div>Earlier studies have documented the risk for sinoatrial node injury and phrenic nerve paralysis as complications following radiofrequency catheter ablation for electrical isolation of the superior vena cava (SVCI).</div></div><div><h3>Objectives</h3><div>The aim of this study was to assess the safety and feasibility of SVCI in patients with atrial fibrillation undergoing pulsed field ablation (PFA)</div></div><div><h3>Methods</h3><div>A total of 1,600 consecutive patients undergoing PFA for pulmonary vein isolation plus SVCI were included in this multicenter analysis. Superior vena cava (SVC) ablation was performed under the continuous guidance of intracardiac echocardiography. The PFA catheter was placed at the junction between the SVC and the right atrium at the level of the lower border of the pulmonary artery. A total of 4 applications were given to achieve complete electrical isolation of the SVC. Sinus node injury and phrenic nerve stunning were checked during the procedure, before discharge, and at 2-month follow-up.</div></div><div><h3>Results</h3><div>A total of 616 patients receiving SVCI were included in the analysis. Acute SVCI was achieved in all 616 patients (100%). In the flower configuration used in the first 10 patients, 2 transient sinus node injuries and 2 episodes of phrenic nerve stunning were observed, which resolved spontaneously during the procedure. In the remaining patients, the basket configuration was used; only 1 episode of phrenic nerve stunning was registered, which regressed before the end of the procedure. No permanent damages were registered at discharge and at 2-month follow-up.</div></div><div><h3>Conclusions</h3><div>Intracardiac echocardiography–guided PFA can effectively isolate the SVC with a good safety profile.</div></div>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 4","pages":"Pages 752-760"},"PeriodicalIF":8.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arrhythmogenic Potential of Heterozygous TECRL Variants in Type 3 Catecholaminergic Polymorphic Ventricular Tachycardia","authors":"Alessandra Pia Porretta MD, PhD ,&nbsp;Mathieu Le Bloa MD ,&nbsp;Zahurul Alam Bhuiyan MD, PhD ,&nbsp;Nicole Sekarski MD ,&nbsp;Isis Atallah MD ,&nbsp;Cédric Le Caignec MD, PhD ,&nbsp;Fabrice Extramiana MD, PhD ,&nbsp;Etienne Pruvot MD","doi":"10.1016/j.jacep.2024.12.015","DOIUrl":"10.1016/j.jacep.2024.12.015","url":null,"abstract":"<div><div><em>TECRL</em> is the causative gene of an autosomal-recessive form of catecholaminergic polymorphic ventricular tachycardia (CPVT), the so-called type 3 CPVT. However, only 17 families have been reported worldwide and no case of symptomatic heterozygous carriers has been described. We report herein genotypes and clinical phenotypes of a family of European ancestry harboring a new <em>TECRL</em> pathogenic variant and, for the first time, a CPVT-like phenotype in a <em>TECRL</em> heterozygous variant carrier. Due to this novel evidence, clinicians should be aware that <em>TECRL</em> heterozygous variant carriers should undergo cardiac assessment and therapy introduction in case of a CPVT clinical diagnosis.</div></div>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 4","pages":"Pages 818-822"},"PeriodicalIF":8.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143407814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking Conduction Velocity in Electroanatomical Mapping","authors":"Elad Anter MD","doi":"10.1016/j.jacep.2024.12.026","DOIUrl":"10.1016/j.jacep.2024.12.026","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 4","pages":"Pages 706-707"},"PeriodicalIF":8.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complexities of Atrial Fibrosis Imaging","authors":"Benjamin Wilk PhD ,&nbsp;Heeseung Lim PhD ,&nbsp;Justin Hicks PhD ,&nbsp;Rebecca Sullivan PhD ,&nbsp;Jonathan D. Thiessen PhD ,&nbsp;Michael Kovacs PhD ,&nbsp;Jane Sykes RVT ,&nbsp;Heather Biernaski BSc ,&nbsp;Stephen Duffett MD ,&nbsp;Frank S. Prato PhD ,&nbsp;Allan Skanes MD","doi":"10.1016/j.jacep.2025.02.012","DOIUrl":"10.1016/j.jacep.2025.02.012","url":null,"abstract":"<div><h3>Background</h3><div>Atrial fibrillation is associated with abnormal synchronization of left atrial electrical activity and substantially increased risk of myocardial infarction, stroke and heart failure.</div></div><div><h3>Objectives</h3><div>This study sought to investigate, in a canine model of atrial fibrosis, the relationship between left atrial sympathetic innervation (by ¹¹C-hydroxyephedrine positron emission tomography [PET]), extracellular volume (by magnetic resonance imaging [MRI]) and endocardial voltage (by voltage mapping), measured in vivo with the extent of left atrial (LA) tissue fibrosis measured post mortem with histology.</div></div><div><h3>Methods</h3><div>A total of 9 adult female canines were imaged with hybrid PET/MRI. The animals were then implanted with a dual chamber pacemaker, and 1 week later, 6 animals were paced at 220 to 240 beats/min for 5 weeks, whereas the other 3 had sham surgeries. After another week, the animals were again imaged with PET/MRI and had voltage maps taken. The animals were then euthanized, hearts were excised, and the extent and location of LA fibrosis was determined using Masson’s trichrome stain.</div></div><div><h3>Results</h3><div>End-diastolic volume and end-systolic volume increased, sympathetic innervation (measured with PET) increased in the left ventricle and LA, interstitial fibrosis increased in the LA, and extracellular volume increased in the LV. There was no significant correlation of the extent of interstitial fibrosis with bipolar voltage, MRI, or fractional uptake rate. A weak, but significant, negative correlation was found between interstitial fibrosis and unipolar voltage. Delayed enhancement failed to detect LA interstitial fibrosis.</div></div><div><h3>Conclusions</h3><div>Mild-to-moderate LA interstitial fibrosis may be present before affecting LA voltage maps. PET may be promising for detecting early atrial fibrillation.</div></div>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 4","pages":"Pages 735-748"},"PeriodicalIF":8.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the Latest ESC, ACC/AHA/ACCP/HRS, and CCS Guidelines on the Management of Atrial Fibrillation","authors":"Julian Wolfes MD,&nbsp;Christian Ellermann MD,&nbsp;Gerrit Frommeyer MD,&nbsp;Lars Eckardt MD","doi":"10.1016/j.jacep.2024.12.018","DOIUrl":"10.1016/j.jacep.2024.12.018","url":null,"abstract":"<div><div>The introduction of evidence-based and structured guidelines has undoubtedly improved the care of cardiologic patients and in many cases simplified decision-making for the treatment team. The European Society of Cardiology in collaboration with the European Association for Cardio-Thoracic Surgery, the American College of Cardiology, the American Heart Association, the American College of Clinical Pharmacy, and the Heart Rhythm Society, and the Canadian Cardiovascular Society/Canadian Heart Rhythm Society have developed guidelines for the management of patients with atrial fibrillation. Because all 3 guidelines refer to almost the same scientific data, their recommendations are undoubtedly largely in agreement. Nevertheless, there are some interesting differences based on different interpretations of the same study, different publication dates, or differences in local conditions and health care resources. The following article aims at lining out these similarities and differences.</div></div>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 4","pages":"Pages 836-849"},"PeriodicalIF":8.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}