Souvik K Das, Joshua Hawson, Youlin Koh, Michael W Lim, Paolo D'Ambrosio, Sohaib A Virk, Danlu Liang, Troy Watts, Jairo Rodriguez Padilla, Kumaraswamy Nanthakumar, Saurabh Kumar, Michael Wong, Paul B Sparks, Ahmed Al-Kaisey, Bhupesh Pathik, Alex McLellan, Joseph B Morton, Peter M Kistler, Jonathan M Kalman, Geoffrey Lee, Robert D Anderson
{"title":"Left Ventricular Summit Arrhythmias: State-of-the-Art Review of Anatomy, Mapping, and Ablation Strategies.","authors":"Souvik K Das, Joshua Hawson, Youlin Koh, Michael W Lim, Paolo D'Ambrosio, Sohaib A Virk, Danlu Liang, Troy Watts, Jairo Rodriguez Padilla, Kumaraswamy Nanthakumar, Saurabh Kumar, Michael Wong, Paul B Sparks, Ahmed Al-Kaisey, Bhupesh Pathik, Alex McLellan, Joseph B Morton, Peter M Kistler, Jonathan M Kalman, Geoffrey Lee, Robert D Anderson","doi":"10.1016/j.jacep.2024.09.008","DOIUrl":"https://doi.org/10.1016/j.jacep.2024.09.008","url":null,"abstract":"<p><p>The left ventricular summit (LVS) is the most common site of epicardial arrhythmias. Ablation of LVS arrhythmias continue to pose a challenge to the electrophysiologist because of its complex and intimate anatomical location. In this review, we undertake a detailed examination of the intricate anatomy of the LVS alongside a comprehensive synthesis of mapping and ablation strategies used to treat LVS arrhythmias.</p>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
María Teresa Barrio-Lopez, Carlos Álvarez-Ortega, Carlos Minguito-Carazo, Eduardo Franco, Pablo Elpidio García-Granja, Óscar Alcalde-Rodríguez, Óscar Salvador-Montañés, Jaume Francisco-Pascual, Rosa Macías-Ruíz, Álvaro Marco Del Castillo, Sebastián Giacoman-Hernández, Víctor Expósito-García, Eusebio Garcia-Izquierdo, Juan Manuel Durán, Naiara Calvo-Galiano, José Luis Ibáñez-Criado, Enrique García-Cuenca, Sofia Calero, Javier Fernandez-Portales, Markus Linhart, Moises Rodriguez-Mañero, Jesús Daniel Martínez-Alday, Damian Sanchez-Quintana, Jesús Almendral-Garrote, Ángel Moya-Mitjáns
{"title":"Predictors of Clinical Success of Cardioneuroablation in Patients With Syncope: Results of a Multicenter Study.","authors":"María Teresa Barrio-Lopez, Carlos Álvarez-Ortega, Carlos Minguito-Carazo, Eduardo Franco, Pablo Elpidio García-Granja, Óscar Alcalde-Rodríguez, Óscar Salvador-Montañés, Jaume Francisco-Pascual, Rosa Macías-Ruíz, Álvaro Marco Del Castillo, Sebastián Giacoman-Hernández, Víctor Expósito-García, Eusebio Garcia-Izquierdo, Juan Manuel Durán, Naiara Calvo-Galiano, José Luis Ibáñez-Criado, Enrique García-Cuenca, Sofia Calero, Javier Fernandez-Portales, Markus Linhart, Moises Rodriguez-Mañero, Jesús Daniel Martínez-Alday, Damian Sanchez-Quintana, Jesús Almendral-Garrote, Ángel Moya-Mitjáns","doi":"10.1016/j.jacep.2024.07.027","DOIUrl":"https://doi.org/10.1016/j.jacep.2024.07.027","url":null,"abstract":"<p><strong>Background: </strong>Cardioneuroablation (CNA) is a promising treatment for syncope.</p><p><strong>Objectives: </strong>This study sought to analyze the success and risk of CNA ,and to describe predictive factors of CNA success in patients with syncope.</p><p><strong>Methods: </strong>Seventy-seven consecutive patients with syncope treated with CNA in 22 hospitals and at least 6 months of follow-up were included. Patients with reflex cardioinhibitory, mixed syncope, functional sinus node dysfunction (SND), or functional atrioventricular block were included. The primary endpoint was the recurrence of syncope after the CNA.</p><p><strong>Results: </strong>Mean age was 49.3 ± 13.4 years and 54.5% were women. Five (6.5%) patients presented complications. Three patients presented SND, 1 required a pacemaker. During a median follow-up of 12 months (Q1-Q3: 8-20 months), 26 (33.8%) patients had recurrence of syncope. Women had a significantly higher risk of recurrence compared with men (HR: 3.3; 95% CI: 1.2-8.8; P = 0.016). Patients >50 years of age had a significantly lower risk of recurrence compared with younger patients (HR: 0.3; 95% CI: 0.1-0.9; P = 0.032). The risk of recurrence in mixed syncope was significantly higher than in cardioinhibitory syncope (HR: 4.4; 95% CI: 1.1-17.5; P = 0.033). Syncope recurrence was significantly less frequent in patients treated with general anesthesia or deep sedation compared with conscious sedation (HR: 0.2; 95% CI: 0.1-0.6; P = 0.002). Finally, the number of radiofrequency applications (≤30 or >30) had a significant association with CNA success (HR: 0.4; 95% CI: 0.2-0.9; P = 0.042). These results were adjusted for confounding factors.