JACC. Clinical electrophysiology最新文献_第2页

Left Bundle Branch Area Pacing With or Without Conduction System Capture in Heart Failure Models 在心衰模型中进行有或无传导系统捕获的左束支区起搏

IF 8 1区医学

JACC. Clinical electrophysiology Pub Date : 2024-10-01 DOI: 10.1016/j.jacep.2024.05.007

{"title":"Left Bundle Branch Area Pacing With or Without Conduction System Capture in Heart Failure Models","authors":"","doi":"10.1016/j.jacep.2024.05.007","DOIUrl":"10.1016/j.jacep.2024.05.007","url":null,"abstract":"<div><h3>Background</h3><div>Left bundle branch area pacing includes left bundle branch pacing (LBBP) and left ventricular septal pacing (LVSP), which is effective in patients with dyssynchronous heart failure (DHF). However, the basic mechanisms are unknown.</div></div><div><h3>Objectives</h3><div>This study aimed to compare LBBP with LVSP and explore potential mechanisms underlying the better clinical outcomes of LBBP.</div></div><div><h3>Methods</h3><div><span>A total of 24 beagles<span> were assigned to the following groups: 1) control group; 2) DHF group, left bundle branch ablation followed by 6 weeks of AOO pacing at 200 ppm; 3) LBBP group, DHF for 3 weeks followed by 3 weeks of DOO pacing at 200 ppm; and 4) LVSP with the same interventions in the LBBP group. Metrics of electrocardiogram, echocardiography, </span></span>hemodynamics, and expression of left ventricular proteins were evaluated.</div></div><div><h3>Results</h3><div>Compared with LVSP, LBBP had better peak strain dispersion (44.67 ± 1.75 ms vs 55.50 ± 4.85 ms; <em>P <</em> 0.001) and hemodynamic effect (dP/dtmax improvement: 27.16% ± 7.79% vs 11.37% ± 4.73%; <em>P <</em> 0.001), whereas no significant differences in cardiac function were shown. The altered expressions of proteins in the lateral wall vs septum in the DHF group were partially reversed by LBBP and LVSP, which was associated with the contraction and adhesion process, separately.</div></div><div><h3>Conclusions</h3><div>The animal study demonstrated that LBBP offered better mechanical synchrony and improved hemodynamics than LVSP, which might be explained by the reversed expression of contraction proteins. These results supported the potential superiority of left bundle branch area pacing with the capture of the conduction system in DHF model.</div></div>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141544830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-Term Safety and Efficacy of Intraoperative Leadless Pacemaker Implantation During Valve Surgery 瓣膜手术期间术中植入无引线起搏器的长期安全性和有效性

IF 8 1区医学

JACC. Clinical electrophysiology Pub Date : 2024-10-01 DOI: 10.1016/j.jacep.2024.06.018

{"title":"Long-Term Safety and Efficacy of Intraoperative Leadless Pacemaker Implantation During Valve Surgery","authors":"","doi":"10.1016/j.jacep.2024.06.018","DOIUrl":"10.1016/j.jacep.2024.06.018","url":null,"abstract":"<div><h3>Background</h3><div>Intraoperative implantation of leadless cardiac pacemakers (LCPs) under direct visualization during cardiac surgery is a novel strategy to provide pacing to patients with an elevated risk of postoperative conduction disorders or with a preexisting pacing indication undergoing valve surgery.</div></div><div><h3>Objectives</h3><div>This study sought to evaluate the long-term safety and efficacy of intraoperative LCP implantation in 100 consecutive patients.</div></div><div><h3>Methods</h3><div>Retrospective single-center cohort study of consecutive patients (n = 100) who underwent intraoperative LCP implantation during valve surgery. Safety and efficacy were assessed at implantation and follow-up visits.</div></div><div><h3>Results</h3><div>A total of 100 patients (age 68 ± 13 years, 47% female) underwent intraoperative LCP implantation. The surgery involved the tricuspid valve in 99 patients (99%), including tricuspid valve repair in 59 (59%) and tricuspid valve replacement in 40 (40%). Most of the patients (78%) underwent multivalve surgery. The indication for LCP implantation was elevated risk of postoperative atrioventricular block in 54% and preexisting bradyarrhythmias in 46%. LCP implantation was successful in all patients. During a median of 10.6 months (IQR: 2.0-22.7 months) of follow-up, no device-related complications occurred. At 12-month follow-up, the pacing thresholds were acceptable (≤2.0 V at 0.24 milliseconds) in 95% of patients.</div></div><div><h3>Conclusions</h3><div>Intraoperative LCP implantation under direct visualization is a safe strategy to provide permanent pacing in patients undergoing valve surgery, with a postoperative electrical performance comparable to percutaneously placed LCPs.</div></div>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141995737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coronary Vasospasm During Pulse-Field Focal Ablation of the Cavotricuspid Isthmus Observed With Intravascular Ultrasound 通过血管内超声观察脉冲场聚焦消融腔静脉峡过程中的冠状动脉血管痉挛

