Hawkins C. Gay MD, MPH, MSAI, Rod S. Passman MD, MSCE
{"title":"AI and Personal Digital Health Tools","authors":"Hawkins C. Gay MD, MPH, MSAI, Rod S. Passman MD, MSCE","doi":"10.1016/j.jacep.2024.09.015","DOIUrl":"10.1016/j.jacep.2024.09.015","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"10 12","pages":"Pages 2655-2657"},"PeriodicalIF":8.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
María Teresa Barrio-Lopez MD, PhD , Carlos Álvarez-Ortega MD, PhD , Carlos Minguito-Carazo MD , Eduardo Franco MD, PhD , Pablo Elpidio García-Granja MD , Óscar Alcalde-Rodríguez MD , Óscar Salvador-Montañés MD , Jaume Francisco-Pascual MD , Rosa Macías-Ruíz MD, PhD , Álvaro Marco Del Castillo MD, PhD , Sebastián Giacoman-Hernández MD , Víctor Expósito-García MD , Eusebio Garcia-Izquierdo MD , Juan Manuel Durán MD , Naiara Calvo-Galiano MD, PhD , José Luis Ibáñez-Criado MD, PhD , Enrique García-Cuenca MD , Sofia Calero MD , Javier Fernandez-Portales MD, PhD , Markus Linhart MD, PhD , Ángel Moya-Mitjáns MD, PhD
{"title":"Predictors of Clinical Success of Cardioneuroablation in Patients With Syncope","authors":"María Teresa Barrio-Lopez MD, PhD , Carlos Álvarez-Ortega MD, PhD , Carlos Minguito-Carazo MD , Eduardo Franco MD, PhD , Pablo Elpidio García-Granja MD , Óscar Alcalde-Rodríguez MD , Óscar Salvador-Montañés MD , Jaume Francisco-Pascual MD , Rosa Macías-Ruíz MD, PhD , Álvaro Marco Del Castillo MD, PhD , Sebastián Giacoman-Hernández MD , Víctor Expósito-García MD , Eusebio Garcia-Izquierdo MD , Juan Manuel Durán MD , Naiara Calvo-Galiano MD, PhD , José Luis Ibáñez-Criado MD, PhD , Enrique García-Cuenca MD , Sofia Calero MD , Javier Fernandez-Portales MD, PhD , Markus Linhart MD, PhD , Ángel Moya-Mitjáns MD, PhD","doi":"10.1016/j.jacep.2024.07.027","DOIUrl":"10.1016/j.jacep.2024.07.027","url":null,"abstract":"<div><h3>Background</h3><div>Cardioneuroablation (CNA) is a promising treatment for syncope.</div></div><div><h3>Objectives</h3><div>This study sought to analyze the success and risk of CNA, and to describe predictive factors of CNA success in patients with syncope.</div></div><div><h3>Methods</h3><div>Seventy-seven consecutive patients with syncope treated with CNA in 22 hospitals and at least 6 months of follow-up were included. Patients with reflex cardioinhibitory, mixed syncope, functional sinus node dysfunction (SND), or functional atrioventricular block were included. The primary endpoint was the recurrence of syncope after the CNA.</div></div><div><h3>Results</h3><div>Mean age was 49.3 ± 13.4 years and 54.5% were women. Five (6.5%) patients presented complications. Three patients presented SND, 1 required a pacemaker. During a median follow-up of 12 months (Q1-Q3: 8-20 months), 26 (33.8%) patients had recurrence of syncope. Women had a significantly higher risk of recurrence compared with men (HR: 3.3; 95% CI: 1.2-8.8; <em>P</em> = 0.016). Patients >50 years of age had a significantly lower risk of recurrence compared with younger patients (HR: 0.3; 95% CI: 0.1-0.9; <em>P</em> = 0.032). The risk of recurrence in mixed syncope was significantly higher than in cardioinhibitory syncope (HR: 4.4; 95% CI: 1.1-17.5; <em>P</em> = 0.033). Syncope recurrence was significantly less frequent in patients treated with general anesthesia or deep sedation compared with conscious sedation (HR: 0.2; 95% CI: 0.1-0.6; <em>P</em> = 0.002). Finally, the number of radiofrequency applications (≤30 or >30) had a significant association with CNA success (HR: 0.4; 95% CI: 0.2-0.9; <em>P</em> = 0.042). These results were adjusted for confounding factors.</div></div><div><h3>Conclusions</h3><div>In this multicenter study, the effectiveness of CNA was less than previously reported. We found a 3.9% risk of SND. Male sex, age >50 years, cardioinhibitory syncope, general anesthesia or deep sedation, and >30 radiofrequency applications could predict success of CNA for syncope.</div></div>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"10 12","pages":"Pages 2711-2724"},"PeriodicalIF":8.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142500589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Richard J. Czosek MD , Shankar Baskar MD , Chad E. Connor MD