</p><p><strong>Conclusions: </strong>In this multicenter study, the effectiveness of CNA was less than previously reported. We found a 3.9% risk of SND. Male sex, age >50 years, cardioinhibitory syncope, general anesthesia or deep sedation, and >30 radiofrequency applications could predict success of CNA for syncope.</p>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142500589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jason G Andrade, Richard G Bennett, Marc W Deyell, Matthew T Bennett, Jobanjit Phulka, Nathaniel M Hawkins, Tolga Aksu, Thalia S Field, Martin Aguilar, Paul Khairy, Laurent Macle
{"title":"Long-Term Differences in Autonomic Alterations After Cryoballoon vs Radiofrequency Atrial Fibrillation Ablation.","authors":"Jason G Andrade, Richard G Bennett, Marc W Deyell, Matthew T Bennett, Jobanjit Phulka, Nathaniel M Hawkins, Tolga Aksu, Thalia S Field, Martin Aguilar, Paul Khairy, Laurent Macle","doi":"10.1016/j.jacep.2024.09.003","DOIUrl":"https://doi.org/10.1016/j.jacep.2024.09.003","url":null,"abstract":"<p><strong>Background: </strong>The long-term natural history of autonomic alterations following catheter ablation of drug-refractory paroxysmal atrial fibrillation is poorly defined.</p><p><strong>Objectives: </strong>The authors sought to define the long-term impact of thermal catheter ablation on the cardiac autonomic system.</p><p><strong>Methods: </strong>The study included 346 patients with drug-refractory paroxysmal atrial fibrillation undergoing pulmonary vein isolation using thermal ablation energy (radiofrequency or cryoballoon ablation). All patients underwent insertion of a Reveal LINQ implantable cardiac monitor prior to ablation. The implantable cardiac monitor continuously recorded physical activity, heart rate variability (HRV) (measured as the standard deviation of the average normal-to-normal), daytime heart rate, and nighttime heart rate (NHR). Longitudinal autonomic data in the 2-month period prior to the date of ablation were compared with the 3 years following ablation.</p><p><strong>Results: </strong>Following ablation, there was a significant decrease in HRV (10-20 ms; P < 0.0001) and significant increases in daytime heart rate and NHR (10 beats/min [P < 0.0001] and 7 beats/min [P < 0.0001], respectively). Changes in autonomic parameters were greatest in the first 3 months following ablation but remained significantly different from baseline for 36 months following ablation. Greater changes in NHR and HRV were associated with improved freedom from recurrent arrhythmia. The type of thermal ablation energy had no influence on the heart rate and autonomic parameters.</p><p><strong>Conclusions: </strong>Pulmonary vein isolation using thermal ablation energy results in significant sustained changes in the heart rate parameters related to autonomic function. These changes are independent of the ablation technology employed and are associated with procedural success. (Cryoballoon vs Irrigated Radiofrequency Catheter Ablation: Double Short vs Standard Exposure Duration [CIRCA-DOSE]; NCT01913522).</p>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Satoshi Higuchi, Ramkumar Venkateswaran, Sungil Im, Chanhee Lee, Shohei Kataoka, Jeffrey Olgin, Carol Stillson, Dwight Bibby, Theodore Abraham, Nelson B Schiller, Edward P Gerstenfeld