IF 8 1区医学

JACC. Clinical electrophysiology Pub Date : 2024-10-01 DOI: 10.1016/j.jacep.2024.06.032

引用次数: 0

Outcomes of Pacemaker Implantation During Pregnancy 妊娠期植入起搏器的结果

IF 8 1区医学

JACC. Clinical electrophysiology Pub Date : 2024-10-01 DOI: 10.1016/j.jacep.2024.06.033

引用次数: 0

Standard Defibrillator Leads for Left Bundle Branch Area Pacing 用于左束支区起搏的标准除颤器导线：首次使用经验和短期随访。

IF 8 1区医学

JACC. Clinical electrophysiology Pub Date : 2024-10-01 DOI: 10.1016/j.jacep.2024.07.011

引用次数: 0

Rate-Dependent Pacemap Matching in Scar-Related Ventricular Tachycardia 瘢痕相关性室性心动过速的心率依赖性起搏图匹配：TR 融合 "现象的影响。

IF 8 1区医学

JACC. Clinical electrophysiology Pub Date : 2024-10-01 DOI: 10.1016/j.jacep.2024.06.034

{"title":"Rate-Dependent Pacemap Matching in Scar-Related Ventricular Tachycardia","authors":"","doi":"10.1016/j.jacep.2024.06.034","DOIUrl":"10.1016/j.jacep.2024.06.034","url":null,"abstract":"<div><h3>Background</h3><div>The impact of varying rates of pacemapping (PM) rates on QRS morphology and PM score matching in patients with scar-related ventricular tachycardia (VT) has not been systematically assessed.</div></div><div><h3>Objectives</h3><div>In this study, the authors sought to assess the variability in PM score matching at different pacing rates.</div></div><div><h3>Methods</h3><div>During substrate mapping for VT ablation, PM was performed at cycle lengths (CLs) of 600 ms, 500 ms, 400 ms, 300 ms, and VT CL. PM scores were compared for the entire QRS, the first half (H1) of QRS, and the second half (H2) of QRS to examine the influence of the preceding T-wave superimposed into the onset of paced QRS complex (TR fusion).</div></div><div><h3>Results</h3><div>A total of 269 PMs in 40 patients undergoing scar-related VT ablation were systematically analyzed. The PM score improved at rates closer to VT with a median difference of 6% (Q1-Q3: 4%-10%; range: 0%-33%) between the lowest and the highest PM scores at a given site. Greater slurring of the QRS onset was observed at faster-paced CL, corresponding to a superimposition of the preceding T-wave into QRS onset, with significant differences in H1 but not H2 of the QRS complex. At faster PM rates, 32% of overall sites developed pseudo delta wave and 69% of endocardial pacing sites fulfilled epicardial criteria.</div></div><div><h3>Conclusions</h3><div>The rate of pacemapping can significantly alter morphologic score matching, with the most optimal match observed closest to VT CL. The onset of QRS complex morphology is influenced by superimposition of the preceding T-wave at faster rates, resulting in an underrecognized TR fusion phenomenon that may confound epicardial electrocardiographic criteria predicated upon the initial QRS slope and vector.</div></div>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142262302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insights Into Left Bundle Branch Area Pacing: Important Lessons Learned. 左束支区起搏的启示：重要经验

