{"title":"Twenty Years at the Crossroads: Is Clinical Cardiac Electrophysiology Science, Procedure, or Both?","authors":"Jeffrey J Goldberger","doi":"10.1016/j.jacep.2026.09.023","DOIUrl":"https://doi.org/10.1016/j.jacep.2026.09.023","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ventricular Tachycardia Ablation in Nonischemic Cardiomyopathy: The Importance of Ring-Like Scar Architecture.","authors":"Robert N Kerley, Usha B Tedrow","doi":"10.1016/j.jacep.2026.08.026","DOIUrl":"https://doi.org/10.1016/j.jacep.2026.08.026","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149193869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michel Haïssaguerre, Karim Benali, Natasja de Groot, Lars Eckardt, John Whitaker, Laurent Roten, Tobias Reichlin, Rafik Tadros, Patrizio Pascale, Olivier Xhaet, Sebastien Knecht, Mattias Duytschaever, Benjamin de Becker, Nawin Ramdat Misier, Benjamin Rath, Mark O'Neill, Jean-Marc Sellal, Christian de Chillou, Pascal Defaye, Peggy Jacon, Raphael Martins, Pierre Groussin, Christophe Leclercq, Dylan Pereira, Laurent Fauchier, Carla Giustetto, Fiorenzo Gaita, Nicolas Lellouche, Kamila Djouadi, Laurence Jesel-Morel, Johannes Steinfurt, Thomas Arentz, Fabrice Extramiana, Elodie Surget, Eloi Marijon, Pedro Adragao, Maria Salomé Carvalho, Paul-Ursmar Milliez, Mikael Laredo, Estelle Gandjbakhch, Roland Tilz, Merwan Wahab, Jacques Mansourati, Claude Kouakam, Francis Bessière, Antoine Delinière, Nawel Babouri, Philippe Chevalier, Alexios Hadjis, Grégoire Massoullié, Romain Eschalier, Florian Finet, Jose Luis Merino, Marcel Martinez Cossiani, Francis E Marchlinski, Alireza Oraii, Helmut Pürerfellner, Philipp Ömer, Prashanthan Sanders, Soundous M'Rabet, Gabriel Laurent, Philippe Maury, Maxime Beneyto, Frank M Bogun, Zoltán Csanádi, Hikmet Yorgun, Julien Barc, Massimo Grimaldi, Paolo Compagnucci, Antonio Dello Russo, Koonlawee Nademanee, Akihiko Nogami, Amir Jadidi, Natascia Cerrato, Hasan Koca, Corentin Chaumont, Antoine Da Costa, Lucas Deville, Julia Isbister, Laurent Macle, Tanner Carbonati, Cinzia Monaco, Josselin Duchateau, Romain Tixier, Nicolas Derval, Thomas Pambrun, Edward Vigmond, Laura Bear, Marc Strik, Pierre Bordachar, Richard Walton, Aude Cathala, Xavier Bouteiller, Aude Farinole, Remi Dubois, Meleze Hocini, Frederic Sacher, Olivier Bernus, Sylvain Ploux
{"title":"Long-Term Outcome Following Idiopathic Ventricular Fibrillation and Potential Emerging Etiologies.","authors":"Michel Haïssaguerre, Karim Benali, Natasja de Groot, Lars Eckardt, John Whitaker, Laurent Roten, Tobias Reichlin, Rafik Tadros, Patrizio Pascale, Olivier Xhaet, Sebastien Knecht, Mattias Duytschaever, Benjamin de Becker, Nawin Ramdat Misier, Benjamin Rath, Mark O'Neill, Jean-Marc Sellal, Christian de Chillou, Pascal Defaye, Peggy Jacon, Raphael Martins, Pierre Groussin, Christophe Leclercq, Dylan Pereira, Laurent Fauchier, Carla Giustetto, Fiorenzo Gaita, Nicolas Lellouche, Kamila Djouadi, Laurence Jesel-Morel, Johannes Steinfurt, Thomas Arentz, Fabrice Extramiana, Elodie Surget, Eloi Marijon, Pedro Adragao, Maria Salomé Carvalho, Paul-Ursmar Milliez, Mikael Laredo, Estelle Gandjbakhch, Roland Tilz, Merwan Wahab, Jacques Mansourati, Claude Kouakam, Francis Bessière, Antoine Delinière, Nawel Babouri, Philippe Chevalier, Alexios Hadjis, Grégoire Massoullié, Romain Eschalier, Florian Finet, Jose Luis Merino, Marcel Martinez Cossiani, Francis E Marchlinski, Alireza Oraii, Helmut Pürerfellner, Philipp Ömer, Prashanthan Sanders, Soundous M'Rabet, Gabriel Laurent, Philippe Maury, Maxime Beneyto, Frank M Bogun, Zoltán Csanádi, Hikmet Yorgun, Julien Barc, Massimo Grimaldi, Paolo Compagnucci, Antonio Dello Russo, Koonlawee Nademanee, Akihiko Nogami, Amir Jadidi, Natascia Cerrato, Hasan Koca, Corentin Chaumont, Antoine Da Costa, Lucas Deville, Julia Isbister, Laurent Macle, Tanner Carbonati, Cinzia Monaco, Josselin Duchateau, Romain Tixier, Nicolas Derval, Thomas Pambrun, Edward Vigmond, Laura Bear, Marc Strik, Pierre Bordachar, Richard Walton, Aude Cathala, Xavier Bouteiller, Aude Farinole, Remi Dubois, Meleze Hocini, Frederic Sacher, Olivier Bernus, Sylvain Ploux","doi":"10.1016/j.jacep.2026.09.028","DOIUrl":"https://doi.org/10.1016/j.jacep.2026.09.028","url":null,"abstract":"<p><strong>Background: </strong>Unexplained cardiac death and cardiac arrest associated with idiopathic ventricular fibrillation (IVF) are heterogeneous pathologies responsible for significant mortality in young people.