{"title":"Shorter Premature Atrial Complex Coupling Interval Leads to Mechanical Dysfunction, Fibrosis, and AF in Swine.","authors":"Satoshi Higuchi, Ramkumar Venkateswaran, Sungil Im, Chanhee Lee, Shohei Kataoka, Jeffrey Olgin, Carol Stillson, Dwight Bibby, Theodore Abraham, Nelson B Schiller, Edward P Gerstenfeld","doi":"10.1016/j.jacep.2024.09.005","DOIUrl":"https://doi.org/10.1016/j.jacep.2024.09.005","url":null,"abstract":"<p><strong>Background: </strong>We have previously shown that dyssynchronous premature atrial complexes (PACs) from the lateral left atrium (LA) lead to greater atrial mechanical dysfunction, remodeling, and sustained atrial fibrillation (AF) than synchronous PACs from the interatrial septum. However, the impact of PAC coupling interval (CI) on atrial remodeling is unclear.</p><p><strong>Objectives: </strong>This study sought to explore the effect of PAC CI on atrial mechanics and remodeling in the swine model.</p><p><strong>Methods: </strong>A 2-phase in vivo study was conducted. In the phase 1 acute study, 5 swine underwent acute invasive hemodynamics and echocardiography while delivering single-paced atrial extrastimuli with CIs varying from 450 ms to 200 ms. Peak LA longitudinal strain and intra-LA dyssynchrony were assessed with 2-dimensional strain echocardiography while LA and aortic pressure were directly measured. In the phase 2 chronic study, a group exposed to paced bigeminy from the lateral LA for 16 weeks with a short CI of 250 ms (Short-PAC, n = 10) was compared with groups with PACs at a long CI of 400 ms (Long-PAC, n = 5) and a nonpaced control group (CTRL, n = 10). Detailed electrophysiology and echocardiography studies were performed with histologic quantification of LA fibrosis at baseline and prior to sacrifice.</p><p><strong>Results: </strong>Phase 1 revealed that as PAC CI shortened, peak LA strain decreased (P = 0.003) and LA dyssynchrony increased (P < 0.001). Phase 2 showed that after 16 weeks of PACs, the Short-PAC group had greater LA dilation (terminal baseline: 5.9 ± 1.2 cm<sup>2</sup> vs Long-PAC 3.9 ± 0.5 cm<sup>2</sup> vs CTRL 0.9 ± 0.4 cm<sup>2</sup>; P < 0.001) and reduced peak LA strain during sinus rhythm (terminal baseline: -17.3 ± 3.2% vs Long-PAC -12.1 ± 2.1% vs CTRL -0.7 ± 4.2%; P < 0.001). The short-PAC group had a more LA fibrosis (8.6 ± 1.0% vs Long-PAC 6.8 ± 1.0% vs CTRL 4.0 ± 1.5%; P < 0.001) and higher AF inducibility (terminal baseline: 49.3 ± 13.0% vs Long-PAC 29.0 ± 6.4% vs CTRL 2.2 ± 16.2%; P < 0.001) than the other groups.</p><p><strong>Conclusions: </strong>In this swine model, shorter PAC CI led to increased acute atrial mechanical dysfunction and dyssynchrony. Chronically, short-CI PACs led to greater atrial fibrosis and induced AF, suggesting that frequent, short-coupled PACs pose the highest risk for LA myopathy and AF. These insights underscore the importance of understanding the impact of PAC characteristics on atrial remodeling and arrhythmogenesis.</p>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aashish Katapadi, Jalaj Garg, Aditya Mansabdar, Nikhila Chelikam, Fnu Ehteshamuddin, Minar Rane, Devi Nair, James Marcum, Theodore Pope, Peter Park, Christopher Ellis, Rajesh Kabra, Monica Lo, Donita Atkins, Jacqueline Saw, Atman Shah, Dhanunjaya Lakkireddy
{"title":"Pulmonary Artery Injury Following Endocardial Left Atrial Appendage Occlusion: The Known and Unknown.","authors":"Aashish Katapadi, Jalaj Garg, Aditya Mansabdar, Nikhila Chelikam, Fnu Ehteshamuddin, Minar Rane, Devi Nair, James Marcum, Theodore Pope, Peter Park, Christopher Ellis, Rajesh Kabra, Monica Lo, Donita Atkins, Jacqueline Saw, Atman Shah, Dhanunjaya Lakkireddy","doi":"10.1016/j.jacep.2024.08.016","DOIUrl":"https://doi.org/10.1016/j.jacep.2024.08.016","url":null,"abstract":"<p><strong>Background: </strong>Left atrial appendage closure (LAAC) is frequent alternative for stroke prophylaxis in patients for whom oral anticoagulation is contraindicated. Pulmonary artery injury (PAI) is a feared yet rare complication of endocardial LAAC, but its surrounding literature is scarce.