{"title":"Emergence of SCAI in Patients With Tetralogy of Fallot","authors":"Richard J. Czosek MD , Shankar Baskar MD , Chad E. Connor MD","doi":"10.1016/j.jacep.2024.09.012","DOIUrl":"10.1016/j.jacep.2024.09.012","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"10 12","pages":"Pages 2625-2627"},"PeriodicalIF":8.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yashasvi Chugh MD, Praveen Ranganath MD, Haojie Wang MD, Purav Mody MD, George Heberton MD, Praveen Rao MD
{"title":"Percutaneous Retrieval of an Embolized Amulet Device From the Aorta Using a Novel Retrieval System","authors":"Yashasvi Chugh MD, Praveen Ranganath MD, Haojie Wang MD, Purav Mody MD, George Heberton MD, Praveen Rao MD","doi":"10.1016/j.jacep.2024.08.007","DOIUrl":"10.1016/j.jacep.2024.08.007","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"10 12","pages":"Pages 2773-2774"},"PeriodicalIF":8.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142371853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Justin Wallet MD , Yoshitaka Kimura MD, PhD , Nico A. Blom MD, PhD , Monique R.M. Jongbloed MD, PhD , Robin A. Bertels MD , Mark. G. Hazekamp MD, PhD , Katja Zeppenfeld MD, PhD
{"title":"Ventricular Tachycardia Substrates in Children and Young Adults With Repaired Tetralogy of Fallot","authors":"Justin Wallet MD , Yoshitaka Kimura MD, PhD , Nico A. Blom MD, PhD , Monique R.M. Jongbloed MD, PhD , Robin A. Bertels MD , Mark. G. Hazekamp MD, PhD , Katja Zeppenfeld MD, PhD","doi":"10.1016/j.jacep.2024.07.016","DOIUrl":"10.1016/j.jacep.2024.07.016","url":null,"abstract":"<div><h3>Background</h3><div>Patients with repaired tetralogy of Fallot (rTOF) have a time-dependent increased risk of ventricular tachycardia (VT). Slow conducting anatomical isthmuses (SCAIs) are the dominant VT substrates in adults with rTOF. It is unknown if they are present at younger age.</div></div><div><h3>Objectives</h3><div>This study aimed to characterize VT substrates in patients with rTOF <30 years of age.</div></div><div><h3>Methods</h3><div>Data of consecutive patients with rTOF aged <30 years who underwent electroanatomical mapping and programmed electrical stimulation between 2005 and 2022 were analyzed.</div></div><div><h3>Results</h3><div>Fifty-five patients were included (median age: 15.8 years, IQR: 13.8-21.8 years; 15 repaired via ventriculotomy; 13 complex TOF variants). Twelve patients had right ventricle-to-pulmonary artery conduits inserted during initial repair or had early pulmonary valve replacement (PVR) (<1 year after repair). Indications for electroanatomical mapping and programmed electrical stimulation were spontaneous VT, before PVR, and risk stratification in 5, 40, and 10 patients, respectively. In 16 patients (29%), SCAI 3 was identified; no other SCAI was present. Monomorphic VT was inducible in 8 and related to SCAI 3 in 7 patients. Identified VT substrates were targeted by ablation. Right ventricle-to-pulmonary artery conduit/early PVR, ventriculotomy, and complex TOF were associated with SCAI 3 in univariable analysis. During a median follow-up of 5.3 years, VT recurred in 2 patients. No patients died.</div></div><div><h3>Conclusions</h3><div>In young patients with rTOF, SCAI 3 is the dominant substrate for VT. Complex TOF and interrelated type and timing of (re-)operation may contribute to the development of SCAI 3 already at a young age.