JACC. Clinical electrophysiology最新文献

{"title":"A Peculiar Pattern of Preexcitation.","authors":"Shohei Kataoka, Jakrin Kewcharoen, Henry H Hsia, Eduardo Back Sternick, Edward P Gerstenfeld, Melvin M Scheinman","doi":"10.1016/j.jacep.2025.02.004","DOIUrl":"https://doi.org/10.1016/j.jacep.2025.02.004","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-Associated Perinexal Narrowing Masks Consequences of Sodium Channel Gain of Function in Guinea Pig Hearts.","authors":"Xiaobo Wu, David Ryan King, Gregory S Hoeker, Xiaoping Wan, Isabelle Deschenes, Scott R Johnstone, Robert G Gourdie, Seth H Weinberg, Steven Poelzing","doi":"10.1016/j.jacep.2024.12.027","DOIUrl":"https://doi.org/10.1016/j.jacep.2024.12.027","url":null,"abstract":"<p><strong>Background: </strong>Voltage-gated sodium channel gain of function (Na_vGOF) is associated with an elevated risk for cardiac arrhythmia. Recent studies have demonstrated that Na_vGOF can be exacerbated by widening the sodium channel-rich perinexus next to gap junction plaques. Clinically, the incidence of Na_vGOF-related cardiac events increases with advancing age. However, the impact of aging on perinexal changes and contribution to age-related risk for arrhythmias in Na_vGOF remains unclear.</p><p><strong>Objectives: </strong>The aim of this study was to test the hypothesis that age-related increase in arrhythmogenic risk is associated with perinexal remodeling in a model of Na_vGOF.</p><p><strong>Methods: </strong>Na_vGOF was pharmacologically induced in isolated adult (3 months, n = 17) and aged (15 months, n = 19) guinea pig hearts. Epicardial action potentials were optically mapped, and age-associated perinexal remodeling was measured with transmission electron microscopy.</p><p><strong>Results: </strong>Na_vGOF electrical phenotypes were comparable between adult and aged hearts despite their exacerbation after perinexal widening. The similarity in these phenotypes may be masked by the narrower perinexus with aging. Furthermore, perinexal widening led to a high incidence of arrhythmias in aged Na_vGOF hearts, whereas no arrhythmias were induced in adult Na_vGOF hearts. This increased incidence of arrhythmias in aged Na_vGOF hearts following perinexal widening may be associated with the increased dispersions of epicardial action potential duration and transmural repolarization.</p><p><strong>Conclusions: </strong>Perinexal widening exacerbates arrhythmogenic propensity with age, primarily by heterogeneously increasing action potential duration, whereas perinexal narrowing appears to be adaptive and cardio protective in the context of Na_vGOF.</p>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Junctions Speak in Volumes: The Role of the Intercellular Space in Cardiac Cell-Cell Propagation.","authors":"Mario Delmar, Xianming Lin","doi":"10.1016/j.jacep.2025.01.006","DOIUrl":"https://doi.org/10.1016/j.jacep.2025.01.006","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulsed-Field vs Thermal Catheter Ablation of Atrial Fibrillation in Patients With Hypertrophic Cardiomyopathy.","authors":"Samy Gribissa, Thomas Kueffer, Sven Knecht, Xavier Waintraub, Nicolas Badenco, Philippe Charron, Pauline Pinon, Raphael King, Estelle Gandjbakhch, Guillaume Duthoit, Christian Sticherling, Tobias Reichlin, Mikael Laredo","doi":"10.1016/j.jacep.2025.01.009","DOIUrl":"https://doi.org/10.1016/j.jacep.2025.01.009","url":null,"abstract":"<p><strong>Background: </strong>Pulsed-field ablation (PFA) may be beneficial for the treatment of atrial fibrillation (AF) in patients with hypertrophic cardiomyopathy (HCM).</p><p><strong>Objectives: </strong>The goal of this study was to compare the safety and efficacy of PFA and thermal ablation in patients with HCM and AF.</p><p><strong>Methods: </strong>From 2016 to 2024, patients with HCM undergoing a first AF ablation using PFA or thermal ablation (cryoballoon or radiofrequency) were retrospectively included from 3 French and Swiss centers. Freedom from atrial arrhythmia (AA) recurrence at the 12-month follow-up was assessed.</p><p><strong>Results: </strong>Overall, 109 patients (median age 60 years; 68% male; 43% paroxysmal AF) with HCM underwent PFA (n = 58) or thermal ablation (n = 51) of AF. In addition to pulmonary vein (PV) isolation, extra-PV ablation was performed in 62% of PFA cases and in 18% of thermal cases. PFA was associated with shorter median procedure times than thermal ablation (81 minutes [Q1-Q3: 60-110 minutes] vs 132 minutes [Q1-Q3: 75-190 minutes]; P < 0.0001) and with less postprocedural heart failure (n = 0 vs n = 4; P = 0.03). Freedom from AA recurrence was 57% (95% CI: 46%-67%) after 12 months. PFA was associated with less AA recurrence than thermal ablation (adjusted HR: 0.46; 95% CI: 0.23-0.91; P = 0.03). Extra-PV ablation was associated with more sustained AA recurrence with thermal ablation (HR: 3.07; 95% CI: 1.21-7.82; P = 0.02) but not with PFA (HR: 1.07; 95% CI: 0.35-3.27; P = 0.91).