</p><p><strong>Objectives: </strong>This retrospective multicenter cohort study evaluated the natural history of a large cohort of IVF survivors including recurrence burden, emerging etiologies, and long-term management.</p><p><strong>Methods: </strong>This study included IVF patients from 46 tertiary centers and followed for at least 5 years. Patients over the age of 15 years who had documented ventricular fibrillation and extensive negative investigations supporting the diagnosis of IVF were included. Patients were followed in each center with their outcome being established on data collection from subsequent clinical records, new investigations, genetic results, and implanted defibrillator recordings. Recurrent arrhythmias and mortality were assessed. Diagnoses were graded as definite (direct evidence) or probable (indirect criteria).</p><p><strong>Results: </strong>A total of 825 patients (37% women; age 35.7 ± 12 years) were followed for a median duration of 120 months (Q1-Q3: 78-180 months). Death occurred in 27 patients (3.3%) from cardiac (n = 10; 1.2%), noncardiac (n = 9; 1.1%), and unknown (n = 8; 1%) causes, and few patients (4.5%) developed overt cardiomyopathy. Overall arrhythmia recurrence increased steadily over 2 decades, reaching 52.7% of patients, with a median time to first recurrence of 20 months (Q1-Q3: 5-48 months) and a similar incidence in men and women. Emergent etiologies occurred in 68.8% of the total population, and were associated with new information during recurrences, structural changes, genetic results, and mapping procedures. They included reclassified inherited arrhythmia conditions in 73 (8.8%), focal sources in 272 (33.0%), and definite or probable microstructural myocardial alterations (MiCMs) with normal imaging in 223 (27.0%), while no diagnosis was identified in 257 (31.2%). Compared with MiCM, focal IVF included more women, occurred more frequently at rest/sleep, and was associated with narrow QRS complexes (90.1 ± 12 milliseconds vs 104.8 ± 16 milliseconds; P < 0.001). Quinidine appeared effective in preventing focal IVF (68.3%) whereas beta-blockers appeared effective (49.3%) in MiCM-IVF. Catheter ablation was performed in 181 patients with no recurrence observed in 75.7%.</p><p><strong>Conclusions: </strong>This multicenter long-term cohort study of IVF survivors shows low cardiac mortality, a persistent risk of arrhythmia recurrences over time, and identifies potential emerging etiologies.</p>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149227804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Arrhythmic Risk in Titin Cardiomyopathy: More Than a Question of Phenotype.","authors":"Kishan Padalia, Matteo Dal Ferro, Luisa Mestroni","doi":"10.1016/j.jacep.2026.09.013","DOIUrl":"https://doi.org/10.1016/j.jacep.2026.09.013","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149193850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marco Marino, Vincenzo Mirco La Fazia, Emanuele Chiarazzo, Kamal Isgandarov, Sanghamitra Mohanty, Carola Gianni, Giuseppe Stifano, Luigi Di Biase, Amin Al-Ahmad, Andrea Natale
{"title":"Durability and Safety of Superior Vena Cava Isolation With a Lattice-Tip Pulsed Field Ablation Catheter: Focal Versus Circumferential Lesion Sets.","authors":"Marco Marino, Vincenzo Mirco La Fazia, Emanuele Chiarazzo, Kamal Isgandarov, Sanghamitra Mohanty, Carola Gianni, Giuseppe Stifano, Luigi Di Biase, Amin Al-Ahmad, Andrea Natale","doi":"10.1016/j.jacep.2026.09.011","DOIUrl":"https://doi.org/10.1016/j.jacep.2026.09.011","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149193821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Silencing the Storm Lazarus, Come Forth! We Found the Purkinje Potentials.","authors":"Andre d'Avila, Timothy R Maher","doi":"10.1016/j.jacep.2026.09.016","DOIUrl":"https://doi.org/10.1016/j.jacep.2026.09.016","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149193828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Thousand Lesions Before We Understood.","authors":"Benjamin A Steinberg","doi":"10.1016/j.jacep.2026.09.014","DOIUrl":"https://doi.org/10.1016/j.jacep.2026.09.014","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149193812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Computed Tomography to Assist in Evaluation of Retrievability of Leadless Pacemakers: To the Moon and Back.","authors":"Charles J Love","doi":"10.1016/j.jacep.2026.09.015","DOIUrl":"https://doi.org/10.1016/j.jacep.2026.09.015","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149193818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}