</div></div>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"10 12","pages":"Pages 2613-2624"},"PeriodicalIF":8.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142346840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nikhil Ahluwalia MBBS, MSc , Shohreh Honarbakhsh MBBS, PhD , Rangeena Assadi MBBS , Samuel Martin BSc , Saidi Mohiddin MB, ChB, MD , Perry M. Elliott MBBS, MD , Antonio Creta PhD , Sarah Zeriouh MD , Serge Boveda MD, PhD , Jakub Baran MD , Felicity de Vere BM, BCh , Christopher A. Rinaldi MBBS, MD , Wern Y. Ding MB, ChB , Dhiraj Gupta MBBS, MD , Muram El-Nayir MBBS , Matthew Ginks MBBS, MD , Semi Ozturk MD , Tom Wong MD , Henry Procter MBBS , Stephen P. Page MB, ChB , Ross J. Hunter MBBS, PhD
{"title":"Impact of Catheter Ablation on Atrial Fibrillation Burden and Symptoms in Patients With Hypertrophic Cardiomyopathy","authors":"Nikhil Ahluwalia MBBS, MSc , Shohreh Honarbakhsh MBBS, PhD , Rangeena Assadi MBBS , Samuel Martin BSc , Saidi Mohiddin MB, ChB, MD , Perry M. Elliott MBBS, MD , Antonio Creta PhD , Sarah Zeriouh MD , Serge Boveda MD, PhD , Jakub Baran MD , Felicity de Vere BM, BCh , Christopher A. Rinaldi MBBS, MD , Wern Y. Ding MB, ChB , Dhiraj Gupta MBBS, MD , Muram El-Nayir MBBS , Matthew Ginks MBBS, MD , Semi Ozturk MD , Tom Wong MD , Henry Procter MBBS , Stephen P. Page MB, ChB , Ross J. Hunter MBBS, PhD","doi":"10.1016/j.jacep.2024.08.018","DOIUrl":"10.1016/j.jacep.2024.08.018","url":null,"abstract":"<div><h3>Background</h3><div>Atrial fibrillation (AF) is more common in patients with hypertrophic cardiomyopathy (HCM) and is often highly symptomatic. The impact of catheter ablation (CA) may be under-reported when evaluated by long-term freedom from any atrial arrhythmia.</div></div><div><h3>Objectives</h3><div>This study aims to evaluate whether CA of AF in patients with HCM would significantly reduce AF burden and improve symptoms.</div></div><div><h3>Methods</h3><div>A multicenter registry was established to enroll HCM patients with pre-existing cardiac implantable electronic devices undergoing CA of AF between 2017 and 2021. The first AF recurrence and burden 12 months before and after CA were determined.</div></div><div><h3>Results</h3><div>A total of 81 HCM patients with cardiac implantable electronic devices underwent CA of AF. Patients were followed-up for a minimum of 1-year (35 [Q1-Q3: 23-50] months). AF was paroxysmal in 38 of 81 (46.9%) patients and burden pre-CA was 27.0% (Q1-Q3: 3.0% to 99.0%). A total of 35 (43.2%) patients had AF/atrial tachycardia recurrence within 12 months. AF burden reduced after CA to 0.5% (Q1-Q3 range: 0.0% to 11.1%) (<em>P</em> = 0.001); a 95% CI (13.8% to 100%) relative reduction. European Hearth Rhythm Association class improved by 1.8 ± 1.3 classes (<em>P</em> < 0.001). Of those with AF/atrial tachycardia recurrence, the reduction in AF burden was −33.7% (Q1-Q3: −88.9% to −13.8%) (<em>P</em> < 0.001) and 20 (57.1%) patients reported symptomatic improvement by ≥1 European Hearth Rhythm Association class. AF burden reduction was associated with symptomatic improvement. (r = −0.67; <em>P</em> < 0.001)</div></div><div><h3>Conclusions</h3><div>AF recurrence is common after CA in HCM patients, but this may under-represent the impact of CA in this cohort. CA significantly reduced AF burden and improved symptoms. A comprehensive evaluation of AF burden, symptoms, and hard endpoints is needed to determine the utility of CA in this context.</div></div>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"10 12","pages":"Pages 2690-2700"},"PeriodicalIF":8.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142500586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}