IF 8 1区医学

JACC. Clinical electrophysiology Pub Date : 2024-10-01 DOI: 10.1016/j.jacep.2024.09.014

Kenneth A Ellenbogen, Pranav Mankad

引用次数: 0

Very Late Atrial Arrhythmia Recurrence After Initial Successful AF Ablation 首次成功房颤消融后极晚的房性心律失常复发：连续监测的启示

IF 8 1区医学

JACC. Clinical electrophysiology Pub Date : 2024-10-01 DOI: 10.1016/j.jacep.2024.07.006

引用次数: 0

Successful Implantation of Defibrillator Leads for Left Bundle Branch Pacing 为左束支起搏成功植入除颤器导线

IF 8 1区医学

JACC. Clinical electrophysiology Pub Date : 2024-10-01 DOI: 10.1016/j.jacep.2024.08.011

引用次数: 0

Optimal Threshold and Interpatient Variability in Left Atrial Ablation Scar Assessment by Dark-Blood LGE CMR 通过暗血 LGE CMR 评估左心房消融瘢痕的最佳阈值和患者间变异性

IF 8 1区医学

JACC. Clinical electrophysiology Pub Date : 2024-10-01 DOI: 10.1016/j.jacep.2024.05.017

{"title":"Optimal Threshold and Interpatient Variability in Left Atrial Ablation Scar Assessment by Dark-Blood LGE CMR","authors":"","doi":"10.1016/j.jacep.2024.05.017","DOIUrl":"10.1016/j.jacep.2024.05.017","url":null,"abstract":"<div><h3>Background</h3><div>Dark-blood late gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) has better correlation with bipolar voltage (BiV) to define ablation scar in the left atrium (LA) compared to conventional bright-blood LGE CMR.</div></div><div><h3>Objectives</h3><div>This study sought to determine the optimal signal intensity threshold of dark-blood LGE CMR to identify LA ablation scar.</div></div><div><h3>Methods</h3><div>In 54 patients scheduled for atrial fibrillation ablation, image intensity ratios (IIRs) were derived from preprocedural dark-blood LGE CMR. In 26 patients without previous ablation, the upper limit of normal was derived from the 95th and 98th percentiles of pooled IIR values. In 28 patients with previous atrial fibrillation ablation, BiV was compared with the corresponding IIR. Receiver-operating characteristics analyses were employed to determine the optimal IIR threshold (ie, the point with the smallest distance to the upper left corner of the receiver-operating characteristics) for LA ablation scar (BiV ≤0.15 mV).</div></div><div><h3>Results</h3><div>Upper limit of normal corresponded to IIR values 1.16 and 1.21, yielding low sensitivities of 0.32 and 0.09 to detect LA ablation scar. Receiver-operating characteristics analysis of IIR and BiV comparison achieved a median area under the curve of 0.77. Median optimal IIR threshold for LA ablation scar was 1.09, with an average sensitivity of 0.73, specificity of 0.75, and accuracy of 0.71. Median IIR thresholds of 1.00 and 1.10 corresponded to 80% sensitivity and 80% specificity, respectively. There was considerable interpatient variability: optimal IIR thresholds per patient ranged from 1.01 to 1.22.</div></div><div><h3>Conclusions</h3><div>The optimal IIR threshold to identify LA ablation scar by dark-blood LGE CMR is 1.09. Because of interpatient variability, the investigators recommend using a lower (1.00) and upper (1.10) threshold to prevent over- or underestimation of ablation scar.</div></div>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141603649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0