</p><p><strong>Objectives: </strong>The aim of the current study was to review prior PAI published reports and the U.S. Food and Drug Administration Manufacturer and User Facility Device Experience (MAUDE) database to understand evidence and mechanisms of PAI after LAAC.</p><p><strong>Methods: </strong>A systematic review was conducted of the literature and MAUDE database for previously reported cases of PAI, and cases were reviewed for patient characteristics and outcomes. In addition, we identify risks and review our strategies to avoid this injury.</p><p><strong>Results: </strong>Thirty-six cases (16 case reports and 20 MAUDE reports) of PAI were found. These patients had a mean age of 73.6 ± 8.2 years with a median CHA<sub>2</sub>DS<sub>2</sub>VASC score of 5 (quartile 1-quartile 3: 3-6). Most commonly, LAAC associated with PAI involved a dual-seal (75%) followed by lobular occlusive devices (19.4%); the device was unspecified in 2.8% of cases. PAI commonly presented postprocedurally, either within the first 24 hours (50%) or beyond (38.9%), with cardiac tamponade (61.1%) or cardiac arrest (19.4%). Overall, 52.8% required surgery with or without antecedent pericardiocentesis, and 16.7% were managed with pericardiocentesis. PAI was associated with a high mortality rate (ie, 33.3%). Unfortunately, no specific cardiac imaging or procedural details to predict PAI were noted in the reports.</p><p><strong>Conclusions: </strong>Presentation of PAI after LAAC can occur immediately following the procedure or be delayed. Thus, the threshold for suspicion, especially with rapid and hemodynamically significant pericardial effusion, after LAAC should be low.</p>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142500590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adam S C Dennis, Michele Orini, Eva Melis Hesselkilde, Arnela Saljic, Benedikt M Linz, Stefan M Sattler, James Williams, Jacob Tfelt-Hansen, Thomas Jespersen, Anthony W C Chow, Pier D Lambiase
{"title":"Impact of Multidirectional Pacing on Activation and Repolarization Parameters to Localize Ischemic Ventricular Tachycardia Circuits.","authors":"Adam S C Dennis, Michele Orini, Eva Melis Hesselkilde, Arnela Saljic, Benedikt M Linz, Stefan M Sattler, James Williams, Jacob Tfelt-Hansen, Thomas Jespersen, Anthony W C Chow, Pier D Lambiase","doi":"10.1016/j.jacep.2024.07.028","DOIUrl":"https://doi.org/10.1016/j.jacep.2024.07.028","url":null,"abstract":"<p><strong>Background: </strong>In ventricular tachycardia (VT), optimal substrate mapping strategies identifying arrhythmogenic sites are not established.</p><p><strong>Objectives: </strong>This study sought to evaluate multidirectional pacing on the distribution of specific conduction and repolarization metrics to localize re-entrant VT sites in a porcine infarct model.</p><p><strong>Methods: </strong>Substrate maps were created in 13 pigs with chronic myocardial infarction using the Advisor HD Grid (Abbott) during right ventricular (RV), left ventricular, biventricular pacing (BIV), and sinus rhythm (SR). Critical VT sites of early-, mid-, and late-diastolic signals were delineated. Vulnerable sites to re-entry were defined as sites of latest activation timing within and post-QRS complex, largest activation and activation-recovery interval gradients. Distances between the 20 most vulnerable sites and diastolic VT points were measured, and identification of VT points was assessed using the area under the receiver-operating characteristic curve.</p><p><strong>Results: </strong>A total of 34 VTs were mapped, and 48 sinus and pacing maps were obtained (10 BIV, 13 left ventricular, 13 RV, 12 SR). Late potential mapping in SR was taken as the established clinical standard for comparison. Latest activation time with BIV pacing provided the closest localization for VT isthmus (median 5.5 mm; IQR: 7.15 mm; P < 0.005). The gradient of activation-recovery interval using RV pacing had closest localization for VT exit and entrance (median 10.6 mm; IQR: 5.0 mm; P < 0.005 and 9.4 mm; IQR: 8.0 mm; P < 0.05). Global sensitivity and specificity analysis showed that gradient of activation-recovery interval in SR achieved the highest area under the receiver-operating characteristic curve, with similar results from the gradient of activation timing.