</p><p><strong>Conclusions: </strong>In patients with HCM and AF, PFA seems to be associated with better safety and efficacy outcomes than thermal ablation.</p>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pacemaker Implantation in a Woman With Transcatheter Edge to Edge Repair of Tricuspid Valve.","authors":"Cheng Zheng, Lucia D'Angelo, Shea Michaela James, Jia-Feng Lin","doi":"10.1016/j.jacep.2024.12.010","DOIUrl":"10.1016/j.jacep.2024.12.010","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden of Premature Ventricular Complexes and Risk of Cardiomyopathy: A Cross-Sectional Study.","authors":"Sarah Slaven, Lohit Garg, Rafay Sabzwari, Christopher Barrett, Alexis Tumolo, Lukasz Cerbin, Amneet Sandhu, Matthew Zipse, Wendy Tzou, Michael Rosenberg","doi":"10.1016/j.jacep.2025.01.004","DOIUrl":"https://doi.org/10.1016/j.jacep.2025.01.004","url":null,"abstract":"<p><strong>Background: </strong>The association between premature ventricular complexes (PVCs) and ventricular function has been described in several observational studies, where it has been implied that a higher burden of PVCs plays a causative role in reducing left ventricular ejection fraction (LVEF). To date, however, few studies have examined the association of PVCs and cardiomyopathy on a population level.</p><p><strong>Objectives: </strong>In this treatment-agnostic, cross-sectional study, we examined the association of PVC burden with depressed LVEF.</p><p><strong>Methods: </strong>We performed an analysis of >30,000 ambulatory monitors obtained on patients from April 22, 2017, and February 20, 2023. Subjects with ≥24 hours of monitoring, a PVC burden of ≥5%, and a transthoracic echocardiogram performed within 3 months of monitoring were included. The presence of cardiomyopathy was defined as LVEF <50%. Clinical factors including comorbidities and relevant medications were included and adjusted for.</p><p><strong>Results: </strong>The included sample included a total of 1,451 patients, with age 68.2 ± 14.5 years, female sex in 39.6%. The average PVC burden was 12.4 ± 7.4% (5%-43.4%). Of 746 subjects with a transthoracic echocardiogram, the mean LVEF was 55.6 ± 9.2% (25%-76.8%), with 171 subjects (22.9%) having an LVEF <50%. In both unadjusted and adjusted analyses, we found no significant association between percentage of PVCs and LVEF (P = 0.78), nor with PVC burden and depressed left ventricular function (P = 0.13).</p><p><strong>Conclusions: </strong>In conclusion, we found no evidence that the PVC burden alone is an independent predictor of cardiomyopathy.</p>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143407816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking Conduction Velocity in Electroanatomical Mapping.","authors":"Elad Anter","doi":"10.1016/j.jacep.2024.12.026","DOIUrl":"https://doi.org/10.1016/j.jacep.2024.12.026","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed Endothelialization of Left Atrial Appendage Closure Device","authors":"Akira Kimata MD, PhD,&nbsp;Hiro Yamasaki MD, PhD,&nbsp;Hiroaki Watabe MD, PhD,&nbsp;Tomoko Ishizu MD, PhD","doi":"10.1016/j.jacep.2024.10.016","DOIUrl":"10.1016/j.jacep.2024.10.016","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 2","pages":"Pages 454-457"},"PeriodicalIF":8.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repolarization Mapping in Brugada Syndrome Patients","authors":"Bastiaan J. Boukens ,&nbsp;Andreu Porta-Sánchez","doi":"10.1016/j.jacep.2024.10.036","DOIUrl":"10.1016/j.jacep.2024.10.036","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 2","pages":"Pages 418-419"},"PeriodicalIF":8.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Different Way to Slow Down in Catecholaminergic Polymorphic Ventricular Tachycardia","authors":"Gregory Webster MD, MPH","doi":"10.1016/j.jacep.2024.12.009","DOIUrl":"10.1016/j.jacep.2024.12.009","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"11 2","pages":"Pages 279-281"},"PeriodicalIF":8.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143480058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}