</p><p><strong>Conclusions: </strong>Multidirectional pacing in combination with conduction and repolarization parameters enables better localization of VT diastolic critical sites vs SR late potentials.</p>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142500587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shohei Kataoka, Haran Yogasundaram, Tomer Mann, Byron Lee, Ramanan Kumareswaran, Gregory E Supple, Henry H Hsia, David J Callans, Melvin M Scheinman
{"title":"A Tale of 2 Troubling Tachycardias.","authors":"Shohei Kataoka, Haran Yogasundaram, Tomer Mann, Byron Lee, Ramanan Kumareswaran, Gregory E Supple, Henry H Hsia, David J Callans, Melvin M Scheinman","doi":"10.1016/j.jacep.2024.09.002","DOIUrl":"https://doi.org/10.1016/j.jacep.2024.09.002","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shunsuke Uetake, Kanae Hasegawa, Masaaki Kurata, Giovanni Ernest Davogustto, Tiffany Ying Hu, Kara K Siergrist, Zachary Yoneda, Travis D Richardson, Arvindh N Kanagasundram, William G Stevenson, Harikrishna Tandri
{"title":"Emergent Ablation for Ventricular Tachycardia: Predictors of Prolonged Hospitalization and Mortality.","authors":"Shunsuke Uetake, Kanae Hasegawa, Masaaki Kurata, Giovanni Ernest Davogustto, Tiffany Ying Hu, Kara K Siergrist, Zachary Yoneda, Travis D Richardson, Arvindh N Kanagasundram, William G Stevenson, Harikrishna Tandri","doi":"10.1016/j.jacep.2024.08.017","DOIUrl":"https://doi.org/10.1016/j.jacep.2024.08.017","url":null,"abstract":"<p><strong>Background: </strong>Patients with ventricular tachycardia (VT) frequently present in unstable VT and are subject to urgent/high-risk ablation procedures. Clinical predictors of prolonged hospitalization and mortality are needed for optimal management of these patients.</p><p><strong>Objectives: </strong>This study seeks to identify factors associated with prolonged hospitalization and mortality in emergent unplanned VT ablation procedures.</p><p><strong>Methods: </strong>Fifty consecutive patients hospitalized emergently for VT with structural heart disease who underwent catheter ablation were prospectively followed up for outcomes and complications.</p><p><strong>Results: </strong>Of the 50 patients (mean ± SD age 67.6 ± 12.8 years), 86.0% were male, 62.0% had ischemic cardiomyopathy, and their median left ventricular ejection fraction was 28.5%. Hospital stay <7 days (median 3 days) occurred in 28 (56.0%) patients (Group 1) and >7 days (median 10 days) or death <7 days occurred in 22 (44.0%) patients (Group 2). PAINESD score and left ventricular ejection fraction were similar between the groups. Compared with Group 1, Group 2 had significantly worse NYHA functional class III or higher (25.0% vs 63.6%; P = 0.006), electrical storm (46.4% vs 77.3%; P = 0.027), and prior failed VT ablation (35.7% vs 68.2%; P = 0.023). Multivariable analysis showed that NYHA functional class III or higher and prior failed VT ablation were predictive of prolonged hospital stay. After ablation, compared with Group 1, Group 2 had worse heart failure (10.7% vs 54.5%; P = 0.001), VT recurrences (3.6% vs 68.2%; P < 0.001), and 7 deaths within 30 days.</p><p><strong>Conclusions: </strong>Patients undergoing emergent VT ablation are at high risk for prolonged hospital stay, which is predicted by NYHA functional class III or higher and a prior failed ablation. Early VT recurrences and worsening heart failure contribute to prolonged hospitalization and a high 30-day mortality.</p>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Genetic Testing in Younger Adults With Pacemakers","authors":"","doi":"10.1016/j.jacep.2024.06.008","DOIUrl":"10.1016/j.jacep.2024.06.008","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141788057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}